Dr David Clancy


Research Overview

My aim is to delay the onset of ageing-related changes so that healthy lifespan is extended. Therefore I investigate the basic biology of ageing, which includes a search for reliable predictive biomarkers of ageing, from the behavioural to the molecular. To test potential drug targets I use the model organism Drosophila, altering expression of potentially ageing-relevant genes during adulthood, thus mimicking drug treatment.

Complete mitochondrial genome sequences of thirteen globally sourced strains of fruit fly (Drosophila melanogaster) form a powerful model for mitochondrial research
Wolff, J.N., Camus, M.F., Clancy, D.J., Dowling, D.K. 12/2016 In: Mitochondrial DNA. 27, 6, p. 4672-4674. 3 p.
Journal article

Flies, worms and the Free Radical Theory of ageing
Clancy, D., Birdsall, J. 01/2013 In: Ageing Research Reviews. 12, 1, p. 404-412. 9 p.
Journal article

Reliability and variability of sleep and activity as biomarkers of ageing in Drosophila
Koudounas, S., Green, E.W., Clancy, D. 10/2012 In: Biogerontology. 13, 5, p. 489-499. 11 p.
Journal article

Mitochondria, maternal inheritance, and male aging
Camus, M.F., Clancy, D.J., Dowling, D.K. 2012 In: Current Biology. 22, 18, p. 1717-1721. 5 p.
Journal article

Cytoplasmic male sterility in Drosophila melanogaster associated with a mitochondrial CYTB variant
Clancy, D.J., Hime, G.R., Shirras, A.D. 10/2011 In: Heredity. 107, 4, 3 p.

Mitochondrial DNA variants in Drosophila melanogaster are expressed at the level of the organismal phenotype
Aw, W.C., Correa, C.C., Clancy, D.J., Ballard, J.W.O. 09/2011 In: Mitochondrion. 11, 5, p. 756-763. 8 p.
Journal article

DmWRNexo is a 3'aEuro"5' exonuclease: phenotypic and biochemical characterization of mutants of the Drosophila orthologue of human WRN exonuclease
Boubriak, I., Mason, P.A., Clancy, D.J., Dockray, J., Saunders, R.D.C., Cox, L.S. 06/2009 In: Biogerontology. 10, 3, p. 267-277. 11 p.
Journal article

Genome instability in Drosophila mutant for WRN-like exonuclease
Boubriak, I., Clancy, D.J., Borer, C., Saunders, R.D.C., Cox, L.S. 01/2009 In: Mutagenesis. 24, 1, 2 p.
Special issue

Variation in mitochondrial genotype has substantial lifespan effects which may be modulated by nuclear background
Clancy, D.J. 12/2008 In: Aging Cell. 7, 6, p. 795-804. 10 p.
Journal article

Identification and characterization of a Drosophila ortholog of WRN exonuclease that is required to maintain genome integrity
Saunders, R.D.C., Boubriak, I., Clancy, D.J., Cox, L.S. 06/2008 In: Aging Cell. 7, 3, p. 418-425. 8 p.
Journal article

Modeling Werner Syndrome in Drosophila melanogaster: hyper-recombination in flies lacking WRN-like exonuclease
Cox, L.S., Clancy, D.J., Boubriak, I., Saunders, R.D. 11/2007 In: Annals of the New York Academy of Sciences. 1119, p. 274-288. 15 p.
Journal article

Water balance and cation levels in Drosophila: can early physiological decline predict aging and longevity?
Johnson, T.K., McKechnie, S.W., Clancy, D.J. 02/2006 In: Journals of Gerontology, Series A. 61, 2, p. 146-152. 7 p.
Journal article

Metabolic rate is not reduced by dietary-restriction or by lowered insulin/IGF-1 signalling and is not correlated with individual lifespan in Drosophila melanogaster
Hulbert, A.J., Clancy, D.J., Mair, W., Braeckman, B.P., Gems, D., Partridge, L. 08/2004 In: Experimental Gerontology. 39, 8, p. 1137-1143. 7 p.
Journal article

Dietary restriction and life-span - Response
Clancy, D.J., Gems, D., Hafen, E., Leevers, S.J., Partridge, L. 21/06/2002 In: Science. 296, 5576, p. 2141-2142. 2 p.
Journal article

Dietary restriction in long-lived dwarf flies
Clancy, D.J., Gems, D., Hafen, E., Leevers, S.J., Partridge, L. 12/04/2002 In: Science. 296, 5566, p. 319. 1 p.
Journal article

Identifying common determinants of lifespan and ageing in model organisms
Clancy, D.J., Keaney, M., Leevers, S.J., Partridge, L., Gems, D. 02/2002 In: Mechanisms of Development. 123, 4, p. 441-442. 2 p.
Journal article

Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein
Clancy, D.J., Gems, D., Harshman, L.G., Oldham, S., Stocker, H., Hafen, E., Leevers, S.J., Partridge, L. 6/04/2001 In: Science. 292, 5514, p. 104-106. 3 p.
Journal article

A simple method to achieve consistent larval density in bottle cultures.
Clancy, D.J., Kennington, W.J. 2001 In: Drosophila Information Service. 84, p. 168-169. 2 p.
Journal article

Environmental effects on cytoplasmic incompatibility and bacterial load in Wolbachia-infected Drosophila simulans
Clancy, D.J., Hoffmann, A.A. 01/1998 In: Entomologia Experimentalis et Applicata. 86, 1, p. 13-24. 12 p.
Journal article

Behavior of Wolbachia endosymbionts from Drosophila simulans in Drosophila serrata, a novel host
Clancy, D.J., Hoffmann, A.A. 05/1997 In: The American Naturalist. 149, 5, p. 975-988. 14 p.
Journal article

Cytoplasmic incompatibility in Drosophila simulans: evolving complexity
Clancy, D.J., Hoffmann, A.A. 04/1996 In: Trends in Ecology and Evolution. 11, 4, p. 145-146. 2 p.
Journal article

Naturally-occurring Wolbachia infection in Drosophila simulans that does not cause cytoplasmic incompatibility
Hoffmann, A.A., Clancy, D., Duncan, J. 1996 In: Heredity. 76, p. 1-8. 8 p.
Journal article

Cytoplasmic Incompatibility in Australian Populations of Drosophila-Melanogaster
Hoffmann, A.A., Clancy, D.J., Merton, E. 1994 In: Genetics. 136, 3, p. 993-999. 7 p.
Journal article