Dr Karen Wright


Research Overview

Dr Wright's research spans the cellular and molecular mechanisms of the cannabinoid system in gastrointestinal epithelium to the translational aspects of realising the therapeutic potential of cannabinoids in diseases such as Crohn's Disease, Ulcerative Colitis and colorectal cancer. Existing projects include intestinal barrier and permeability studies.

She is currently developing a new model of intestinal tissue culture that takes into account physiological levels of oxygen and energy sources, in partnership with GI physicians, surgeons and pathologists at the Royal Lancaster Infirmary and involves patients and human volunteers.

The role of CB1 in intestinal permeability and inflammation
Karwad, M.A., Couch, D.G., Theophilidou, E., Sarmad, S., Barrett, D.A., Larvin, M., Wright, K.L., Lund, J.N., O'Sullivan, S.E. 08/2017 In: FASEB Journal. 31, 8, p. 3267-3277. 11 p.
Journal article

Cannabidiol Reduces Leukemic Cell Size - But Is It Important?
Kalenderoglou, N., Macpherson, T., Wright, K.L. 24/03/2017 In: Frontiers in Pharmacology. 8, 9 p.
Journal article

Oleoylethanolamine and palmitoylethanolamine modulate intestinal permeability in vitro via TRPV1 and PPARα
Karwad, M.A., Macpherson, T., Wang, B., Theophilidou, E., Sarmad, S., Barrett, D.A., Larvin, M., Wright, K.L., Lund, J.N., O'Sullivan, S.E. 02/2017 In: FASEB Journal. 31, 2, p. 469-481. 13 p.
Journal article

Raman spectroscopy: an evolving technique for live cell studies
Smith, R., Wright, K.L., Ashton, L. 21/06/2016
Literature review

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Wright, K.L. 21/01/2016 In: Autophagy. 12, 1, 222 p.

Cannabinoid-induced autophagy regulates suppressor of cytokine signaling (SOCS)-3 in intestinal epithelium
Koay, L., Rigby, R., Wright, K. 15/07/2014 In: American Journal of Physiology-Gastrointestinal and Liver Physiology. 307, p. G140-G148. 9 p.
Journal article

Physiological intestinal oxygen modulates the Caco-2 cell model and increases sensitivity to the phytocannabinoid cannabidiol
MacPherson, T., Armstrong, J., Criddle, D., Wright, K. 2014 In: In Vitro Cellular and Developmental Biology - Animal. 50, 5, p. 417-426. 10 p.
Journal article

Cannabinoids mediate opposing effects on inflammation-induced intestinal permeability
Alhamoruni, A., Wright, K., Larvin, M., O'Sullivan, S.E. 04/2012 In: British Journal of Pharmacology. 165, 8, p. 2598-610. 13 p.
Journal article

Safety of medicine and the use of animals in research
Archibald, K., Baxter, A.D., BéruBé, K., Bunton, D., Clotworthy, M., Coleman, B., Foster, C.S., Hillier, C., McFarlane, M., Patel, A., Pierscionek, B., Root, J., Thomas, G., Tsaioun, K., Wilkinson, J.M., Wilmut, I., Wright, K.L. 29/10/2011 In: The Lancet. 378, 9802, 1 p.

Open letter to UK Prime Minister David Cameron and Health Secretary Andrew Lansley on safety of medicines
Archibald, K., Coleman, R., Foster, C., Wright, K. 4/06/2011 In: The Lancet. 377, 9781, p. 1915. 1 p.
Journal article

Pharmacological effects of cannabinoids on the Caco-2 cell culture model of intestinal permeability.
Alhamoruni, A., Lee, A.C., Wright, K.L., Larvin, M., O'Sullivan, S.E. 10/2010 In: Journal of Pharmacology and Experimental Therapeutics. 335, 1, p. 92-102. 11 p.
Journal article

Long term cannabinoid receptor (CB1) blockade in obesity : implications for the development of colorectal cancer.
Wright, K.L., Robertson, D.A.F., Moyer, M.P., Ward, S.G. 15/04/2008 In: International Journal of Cancer. 122, 8, p. 1920-1921. 2 p.
Journal article

Cannabinoid CB2 receptors in the gastrointestinal tract : a regulatory system in states of inflammation.
Wright, K.L., Duncan, M., Sharkey, K.A. 01/2008 In: British Journal of Pharmacology. 153, 2, p. 263-270. 8 p.
Journal article

Temporal variation in CB2R levels following T lymphocyte activation : evidence that cannabinoids modulate CXCL12-induced chemotaxis.
Coopman, K., Smith, L.D., Wright, K.L., Ward, S.G. 03/2007 In: International Immunopharmacology. 7, 3, p. 360-371. 12 p.
Journal article

Peripheral cannabinoid receptor, CB2, regulates bone mass.
Ofek, O., Karsak, M., Leclerc, N., Fogel, M., Frenkel, B., Wright, K., Tam, J., Attar-Namdar, M., Kram, V., Shohami, E., Mechoulam, R., Zimmer, A., Bab, I. 17/01/2006 In: Proceedings of the National Academy of Sciences. 103, 3, p. 696-701. 6 p.
Journal article

The Chemokines CXCL9, CXCL10, and CXCL11 Differentially Stimulate Gαi-Independent Signaling and Actin Responses in Human Intestinal Myofibroblasts.
Kouroumalis, A., Nibbs, R.J., Aptel, H., Wright, K.L., Kolios, G., Ward, S.G. 15/10/2005 In: Journal of Immunology. 175, 8, p. 5403-5411. 9 p.
Journal article

Differential modulation of COX-2 expression in A549 airway epithelial cells by structurally distinct PPARγ agonists: evidence for disparate functional effects which are independent of NF-κB and PPARγ
Patel, K.M., Wright, K.L., Whittaker, P., Chakravarty, P., Watson, M.L., Ward, S.G. 09/2005 In: Cellular Signalling. 17, 9, p. 1098-1110. 13 p.
Journal article

Differential Expression of Cannabinoid Receptors in the Human Colon : Cannabinoids Promote Epithelial Wound Healing.
Wright, K., Rooney, N., Feeney, M., Tate, J., Robertson, D., Welham, M., Ward, S. 08/2005 In: Gastroenterology. 129, 2, p. 437-453. 17 p.
Journal article

Differential regulation of prostaglandin E biosynthesis by interferon-γ in colonic epithelial cells.
Wright, K.L., Weaver, S.A., Patel, K., Coopman, K., Feeney, M., Kolios, G., Robertson, D.A.F., Ward, S.G. 04/2004 In: British Journal of Pharmacology. 141, 7, p. 1091-1097. 7 p.
Journal article

Optimal Chemotactic Responses of Leukemic T Cells to Stromal Cell-Derived Factor-1 Requires the Activation of Both Class IA and IB Phosphoinositide 3-Kinases.
Curnock, A.P., Sotsios, Y., Wright, K.L., Ward, S.G. 15/04/2003 In: Journal of Immunology. 170, 8, p. 4021-4030. 10 p.
Journal article

Evidence That SHIP-1 Contributes to Phosphatidylinositol 3,4,5-Trisphosphate Metabolism in T Lymphocytes and Can Regulate Novel Phosphoinositide 3-Kinase Effectors.
Freeburn, R.W., Wright, K.L., Burgess, S.J., Astoul, E., Cantrell, D.A., Ward, S.G. 15/11/2002 In: Journal of Immunology. 169, 10, p. 5441-5450. 10 p.
Journal article

Regulatory role of phosphatidylinositol 3-kinase on TNF-α-induced cyclooxygenase 2 expression in colonic epithelial cells.
Weaver, S.A., Russo, M.P., Wright, K.L., Kolios, G., Jobin, C., Robertson, D.A.F., Ward, S.G. 04/2001 In: Gastroenterology. 120, 5, p. 1117-1127. 11 p.
Journal article

Interactions between Phosphatidylinositol 3-Kinase and Nitric Oxide: Explaining the Paradox
Wright, K.L., Ward, S.G. 09/2000 In: Molecular Cell Biology Research Communications. 4, 3, p. 137-143. 7 p.
Journal article

Interleukin-13 inhibits nitric oxide production in human colonic mucosa.
Kolios, G., Wright, K.L., Linehan, J.D., Robertson, D.A.F., Westick, J. 2000 In: Hepato-Gastroenterology. 47, p. 714-717. 4 p.
Journal article

Cytokine-induced apoptosis in epithelial HT-29 cells is independent of nitric oxide formation : evidence for an IL-13-driven PI3-kinase-dependent survival mechanism.
Wright, K., Kolios, G., Westwick, J., Ward, S.G. 11/06/1999 In: Journal of Biological Chemistry. 274, 24, p. 17193-17201. 9 p.
Journal article

C-X-C and C-C chemokine expression and secretion by the human colonic epithelial cell line, HT-29 : differential effect of T lymphocyte-derived cytokines.
Kolios, G., Wright, K.L., Jordan, N.J., Leithead, J.B., Robertson, D.A.F., Westwick, J. 02/1999 In: European Journal of Immunology. 29, 2, p. 530-536. 7 p.
Journal article

Activation of phosphatidylinositol 3-kinase by interleukin-13 - An inhibitory signal for inducible nitric-oxide synthase expression in the epithelial, cell line HT-29.
Wright, K., Ward, S.G., Kolios, G., Westwick, J. 9/05/1997 In: Journal of Biological Chemistry. 272, p. 12626-12633. 8 p.
Journal article

Regulation of inflammatory mediator production in human colonic epithelial cells.
Kolios, G., Wright, K.L., Jordan, N.J., Leithead, J.B., Murphy, C.T., Robertson, D.A.F., Westwick, J. 1997 In: Hellenic Journal of Gastroenterology. 10, 2, p. 135-147. 13 p.
Journal article