Dr Bob Lauder

Senior Lecturer

Research Overview

Research in the Lauder Lab falls under two themes, both of which seek to understand the molecular processes underpinning disease;

  1. Structure and Function of Glycosaminoglycans, and,
  2. Bacterial Toxins and Sudden Death.

We are elucidating the structure and function of glycosaminoglycans (GAGs) and the proteoglycans (PGs) to which they are attached because normal age- and abnormal pathology-related changes may represent early markers of damage and disease, especially in osteoarthritis.

We are examining the mechanisms of bacterial toxin production because these toxins may be responsible for previously unexplained deaths, and, production of the toxins can be massively influenced by a range of environmental and systemic factors.

Nasopharyngeal metagenomic deep sequencing data, Lancaster, UK, 2014-2015
Atkinson, K.V., Bishop, L.A., Rhodes, G., Salez, N., McEwan, N.R., Hegarty, M.J., Robey, J., Harding, N., Wetherell, S., Lauder, R.M., Pickup, R.W., Wilkinson, M., Gatherer, D. 24/10/2017 In: Scientific Data. 4, 7 p.
Journal article

Genome Sequence of Human Papillomavirus Type 20, Strain HPV-20/Lancaster/2015
Atkinson, K., Bishop, L.A., Rhodes, G., Salez, N., McEwan, N.R., Hegarty, M.J., Robey, J., Harding, N., Wetherell, S., Lauder, R.M., Pickup, R.W., Wilkinson, M., Gatherer, D. 3/08/2017 In: Genome Announcements. 5, 31, p. e00712-17. 6 p.
Journal article

Genome Sequence of Human Papillomavirus 23 Strain HPV-23/Lancaster/2015
Atkinson, K.V., Bishop, L.A., Rhodes, G., Salez, N., McEwan, N.R., Hegarty, M.J., Robey, J., Harding, N., Wetherell, S., Lauder, R.M., Pickup, R.W., Wilkinson, M., Gatherer, D. 18/05/2017 In: Genome Announcements. 5, 20, 2 p.
Journal article

Influenza C in Lancaster, UK, in the winter of 2014-2015
Atkinson, K.V., Bishop, L.A., Rhodes, G., Salez, N., McEwan, N.R., Hegarty, M.J., Robey, J., Harding, N., Wetherell, S., Lauder, R.M., Pickup, R.W., Wilkinson, M., Gatherer, D. 13/04/2017 In: Scientific Reports. 7, 9 p.
Journal article

Genome sequence of human rhinovirus A22, strain Lancaster/2015
Atkinson, K.V., Bishop, L.A., Rhodes, G., Salez, N., McEwan, N.R., Hegarty, M.J., Robey, J., Harding, N., Wetherell, S., Lauder, R.M., Pickup, R.W., Wilkinson, M., Gatherer, D. 23/03/2017 In: Genome Announcements. 5, 12
Journal article

Bacterial toxins in the urine of patients with rheumatoid arthritis: a cause of the condition or an opportunistic result of it?
Grace, L., Bukhari, M., Lauder, R.M., Bishop, L.A., Taylor, A.M. 04/2016
Meeting abstract

Staphylococcal Toxaemia and Myocardial Infarction
Bull, K.L., Bishop, L., Wilkinson, M., Pasztor, M., Morris, J.A., Lauder, R.M. 03/2016
Meeting abstract

WHO collaborative study to assess the suitability of an interim standard for antibodies to Ebola virus
Dianna, W., Page, M., Almond, N., Anderson, R., Berry, N., Dougall, T., Efstathiou, S., Hassall, M., Mattiuzzo, G., Peter, R., Rose, N., Schepelmann, S., Stone, L., Minor, P.D., Labrosse, B., Leculier, C., Pannetier, D., Strecker, T., Krahling, V., Schnierle, B., Capobianchi, M., Castilletti, C., Gatherer, D., Bishop, L., Hartman, K., Lauder, R., Wright, E., Tedder, R., Samuel, D., Dicks, S., Rudge, T., Simmons, G., Kaplan, G., Khuran, S., Weiss, C.D., Hogrefe, W., Rodriguez, N., Hsu, A., Honko, A.N., Bennett, R.S., Pettitt, J., Janosko, K., Marchand, J., Postnikova, E., Wu, H., Griffiths, A., Hooper, J.W. 1/01/2016 Geneva : World Health Organization
Working paper

Proteoglycan and acidic polysaccharide analysis
Lauder, R.M. 15/09/2015 In: Encyclopedia of Analytical Chemistry. Wiley
Chapter (peer-reviewed)

Development of a technique to identify Staphylococcal Enterotoxin fragments in urine from patients with Rheumatoid Arthritis
Grace, L.E., Bukhari, M.A.S., Lauder, R.M., Taylor, A.M. 20/04/2015
Meeting abstract

Low dose, early mucosal exposure will minimize the risk of microbial disease
Morris, J.A., Harrison, L.M., Lauder, R.M., Telford, D.R., Neary, R. 11/2012 In: Medical Hypotheses. 79, 5, p. 630-634. 5 p.
Journal article

SIDS Implications of Temperature Dependent Toxin Production by Staphylococcus aureus Strains
McConnell, T.J., Bishop, L., Lauder, R.M., Harrison, L., Morris, J. 09/2012
Meeting abstract

Fabrication of carbohydrate surfaces by using non-derivatised oligosaccharides
Popplewell, J., Swann, M., Brown, G., Lauder, B. 1/01/2012 In: Methods in Molecular Biology. 808, p. 221-229. 9 p.
Journal article

Characterisation of oligosaccharides from the chondroitin/dermatan sulphates: 1H and 13C NMR studies of oligosaccharides generated by nitrous acid depolymerisation
Lauder, R.M., Huckerby, T., Nieduszynski, I., Sadler, I.H. 18/10/2011 In: Carbohydrate Research. 346, 14, p. 2222-2227 . 6 p.
Journal article

Lectin affinity chromatography of articular cartilage fibromodulin: some molecules have keratan sulphate chains exclusively capped by α(2-3)-linked sialic acid.
Lauder, R.M., Huckerby, T., Nieduszynski, I. 10/2011 In: Glycoconjugate Journal. 28, 7, p. 453–461. 9 p.
Journal article

Sudden death from infectious disease
Morris, J., Harrison, L., Lauder, R. 1/08/2011 In: Forensic Pathology Reviews. Springer p. 121-144. 24 p. ISBN: 978-1-61779-248-9.
Chapter

The potential for circular dichroism as an additional facile and sensitive method of monitoring low-molecular-weight heparins and heparinoids
Rudd, T.R., Skidmore, M.A., Guimond, S.E., Holman, J., Turnbull, J.E., Lauder, R.M., Fernig, D.G., Yates, E.A. 11/2009 In: Thrombosis and Haemostasis. 102, 5, p. 874-878. 5 p.
Journal article

Chondroitin sulphate: a complex molecule with potential impacts on a wide range of biological systems
Lauder, R.M. 01/2009 In: Complementary Therapies in Medicine. 17, 1, p. 56-62. 7 p.
Journal article

Glycosaminoglycan origin and structure revealed by multivariate analysis of NMR and CD spectra.
Rudd, T.R., Skidmore, M.A., Guimond, S.E., Cosentino, C., Torri, G., Fernig, D.G., Lauder, R.M., Guerrini, M., Yates, E.A. 2009 In: Glycobiology. 19, 1, p. 52-67. 16 p.
Journal article

Staphylococcal pyrogenic toxins in infant urine samples: a possible marker of transient bacteraemia.
Harrison, L.M., Morris, J.A., Lauder, R.M., Telford, D.R. 2009 In: Journal of Clinical Pathology. 62, 8, p. 735-738. 4 p.
Journal article

Sudden infant death syndrome and cardiac arrhythmias.
Morris, J.A., Harrison, L., Brodison, A., Lauder, R. 2009 In: Future Cardiology. 5, 2, p. 201-207. 7 p.
Journal article

POLY 73-NMR analysis of chondroitin sulphates
Huckerby, T.N., Lauder, R.M. 6/04/2008 In: Abstracts of Papers of the American Chemical Society. 235, 1 p.
Special issue

NMR analysis of chondroitin sulphates
Huckerby, T., Lauder, R.M. 2008 In: ACS Polymer Preprints. 49, 1, p. 702-703. 2 p.
Journal article

Practical Skills.
Lauder, R., Lauder, R. 2008 London : Pearson. 564 p. ISBN: 978-1-84658-777-1.
Book

The effect of Staphylococcus aureus carriage in late pregnancy on antibody levels to staphylococcal toxins in cord blood and breast milk.
Harrison, L.M., Morris, J.A., Lauder, R.M., Telford, D.R. 2008 In: FEMS Immunology and Medical Microbiology. 54, 1, p. 137-143. 7 p.
Journal article

Structure and Function of chondroitin / dermatan sulphates.
Lauder, R. 2007 In: Glycobiology. Bloxham : Scion p. 38-48. 11 p. ISBN: 9781904842279 1904842275.
Chapter

Structural domains within chondroitin sulphate / dermatan sulphate glycosaminoglycans.
Lauder, R.M., Ellis, T., Huckerby, T., Morris, H., Burger, F. 2006
Meeting abstract

Characterization of oligosaccharides from the chondroitin/dermatan sulfates. 1H-NMR and 13C-NMR studies of reduced trisaccharides and hexasaccharides.
Huckerby, T.N., Nieduszynski, I.A., Giannopoulos, M., Weeks, S.D., Sadler, I.H., Lauder, R.M. 12/2005 In: FEBS Journal. 272, 24, p. 6276-6286. 11 p.
Journal article

A method for fluorescent HPLC analysis of CS/DS glycosaminoglycans
Ellis, T., Burger, F., Lauder, R. 06/2005 In: International Journal of Experimental Pathology. 86, 3, 1 p.
Special issue

Detection of specific antibodies in cord blood, infant and maternal saliva and breast milk to staphylococcal toxins implicated in sudden infant death syndrome (SIDS)
Harrison, L.M., Morris, J.A., Bishop, L.A., Lauder, R.M., Taylor, C.A.M., Telford, D.R. 1/09/2004 In: FEMS Immunology and Medical Microbiology. 42, 1, p. 94-104. 11 p.
Journal article

A method for fluorescent HPLC analysis of CS/DS glycosaminoglycans
Lauder, R. 12/08/2004 In: International Journal of Experimental Pathology. 85, 4, 1 p.
Special issue

Age-related changes in human meniscal glycosaminoglycans
Blackburn, G., Al-Jafary, M., Huckerby, T., Lauder, R. 08/2004 In: International Journal of Experimental Pathology. 85, 4, 2 p.
Special issue

Recent studies on the chondroitin sulfate/dermatan sulfate polymer systems using NMR spectroscopy.
Huckerby, T.N., Lauder, B., Nieduszynski, I. 03/2003
Meeting abstract

Recent studies on the chondroitin sulfate/dermatan sulfate polymer systems using NMR spectroscopy
Huckerby, T.N., Lauder, R.M., Nieduszynski, I.A. 2003 In: ACS Polymer Preprints. 44, 1, p. 328-329. 2 p.
Journal article

Keratan sulfates : structural investigations using NMR spectroscopy.
Huckerby, T.N., Brown, G.M., Lauder, R.M., Nieduszynski, I.A. 2002 In: NMR Spectroscopy of Polymers in Solution and in the Solid State (Chapter 22). p. 289-297. 9 p.
Chapter (peer-reviewed)

Age-related changes in the sulphation of the chondroitin sulphate linkage region from human articular cartilage aggrecan.
Lauder, R.M., Huckerby, T.N., Brown, G., Bayliss, M.T., Nieduszynski, I.A. 1/09/2001 In: Biochemical Journal. 358, 2, p. 523-528. 6 p.
Journal article

Characterisation of oligosaccharides from the chondroitin sulfates. 1H-NMR and 13C-NMR studies of reduced disaccharides and tetrasaccharides.
Huckerby, T.N., Lauder, R.M., Brown, G.M., Nieduszynski, I.A., Anderson, K., Boocock, J., Sandall, P.L., Weeks, S.D. 03/2001 In: European Journal of Biochemistry. 268, 5, p. 1181-1189. 9 p.
Journal article

Keratan sulfates : structural investigations using NMR spectroscopy.
Huckerby, T.N., Brown, G.M., Lauder, R.M., Nieduszynski, I.A. 2001 In: Abstracts of Papers of the American Chemical Society. 221, 2, p. 396.
Journal article

Keratan sulfates : structural investigations using NMR spectroscopy.
Huckerby, T.N., Brown, G.M., Lauder, R.M., Nieduszynski, I.A. 2001 In: ACS Polymer Preprints. 42, 1, p. 78-79. 2 p.
Journal article

Keratan sulfates from bovine tracheal cartilage. Structural studies of intact polymer chains using 1H and 13C NMR spectroscopy.
Huckerby, T.N., Lauder, R.M. 06/2000 In: European Journal of Biochemistry. 267, 11, p. 3360-3369. 10 p.
Journal article

Plasmodium falciparum: Adhesion of Placental Isolates Modulated by the Sulfation Characteristics of the Glycosaminoglycan Receptor.
Fried, M., Lauder, R.M., Duffy, P.E. 05/2000 In: Experimental Parasitology. 95, 1, p. 75-78. 4 p.
Journal article

Increased incidence of unsulphated and 4-sulphated residues in the chondroitin sulphate linkage region observed by high-pH anion-exchange chromatography.
Lauder, R.M., Huckerby, T.N., Nieduszynski, I.A. 15/04/2000 In: Biochemical Journal. 347, 2, p. 339-348. 10 p.
Journal article

A fingerprinting method for chondroitin/dermatan sulfate and hyaluronan oligosaccharides.
Lauder, R.M., Huckerby, T.N., Nieduszynski, I.A. 04/2000 In: Glycobiology. 10, 4, p. 393-401. 9 p.
Journal article

Analysis of proteoglycans and glycosaminoglycans.
Lauder, R.M. 2000 In: Encyclopedia of analytical chemistry. London : John Wiley p. 860-895. 36 p. Electronic ISBN: 9780470027318.
Chapter

Isolation and identification of an octasaccharide chondroitin sulphate linkage region fragment.
Lauder, R.M., Huckerby, T.N., Nieduszynski, I.A. 1999 In: Carbohydrate Letters. 3, 5, p. 381-388. 8 p.
Journal article

Minimal chondroitin sulfate structures required to support Plasmodium falciparum adhesion
Fried, M., Lauder, R., Duffy, P.E. 11/1998 In: Glycobiology. 8, 11, 1 p.
Special issue

Age-related changes in the structure of the keratan sulphate chains attached to fibromodulin isolated from articular cartilage.
Lauder, R.M., Huckerby, T.N., Nieduszynski, I.A., Plaas, A.H. 1998 In: Biochemical Journal. 330 , p. 753-757. 5 p.
Journal article

Structure determination for octasaccharides derived from the carbohydrate-protein linkage region of chondroitin sulphate chains in the proteoglycan aggrecan from bovine articular cartilage.
Huckerby, T.N., Lauder, R.M., Nieduszynski, I.A. 1998 In: European Journal of Biochemistry. 258, 2, p. 669-676. 8 p.
Journal article

The structure of the keratan sulphate chains attached to fibromodulin from human articular cartilage
Lauder, R.M., Huckerby, T.N., Nieduszynski, I.A. 08/1997 In: Glycoconjugate Journal. 14, 5, p. 651-660. 10 p.
Journal article

The structure of keratan sulphate chains attached to fibromodulin from bovine articular cartilage.
Lauder, R.M., Huckerby, T.N., Nieduszynski, I.A. 1996 In: European Journal of Biochemistry. 242, 2, p. 402-409. 8 p.
Journal article

THE STRUCTURE OF THE KERATAN SULFATE CHAINS ATTACHED TO FIBROMODULIN ISOLATED FROM BOVINE TRACHEAL CARTILAGE - OLIGOSACCHARIDES GENERATED BY KERATANASE-II DIGESTION
LAUDER, R.M., HUCKERBY, T.N., NIEDUSZYNSKI, I.A. 10/1995 In: Glycoconjugate Journal. 12, 5, p. 651-659. 9 p.
Journal article

The structure of the keratan sulphate attached to fibromodulin isolated from bovine tracheal cartilage, Oligosaccharides isolated following keratanase digestion.
Lauder, R.M., Huckerby, T.N., Nieduszynski, I.A. 1/09/1994 In: Biochemical Journal. 302, 2, p. 417-423. 7 p.
Journal article

Isolation and extractability of fibromodulin.
Lauder, R.M., Morris, H.G., Nieduszynski, I.A., Huckerby, T.N. 1994 In: Bone. 15, 1, p. 128-129. 2 p.
Journal article

Structure of the keratan sulphate chains attached to fibromodulin isolated from bovine tracheal cartilage. Oligosaccharides generated by keratanase digestion.
Lauder, R.M., Huckerby, T.N., Nieduszynski, I.A. 1994 In: Biochemical Journal. 302, p. 417-423. 7 p.
Journal article

The structure of keratan sulphate attached to fibromodulin from bovine tracheal cartilage.
Lauder, R.M., Huckerby, T.N., Nieduszynski, I.A. 1994 In: International Journal of Experimental Pathology. 74, p. A9-A10.
Journal article

Types of computer programs.
Lauder, R. 1994 In: School Science Review. 76, p. 124-126. 3 p.
Journal article

13C NMR spectroscopy of keratan sulphates : assignments for the reduced form of a repeat unit tetrasaccharide derived from keratan sulphate by a keratanase digestion and partial assignments for two fucosylated pentasaccharides.
Huckerby, T., Dickerson, J., Tai, G., Lauder, R., Brown, G., Nieduszynski, I. 1993 In: Magnetic Resonance in Chemistry. 31, 4, p. 394-398. 5 p.
Journal article

Unmasking and abolition of mineralising front sudanophilia.
Lauder, R., Beynon, D. 1993 In: Biotechnic and Histochemistry. 68, 3, p. 180-185. 6 p.
Journal article

The effects of catabolic and anabolic cytokines on proteoglycan biosynthesis in young old and osteoarthritic canine cartilage.
Venn, G., Lauder, R., Hardingham, T., Muir, H. 1990 In: Biochemical Society Transactions. 18, p. 973-974. 2 p.
Journal article

Evidence against the existence of acetylated Sudan Black B.
Lauder, R., Beynon, D. 1989 In: Histochemistry. 91, p. 213-216. 4 p.
Journal article

LIPID HISTOCHEMISTRY OF RAT INCISOR DENTIN
LAUDER, R.M., BEYNON, A.D. 04/1987 In: Journal of Dental Research. 66, 4, 1 p.
Special issue

LIPIDS IN IMMATURE ENAMEL MATRIX
LAUDER, R.M., BEYNON, A.D. 04/1986 In: Journal of Dental Research. 65, 4, 1 p.
Special issue