Professor David Allsop

Professor

Research Overview

I am interested in the pathological role of misfolded 'amyloid' proteins in a range of different human diseases, including some important neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, and also Type 2 diabetes.

My research is concerned with the devopment of peptide-based inhibitors of amyloid aggregation as a novel approach to treatment of these diseases, and on the development of new blood-based biomarkers for improved early diagnosis. I am also interested in the interaction between amyloid proteins and redox-active metal ions, and the role that this might play in tissue damage.

My research is supported by the Defying Dementia campaign (http://www.lancaster.ac.uk/defyingdementia/)

Differential diagnosis of Alzheimer’s disease using spectrochemical analysis of blood
Paraskevaidi, M., Morais, C., Lima, K., Snowden, J., Saxon, J., Richardson, A., Jones, M., Mann, D., Allsop, D., Martin-Hirsch, P., Martin, F. 19/09/2017 In: Proceedings of the National Academy of Sciences. 114, 38, p. E7929–E7938. 10 p.
Journal article

α-Synuclein interacts with lipoproteins in plasma
Nouri Emamzadeh, F., Allsop, D. 8/09/2017 In: Journal of Molecular Neuroscience .
Journal article

Quantification of plasma phosphorylated tau to use as a biomarker for brain Alzheimer pathology: pilot case-control studies including patients with Alzheimer’s disease and Down syndrome
Tatebe, H., Kasai, T., Ohmichi, T., Kishi, Y., Kakeya, T., Waragai, M., Kondo, M., Allsop, D., Tokuda, T. 4/09/2017 In: Molecular Neurodegeneration. 12, 63, 11 p.
Journal article

Development of proteolytically stable N-methylated peptide inhibitors of aggregation of the amylin peptide implicated in type 2 diabetes
Obasse, I.C., Taylor, M.N., Fullwood, N.J., Allsop, D. 1/09/2017 In: Interface Focus.
Journal article

Aβ levels in the jugular vein and high molecular weight Aβ oligomer levels in CSF can be used as biomarkers to indicate the anti-amyloid effect of IVIg for Alzheimer's disease
Kasai, T., Kondo, M., Ishii, R., Tanaka, A., Ataka, S., Shimada, H., Tomiyama, T., Mori, H., Taylor, M.N., Allsop, D., Nakagawa, M., Mizuno, T., Tokuda, T. 10/04/2017 In: PLoS ONE. 12, 4
Journal article

Self-Assembly and Anti-Amyloid Cytotoxicity Activity of Amyloid beta Peptide Derivatives
Castelletto, V., Ryumin, P., Cramer, R., Hamley, I., Taylor, M.N., Allsop, D., Reza, M., Ruokolainen, J., Arnold, T., Hermida-Merino, D., Garcia, C., Leal, M., Castaño, E. 8/03/2017 In: Scientific Reports. 7, 12 p.
Journal article

ß-Hairpin mimics containing a piperidine-pyrrolidine scaffold modulate the ß-amyloid aggregation process preserving the monomer species
Pellegrino, S., Tonali, N., Erba, E., Kaffy, J., Taverna, M., Contini, A., Taylor, M.N., Allsop, D., Gelmi, M.L., Ongeri, S. 1/02/2017 In: Chemical Science. 8, 2, p. 1295-1302. 8 p.
Journal article

Retro-inverso peptide inhibitor nanoparticles as potent inhibitors of aggregation of the Alzheimer’s Aβ peptide
Gregori, M., Taylor, M.N., Salvati, E., Re, F., Mancini, S., Balducci, C., Forloni, G., Zambelli, V., Sesana, S., Michael, M., Michail, C., Kolosov, O.V., Tinker-Mill, C.L., Sherer, M., Harris, S., Fullwood, N.J., Masserini, M., Allsop, D. 02/2017 In: Nanomedicine: Nanotechnology, Biology, and Medicine. 13, 2, p. 723-732. 10 p.
Journal article

Development and automation of a novel [18F]Fprosthetic group, 2-[18F]-fluoro-3-pyridinecarboxaldehyde, and its application to an amino(oxy)-functionalised Aβ peptide
Morris, O., Gregory, J., Kadirvel, M., Henderson, F., Blykers, A., McMahon, A., Taylor, M.N., Allsop, D., Allan, S., Grigg, J., Boutin, H., Prenant, C. 10/2016 In: Applied Radiation and Isotopes. 116, p. 120-127. 8 p.
Journal article

Magnetite pollution nanoparticles in the human brain
Maher, B.A., Ahmed, I., Karloukovski, V.V., MacLaren, D., Foulds, P., Allsop, D., Mann, D., Torres-Jardon, R., Calderon-Garciduenas, L. 27/09/2016 In: Proceedings of the National Academy of Sciences. 113, 39, p. 10797-10801. 5 p.
Journal article

Effects of different isoforms of apoE on aggregation of the α- synuclein protein implicated in Parkinson's disease
Nouri Emamzadeh, F., Aojula, H., McHugh, P., Allsop, D. 8/04/2016 In: Neuroscience Letters. 618, p. 146-151. 6 p.
Journal article

Designed glycopeptidomimetics disrupt protein−protein interactions mediating amyloid β‑peptide aggregation and restore neuroblastoma cell viability
Kaffy, J., Brinet, D., Soulier, J., Tonali, N., Fera, K.F., Iacone, Y., Hoffmann, A.R.F., Khemtemourian, L., Crousse, B., Taylor, M.N., Allsop, D., Taverna, M., Lequin, O., Ongeri, S. 10/03/2016 In: Journal of Medicinal Chemistry. 59, 5, p. 2025-2040. 16 p.
Journal article

A preliminary electron microscopic investigation into the interaction between Aβ1-42 peptide and a novel nanoliposome- coupled retro-inverso peptide inhibitor, developed as a potential treatment for Alzheimer's disease
Sherer, M., Fullwood, N.J., Taylor, M., Allsop, D. 1/10/2015 In: Journal of Physics: Conference Series. 644, 1, 4 p.
Journal article

Nanomechanical and nanothermal mapping of initial stages of amyloid fibres formation
Kolosov, O., Tovee, P., Tinker-Mill, C., Allsop, D. 15/09/2014
Abstract

Amyloid β-peptide and Alzheimer's disease
Allsop, D., Mayes, J. 18/08/2014
Literature review

Amyloid-β fibrils in Alzheimer's Disease are not inert when bound to copper ions but can degrade hydrogen peroxide and generate reactive oxygen species
Mayes, J., Tinker-Mill, C., Kolosov, O., Zhang, H., Tabner, B., Allsop, D. 25/04/2014 In: Journal of Biological Chemistry. 289, p. 12052-12062. 11 p.
Journal article

Ultrasonic force microscopy for nanomechanical characterization of early and late-stage amyloid-β peptide aggregation
Tinker-Mill, C., Mayes, J., Allsop, D., Kolosov, O. 6/02/2014 In: Scientific Reports. 4, 7 p.
Journal article

Correlation of Aβ oligomer levels in matched cerebrospinal fluid and serum samples
Kasai, T., Tokuda, T., Taylor, M., Kondo, M., Mann, D.M.A., Foulds, P., Nakagawa, M., Allsop, D. 13/09/2013 In: Neuroscience Letters. 551, p. 17-22. 6 p.
Journal article

A longitudinal study on α-synuclein in blood plasma as a biomarker for Parkinson’s disease
Foulds, P., Diggle, P., Mitchell, J.D., Parker, A., Hasegawa, M., Masuda-Suzukake, M., Mann, D.M.A., Allsop, D. 29/08/2013 In: Scientific Reports. 3, 6 p.
Journal article

A novel retro-inverso peptide inhibitor reduces amyloid deposition, oxidation and inflammation and stimulates neurogenesis in the APPswe/PS1ΔE9 mouse model of Alzheimer's Disease
Parthsarathy, V., McClean, P.L., Hölscher, C., Taylor, M., Tinker, C., Jones, G., Kolosov, O., Salvati, E., Gregori, M., Masserini, M., Allsop, D. 2013 In: PLoS ONE. 8, 1, 11 p.
Journal article

A possible key role for redox-active metal ions and soluble oligomers in neurodegenerative diseases
Tabner, B., Moore, S., Mayes, J., Allsop, D. 2013 In: Brain diseases and metalloproteins. Boca Raton, Fla. : Pan Stanford p. 11-32. 22 p. ISBN: 978-981-4316-01-9. Electronic ISBN: 978-981-4364-07-2.
Chapter

Utilization of a multiple antigenic peptide as a calibration standard in the BAN50 single antibody sandwich ELISA for Aß oligomers
Kasai, T., Tokuda, T., Taylor, M., Nakagawa, M., Allsop, D. 8/06/2012 In: Biochemical and Biophysical Research Communications. 422, 3, p. 375-380. 6 p.
Journal article

Post mortem cerebrospinal fluid α-synuclein levels are raised in multiple system atrophy and distinguish this from the other α-synucleinopathies, Parkinson's disease and Dementia with Lewy bodies
Foulds, P., Yokota, O., Thurston, A., Davidson, Y., Ahmed, Z., Holton, J., Thompson, J.C., Akiyama, H., Arai, T., Hasegawa, M., Gerhard, A., Allsop, D., Mann, D.M.A. 01/2012 In: Neurobiology of Disease. 45, 1, p. 188-195. 8 p.
Journal article

Nanoscale SPM characterisation of nacre aragonite plates and synthetic human amyloid fibres
Grishin, I., Tinker, C., Allsop, D., Robson, A., Kolosov, O. 2012 In: NSTI-Nanotech 2012. Santa Clara, USA : CRC PRESS-TAYLOR & FRANCIS GROUP p. 110-113. 4 p.
Paper

Phosphorylated α-synuclein as a potential biomarker for Parkinson's disease (Editorial)
Foulds, P., Mann, D., Allsop, D. 2012 In: Expert Review of Molecular Diagnostics. 12, 2, 3 p.
Editorial

TDP-43 pathological changes in early onset familial and sporadic Alzheimer's disease, late onset Alzheimer's disease and Down's Syndrome: association with age, hippocampal sclerosis and clinical phenotype
Davidson, Y.S., Raby, S., Foulds, P., Robinson, A., Thompson, J.C., Sikkink, S., Yusuf, I., Amin, H., Duplessis, D., Troakes, C., Al-Sarraj, S., Sloan, C., Esiri, M.M., Prasher, V.P., Allsop, D., Neary, D., Pickering-Brown, S.M., Snowden, J.S., Mann, D.M.A. 12/2011 In: Acta Neuropathologica. 122, 6, p. 703-713. 11 p.
Journal article

Effect of curcumin-associated and lipid ligand-functionalized nanoliposomes on aggregation of the Alzheimer's Aβ peptide
Taylor, M., Moore, S., Mourtas, S., Niarakis, A., Re, F., Zona, C., La Ferla, B., Nicotra, F., Masserini, M., Antimisiaris, S.G., Gregori, M., Allsop, D. 10/2011 In: Nanomedicine: Nanotechnology, Biology, and Medicine. 7, 5, p. 541-550. 10 p.
Journal article

The amylin peptide implicated in type 2 diabetes stimulates copper-mediated carbonyl group and ascorbate radical formation
Masad, A., Tabner, B.J., Mayes, J., Allsop, D. 15/08/2011 In: Free Radical Biology and Medicine. 51, 4, p. 869-875. 7 p.
Journal article

Phosphorylated α-synuclein can be detected in blood plasma and is potentially a useful biomarker for Parkinson's disease
Foulds, P., Mitchell, J.D., Parker, A., Turner, R., Green, G., Diggle, P., Hasegawa, M., Taylor, M., Mann, D., Allsop, D. 2011 In: FASEB Journal. 25, 12, p. 4127-4137. 11 p.
Journal article

Hypothesis: soluble Aβ oligomers in association with redox-active metal ions are the optimal generators of reactive oxygen species in Alzheimer's disease
Tabner, B.J., Mayes, J., Allsop, D. 8/10/2010 In: International Journal of Alzheimer's Disease. 2011, 6 p.
Journal article

Parkinson disease: progress towards a molecular biomarker for Parkinson disease
Foulds, P., Mann, D.M.A., Mitchell, J.D., Allsop, D. 07/2010 In: Nature Reviews Neurology. 6, 7, p. 359-361. 3 p.
Journal article

Development of a proteolytically stable retro-inverso peptide inhibitor of β-amyloid oligomerization as a potential novel treatment for Alzheimer's disease
Taylor, M., Moore, S., Mayes, J., Parkin, E., Beeg, M., Canovi, M., Gobbi, M., Mann, D.M.A., Allsop, D. 2010 In: Biochemistry. 49, 15, p. 3261-3272. 12 p.
Journal article

High-molecular-weight β-amyloid oligomers are elevated in cerebrospinal fluid of Alzheimer patients
Fukumoto, H., Tokuda, T., Kasai, T., Ishigami, N., Hidaka, H., Kondo, M., Allsop, D., Nakagawa, M. 2010 In: FASEB Journal. 24, 8, p. 2716-2726. 11 p.
Journal article

Galantamine inhibits β-amyloid aggregation and cytotoxicity
Matharu, B., Gibson, G., Parsons, R., Huckerby, T.N., Moore, S.A., Cooper, L.J., Millichamp, R., Allsop, D., Austen, B. 15/05/2009 In: Journal of the Neurological Sciences. 280, 1-2, p. 49-58. 10 p.
Journal article

Detection of elevated levels of soluble α-synuclein oligomers in post-mortem brain extracts from patients with dementia with Lewy bodies
Paleologou, K.E., Kragh, C.L., Mann, D.M.A., Salem, S.A., Al-Shami, R., Allsop, D., Hassan, A.H., Jensen, P.H., El-Agnaf, O.M.A. 2009 In: Brain. 132, 4, p. 1093-1101. 9 p.
Journal article

Increased TDP-43 protein in cerebrospinal fluid of patients with amyotrophic lateral sclerosis
Kasai, T., Tokuda, T., Ishigami, N., Sasayama, H., Foulds, P., Mitchell, D.J., Mann, D.M.A., Allsop, D., Nakagawa, M. 2009 In: Acta Neuropathologica. 117, 1, p. 55-62. 8 p.
Journal article

Plasma phosphorylated-TDP-43 protein levels correlate with brain pathology in frontotemporal lobar degeneration
Foulds, P., Davidson, Y., Mishra, M., Hobson, D.J., Humphreys, K.M., Taylor, M., Johnson, N., Weintraub, S., Akiyama, H., Arai, T., Hasegawa, M., Bigio, E.H., Benson, F.E., Allsop, D., Mann, D.M.A. 2009 In: Acta Neuropathologica. 118, 5, p. 647-658. 12 p.
Journal article

Designing peptide inhibitors for oligomerization and toxicity of Alzheimer's β-amyloid peptide
Austen, B.M., Paleologou, K.E., Ali, S.A.E., Qureshi, M.M., Allsop, D., El-Agnaf, O.M.A. 2008 In: Biochemistry. 47, 7, p. 1984-1992. 9 p.
Journal article

Metal-dependent generation of reactive oxygen species from amyloid proteins implicated in neurodegenerative disease
Allsop, D., Mayes, J., Moore, S., Masad, A., Tabner, B.J. 2008 In: Biochemical Society Transactions. 36, 6, p. 1293-1298. 6 p.
Journal article

TDP-43 protein in plasma may index TDP-43 brain pathology in Alzheimer's disease and frontotemporal lobar degeneration
Foulds, P., McAuley, E., Gibbons, L., Davidson, Y., Pickering-Brown, S.M., Neary, D., Snowden, J.S., Allsop, D., Mann, D.M.A. 2008 In: Acta Neuropathologica. 116, 2, p. 141-146. 6 p.
Journal article

An investigation into the lipid-binding properties of α-, β- and γ-synucleins in human brain and cerebrospinal fluid
Salem, S.A., Allsop, D., Mann, D.M.A., Tokuda, T., El-Agnaf, O.M.A. 19/09/2007 In: Experimental Brain Research. 1170, p. 103-111. 9 p.
Journal article

Copper-mediated formation of hydrogen peroxide from the amylin peptide: a novel mechanism for degeneration of islet cells in type-2 diabetes mellitus?
Masad, A., Hayes, L., Tabner, B., Turnbull, S., Cooper, L., Fullwood, N.J., German, M., Kametani, F., El-Agnaf, O.M.A., Allsop, D. 2007 In: FEBS Letters. 581, 18, p. 3489-3493. 5 p.
Journal article

Plasma amyloid-β concentrations in Alzheimer's disease : an alternative hypothesis.
Fullwood, N.J., Hayashi, Y., Allsop, D. 12/2006 In: Lancet Neurology. 5, 12, p. 1000-1001. 2 p.
Journal article

Decreased α-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson’s disease.
Tokuda, T., Salem, S.A., Allsop, D., Mizuno, T., Nakagawa, M., Qureshi, M.M., Locascio, J.J., Schlossmacher, M.G., El-Agnaf, O. 13/10/2006 In: Biochemical and Biophysical Research Communications. 349, 1, p. 162-166. 5 p.
Journal article

Donepezil for severe Alzheimer's disease.
Allsop, D., Martin, F., Moore, S., Fullwood, N.J. 29/07/2006 In: The Lancet. 368, 9533, p. 361-362. 2 p.
Journal article

A spectroscopic study of some of the peptidyl radicals formed following hydroxyl radical attack on β-amyloid and α-synuclein.
Tabner, B.J., Turnbull, S., King, J., Benson, F.E., El-Agnaf, O.M.A., Allsop, D. 07/2006 In: Free Radical Research. 40, 7, p. 731-739. 9 p.
Journal article

Detection of oligomeric forms of α-synuclein protein in human plasma as a potential biomarker for Parkinson’s disease
El-Agnaf, O.M.A., Salem, S.A., Paleologou, K.E., Curran, M.D., Gibson, M.J., Court, J.A., Schlossmacher, M.G., Allsop, D. 2006 In: FASEB Journal. 20, 3, p. 419-425. 7 p.
Journal article

Protein aggregation, metals and oxidative stress in neurodegenerative diseases.
Tabner, B.J., El-Agnaf, O.M.A., German, M.J., Fullwood, N.J., Allsop, D. 11/2005 In: Biochemical Society Transactions. 33, 5, p. 1082-1086. 5 p.
Journal article

Hydrogen peroxide is generated during the very early stages of aggregation of the amyloid peptides implicated in Alzheimer's disease and familial British dementia.
Tabner, B.J., El-Agnaf, O.M.A., Turnbull, S., German, M.J., Paleologou, K.E., Hayashi, Y., Cooper, L.J., Fullwood, N., Allsop, D. 28/10/2005 In: Journal of Biological Chemistry. 280, 43, p. 35789-35792. 4 p.
Journal article

The production of hydrogen peroxide during early-stage protein aggregation: a common pathological mechanism in different neurodegenerative diseases?
Tabner, B., Turnbull, S., Fullwood, N.J., German, M., Allsop, D. 08/2005 In: Biochemical Society Transactions. 33, 4, p. 548-550. 3 p.
Journal article

A strategy for designing inhibitors of α-synuclein aggregation and toxicity as a novel treatment for Parkinson's disease and related disorders.
El-Agnaf, O.M.A., Paleologou, K.E., Greer, B., Abogrein, A.M., King, J., Salem, S.A., Fullwood, N.J., Benson, F.E., Hewitt, R., Ford, K.J., Martin, F., Harriott, P., Cookson, M.R., Allsop, D. 08/2004 In: FASEB Journal. 18, 11, p. 1315-1317. 3 p.
Journal article

Both the D-(+) and L-(-) enantiomers of nicotine inhibit Aβ aggregation and cytotoxicity.
Moore, S.A., Huckerby, T.N., Gibson, G.L., Fullwood, N.J., Turnbull, I., Tabner, B.J., El-Agnaf, O.M.A., Allsop, D. 01/2004 In: Biochemistry. 43, 3, p. 819-826. 8 p.
Journal article

Induction of cellular oxidative stress by the β-amyloid peptide involved in Alzheimer's disease.
Gibson, G.L., Allsop, D., Austen, B.M. 2004 In: Protein and Peptide Letters. 11, 3, p. 257-270. 14 p.
Journal article

α-Synuclein and the pathogenesis of Parkinson’s disease.
Martin, F., Allsop, D., Williamson, S.J.M., Paleologou, K.E., El-Agnaf, O.M.A. 2004 In: Protein and Peptide Letters. 11, 3, p. 229-237. 9 p.
Journal article

Fe(II)-induced DNA damage in α-synuclein-transfected human dopaminergic BE(2)-M17 neuroblastoma cells: detection by the Comet assay.
Martin, F., Williamson, S.J.M., Paleologou, K.E., Hewitt, R., El-Agnaf, O.M.A., Allsop, D. 11/2003 In: Journal of Neurochemistry. 87, 3, p. 620-630. 11 p.
Journal article

α-Synuclein implicated in Parkinson’s disease is present in extracellular biological fluids, including human plasma.
El-Agnaf, O.M.A., Salem, S.A., Paleologou, K.E., Cooper, L.J., Fullwood, N.J., Gibson, M.J., Curran, M.D., Court, J.A., Mann, D.M.A., Ikeda, S., Cookson, M.R., Hardy, J., Allsop, D. 10/2003 In: FASEB Journal. 17, 13, p. 1945-1947. 3 p.
Journal article

Quinacrine acts as an antioxidant and reduces the toxicity of the prion peptide PrP106-126.
Turnbull, S., Tabner, B.J., Brown, D.R., Allsop, D. 15/09/2003 In: NeuroReport. 14, 13, p. 1743-1745. 3 p.
Journal article

Soluble oligomers for the diagnosis of neurodegenerative diseases.
El-Agnaf, O.M.A., Walsh, D.M., Allsop, D. 08/2003 In: Lancet Neurology. 2, 8, p. 461-462. 2 p.
Journal article

Generation of hydrogen peroxide from mutant forms of the prion protein fragment PrP121-231.
Turnbull, S., Tabner, B.J., Brown, D.R., Allsop, D. 1/07/2003 In: Biochemistry. 42, 25, p. 7675-7681. 7 p.
Journal article

Copper-dependent generation of hydrogen peroxide from the toxic prion protein fragment PrP106-126.
Turnbull, S., Tabner, B.J., Brown, D.R., Allsop, D. 23/01/2003 In: Neuroscience Letters. 336, 3, p. 159-162. 4 p.
Journal article

Direct production of reactive oxygen species from aggregating proteins and peptides implicated in the pathogenesis of neurodegenerative diseases.
Tabner, B.J., Turnbull, S., El-Agnaf, O.M.A., Allsop, D. 2003 In: Current Medicinal Chemistry Immunology Endocrine and Metabolic Agents. 3, 4, p. 299-308. 10 p.
Journal article

Formation of hydrogen peroxide and hydroxyl radicals from Aβ and α-synuclein as a possible mechanism of cell death in Alzheimer’s disease and Parkinson’s disease.
Tabner, B.J., Turnbull, S., El-Agnaf, O.M.A., Allsop, D. 1/06/2002 In: Free Radical Biology and Medicine. 32, 11, p. 1076-1083. 8 p.
Journal article

Inherited frontotemporal dementia in 9 British families associated with intronic mutations in the tau gene.
Pickering-Brown, S.M., Richardson, A.M.T., Snowden, J.S., McDonagh, A., Burns, A., Braudie, W., Baker, M., Yen, S., Hardy, J., Hutton, M., Davies, Y., Allsop, D., Craufurd, D., Neary, D., Mann, D.M.A. 04/2002 In: Brain. 125, 4, p. 732-751. 20 p.
Journal article

Fluorescence anisotropy: a method for early detection of Alzheimer β-peptide (Aβ) aggregation.
Allsop, D., Swanson, L., Moore, S., Davies, Y., York, A., El-Agnaf, O.M.A., Soutar, I. 6/07/2001 In: Biochemical and Biophysical Research Communications. 285, 1, p. 58-63. 6 p.
Journal article

New evidence that the Alzheimer β-amyloid peptide does not spontaneously form free radicals: An ESR study using a series of spin-traps.
Turnbull, S., Tabner, B.J., El-Agnaf, O.M.A., Twyman, L.J., Allsop, D. 15/05/2001 In: Free Radical Biology and Medicine. 30, 10, p. 1154-1162. 9 p.
Journal article

α-synuclein implicated in Parkinson’s disease catalyses the formation of hydrogen peroxide in vitro.
Turnbull, S., Tabner, B.J., Moore, S., Davies, Y., El-Agnaf, O.M.A., Allsop, D. 15/05/2001 In: Free Radical Biology and Medicine. 30, 10, p. 1163-1170. 8 p.
Journal article

3-p-toluoyl-2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran and 2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran do not act as surfactants or micelles when inhibiting the aggregation of β-amyloid peptide.
Allsop, D., Gibson, G., Martin, I.K., Moore, S., Turnbull, S., Twyman, L.J. 01/2001 In: Bioorganic and Medicinal Chemistry Letters. 11, 2, p. 255-257. 3 p.
Journal article

Production of reactive oxygen species from aggregating proteins implicated in Alzheimer's disease, Parkinson's disease and other neurodegenerative diseases.
Tabner, B.J., Turnbull, S., El-Agnaf, O.M.A., Allsop, D. 2001 In: Current Topics in Medicinal Chemistry. 1, p. 483-493. 11 p.
Journal article

The biology and molecular neuropathology of β-amyloid protein.
Howlett, D.R., Allsop, D., Karran, E.H. 2001 In: Neurobiology of Alzheimer's disease . Oxford : Oxford University Press p. 75-102. 28 p. ISBN: 0198524595.
Chapter

Pick's disease is associated with mutations in the tau gene.
Pickering-Brown, S., Baker, M., Yen, S., Liu, W., Hasegawa, M., Cairns, N., Lantos, P.L., Rossor, M., Iwatsubo, T., Davies, Y., Allsop, D., Furlong, R., Owen, F., Hardy, J., David Mann, D., Hutton, M. 12/2000 In: Annals of Neurology. 48, 6, p. 589-867. 279 p.
Journal article

Characterisation of peptidyl boronic acid inhibitors of mammalian 20S and 26S proteasomes and their inhibition of proteasomes in cultured cells
Gardner, R.C., Assinder, S.J., Christie, G., Mason, G.G.F., Markwell, R., Wadsworth, H., McLaughlin, M., King, R., Chabot-Fletcher, M.C., Breton, J., Allsop, D., Rivett, A.J. 2000 In: Biochemical Journal. 346, p. 447-454. 8 p.
Journal article

Introduction to Alzheimer's disease.
Allsop, D. 2000 In: Alzheimer's disease : methods and protocols. Totawa, New Jersey : Humana Press p. 1-21. 21 p.
Chapter

Modulation of β-amyloid production and fibrillisation
Allsop, D., Twyman, L., Davies, Y., Moore, S., York, A., Swanson, L., Soutar, I. 2000
Literature review

A short synthesis of the β-amyloid (Aβ) aggregation inhibitor 3-p-toluoyl-2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran.
Twyman, L.J., Allsop, D. 12/1999 In: Tetrahedron Letters. 40, 52, p. 9383-9384. 2 p.
Journal article

Alzheimer's Disease: correlation of the suppression of β-Amyloid peptide secretion from cultured cells with inhibition of the chymotrypsin-like activity of the proteasome
Christie, G., Markwell, R.E., Gray, C.W., Smith, L., Godfrey, F., Mansfield, F., Wadsworth, H., King, R., McLaughlin, M., Cooper, D.G., Ward, R.V., Howlett, D.R., Hartmann, T., Lichtenthaler, S.F., Beyreuther, K., Underwood, J., Gribble, S.K., Cappai, R., Masters, C.L., Tamaoka, A., Gardner,, R.L., Rivett, A.J., Karran, E.H., Allsop, D. 07/1999 In: Journal of Neurochemistry. 73, 1, p. 195-204. 10 p.
Journal article

Biological activity associated with a high molecular weight form of β-amyloid.
Howlett, D.R., Ward, R.V., Bresciani, L., Jennings, K.H., Christie, G., Allsop, D., Gray, C.W., Karran, E.H. 1999 In: Alzheimer's Reports. 2, p. 171-177. 7 p.
Journal article

Characterization of an α-secretase candidate from human brain using a new western blot assay
Evin, G., Reed, G., Tanner, J., Li, Q., Culvenor, J., Fuller, S., Wadsworth, H., Allsop, D., Ward, R., Karran, E., Gray, C., Hartmann, T., Lichtenthaler, S., Weidemann, A., Beyreuther, K., Masters, C. 1999 In: Alzheimer's disease and related disorders. Wiley p. 411-418. 8 p.
Conference contribution

Fibrillogenesis of β-amyloid
Allsop, D., Howlett, D., Christie, G., Karran, E. 08/1998 In: Biochemical Society Transactions. 26, 3, p. 459-463. 5 p.
Journal article

Presenilins: in search of functionality
Karran, E.H., Allsop, D., Christie, G., Davis, J., Gray, C., Mansfield, F., Ward, R.V. 08/1998 In: Biochemical Society Transactions. 26, 3, p. 491-496. 6 p.
Journal article

Distinct sites of intracellular production for Alzheimer's disease Aβ40/42 amyloid peptides
Hartmann, T., Bieger, S.C., Brühl, B., Tienari, P.J., Ida, N., Allsop, D., Roberts, G.W., Masters, C.L., Dotti, C.G., Unsicker, K., Beyreuther, K. 09/1997 In: Nature Medicine. 3, 9, p. 1016-1020. 5 p.
Journal article

Studies on inhibition of β-amyloid formation in APP-751-transfected IMR-32 cells, and SPA4CT-transfected SHSY5Y cells
Allsop, D., Christie, G., Gray, C., Holmes, S., Markwell, R., Owen, D., Smith, L., Wadsworth, H., Ward, R., Hartmann, T., Lichtenthaler, S., Evin, G., Fuller, S., Tanner, J., Masters, C., Beyreuther, K., Roberts, G. 1997 In: Alzheimer's disease. New York : Wiley p. 717-727. 11 p.
Conference contribution

Effect of aluminium on expression and processing of amyloid precursor protein
Neill, D., Leake, A., Hughes, D., Keith, A.B., Taylor, G.A., Allsop, D., Rima, B.K., Morris, C., Candy, J.M., Edwardson, J.A. 15/11/1996 In: Journal of Neuroscience Research. 46, 4, p. 395-403. 9 p.
Journal article

Aggregation and metal-binding properties of mutant forms of the amyloid Aβ peptide of Alzheimer's disease
Clements, A., Allsop, D., Walsh, D.M., Williams, C.H. 02/1996 In: Journal of Neurochemistry. 66, 2, p. 740-747. 8 p.
Journal article

Mechanism of cerebral amyloidosis in Alzheimer's disease
Howlett, D., James, S., Allsop, D., Roberts, G. 1996 In: Neurobiology of Alzheimer's disease. Oxford : BIOS Scientific Publishers p. 46-59. 14 p. ISBN: 1872748147.
Chapter

The immunoreactive profile at the N-terminal region of Aβ1-39/40 but not Aβ1-42 changes with transition from monomer/dimer to further peptide aggregates
Kametani, F., Tanaka, K., Tokuda, T., Allsop, D. 12/12/1995 In: Brain Research. 703, 1-2, p. 237-241. 5 p.
Journal article

Inflammatory mechanisms in Alzheimer's disease
Eikelenboom, P., Zhan, S.S., van Gool, W.A., Allsop, D. 12/1994 In: Trends in Pharmacological Sciences. 15, 12, p. 447-450. 4 p.
Journal article

Gerstmann-Sträussler-Scheinker disease showing β-protein type cerebellar and cerebral amyloid angiopathy
Ikeda, S.I., Yanagisawa, N., Allsop, D., Glenner, G.G. 09/1994 In: Acta Neuropathologica. 88, 3, p. 262-266. 5 p.
Journal article

Aggregation of Alzheimer's peptides
Clements, A., Walsh, D.M., Williams, C.H., Allsop, D. 1994 In: Biochemical Society Transactions. 22, 1, p. 16S. 1 p.
Journal article

Amyloidosis in Alzheimer's disease
Allsop, D., Williams, C.H. 1994 In: Biochemical Society Transactions. 22, 1, p. 171-175. 5 p.
Journal article

An investigation into the proteolytic cleavage of Alzheimer amyloid precursor protein in PC-12 cells
Walsh, D.M., Williams, C.H., Kennedy, H.E., Allsop, D. 1994 In: Biochemical Society Transactions. 22, 1, p. 14S. 1 p.
Journal article

Gelatinase A not α-secretase?
Walsh, D.M., Williams, C.H., Kennedy, H.E., Allsop, D., Murphy, G. 1994 In: Nature. 367, 6458, p. 27-28. 2 p.
Journal article

Human IMR-32 neuroblastoma cells as a model cell line in Alzheimer's disease research
Neill, D., Hughes, D., Edwardson, J.A., Rima, B.K., Allsop, D. 1994 In: Journal of Neuroscience Research. 39, 4, p. 482-493. 12 p.
Journal article

Mechanism of cerebral amyloidosis in Alzheimer's disease
Allsop, D., Clements, A., Kennedy, H., Walsh, D., Williams, C. 1994 In: Amyloid precursor protein in development, ageing and Alzheimer's disease. Berlin : Springer Verlag p. 46-59. 14 p.
Conference contribution

Variability of β-amyloid protein deposited lesions in Down's syndrome brains
Ikeda, S., Tokuda, T., Yanagisawa, N., Kametani, F., Ohshima, T., Allsop, D. 1994 In: The Tohoku Journal of Experimental Medicine. 174, 3, p. 189-198. 10 p.
Journal article

Effects of the mutations Glu22 to Gln and Ala21 to Gly on the aggregation of a synthetic fragment of the Alzheimer's amyloid β/A4 peptide
Clements, A., Walsh, D.M., Williams, C.H., Allsop, D. 14/10/1993 In: Neuroscience Letters. 161, 1, p. 17-20. 4 p.
Journal article

Endopeptidase 3.4.24.11 converts N-1-(R,S)carboxy-3-phenylpropyl-Ala-Ala-Phe-p-carboxyanilide into a potent inhibitor of angiotensin-converting enzyme
Williams, C.H., Yamamoto, T., Walsh, D.M., Allsop, D. 15/09/1993 In: Biochemical Journal. 294 , 3, p. 681-684. 4 p.
Journal article

Secretory form of Alzheimer amyloid precursor protein 695 in human brain lacks β/A4 amyloid immunoreactivity
Kametani, F., Tanaka, K., Ishii, T., Ikeda, S., Kennedy, H.E., Allsop, D. 15/03/1993 In: Biochemical and Biophysical Research Communications. 191, 2, p. 392-398. 7 p.
Journal article

Secretory derivatives of Alzheimer amyloid precursor protein in cerebrospinal fluid and brain: only Kunitz-containing forms show amyloid immunoreactivity
Allsop, D., Kennedy, H., Kametani, F. 1993 In: Alzheimer's disease. Chichester : Wiley p. 421-429. 9 p.
Conference contribution

Quantification of βA4 protein deposition in the medial temporal lobe: a comparison of Alzheimer's disease and senile dementia of the Lewy body type
Gentleman, S.M., Williams, B., Royston, M.C., Jagoe, R., Clinton, J., Perry, R.H., Ince, P.G., Allsop, D., Polak, J.M., Roberts, G.W. 3/08/1992 In: Neuroscience Letters. 142, 1, p. 9-12. 4 p.
Journal article

Quantitative differences in the deposition of βA4 protein in the sulci and gyri of frontal and temporal isocortex in Alzheimer's disease
Gentleman, S.M., Allsop, D., Bruton, C.J., Jagoe, R., Polak, J.M., Roberts, G.W. 17/02/1992 In: Neuroscience Letters. 136, 1, p. 27-30. 4 p.
Journal article

Alzheimer amyloid β/A4 peptide binding sites and a possible 'APP-secretase' activity associated with rat brain cortical membranes
Allsop, D., Yamamoto, T., Kametani, F., Miyazaki, N., Ishii, T. 14/06/1991 In: Brain Research. 551, 1-2, p. 1-9. 9 p.
Journal article

β(A4)-amyloid protein and parkinsonian dementia complex of Guam
Gentleman, S.M., Perl, D., Allsop, D., Clinton, J., Royston, M.C., Roberts, G.W. 5/01/1991 In: The Lancet. 337, 8732, 2 p.
Letter

A monoclonal antibody to common acute lymphoblastic leukemia antigen (neutral endopeptidase) immunostains senile plaques in the brains of patients with Alzheimer's disease
Sato, M., Ikeda, K., Haga, S., Allsop, D., Ishii, T. 2/01/1991 In: Neuroscience Letters. 121, 1-2, p. 271-273. 3 p.
Journal article

Amyloid deposition as the central event in the aetiology of Alzheimer's disease
Hardy, J., Allsop, D. 1991 In: Trends in Pharmacological Sciences. 12, 10, p. 383-388. 6 p.
Journal article

High affinity amyloid peptide β/A4 binding sites and a putative "APP secretase" in rat brain
Allsop, D., Yamamoto, T., Kametani, F., Miyazaki, N., Ishii, T. 1991 In: Proceedings of the XIth International Congress of Neuropathology. Sasaki, Japan p. 119-127. 9 p.
Conference contribution

Studies on the binding and proteolytic cleavage of an Alzheimer amyloid synthetic peptide
Allsop, D., Yamamoto, T., Kametani, F., Miyazaki, N., Ishii, T. 1991 In: Frontiers of Alzheimer research. Amsterdam : Elsevier p. 171-183. 13 p.
Conference contribution

Early senile plaques in Alzheimer's disease demonstrated by histochemistry, immunocytochemistry, and electron microscopy
Ikeda, S., Yanagisawa, N., Allsop, D., Glenner, G.G. 12/1990 In: Human Pathology. 21, 12, p. 1221-1226. 6 p.
Journal article

Early senile plaques in Down's syndrome brains show a close relationship with cell bodies of neurons
Allsop, D., Haga, S.I., Haga, C., Ikeda, S.I., Mann, D.M., Ishii, T. 12/1990 In: Neuropathology and Applied Neurobiology. 15, 6, p. 531-542. 12 p.
Journal article

The occult aftermath of boxing
Roberts, G.W., Allsop, D., Bruton, C. 05/1990 In: Journal of Neurology, Neurosurgery and Psychiatry. 53, 5, p. 373-378. 6 p.
Journal article

Cerebral amyloid angiopathy as a cause of subarachnoid hemorrhage
Ohshima, T., Endo, T., Nukui, H., Ikeda, S., Allsop, D., Onaya, T. 03/1990 In: Stroke. 21, 3, p. 480-483. 4 p.
Journal article

Immunohistochemical characterization of cerebrovascular amyloid in 46 autopsied cases using antibodies to β protein and cystatin C
Maruyama, K., Ikeda, S., Ishihara, T., Allsop, D., Yanagisawa, N. 03/1990 In: Stroke. 21, 3, p. 397-403. 7 p.
Journal article

Neurofibrillary tangles in some cases of dementia pugilistica share antigens with amyloid β-protein of Alzheimer's disease
Allsop, D., Haga, S., Bruton, C., Ishii, T., Roberts, G.W. 02/1990 In: American Journal of Pathology. 136, 2, p. 255-260. 6 p.
Journal article

A possible unified nomenclature for Alzheimer amyloid protein, precursors and gene
Allsop, D. 01/1990 In: Neurobiology of Aging. 11, 1, p. 69. 1 p.
Journal article

The nomenclature of the cerebral amyloid fibril protein in Alzheimer's disease
Allsop, D. 01/1990 In: Neurobiology of Aging. 11, 1, p. 63-64. 2 p.
Journal article

Amyloid β-protein pathology (in Japanese)
Ikeda, S., Allsop, D. 1990 In: 1990 Annual Review of Neurology (in Japanese). Tokyo : Chugai Igaku Publishers p. 9-19. 11 p.
Chapter

Amyloids in neurodegenerative diseases: immunocytochemical studies
Roberts, G., Lofthouse, R., Allsop, D., Landon, M., Kidd, M., Prusiner, S., Crowe, T. 1990 In: Proceedings of II International Symposium on Unconventional Viruses of the Central Nervous System. Paris p. 602-616. 15 p.
Conference contribution

Early senile plaques in Down's syndrome brains show a close relationship with cell bodies of neurons: evidence for a neuronal origin of senile plaque amyloid
Allsop, D., Haga, S., Haga, C., Ishii, T. 1990 In: Molecular biology and genetics of Alzheimer disease. Amsterdam : Elsevier p. 95-104. 10 p.
Conference contribution

Evidence for a neuronal origin of senile plaques in Down's syndrome brains
Allsop, D., Haga, S., Haga, C., Ishii, T. 1990 In: Basic and therapeutic aspects of Alzheimer's and Parkinson's diseases. New York : Plenum Press p. 83-86. 4 p.
Conference contribution

A demonstration of the advantages of immunostaining in the quantification of amyloid plaque deposits
Gentleman, S.M., Bruton, C., Allsop, D., Lewis, S.J., Polak, J.M., Roberts, G.W. 1989 In: Histochemistry. 92, 4, p. 355-358. 4 p.
Journal article

A study of the morphology and distribution of amyloid β protein immunoreactive plaque and related lesions in the brains of Alzheimer's disease and adult Down's syndrome
Ikeda, S., Allsop, D., Glenner, G.G. 1989 In: Progress in Clinical and Biological Research. 317, p. 313-323. 11 p.
Journal article

A study of the morphology and distribution of amyloid β-protein immunoreactive plaque and related lesions in the brains of Alzheimer's disease and adult Down's syndrome
Ikeda, S., Allsop, D., Glenner, G. 1989 In: Alzheimer's disease and related disorders. New York : Alan R. Liss p. 313-323. 11 p.
Conference contribution

Evidence for the derivation of a peptide ligand from the amyloid β protein precursor of Alzheimer's disease
Allsop, D., Ikeda, S., Glenner, G. 1989 In: Alzheimer's disease and related disorders. New York : Alan R. Liss p. 893-902. 10 p. ISBN: 0845151673.
Conference contribution

Evidence for the derivation of a peptide ligand from the amyloid β-protein precursor of Alzheimer's disease
Allsop, D., Ikeda, S., Glenner, G.G. 1989 In: Progress in Clinical and Biological Research. 317, p. 893-902. 10 p.
Journal article

Evidence of amyloid β-protein immunoreactive early plaque lesions in Down's syndrome brains
Ikeda, S., Yanagisawa, N., Allsop, D., Glenner, G.G. 1989 In: Laboratory Investigation. 61, 1, p. 133-137. 5 p.
Journal article

Immunohistochemical studies of cerebrovascular amyloid deposits in brains with cerebral amyloid angiopathy
Shoji, S., Maruyama, K., Ikeda, S., Yanagisawa, N., Ishihara, T., Allsop, D. 1989 In: 1988 Annual Report of the Primary Amyloidosis Research Committee. The Ministry of Health and Welfare of Japan p. 27-30. 4 p.
Chapter

Morphology and distribution of plaque and related deposits in the brains of Alzheimer's disease and control cases: an immunohistochemical study using amyloid β-protein antibody
Ikeda, S., Allsop, D., Glenner, G.G. 1989 In: Laboratory Investigation. 60, 1, p. 113-122. 10 p.
Journal article

Cerebrovascular amyloid in scrapie-affected sheep reacts with antibodies to prion protein
Allsop, D., Ikeda, S., Bruce, M., Glenner, G.G. 5/10/1988 In: Neuroscience Letters. 92, 2, p. 234-239. 6 p.
Journal article

CNS amyloid proteins in neurodegenerative diseases
Roberts, G.W., Lofthouse, R., Allsop, D., Landon, M., Kidd, M., Prusiner, S.B., Crow, T.J. 1988 In: Neurology. 38, 10, p. 1534-40. 7 p.
Journal article

Immunohistochemical evidence for the derivation of a peptide ligand from the amyloid β-protein precursor of Alzheimer disease
Allsop, D., Wong, C.W., Ikeda, S., Landon, M., Kidd, M., Glenner, G.G. 1988 In: Proceedings of the National Academy of Sciences. 85, 8, p. 2790-2794. 5 p.
Journal article

Antibody staining of cerebral amyloid in Alzheimer’s disease, Down’s syndrome, Creutzfeldt-Jakob disease and Gerstmann-Straussler syndrome
Allsop, D., Roberts, G., Landon, M., Kidd, M., Lowe, J., Reynolds, G., Crowe, T. 1987 In: Advancing Frontiers in Alzheimer’s Disease Research. Austin : University of Texas Press p. 137-153. 17 p.
Conference contribution

Immunogold labeling of cerebrovascular and neuritic plaque amyloid fibrils in Alzheimer's disease with an anti-β protein monoclonal antibody
Ikeda, S., Wong, C.W., Allsop, D., Landon, M., Kidd, M., Glenner, G.G. 1987 In: Laboratory Investigation. 57, 4, p. 446-9. 4 p.
Journal article

Biochemistry of cerebral amyloid in Alzheimer’s disease, the unconventional slow virus diseases, and Icelandic cerebrovascular amyloidosis
Allsop, D. 1986 In: Amyloidosis. Dordrecht : Martinus Nijhoff Publishers/ Brill Academic p. 243-253. 11 p.
Conference contribution

Isolated senile plaque cores in Alzheimer's disease and Down's syndrome show differences in morphology
Allsop, D., Kidd, M., Landon, M., Tomlinson, A. 1986 In: Journal of Neurology, Neurosurgery and Psychiatry. 49, 8, p. 886-892. 7 p.
Journal article

Monoclonal antibodies raised against a subsequence of senile plaque core protein react with plaque cores, plaque periphery and cerebrovascular amyloid in Alzheimer's disease
Allsop, D., Landon, M., Kidd, M., Lowe, J.S., Reynolds, G.P., Gardner, A. 1986 In: Neuroscience Letters. 68, 2, p. 252-6. 5 p.
Journal article

Senile plaque amyloid
Kidd, M., Allsop, D., Landon, M. 1985 In: Modern approaches to the dementias, part 1. Basel : Karger p. 114-126. 13 p.
Conference contribution

Senile plaque amyloid, paired helical filaments, and cerebrovascular amyloid in Alzheimer's disease are all deposits of the same protein
Kidd, M., Allsop, D., Landon, M. 1985 In: The Lancet. 1, 8423, p. 278.
Journal article

The isolation and amino acid composition of senile plaque core protein
Allsop, D., Landon, M., Kidd, M. 1983 In: Experimental Brain Research. 259, 2, p. 348-52. 5 p.
Journal article

Chloroplast development in normal and mutant lines of barley
Atkinson, Y., Allsop, D., Bradbeer, J. 1981 In: Photosynthesis V. Philadelphia : Balaban International Science Services p. 797-808. 12 p.
Conference contribution

The effect of a high non-permissive temperature on chloroplast development in barley
Allsop, D., Atkinson, Y., Bradbeer, J. 1981 In: Photosynthesis V. Philadelphia : Balaban International Science Services p. 787-795. 9 p.
Conference contribution