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Dr Thomas Jaki

Dr Thomas Jaki

Reader

Fylde College
Lancaster University
Bailrigg
Lancaster
United Kingdom
LA1 4YF

+44 (0)1524 592318

Research Interests

  • Biostatistics
  • Pharmaceutical Statistics
  • Statistical Education

Thomas Jaki's Publications

In Press

Statistical evaluation of toxicological assays with zero or near-to-zero proportions or counts in the concurrent negative control group: a tutorial

Jaki, T., Kitsche, A. & Hothorn, L. A. 2014 In : JP Journal of Biostatistics.

Research output: Contribution to journalJournal article

2014

Flexible sequential designs for multi-arm clinical trials

Magirr, D., Stallard, N. & Jaki, T. 30/08/2014 In : Statistics in Medicine. 33, 19, p. 3269-3279 11 p.

Research output: Contribution to journalJournal article

A comparison of methods for classifying samples as truly specific with confirmatory immunoassays

Jaki, T., Lawo, J-P., Wolfsegger, M. J., Allacher, P. & Horling, F. 25/01/2014 In : Journal of Pharmaceutical and Biomedical Analysis. 88, p. 27-35 9 p.

Research output: Contribution to journalJournal article

A hybrid method to estimate the minimum effective dose for monotone and non-monotone dose-response relationships

Wolfsegger, M. J., Gutjahr, G., Engl, W. & Jaki, T. 2014 In : Biometrics. 70, 1, p. 103-109 7 p.

Research output: Contribution to journalJournal article

Some recommendations for multi-arm multi-stage trials

Wason, J., Magirr, D., Law, M. & Jaki, T. 2014 In : Statistical Methods in Medical Research.

Research output: Contribution to journalJournal article

2013

Estimation in AB/BA cross-over trials with application to bioequivalence studies with incomplete and complete data designs

Jaki, T., Pallmann, P. & Wolfsegger, M. J. 30/12/2013 In : Statistics in Medicine. 32, 30, p. 5469-5483 15 p.

Research output: Contribution to journalJournal article

Statistical evaluation of toxicological assays: Dunnett or Williams test? − take both

Jaki, T. & Hothorn, L. A. 11/2013 In : Archives of Toxicology. 87, 11, p. 1901-1910 10 p.

Research output: Contribution to journalJournal article

Planning multi-arm screening studies within the context of a drug development programme

Wason, J., Jaki, T. & Stallard, N. 10/09/2013 In : Statistics in Medicine. 32, 20, p. 3424-3435 12 p.

Research output: Contribution to journalJournal article

Differential effects of parental controls on adolescent substance use: for whom is the family most important?

Fagan, A. A., Van Horn, M. L., Hawkins, J. D. & Jaki, T. 09/2013 In : Journal of Quantitative Criminology. 29, 3, p. 347-368 22 p.

Research output: Contribution to journalJournal article

Multiplicity: discussion points from the PSI multiplicity expert group

Phillips, A., Fletcher, C., Atkinson, G., Channon, E., Douiri, A., Jaki, T., Maca, J., Morgan, D., Roger, J. H. & Terrill, P. 09/2013 In : Pharmaceutical Statistics. 12, 5, p. 255-259 5 p.

Research output: Contribution to journalJournal article

Analysing malaria drug trials on a per individual or a per clone basis: a comparison of methods

Jaki, T., Parry, A., Winter, K. & Hastings, I. 30/07/2013 In : Statistics in Medicine. 32, 17, p. 3020-3038 19 p.

Research output: Contribution to journalJournal article

Designing exploratory cancer trials using change in tumour size as primary endpoint

Jaki, T., Andre, V., Su, T-L. & Whitehead, J. 10/07/2013 In : Statistics in Medicine. 32, 15, p. 2544-2554 11 p.

Research output: Contribution to journalJournal article

Principles of dose finding studies in cancer: a comparison of trial designs

Jaki, T., Clive, S. & Weir, C. 05/2013 In : Cancer Chemotherapy and Pharmacology. 71, 5, p. 1107-1114 8 p.

Research output: Contribution to journalJournal article

Uptake of novel statistical methods for early phase clinical studies in the UK public sector

Jaki, T. 04/2013 In : Clinical Trials. 10, 2, p. 344-346 3 p.

Research output: Contribution to journalJournal article

Considerations on covariates and endpoints in multi-arm multi-stage clinical trials selecting all promising treatments

Jaki, T. & Magirr, D. 30/03/2013 In : Statistics in Medicine. 32, 7, p. 1150-1163 14 p.

Research output: Contribution to journalJournal article

Finite mixtures for simultaneously modelling differential effects and non-normal distributions

George, M., Yang, N., Jaki, T., Feaster, D., Lamont, A. E., Van Horn, M. L. & Wilson, D. K. 2013 In : Multivariate Behavioral Research. 48, 6, p. 816-844 29 p.

Research output: Contribution to journalJournal article

Simultaneous confidence intervals that are compatible with closed testing in adaptive designs

Magirr, D., Jaki, T., Posch, M. & Klingelmueller, F. 2013 In : Biometrika. 100, 4, p. 985-996 12 p.

Research output: Contribution to journalJournal article

Using regression mixture models with non-normal data: examining an ordered polytomous approach

George, M., Yang, N., Van Horn, M. L., Smith, J., Jaki, T., Feaster, D., Maysn, K. & Howe, G. 2013 In : Journal of Statistical Computation and Simulation. 83, 4, p. 757-770 14 p.

Research output: Contribution to journalJournal article

2012

Optimal design of multi-arm multi-stage trials

Wason, J. & Jaki, T. 30/12/2012 In : Statistics in Medicine. 31, 30, p. 4269-4279 11 p.

Research output: Contribution to journalJournal article

A novel phase I/IIa design for early phase oncology studies and its application in the evaluation of MK-0752 in pancreatic cancer

Whitehead, J., Thygesen, H., Jaki, T., Davis, S., Halford, S., Turner, H., Cook, N. & Jodrell, D. 15/08/2012 In : Statistics in Medicine. 31, 18, p. 1931-1943 13 p.

Research output: Contribution to journalJournal article

Recovering Independent Associations in Genetics: A Comparison

Sperrin, M. & Jaki, T. 08/2012 In : Journal of Computational Biology. 19, 8, p. 978–987 10 p.

Research output: Contribution to journalJournal article

A generalized Dunnett Test for Multi-arm Multi-stage Clinical Studies with Treatment Selection

Magirr, D., Jaki, T. & Whitehead, J. 06/2012 In : Biometrika. 99, 2, p. 494-501 8 p.

Research output: Contribution to journalJournal article

Non-compartmental estimation of pharmacokinetic parameters for flexible sampling designs

Jaki, T. & Wolfsegger, M. J. 2012 In : Statistics in Medicine. 31, 11-12, p. 1059-1073 25 p.

Research output: Contribution to journalJournal article

Not quite normal: Consequences of violating the assumption of normality with regression mixture models

Van Horn, M. L., Smith, J., Fagan, A., Jaki, T., Maysn, K., Hawkins, D., Feaster, D. & Howe, G. 2012 In : Structural Equation Modeling. 19, 2, p. 227-249 23 p.

Research output: Contribution to journalJournal article

2011

A formal comparison of different methods for establishing cut points to distinguish positive and negative samples in immunoassays.

Jaki, T., Lawo, J-P., Wolfsegger, M. J., Singer, J., Allacher, P. & Horling, F. 15/07/2011 In : Journal of Pharmaceutical and Biomedical Analysis. 55, 5, p. 1148-1156 9 p.

Research output: Contribution to journalJournal article

Estimation of pharmacokinetic parameters with the R package PK.

Jaki, T. & Wolfsegger, M. J. 05/2011 In : Pharmaceutical Statistics. 10, 2, p. 284-288 5 p.

Research output: Contribution to journalJournal article

Symmetric maximum kernel likelihood estimation.

Jaki, T. & West, R. W. 02/2011 In : Journal of Statistical Computation and Simulation. 81, 2, p. 193-206 14 p.

Research output: Contribution to journalJournal article

2010

Direct effects testing : a two-stage procedure to test for effect size and variable importance for correlated binary predictors and a binary response.

Sperrin, M. & Jaki, T. 30/10/2010 In : Statistics in Medicine. 29, 24, p. 2544-2556 13 p.

Research output: Contribution to journalJournal article

Establishing bioequivalence in complete and incomplete data designs using AUCs.

Jaki, T., Wolfsegger, M. J. & Lawo, J-P. 07/2010 In : Journal of Biopharmaceutical Statistics. 20, 4, p. 803-820 18 p.

Research output: Contribution to journalJournal article

Optimization, refinement and reduction of murine in vivo experiments to assess therapeutic approaches for hemophilia A.

Baumgartner, B., Jaki, T., Wolfsegger, M. J., Eder, B., Schiviz, A., Schwarz, H. P. & Muchitsch, E. M. 07/2010 In : Laboratory Animals. 44, 3, p. 211-217 7 p.

Research output: Contribution to journalJournal article

Probabilistic relabelling strategies for the label switching problem in Bayesian mixture models.

Sperrin, M., Jaki, T. & Wit, E. 07/2010 In : Statistics and Computing. 20, 3, p. 357-366 10 p.

Research output: Contribution to journalJournal article

Book review : Bioequivalence and statistics in clinical pharmacology.

Jaki, T. 04/2010 In : Journal of the Royal Statistical Society Series A. 173, 2, p. 467-468 2 p.

Research output: Contribution to journalBook/Film/Article review

2009

Assessing systemic drug exposure in repeated dose toxicity studies in the case of complete and incomplete sampling.

Wolfsegger, M. J. & Jaki, T. 12/2009 In : Biometrical Journal. 51, 6, p. 1017-1026 10 p.

Research output: Contribution to journalJournal article

Recording lectures as a service in a service course.

Jaki, T. 11/2009 In : Journal of Statistics Education. 17, 3

Research output: Contribution to journalJournal article

A note on statistical analysis of organ weights in non-clinical toxicological studies.

Wolfsegger, M. J., Jaki, T., Dietrich, B., Kunzler, J. A. & Barker, K. 10/2009 In : Toxicology and Applied Pharmacology. 240, 1, p. 117-122 6 p.

Research output: Contribution to journalJournal article

Non-compartmental estimation of pharmacokinetic parameters in serial sampling designs.

Wolfsegger, M. J. & Jaki, T. 10/2009 In : Journal of Pharmacokinetics and Pharmacodynamics. 36, 5, p. 479-494

Research output: Contribution to journalJournal article

Assessing differential effects: Applying regression mixture models to identify variations in the influence of family resources on academic achievement.

Van Horn, M. L., Jaki, T., Maysn, K., Ramey, S. L., Smith, J. A. & Antaramian, S. 09/2009 In : Developmental Psychology. 45, 5, p. 1298-1313 16 p.

Research output: Contribution to journalJournal article

A theoretical framework for estimation of AUCs in complete and incomplete sampling designs.

Jaki, T. & Wolfsegger, M. J. 05/2009 In : Statistics in Biopharmaceutical Research. 1, 2, p. 176-184 9 p.

Research output: Contribution to journalJournal article

Using a problem-based approach to teach statistics to postgraduate science students : a case study.

Jaki, T. & Autin, M. 05/2009 In : MSOR Connections. 9, 2, p. 40-47 8 p.

Research output: Contribution to journalJournal article

One- and two-stage design proposals for a phase II trial comparing three active treatments with control using an ordered categorical endpoint.

Whitehead, J. & Jaki, T. 28/02/2009 In : Statistics in Medicine. 28, 5, p. 828-847 20 p.

Research output: Contribution to journalJournal article

Confidence Intervals for Ratios of AUC's in the Case of Serial Sampling : A Comparison of Seven Methods.

Jaki, T., Wolfsegger, M. J. & Ploner, M. 01/2009 In : Pharmaceutical Statistics. 8, 1, p. 12-24 13 p.

Research output: Contribution to journalJournal article

2008

Using Multilevel Mixtures to Evaluate Intervention Effects in Group Randomized Trials.

Van Horn, M. L., Fagan, A. A., Jaki, T., Brown, E. C., Hawkins, J. D., Arthur, M. W., Abbott, R. D. & Catalano, R. F. 04/2008 In : Multivariate Behavioral Research. 43, 2, p. 289-326 38 p.

Research output: Contribution to journalJournal article

Book review: Applied Nonparametric Statistical Methods.

Jaki, T. 2008 In : Journal of Biopharmaceutical Statistics. 18, 2, p. 393-395 3 p.

Research output: Contribution to journalJournal article

Maximum Kernel Likelihood Estimation.

Jaki, T. & West, R. W. 2008 In : Journal of Computational and Graphical Statistics. 17, 4, p. 976-993 18 p.

Research output: Contribution to journalJournal article

2006

Simultaneous confidence intervals by iteratively adjusted alpha for relative effects in the one-way layout.

Wolfsegger, M. J. & Jaki, T. 2006 In : Statistics and Computing. 16, 1, p. 15-23 9 p.

Research output: Contribution to journalJournal article

2005

Estimation of AUC from 0 to Infinity in Serial Sacrifice Designs.

Wolfsegger, M. J. & Jaki, T. 12/2005 In : Journal of Pharmacokinetics and Pharmacodynamics. 32, 5-6, p. 757-766 10 p.

Research output: Contribution to journalJournal article

Current Students

Research students currently supervised by Thomas Jaki include: