Dr Joanne Knight

Reader in Applied Data Science

PhD Supervision Interests

Please contact me if you are interested in undertaking a PhD in the areas of statistical genetics or bioinformatics.

Genome-wide association study of a nicotine metabolism biomarker in African American smokers: impact of chromosome 19 genetic influences
Chenoweth, M.J., Ware, J.J., Zhu, A.Z.X., Cole, C.B., Cox, L.S., Nollen, N., Ahluwalia, J.S., Benowitz, N.L., Schnoll, R.A., Hawk, L.W., Cinciripini, P.M., George, T.P., Lerman, C., Knight, J., Tyndale, R.F., PGRN-PNAT Research Group 2/11/2017 In: Addiction. 15 p.
Journal article

Genetic epistasis regulates amyloid deposition in resilient aging
Felsky, D., Xu, J., Chibnik, L., Schneider, J., Knight, J., Kennedy, J.L., Bennett, D.A., De Jager, P.L., Voineskos, A.N. 10/2017 In: Alzheimer's and Dementia. 13, 10, p. 1107-1116. 10 p.
Journal article

A Comparison Between Genetics Papers Relating to Immune Disorders and Psychiatric Disorders
El-Haj, M., Piao, S.S., Rayson, P.E., Knight, J. 11/09/2017
Poster

Heritability of hippocampal subfield volumes using a twin and non-twin siblings design
Patel, S., Park, M.T.M., Devenyi, G.A., Patel, R., Masellis, M., Knight, J., Chakravarty, M.M. 09/2017 In: Human Brain Mapping. 38, 9, p. 4337-4352. 16 p.
Journal article

Fine-mapping inflammatory bowel disease loci to single-variant resolution
Huang, H., Fang, M., Jostins, L., Umićević Mirkov, M., Boucher, G., Anderson, C.A., Andersen, V., Cleynen, I., Cortes, A., Crins, F., D'Amato, M., Deffontaine, V., Dmitrieva, J., Docampo, E., Elansary, M., Farh, K.K., Franke, A., Gori, A., Goyette, P., Halfvarson, J., Haritunians, T., Knight, J., Lawrance, I.C., Lees, C.W., Louis, E., Mariman, R., Meuwissen, T., Mni, M., Momozawa, Y., Parkes, M., Spain, S.L., Théâtre, E., Trynka, G., Satsangi, J., van Sommeren, S., Vermeire, S., Xavier, R.J., Weersma, R.K., Duerr, R.H., Mathew, C.G., Rioux, J.D., McGovern, D.P.B., Cho, J.H., Georges, M., Daly, M.J., Barrett, J.C., International Inflammatory Bowel Disease Genetics Consortium 13/07/2017 In: Nature. 547, 7662, p. 173-178. 6 p.
Journal article

Genetic correlation between amyotrophic lateral sclerosis and schizophrenia
Knight, J., Project MinE GWAS Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium 21/03/2017 In: Nature Communications. 8, 12 p.
Journal article

Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk
Warren, H.R., Evangelou, E., Cabrera, C.P., Gao, H., Ren, M., Mifsud, B., Ntalla, I., Surendran, P., Liu, C., Cook, J.P., Kraja, A.T., Drenos, F., Loh, M., Verweij, N., Marten, J., Karaman, I., Lepe, M.P.S., O'Reilly, P.F., Knight, J., Snieder, H., Kato, N., He, J., Tai, E.S., Said, M.A., Porteous, D., Alver, M., Poulter, N., Farrall, M., Gansevoort, R.T., Padmanabhan, S., Mägi, R., Stanton, A., Connell, J., Bakker, S.J.L., Metspalu, A., Shields, D.C., Thom, S., Brown, M., Sever, P., Esko, T., Hayward, C., van der Harst, P., Saleheen, D., Chowdhury, R., Chambers, J.C., Chasman, D.I., Chakravarti, A., Newton-Cheh, C., Lindgren, C.M., Levy, D., Kooner, J.S., Keavney, B., Tomaszewski, M., Samani, N.J., Howson, J.M.M., Tobin, M.D., Munroe, P.B., Ehret, G.B., Wain, L.V., Barnes, M.R., Tzoulaki, I., Caulfield, M.J., Elliott, P., International Consortium of Blood Pressure (ICBP) 1000G Analyses 20/02/2017 In: Nature Genetics. 49, p. 403-415. 13 p.
Journal article

Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects
CNV and Schizophrenia Working Groups of the Psychiatric Genomics Consortium 01/2017 In: Nature Genetics. 49, p. 27-35. 9 p.
Journal article

Genomics implicates adaptive and innate immunity in Alzheimer’s and Parkinson’s diseases
Gagliano, S.A., Pouget, J.G., Hardy, J., Knight, J., Barnes, M.R., Ryten, M., Weale, M. 12/2016 In: Annals of Clinical and Translational Neurology. 3, 12, p. 924-933. 10 p.
Journal article

CEREBRAL PERFUSION AS AN IMAGING BIOMARKER OF PRESYMPTOMATIC GENETIC FRONTOTEMPORAL DEMENTIA: PRELIMINARY RESULTS FROM THE GENETIC FRONTOTEMPORAL DEMENTIA INITIATIVE (GENFI)
Mutsaerts, H.J.M.M., Knight, J. 07/2016
Meeting abstract

Dopamine D2 receptor gene variants and response to rasagiline in early Parkinson's disease: a pharmacogenetic study
Masellis, M., Collinson, S., Freeman, N., Tampakeras, M., Levy, J., Tchelet, A., Eyal, E., Berkovich, E., Eliaz, R.E., Abler, V., Grossman, I., Fitzer-Attas, C., Tiwari, A., Hayden, M.R., Kennedy, J.L., Lang, A.E., Knight, J., ADAGIO investigators 07/2016 In: Brain. 139, 7, p. 2050-2062. 13 p.
Journal article

Investigating the causal relationship of C-reactive protein with 32 complex somatic and psychiatric outcomes: a large-scale cross-consortium Mendelian randomization study
Prins, B.P., Abbasi, A., Wong, A., Vaez, A., Nolte, I., Franceschini, N., Stuart, P.E., Guterriez Achury, J., Mistry, V., Bradfield, J.P., Valdes, A.M., Bras, J., Shatunov, A., Lu, C., Han, B., Raychaudhuri, S., Bevan, S., Mayes, M.D., Tsoi, L.C., Evangelou, E., Nair, R.P., Grant, S.F.A., Polychronakos, C., Radstake, T.R.D., van Heel, D.A., Dunstan, M.L., Wood, N.W., Al-Chalabi, A., Dehghan, A., Hakonarson, H., Markus, H.S., Elder, J.T., Knight, J., Arking, D.E., Spector, T.D., Koeleman, B.P.C., van Duijn, C.M., Martin, J., Morris, A.P., Weersma, R.K., Wijmenga, C., Munroe, P.B., Perry, J.R.B., Pouget, J.G., Jamshidi, Y., Snieder, H., Alizadeh, B.Z., PAGE Consortium 21/06/2016 In: PLoS Medicine. 13, 6, 29 p.
Journal article

Genome-wide association studies suggest limited immune gene enrichment in schizophrenia compared to 5 autoimmune diseases
Pouget, J.G., Gonçalves, V.F., Spain, S.L., Finucane, H.K., Raychaudhuri, S., Kennedy, J.L., Knight, J., Schizophrenia Working Group of the Psychiatric Genomics Consortium 30/05/2016 In: Schizophrenia Bulletin. 42, 5, p. 1176-1184. 9 p.
Journal article

Allele-skewed DNA modification in the brain: relevance to a schizophrenia GWAS
Gagliano, S.A., Ptak, C., Mak, D.Y.F., Shamsi, M., Oh, G., Knight, J., Boutros, P.C., Petronis, A. 5/05/2016 In: American Journal of Human Genetics. 98, 5, p. 956-962. 7 p.
Journal article

Gene prioritization for imaging genetics studies using gene ontology and a stratified false discovery rate approach
Patel, S., Park, M.T.M., Chakravarty, M.M., Knight, J., Alzheimer's Disease Neuroimaging Initiative 7/04/2016 In: Frontiers in Neuroinformatics. 10, 13 p.
Journal article

Genetic association analysis of N-methyl-d-aspartate receptor subunit gene GRIN2B and clinical response to clozapine
Taylor, D.L., Tiwari, A.K., Lieberman, J.A., Potkin, S.G., Meltzer, H.Y., Knight, J., Remington, G., Müller, D.J., Kennedy, J.L. 03/2016 In: Human Psychopharmacology: Clinical and Experimental. 31, 2, p. 121-134. 14 p.
Journal article

Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept
Franke, B., Stein, J.L., Ripke, S., Anttila, V., Hibar, D.P., van Hulzen, K.J.E., Arias-Vasquez, A., Smoller, J.W., Nichols, T.E., Neale, M.C., McIntosh, A.M., Lee, P., McMahon, F.J., Meyer-Lindenberg, A., Mattheisen, M., Andreassen, O.A., Gruber, O., Sachdev, P.S., Roiz-Santiañez, R., Saykin, A.J., Ehrlich, S., Mather, K.A., Turner, J.A., Schwarz, E., Thalamuthu, A., Yao, Y., Ho, Y.Y.W., Martin, N.G., Wright, M.J., O'Donovan, M.C., Thompson, P.M., Neale, B.M., Medland, S.E., Sullivan, P.F., Knight, J., Schizophrenia Working Group of the Psychiatric Genomics Consortium 03/2016 In: Nature Reviews Neuroscience. 19, 3, p. 420-431. 12 p.
Journal article

Schizophrenia risk from complex variation of complement component 4
Sekar, A., Bialas, A.R., de Rivera, H., Davis, A., Hammond, T.R., Kamitaki, N., Tooley, K., Presumey, J., Baum, M., Van Doren, V., Genovese, G., Rose, S.A., Handsaker, R.E., Daly, M.J., Carroll, M.C., Stevens, B., McCarroll, S.A., Knight, J., Schizophrenia Working Group of the Psychiatric Genomics Consortium 11/02/2016 In: Nature. 530, 7589, p. 177-183. 7 p.
Journal article

IBD genetic risk profile in healthy first-degree relatives of Crohn's disease patients
Kevans, D., Silverberg, M.S., Borowski, K., Griffiths, A., Xu, W., Onay, V., Paterson, A.D., Knight, J., Croitoru, K., GEM Project 02/2016 In: Journal of Crohn's and Colitis. 10, 2, p. 209-215. 7 p.
Journal article

Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis
Loh, P., Bhatia, G., Gusev, A., Finucane, H.K., Bulik-Sullivan, B.K., Pollack, S.J., de Candia, T.R., Lee, S.H., Wray, N.R., Kendler, K.S., O'Donovan, M.C., Neale, B.M., Patterson, N., Price, A.L., Knight, J., Schizophrenia Working Group of Psychiatric Genomics Consortium 12/2015 In: Nature Genetics. 47, 12, p. 1385-1392. 8 p.
Journal article

Modeling linkage disequilibrium increases accuracy of polygenic risk scores
Vilhjálmsson, B.J., Yang, J., Finucane, H.K., Gusev, A., Lindström, S., Ripke, S., Genovese, G., Loh, P., Bhatia, G., Do, R., Hayeck, T., Won, H., Kathiresan, S., Pato, M., Pato, C., Tamimi, R., Stahl, E., Zaitlen, N., Pasaniuc, B., Belbin, G., Kenny, E.E., Schierup, M.H., De Jager, P., Patsopoulos, N.A., McCarroll, S., Daly, M., Purcell, S., Chasman, D., Neale, B., Goddard, M., Visscher, P.M., Kraft, P., Patterson, N., Price, A.L., Knight, J., Schizophrenia Working Group of the Psychiatric Genomics Consortium, Discovery, Biology, and Risk of Inherited Variants in Breast Cancer (DRIVE) study 1/10/2015 In: American Journal of Human Genetics. 97, 4, p. 576-592. 17 p.
Journal article

Predictors of outcome in ulcerative colitis
Waterman, M., Knight, J., Dinani, A., Xu, W., Stempak, J.M., Croitoru, K., Nguyen, G.C., Cohen, Z., McLeod, R.S., Greenberg, G.R., Steinhart, A.H., Silverberg, M.S. 09/2015 In: Inflammatory Bowel Diseases. 21, 9, p. 2097-2105. 9 p.
Journal article

Smoking gun or circumstantial evidence?: comparison of statistical learning methods using functional annotations for prioritizing risk variants
Gagliano, S.A., Ravji, R., Barnes, M.R., Weale, M.E., Knight, J. 24/08/2015 In: Scientific Reports. 5, 11 p.
Journal article

Addiction-related genes in gambling disorders: new insights from parallel human and pre-clinical models
Lobo, D.S.S., Aleksandrova, L., Knight, J., Casey, D.M., el-Guebaly, N., Nobrega, J.N., Kennedy, J.L. 08/2015 In: Molecular Psychiatry. 20, 8, p. 1002-1010. 9 p.
Journal article

A genome-wide association study of suicide severity scores in bipolar disorder
Zai, C.C., Gonçalves, V.F., Tiwari, A.K., Gagliano, S.A., Hosang, G., de Luca, V., Shaikh, S.A., King, N., Chen, Q., Xu, W., Strauss, J., Breen, G., Lewis, C.M., Farmer, A.E., McGuffin, P., Knight, J., Vincent, J.B., Kennedy, J.L. 06/2015 In: Journal of Psychiatric Research. 65, p. 23-29. 7 p.
Journal article

Assessing models for genetic prediction of complex traits: a comparison of visualization and quantitative methods
Gagliano, S.A., Paterson, A.D., Weale, M.E., Knight, J. 22/05/2015 In: BMC Genomics. 16, 11 p.
Journal article

Enhanced meta-analysis and replication studies identify five new psoriasis susceptibility loci
Tsoi, L.C., Spain, S.L., Ellinghaus, E., Stuart, P.E., Capon, F., Knight, J., Tejasvi, T., Kang, H.M., Allen, M.H., Lambert, S., Stoll, S.W., Weidinger, S., Gudjonsson, J.E., Koks, S., Kingo, K., Esko, T., Das, S., Metspalu, A., Weichenthal, M., Enerback, C., Krueger, G.G., Voorhees, J.J., Chandran, V., Rosen, C.F., Rahman, P., Gladman, D.D., Reis, A., Nair, R.P., Franke, A., Barker, J.N.W.N., Abecasis, G.R., Trembath, R.C., Elder, J.T. 5/05/2015 In: Nature Communications. 6, 8 p.
Journal article

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies
Bulik-Sullivan, B.K., Loh, P., Finucane, H.K., Ripke, S., Yang, J., Patterson, N., Daly, M.J., Price, A.L., Neale, B.M., Knight, J., Schizophrenia Working Group of the Psychiatric Genomics Consortium 03/2015 In: Nature Genetics. 47, 3, p. 291-295. 5 p.
Journal article

Pooled sequencing of 531 genes in inflammatory bowel disease identifies an associated rare variant in BTNL2 and implicates other immune related genes
Prescott, N.J., Lehne, B., Stone, K., Lee, J.C., Taylor, K., Knight, J., Papouli, E., Mirza, M.M., Simpson, M.A., Spain, S.L., Lu, G., Fraternali, F., Bumpstead, S.J., Gray, E., Amar, A., Bye, H., Green, P., Chung-Faye, G., Hayee, B., Pollok, R., Satsangi, J., Parkes, M., Barrett, J.C., Mansfield, J.C., Sanderson, J., Lewis, C.M., Weale, M.E., Schlitt, T., Mathew, C.G., UK IBD Genetics Consortium 11/02/2015 In: PLOS Genetics. 11, 2
Journal article

CYP2A6 reduced activity gene variants confer reduction in lung cancer risk in African American smokers: findings from two independent populations
Wassenaar, C.A., Ye, Y., Cai, Q., Aldrich, M.C., Knight, J., Spitz, M.R., Wu, X., Blot, W.J., Tyndale, R.F. 01/2015 In: Carcinogenesis. 36, 1, p. 99-103. 5 p.
Journal article

Investigation of TSPO variants in schizophrenia and antipsychotic treatment outcomes
Pouget, J.G., Gonçalves, V.F., Nurmi, E.L., Laughlin, C.P., Mallya, K.S., McCracken, J.T., Aman, M.G., McDougle, C.J., Scahill, L., Misener, V.L., Tiwari, A.K., Zai, C.C., Brandl, E.J., Felsky, D., Leung, A.Q., Lieberman, J.A., Meltzer, H.Y., Potkin, S.G., Niedling, C., Steimer, W., Leucht, S., Knight, J., Müller, D.J., Kennedy, J.L. 01/2015 In: Pharmacogenomics. 16, 1, p. 5-22. 18 p.
Journal article

Complex host genetics influence the microbiome in inflammatory bowel disease
Knights, D., Silverberg, M.S., Weersma, R.K., Gevers, D., Dijkstra, G., Huang, H., Tyler, A.D., van Sommeren, S., Imhann, F., Stempak, J.M., Huang, H., Vangay, P., Al-Ghalith, G.A., Russell, C., Sauk, J., Knight, J., Daly, M.J., Huttenhower, C., Xavier, R.J. 2/12/2014 In: Genome Biology. 6, 12, 11 p.
Journal article

Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases
Gusev, A., Lee, S.H., Trynka, G., Finucane, H., Vilhjálmsson, B.J., Xu, H., Zang, C., Ripke, S., Bulik-Sullivan, B., Stahl, E., Kähler, A.K., Hultman, C.M., Purcell, S.M., McCarroll, S.A., Daly, M., Pasaniuc, B., Sullivan, P.F., Neale, B.M., Wray, N.R., Raychaudhuri, S., Price, A.L., Knight, J., Schizophrenia Working Group of the Psychiatric Genomics Consortium 6/11/2014 In: American Journal of Human Genetics. 95, 5, p. 535-552. 18 p.
Journal article

The role of leptin, melanocortin, and neurotrophin system genes on body weight in anorexia nervosa and bulimia nervosa
Yilmaz, Z., Kaplan, A.S., Tiwari, A.K., Levitan, R.D., Piran, S., Bergen, A.W., Kaye, W.H., Hakonarson, H., Wang, K., Berrettini, W.H., Brandt, H.A., Bulik, C.M., Crawford, S., Crow, S., Fichter, M.M., Halmi, K.A., Johnson, C.L., Keel, P.K., Klump, K.L., Magistretti, P., Mitchell, J., Strober, M., Thornton, L.M., Treasure, J., Woodside, D.B., Knight, J., Kennedy, J.L. 08/2014 In: Journal of Psychiatric Research. 55, p. 77-86. 10 p.
Journal article

Biological insights from 108 schizophrenia-associated genetic loci
Knight, J., Schizophrenia Working Group of the Psychiatric Genomics Consortium 24/07/2014 In: Nature. 511, 7510, p. 421-427. 7 p.
Journal article

Protein kinase cAMP-dependent regulatory type II beta (PRKAR2B) gene variants in antipsychotic-induced weight gain
Gagliano, S.A., Tiwari, A.K., Freeman, N., Lieberman, J.A., Meltzer, H.Y., Kennedy, J.L., Knight, J., Müller, D.J. 07/2014 In: Human Psychopharmacology: Clinical and Experimental. 29, 4, p. 330-335. 6 p.
Journal article

Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris
Navarini, A.A., Simpson, M.A., Weale, M., Knight, J., Carlavan, I., Reiniche, P., Burden, D.A., Layton, A., Bataille, V., Allen, M., Pleass, R., Pink, A., Creamer, D., English, J., Munn, S., Walton, S., Willis, C., Déret, S., Voegel, J.J., Spector, T., Smith, C.H., Trembath, R.C., Barker, J.N.W.N., Acne Genetic Study Group 13/06/2014 In: Nature Communications. 5, 6 p.
Journal article

A Bayesian method to incorporate hundreds of functional characteristics with association evidence to improve variant prioritization
Gagliano, S.A., Barnes, M.R., Weale, M.E., Knight, J. 20/05/2014 In: PLoS ONE. 9, 5, 14 p.
Journal article

Genome-wide association study of bipolar disorder in Canadian and UK populations corroborates disease loci including SYNE1 and CSMD1
Xu, W., Cohen-Woods, S., Chen, Q., Noor, A., Knight, J., Hosang, G., Parikh, S.V., De Luca, V., Tozzi, F., Muglia, P., Forte, J., McQuillin, A., Hu, P., Gurling, H.M.D., Kennedy, J.L., McGuffin, P., Farmer, A., Strauss, J., Vincent, J.B. 4/01/2014 In: Journal of Medical Genetics. 15, 13 p.
Journal article

Conditional analysis identifies three novel major histocompatibility complex loci associated with psoriasis
Knight, J., Spain, S.L., Capon, F., Hayday, A., Nestle, F.O., Clop, A., Barker, J.N.W.N., Weale, M.E., Trembath, R.C., Wellcome Trust Case Control Consortium 1/12/2012 In: Human Molecular Genetics. 21, 23, p. 5185-5192. 8 p.
Journal article

Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity
Tsoi, L.C., Spain, S.L., Knight, J., Ellinghaus, E., Stuart, P.E., Capon, F., Ding, J., Li, Y., Tejasvi, T., Gudjonsson, J.E., Kang, H.M., Allen, M.H., McManus, R., Novelli, G., Samuelsson, L., Schalkwijk, J., Ståhle, M., Burden, A.D., Smith, C.H., Cork, M.J., Estivill, X., Bowcock, A.M., Krueger, G.G., Weger, W., Worthington, J., Tazi-Ahnini, R., Nestle, F.O., Hayday, A., Hoffmann, P., Winkelmann, J., Wijmenga, C., Langford, C., Edkins, S., Andrews, R., Blackburn, H., Strange, A., Band, G., Pearson, R.D., Vukcevic, D., Spencer, C.C.A., Deloukas, P., Mrowietz, U., Schreiber, S., Weidinger, S., Koks, S., Kingo, K., Esko, T., Metspalu, A., Lim, H.W., Voorhees, J.J., Weichenthal, M., Wichmann, H.E., Chandran, V., Rosen, C.F., Rahman, P., Gladman, D.D., Griffiths, C.E.M., Reis, A., Kere, J., Nair, R.P., Franke, A., Barker, J.N.W.N., Abecasis, G.R., Elder, J.T., Trembath, R.C., Collaborative Association Study of Psoriasis (CASP) 12/2012 In: Nature Genetics. 44, 12, 8 p.
Letter

Introduction to genetic association studies
Lewis, C.M., Knight, J. 03/2012 In: Cold Spring Harbor Protocols. 2012, 3, p. 297-306. 10 p.
Journal article

Mutations in IL36RN/IL1F5 are associated with the severe episodic inflammatory skin disease known as generalized pustular psoriasis
Onoufriadis, A., Simpson, M.A., Pink, A.E., Di Meglio, P., Smith, C.H., Pullabhatla, V., Knight, J., Spain, S.L., Nestle, F.O., Burden, A.D., Capon, F., Trembath, R.C., Barker, J.N.W.N. 9/09/2011 In: American Journal of Human Genetics. 89, 3, p. 432-437. 6 p.
Journal article

A genome-wide significant linkage for severe depression on chromosome 3: the depression network study
Breen, G., Webb, B.T., Butler, A.W., van den Oord, E.J.C.G., Tozzi, F., Craddock, N., Gill, M., Korszun, A., Maier, W., Middleton, L., Mors, O., Owen, M.J., Cohen-Woods, S., Perry, J., Galwey, N.W., Upmanyu, R., Craig, I., Lewis, C.M., Ng, M., Brewster, S., Preisig, M., Rietschel, M., Jones, L., Knight, J., Rice, J., Muglia, P., Farmer, A.E., McGuffin, P. 08/2011 In: American Journal of Psychiatry. 168, 8, p. 840-847. 8 p.
Journal article

Using functional annotation for the empirical determination of Bayes Factors for genome-wide association study analysis
Knight, J., Barnes, M.R., Breen, G., Weale, M.E. 27/04/2011 In: PLoS ONE. 6, 4, 8 p.
Journal article

Common variants in DGKK are strongly associated with risk of hypospadias
van der Zanden, L.F.M., van Rooij, I.A.L.M., Feitz, W.F.J., Knight, J., Donders, A.R.T., Renkema, K.Y., Bongers, E.M.H.F., Vermeulen, S.H.H.M., Kiemeney, L.A.L.M., Veltman, J.A., Arias-Vásquez, A., Zhang, X., Markljung, E., Qiao, L., Baskin, L.S., Nordenskjöld, A., Roeleveld, N., Franke, B., Knoers, N.V.A.M. 01/2011 In: Nature Genetics. 43, 1, 3 p.
Letter

A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1
Strange, A., Capon, F., Spencer, C.C.A., Knight, J., Weale, M.E., Allen, M.H., Barton, A., Band, G., Bellenguez, C., Bergboer, J.G.M., Blackwell, J.M., Bramon, E., Bumpstead, S.J., Casas, J.P., Cork, M.J., Corvin, A., Deloukas, P., Dilthey, A., Duncanson, A., Edkins, S., Estivill, X., Fitzgerald, O., Freeman, C., Giardina, E., Gray, E., Hofer, A., Hüffmeier, U., Hunt, S.E., Irvine, A.D., Jankowski, J., Kirby, B., Langford, C., Lascorz, J., Leman, J., Leslie, S., Mallbris, L., Markus, H.S., Mathew, C.G., McLean, W.H.I., McManus, R., Mössner, R., Moutsianas, L., Naluai, A.T., Nestle, F.O., Novelli, G., Onoufriadis, A., Palmer, C.N.A., Perricone, C., Pirinen, M., Plomin, R., Potter, S.C., Pujol, R.M., Rautanen, A., Riveira-Munoz, E., Ryan, A.W., Salmhofer, W., Samuelsson, L., Sawcer, S.J., Schalkwijk, J., Smith, C.H., Ståhle, M., Su, Z., Tazi-Ahnini, R., Traupe, H., Viswanathan, A.C., Warren, R.B., Weger, W., Wolk, K., Wood, N., Worthington, J., Young, H.S., Zeeuwen, P.L.J.M., Hayday, A., 11/2010 In: Nature Genetics. 42, 11, 6 p.
Letter

An investigation of candidate regions for association with bipolar disorder
Knight, J., Rochberg, N.S., Saccone, S.F., Nurnberger, J.I., Rice, J.P., NIMH Genetics Initiative Bipolar Disorder Consortium 5/10/2010 In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics . 153B, 7, p. 1292-1297. 6 p.
Journal article

The Bipolar Association Case-Control Study (BACCS) and meta-analysis: no association with the 5,10-Methylenetetrahydrofolate reductase gene and bipolar disorder
Cohen-Woods, S., Craig, I., Gaysina, D., Gray, J., Gunasinghe, C., Craddock, N., Elkin, A., Jones, L., Kennedy, J., King, N., Korszun, A., Knight, J., Owen, M., Parikh, S., Strauss, J., Sterne, A., Tozzi, F., Perry, J., Muglia, P., Vincent, J., McGuffin, P., Farmer, A. 5/10/2010 In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics . 153B, 7, p. 1298-1304. 7 p.
Journal article

Natural selection on EPAS1 (HIF2alpha) associated with low hemoglobin concentration in Tibetan highlanders
Beall, C.M., Cavalleri, G.L., Deng, L., Elston, R.C., Gao, Y., Knight, J., Li, C., Li, J.C., Liang, Y., McCormack, M., Montgomery, H.E., Pan, H., Robbins, P.A., Shianna, K.V., Tam, S.C., Tsering, N., Veeramah, K.R., Wang, W., Wangdui, P., Weale, M.E., Xu, Y., Xu, Z., Yang, L., Zaman, M.J., Zeng, C., Zhang, L., Zhang, X., Zhaxi, P., Zheng, Y.T. 22/06/2010 In: Proceedings of the National Academy of Sciences. 107, 25, p. 11459-11464. 6 p.
Journal article

Software for generating liability distributions for pedigrees conditional on their observed disease states and covariates
Campbell, D.D., Sham, P.C., Knight, J., Wickham, H., Landau, S. 02/2010 In: Genetic Epidemiology. 34, 2, p. 159-170. 12 p.
Journal article

Depression Case Control (DeCC) study fails to support involvement of the muscarinic acetylcholine receptor M2 (CHRM2) gene in recurrent major depressive disorder
Cohen-Woods, S., Gaysina, D., Craddock, N., Farmer, A., Gray, J., Gunasinghe, C., Hoda, F., Jones, L., Knight, J., Korszun, A., Owen, M.J., Sterne, A., Craig, I.W., McGuffin, P. 15/04/2009 In: Human Molecular Genetics. 18, 8, p. 1504-1509. 6 p.
Journal article

A comparison of association statistics between pooled and individual genotypes
Knight, J., Saccone, S.F., Zhang, Z., Ballinger, D.G., Rice, J.P. 03/2009 In: Human Heredity. 67, 4, p. 219-225. 7 p.
Journal article

Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration
Simpson, C.L., Lemmens, R., Miskiewicz, K., Broom, W.J., Hansen, V.K., van Vught, P.W.J., Landers, J.E., Sapp, P., Van Den Bosch, L., Knight, J., Neale, B.M., Turner, M.R., Veldink, J.H., Ophoff, R.A., Tripathi, V.B., Beleza, A., Shah, M.N., Proitsi, P., Van Hoecke, A., Carmeliet, P., Horvitz, H.R., Leigh, P.N., Shaw, C.E., van den Berg, L.H., Sham, P.C., Powell, J.F., Verstreken, P., Brown, R.H., Robberecht, W., Al-Chalabi, A. 1/02/2009 In: Human Molecular Genetics. 18, 3, p. 472-481. 10 p.
Journal article

DSM-IV combined type ADHD shows familial association with sibling trait scores: a sampling strategy for QTL linkage
Chen, W., Zhou, K., Sham, P., Franke, B., Kuntsi, J., Campbell, D., Fleischman, K., Knight, J., Andreou, P., Arnold, R., Altink, M., Boer, F., Boholst, M.J., Buschgens, C., Butler, L., Christiansen, H., Fliers, E., Howe-Forbes, R., Gabriëls, I., Heise, A., Korn-Lubetzki, I., Marco, R., Medad, S., Minderaa, R., Müller, U.C., Mulligan, A., Psychogiou, L., Rommelse, N., Sethna, V., Uebel, H., McGuffin, P., Plomin, R., Banaschewski, T., Buitelaar, J., Ebstein, R., Eisenberg, J., Gill, M., Manor, I., Miranda, A., Mulas, F., Oades, R.D., Roeyers, H., Rothenberger, A., Sergeant, J., Sonuga-Barke, E., Steinhausen, H., Taylor, E., Thompson, M., Faraone, S.V., Asherson, P. 5/12/2008 In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics . 147B, 8, p. 1450-1460. 11 p.
Journal article

A simple method for assessing the strength of evidence for association at the level of the whole gene
Curtis, D., Vine, A.E., Knight, J. 17/11/2008 In: Advances and Applications in Bioinformatics and Chemistry : AABC. 1, p. 115-120. 6 p.
Journal article

CLUMPHAP: a simple tool for performing haplotype-based association analysis
Knight, J., Curtis, D., Sham, P.C. 09/2008 In: Genetic Epidemiology. 32, 6, p. 539-545. 7 p.
Journal article

Investigation into the ability of SNP chipsets and microsatellites to detect association with a disease locus
Curtis, D., Vine, A.E., Knight, J. 07/2008 In: Annals of Human Genetics. 72, 4, p. 547-556. 10 p.
Journal article

Differential methylation of the X-chromosome is a possible source of discordance for bipolar disorder female monozygotic twins
Rosa, A., Picchioni, M.M., Kalidindi, S., Loat, C.S., Knight, J., Toulopoulou, T., Vonk, R., van der Schot, A.C., Nolen, W., Kahn, R.S., McGuffin, P., Murray, R.M., Craig, I.W. 5/06/2008 In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics . 147B, 4, p. 459-462. 4 p.
Journal article

Study of regions of extended homozygosity provides a powerful method to explore haplotype structure of human populations
Curtis, D., Vine, A.E., Knight, J. 03/2008 In: Annals of Human Genetics. 72, 2, p. 261-278. 18 p.
Journal article

Association of the serotonin transporter gene, neuroticism and smoking behaviours
O'Gara, C., Knight, J., Stapleton, J., Luty, J., Neale, B., Nash, M., Heuzo-Diaz, P., Hoda, F., Cohen, S., Sutherland, G., Collier, D., Sham, P., Ball, D., McGuffin, P., Craig, I. 10/01/2008 In: Journal of Human Genetics . 53, 3, p. 239-246. 8 p.
Journal article

Dopamine genes and pathological gambling in discordant sib-pairs
da Silva Lobo, D.S., Vallada, H.P., Knight, J., Martins, S.S., Tavares, H., Gentil, V., Kennedy, J.L. 12/2007 In: Journal of Gambling Studies. 23, 4, p. 421-433. 13 p.
Journal article

Application of multi-locus analytical methods to identify interacting loci in case-control studies
Vermeulen, S.H.H.M., Den Heijer, M., Sham, P.C., Knight, J. 09/2007 In: Annals of Human Genetics. 71, 5, p. 689-700. 12 p.
Journal article

Age at onset in sod1-mediated amyotrophic lateral sclerosis shows familiality
Fogh, I., Rijsdijk, F., Andersen, P.M., Sham, P.C., Knight, J., Neale, B., McKenna-Yasek, D., Silani, V., Brown, R.H., Powell, J.F., Al-Chalabi, A. 08/2007 In: Neurogenetics. 8, 3, 2 p.
Letter

A pragmatic suggestion for dealing with results for candidate genes obtained from genome wide association studies
Curtis, D., Vine, A.E., Knight, J. 10/05/2007 In: Genetics. 8, 6 p.
Journal article

Homing in on depression genes
McGuffin, P., Cohen, S., Knight, J. 02/2007 In: American Journal of Psychiatry. 164, 2, 3 p.
Editorial

Regional multi-locus association models
Knight, J., Sham, P., Shaun, P., Neale, B. 2007 In: Statistical genetics. London : Taylor and Francis ISBN: 9780415410403.
Chapter

Investigation of the ability of haplotype association and logistic regression to identify associated susceptibility loci
North, B.V., Sham, P.C., Knight, J., Martin, E.R., Curtis, D. 11/2006 In: Annals of Human Genetics. 70, 6, p. 893-906. 14 p.
Journal article

The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes
Brookes, K., Xu, X., Chen, W., Zhou, K., Neale, B., Lowe, N., Anney, R., Franke, B., Gill, M., Ebstein, R., Buitelaar, J., Sham, P., Campbell, D., Knight, J., Andreou, P., Altink, M., Arnold, R., Boer, F., Buschgens, C., Butler, L., Christiansen, H., Feldman, L., Fleischman, K., Fliers, E., Howe-Forbes, R., Goldfarb, A., Heise, A., Gabriëls, I., Korn-Lubetzki, I., Johansson, L., Marco, R., Medad, S., Minderaa, R., Mulas, F., Müller, U., Mulligan, A., Rabin, K., Rommelse, N., Sethna, V., Sorohan, J., Uebel, H., Psychogiou, L., Weeks, A., Barrett, R., Craig, I., Banaschewski, T., Sonuga-Barke, E., Eisenberg, J., Kuntsi, J., Manor, I., McGuffin, P., Miranda, A., Oades, R.D., Plomin, R., Roeyers, H., Rothenberger, A., Sergeant, J., Steinhausen, H., Taylor, E., Thompson, M., Faraone, S.V., Asherson, P. 10/2006 In: Molecular Psychiatry. 11, 10, p. 934-953. 20 p.
Journal article

Design and analysis of association studies using pooled DNA from large twin samples
Knight, J., Sham, P. 09/2006 In: Behavior Genetics. 36, 5, p. 665-677. 13 p.
Journal article

NADPH oxidase (CYBA) and FcgammaR polymorphisms as risk factors for aggressive periodontitis: a case-control association study
Nibali, L., Parkar, M., Brett, P., Knight, J., Tonetti, M.S., Griffiths, G.S. 08/2006 In: Journal of Clinical Periodontology. 33, 8, p. 529-539. 11 p.
Journal article

Polymorphisms in the phosphate and tensin homolog gene are not associated with late-onset Alzheimer's disease
Hamilton, G., Samedi, F., Knight, J., Archer, N., Foy, C., Walter, S., Turic, D., Jehu, L., Moore, P., Hollingworth, P., O'Donovan, M.C., Williams, J., Owen, M.J., Lovestone, S., Powell, J.F. 19/06/2006 In: Neuroscience Letters. 401, 1-2, p. 77-80. 4 p.
Journal article

Program report: GENECOUNTING support programs
Curtis, D., Knight, J., Sham, P.C. 03/2006 In: Annals of Human Genetics. 70, Pt 2, p. 277-279. 3 p.
Journal article

A common haplotype of the dopamine transporter gene associated with attention-deficit/hyperactivity disorder and interacting with maternal use of alcohol during pregnancy
Brookes, K., Mill, J., Guindalini, C., Curran, S., Xu, X., Knight, J., Chen, C., Huang, Y., Sethna, V., Taylor, E., Chen, W., Breen, G., Asherson, P. 01/2006 In: Archives of General Psychiatry. 63, 1, p. 74-81. 8 p.
Journal article

Whole genome linkage scan of recurrent depressive disorder from the depression network study
McGuffin, P., Knight, J., Breen, G., Brewster, S., Boyd, P.R., Craddock, N., Gill, M., Korszun, A., Maier, W., Middleton, L., Mors, O., Owen, M.J., Perry, J., Preisig, M., Reich, T., Rice, J., Rietschel, M., Jones, L., Sham, P., Farmer, A.E. 15/11/2005 In: Human Molecular Genetics. 14, 22, p. 3337-3345. 9 p.
Journal article

DNA pooling analysis of ADHD and genes regulating vesicle release of neurotransmitters
Brookes, K.J., Knight, J., Xu, X., Asherson, P. 5/11/2005 In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics . 139B, 1, p. 33-37. 5 p.
Journal article

A new method of linkage analysis using LOD scores for quantitative traits supports linkage of monoamine oxidase activity to D17S250 in the Collaborative Study on the Genetics of Alcoholism pedigrees
Curtis, D., Knight, J., Sham, P.C. 09/2005 In: Psychiatric Genetics. 15, 3, p. 181-187. 7 p.
Journal article

SNPs, microarrays and pooled DNA: identification of four loci associated with mild mental impairment in a sample of 6000 children
Butcher, L.M., Meaburn, E., Knight, J., Sham, P.C., Schalkwyk, L.C., Craig, I.W., Plomin, R. 15/05/2005 In: Human Molecular Genetics. 14, 10, p. 1315-1325. 11 p.
Journal article

DNA pooling analysis of 21 norepinephrine transporter gene SNPs with attention deficit hyperactivity disorder: no evidence for association
Xu, X., Knight, J., Brookes, K., Mill, J., Sham, P., Craig, I., Taylor, E., Asherson, P. 5/04/2005 In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics . 134B, 1, p. 115-118. 4 p.
Journal article

A central resource for accurate allele frequency estimation from pooled DNA genotyped on DNA microarrays
Simpson, C.L., Knight, J., Butcher, L.M., Hansen, V.K., Meaburn, E., Schalkwyk, L.C., Craig, I.W., Powell, J.F., Sham, P.C., Al-Chalabi, A. 8/02/2005 In: Nucleic Acids Research. 33, 3
Journal article

Quantitative trait locus analysis of candidate gene alleles associated with attention deficit hyperactivity disorder (ADHD) in five genes: DRD4, DAT1, DRD5, SNAP-25, and 5HT1B
Mill, J., Xu, X., Ronald, A., Curran, S., Price, T., Knight, J., Craig, I., Sham, P., Plomin, R., Asherson, P. 5/02/2005 In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics . 133B, 1, p. 68-73. 6 p.
Journal article

TTF-1 and RET promoter SNPs: regulation of RET transcription in Hirschsprung's disease
Garcia-Barcelo, M., Ganster, R.W., Lui, V.C.H., Leon, T.Y.Y., So, M., Lau, A.M.F., Fu, M., Sham, M., Knight, J., Zannini, M.S., Sham, P.C., Tam, P.K.H. 15/01/2005 In: Human Molecular Genetics. 14, 2, p. 191-204. 14 p.
Journal article

The effect of haplotype-block definitions on inference of haplotype-block structure and htSNPs selection
Ding, K., Zhou, K., Zhang, J., Knight, J., Zhang, X., Shen, Y. 01/2005 In: Molecular Biology and Evolution. 22, 1, p. 148-159. 12 p.
Journal article

Haplotype analysis of SNAP-25 suggests a role in the aetiology of ADHD
Mill, J., Richards, S., Knight, J., Curran, S., Taylor, E., Asherson, P. 08/2004 In: Molecular Psychiatry. 9, 8, p. 801-810. 10 p.
Journal article

Attention-Deficit Hyperactivity Disorder in the post-genomic era
Asherson, P., Knight, J., IMAGE Consortium 07/2004 In: European Child and Adolescent Psychiatry. 13 , Suppl 1, p. I50-70. 21 p.
Journal article

Evidence that RNA editing modulates splice site selection in the 5-HT2C receptor gene
Flomen, R., Knight, J., Sham, P., Kerwin, R., Makoff, A. 1/04/2004 In: Nucleic Acids Research. 32, 7, p. 2113-2122. 10 p.
Journal article

A survey of current software for genetic power calculations
Knight, J. 2/03/2004 In: BMC Genomics. 1, 3, p. 225-227. 3 p.
Journal article

Endothelial nitric oxide gene haplotypes and risk of cerebral small-vessel disease
Hassan, A.E.M., Gormley, K., O'Sullivan, M., Knight, J., Sham, P.C., Vallance, P., Bamford, J., Markus, H.S. 03/2004 In: Stroke. 35, 3, p. 654-659. 6 p.
Journal article

Haplotype association analysis of discrete and continuous traits using mixture of regression models
Sham, P.C., Rijsdijk, F.V., Knight, J., Makoff, A., North, B., Curtis, D. 03/2004 In: Behavior Genetics. 34, 2, p. 207-214. 8 p.
Journal article

Mapping loci influencing blood pressure in the Framingham pedigrees using model-free LOD score analysis of a quantitative trait
Knight, J., North, B.V., Sham, P.C., Curtis, D. 31/12/2003 In: Genetics. 4 , Suppl. 1, 4 p.
Journal article

Genome-wide mapping of human loci for essential hypertension
Caulfield, M., Munroe, P., Pembroke, J., Samani, N., Dominiczak, A., Brown, M., Benjamin, N., Webster, J., Ratcliffe, P., O'Shea, S., Papp, J., Taylor, E., Dobson, R., Knight, J., Newhouse, S., Hooper, J., Lee, W., Brain, N., Clayton, D., Lathrop, G.M., Farrall, M., Connell, J., MRC British Genetics of Hypertension Study 21/06/2003 In: The Lancet. 361, 9375, p. 2118-2123. 6 p.
Journal article

Human chromosome 17 in essential hypertension
Knight, J., Munroe, P.B., Pembroke, J.C., Caulfield, M.J. 7/03/2003 In: Annals of Human Genetics. 67, 2, p. 193-206. 14 p.
Journal article

Haplotype and linkage disequilibrium analysis to characterise a region in the calcium channel gene CACNA1A associated with idiopathic generalised epilepsy
Chioza, B., Osei-Lah, A., Nashef, L., Suarez-Merino, B., Wilkie, H., Sham, P., Knight, J., Asherson, P., Makoff, A.J. 12/2002 In: European Journal of Human Genetics. 10, 12, p. 857-864. 8 p.
Journal article

Genes for hypertension
Caulfield, M., Knight, J., Gardener, G., O’Shea, S., Monroe, P. 2002 In: An introduction to vascular biology. Cambridge : Cambridge University Press ISBN: 9780521796521.
Chapter

Investigation of chromosome 17q as a locus for human essential hypertension in African Caribbeans
Knight, J., Gardner, G.T., Clark, A.J., Caulfield, M.J. 06/2000 In: Journal of Human Hypertension. 14, 6, p. 385-387. 3 p.
Journal article

1990-2000: progress in determining high blood pressure genes
Munroe, P.B., Knight, J., Caulfield, M.J. 05/2000 In: Annals of the Academy of Medicine, Singapore. 29, 3, p. 357-363. 7 p.
Journal article