Dr Geoffrey Akien MRSC

Experimental Officer (NMR)

Professional Role

I run the solution state NMR facility in the Department of Chemistry at Lancaster: currently a Bruker Fourier 300 and an Avance III 400. I also play a supporting role for the solid state NMR facility: a Bruker Avance III HD 400WB and 700WB.

I maintain the instruments and the supporting infrastructure, and provide training and advice on everything from sample preparation through to data analysis. If you have any questions, just ask!

Rapid and simultaneous synthesis of a hydrogen bond template [3]rotaxane and its related [2]rotaxane molecular shuttle
Evans, N.H., Akien, G.R. expected in 2018 In: Supramolecular Chemistry. 30, 2, p. 158-164. 7 p.
Journal article

3d/4f Coordination Clusters as Cooperative Catalysts for Highly Diastereoselective Michael Addition Reactions
Griffiths, K., Tsipis, A.C., Kumar, P., Townrow, O.P.E., Abdul-Sada, A., Akien, G.R., Baldansuren, A., Spivey, A.C., Kostakis, G.E. 21/08/2017 In: Inorganic Chemistry. 56, 16, p. 9563-9573. 11 p.
Journal article

Intensified and safe ozonolysis of fatty acid methyl esters in liquid CO2 in a continuous reactor
Lundin, M.D., Danby, A.M., Akien, G.R., Venkitasubramanian, P., Martin, K.J., Busch, D.H., Subramaniam, B. 07/2017 In: AIChE Journal. 63, 7, p. 2819-2826. 8 p.
Journal article

Rapid multistep kinetic model generation from transient flow data
Hone, C.A., Holmes, N., Akien, G.R., Bourne, R.A., Muller, F.L. 1/04/2017 In: Reaction Chemistry and Engineering. 2, 2, p. 103-108. 6 p.
Journal article

[N,N-Bis(2-hy­droxy­eth­yl)di­thio­carbamato-[kappa]2S,S']bis­(tri­phenyl­phosphane-[kappa]P)copper(I) chloro­form monosolvate: crystal structure, Hirshfeld surface analysis and solution NMR measurements
Tan, S.L., Yeo, C.I., Heard, P.J., Akien, G.R., Halcovitch, N.R., Tiekink, E.R. 12/2016 In: Acta Crystallographica Section E: Crystallographic Communications. 72, 12, p. 1799-1805. 7 p.
Journal article

Self-optimisation of the final stage in the synthesis of EGFR kinase inhibitor AZD9291 using an automated flow reactor
Holmes, N., Akien, G.R., Blacker, A.J., Woodward, R.L., Meadows, R.E., Bourne, R.A. 1/08/2016 In: Reaction Chemistry and Engineering. 1, 4, p. 366-371. 6 p.
Journal article

Atomic details of the interactions of Glycosaminoglycans with amyloid-β fibrils
Stewart, K., Hughes, E., Yates, E., Akien, G.R., Huang, T., Lima, M., Rudd, T., Guerrini, M., Hung, S., Radford, S., Middleton, D.A. 13/07/2016 In: Journal of the American Chemical Society. 138, 27, p. 8328-8331. 4 p.
Journal article

Tetranuclear Zn/4f coordination clusters as highly efficient catalysts for Friedel–Crafts alkylation
Griffiths, K., Kumar, P., Akien, G.R., Chilton, N.F., Abdul-Sada, A., Tizzard, G.J., Coles, S.J., Kostakis, G.E. 25/06/2016 In: Chemical Communications. 52, 50, p. 7866-7869. 4 p.
Journal article

Online quantitative mass spectrometry for the rapid adaptive optimisation of automated flow reactors
Holmes, N., Akien, G.R., Savage, R.J.D., Stanetty, C., Baxendale, I.R., Blacker, A.J., Taylor, B.A., Woodward, R.L., Meadows, R.E., Bourne, R.A. 2016 In: Reaction Chemistry and Engineering. 2016, 1, p. 96-100. 5 p.
Journal article

Liquid CO2 as a safe and benign solvent for the ozonolysis of fatty acid methyl esters
Akien, G.R., Lundin, M.D., Danby, A.M., Binder, T.P., Busch, D.H., Subramaniam, B. 7/12/2015 In: ACS Sustainable Chemistry & Engineering. 3, 12, p. 3307-3314. 8 p.
Journal article

Continuous hydroformylation with phosphine-functionalized polydimethylsiloxane rhodium complexes as nanofilterable homogeneous catalysts
Xie, Z., Akien, G.R., Sarkar, B.R., Subramaniam, B., Chaudhari, R.V. 14/10/2015 In: Industrial and Engineering Chemistry Research. 54, 43, p. 10656-10660. 5 p.
Journal article

Definition and application of ethanol equivalent: sustainability performance metrics for biomass conversion to carbon-based fuels and chemicals
Csefalvay, E., Akien, G.R., Qi, L., Horvath, I.T. 1/01/2015 In: Catalysis Today. 239, p. 50-55. 6 p.
Journal article

Supercritical fluids and gas-expanded liquids as tunable media for multiphase catalytic reactions
Subramaniam, B., Chaudhari, R.V., Chaudhari, A.S., Akien, G.R., Xie, Z. 1/08/2014 In: Chemical Engineering Science. 115, p. 3-18. 16 p.
Journal article

Catalytic conversion of fructose, glucose, and sucrose to 5-(hydroxymethyl)furfural and levulinic and formic acids in gamma-valerolactone as a green solvent
Qi, L., Mui, Y.F., Lo, S.W., Lui, M.Y., Akien, G.R., Horvath, I.T. 05/2014 In: ACS Catalysis. 4, 5, p. 1470-1477. 8 p.
Journal article

Generation and characterization of the pyranosyl and furanosyl oxocarbenium ions from 2-deoxyaldoses
Akien, G., Subramaniam, B. 20/03/2014

Direct observation of the fructofuranosyl oxocarbenium ion: a critical intermediate in the valorization of carbohydrates
Akien, G., Subramaniam, B. 10/04/2013

Mechanistic studies on the dehydration of glucose to 5-hydroxymethylfurfural and xylose to furfural
Akien, G., Qi, L., Horvath, I.T. 10/04/2013

Sustainable catalytic reaction engineering with gas-expanded liquids
Subramaniam, B., Akien, G.R. 1/08/2012 In: Current Opinion in Chemical Engineering. 1, 3, p. 336-341. 6 p.
Journal article

Molecular mapping of the acid catalysed dehydration of fructose
Akien, G.R., Qi, L., Horvath, I.T. 2012 In: Chemical Communications. 48, 47, p. 5850-5852. 3 p.
Journal article

Self-optimizing continuous reactions in supercritical carbon dioxide
Parrott, A.J., Bourne, R.A., Akien, G.R., Irvine, D.J., Poliakoff, M. 11/04/2011 In: Angewandte Chemie International Edition. 50, 16, p. 3788-3792. 5 p.
Journal article

Sustainable synthesis of gamma-valerolactone
Horvath, I.T., Qi, L., Akien, G.R. 27/03/2011
Meeting abstract

Detecting phase transitions in supercritical mixtures: an enabling tool for greener chemical reactions
Ke, J., Sanchez-Vicente, Y., Akien, G.R., Novitskiy, A.A., Comak, G., Bagratashvili, V.N., George, M.W., Poliakoff, M. 8/10/2010
Literature review

Pressure drop as a simple method for locating phase transitions in continuous flow high pressure reactors
Akien, G.R., Skilton, R.A., Poliakoff, M. 19/05/2010 In: Industrial and Engineering Chemistry Research. 49, 10, p. 4974-4980. 7 p.
Journal article

Continuous heterogeneous catalytic oxidation of primary and secondary alcohols in scCO(2)
Chapman, A.O., Akien, G.R., Arrowsmith, N.J., Licence, P., Poliakoff, M. 2010 In: Green Chemistry. 12, 2, p. 310-315. 6 p.
Journal article

Conversion of carbohydrates to liquid fuels
Akien, G., Qi, L., Horváth, I.T. 2010 In: Thermochemical Conversion of Biomass to Liquid Fuels and Chemicals. Cambridge : RSC Publishing p. 365-381. 17 p.
Chapter (peer-reviewed)

The continuous catalytic debenzylation of 1,4-Dibenzyloxybenzene with H-2 in THF expanded with high pressure CO2
Akien, G.R., Legeay, J., Wells, A., Poliakoff, M. 2010 In: Organic Process Research and Development. 14, 5, p. 1202-1208. 7 p.
Journal article

A critical look at reactions in class I and II gas-expanded liquids using CO2 and other gases
Akien, G.R., Poliakoff, M. 2009
Literature review