Dr Howard Lindsay

Lecturer in Biomedical Sciences & Year 1 Director

Research Overview

My main research interests are the mechanisms that maintain genome stability, in particular the cellular responses to DNA damage and DNA replication stress. Using Xenopus cell-free egg extracts as a model system, the primary aim of this work is a greater understanding of the way the various DNA damage response pathways are integrated with the cell cycle machinery and how failure of these pathways can contribute to the development and progression of cancer.

Cip29 is phosphorylated following activation of the DNA damage response in Xenopus egg extracts
Holden, J., Taylor, E.M., Lindsay, H.D. 17/07/2017 In: PLoS ONE. 12, 7, 20 p.
Journal article

Molecular basis for PrimPol recruitment to replication forks by RPA
Guilliam, T.A., Brissett, N.C., Ehlinger, A., Keen, B.A., Kolesar, P., Taylor, E.M., Bailey, L., Lindsay, H.D., Chazin, W.J., Doherty, A.J. 23/05/2017 In: Nature Communications. 8, 14 p.
Journal article

DNA replication stress and cancer: cause or cure?
Taylor, E.M., Lindsay, H.D. 01/2016 In: Future Oncology. 12, 2, p. 221-237. 17 p.
Journal article

PrimPol bypasses UV photoproducts during chromosomal DNA replication
Bianchi, J., Rudd, S.G., Jozwiakowski, S.K., Bailey, L.J., Soura, V., Taylor, E., Stevanovic, I., Green, A.J., Stracker, T.H., Lindsay, H., Doherty, A.J. 21/11/2013 In: Molecular Cell. 52, 4, p. 566-573. 8 p.
Journal article

Depletion of Uhrf1 inhibits chromosomal DNA replication in Xenopus egg extracts
Taylor, E., Bonsu-Dartnall, N., Price, J., Lindsay, H. 20/06/2013 In: Nucleic Acids Research. 41, 16, p. 7725-7737. 13 p.
Journal article

The Mre11/Rad50/Nbs1 complex functions in resection-based DNA end joining in Xenopus laevis.
Taylor, E.M., Cecillon, S.M., Bonis, A., Chapman, J.R., Povirk, L.F., Lindsay, H.D. 01/2010 In: Nucleic Acids Research. 38, 2, p. 441-454. 14 p.
Journal article

A direct requirement for Xmus101 in ATR-mediated phosphorylation of Claspin bound Chk1 during checkpoint signaling.
Yan, S., Lindsay, H.D., Michael, W.M. 04/2006 In: Journal of Cell Biology. 173, 2, p. 181-186. 6 p.
Journal article

Delineating the position of rad4+/cut5+ within the DNA-structure checkpoint pathways in Schizosaccharomyces pombe.
Harris, S., Kemplen, C., Caspari, T., Chan, C., Lindsay, H.D., Poitelea, M., Carr, A.M., Price, C. 1/09/2003 In: Journal of Cell Science. 116, 17, p. 3519-3529. 11 p.
Journal article

Molecular Characterization of the Schizosaccharomyces pombe nbs1+ Gene Involved in DNA Repair and Telomere Maintenance.
Ueno, M., Nakazaki, T., Akamatsu, Y., Watanabe, K., Tomita, K., Lindsay, H.D., Shinagawa, H., Iwasaki, H. 09/2003 In: Molecular and Cellular Biology. 23, 18, p. 6553-6563. 11 p.
Journal article

XRad17 Is Required for the Activation of XChk1 But Not XCds1 during Checkpoint Signaling in Xenopus.
Jones, R.E., Chapman, J.R., Puligilla, C., Murray, J.M., Car, A.M., Ford, C.C., Lindsay, H.D. 2003 In: Molecular Biology of the Cell. 14, 9, p. 3898-3910. 13 p.
Journal article

DNA replication is required for the checkpoint response to damaged DNA in Xenopus egg extracts.
Stokes, M.P., Van Hatten, R., Lindsay, H.D., Michael, W.M. 09/2002 In: Journal of Cell Biology. 158, 5, p. 863-872. 10 p.
Journal article

Characterization of Schizosaccharomyces pombe Hus1: a PCNA-Related Protein That Associates with Rad1 and Rad9.
Caspari, T., Dahlen, M., Kanter-Smoler, G., Lindsay, H.D., Hofmann, K., Papadimitriou, K., Sunnerhagen, P., Carr, A.M. 02/2000 In: Molecular and Cellular Biology. 20, 4, p. 1254-1262. 9 p.
Journal article

Rad18 Is Required for DNA Repair and Checkpoint Responses in Fission Yeast.
Verkade, H.M., Bugg, S.J., Lindsay, H.D., Carr, A.M., O'Connell, M.J. 09/1999 In: Molecular Biology of the Cell. 10, 9, p. 2905-2918. 14 p.
Journal article

Analysis of Rad3 and Chk1 protein kinases defines different checkpoint responses.
Martinho, R.G., Lindsay, H.D., Flaggs, G., DeMaggio, A.J., Hoekstra, M.F., Carr, A.M., Bentley, N.J. 15/12/1998 In: EMBO Journal. 17, 24, p. 7239-7249. 11 p.
Journal article

S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe.
Lindsay, H.D., Griffiths, D.J.F., Edwards, R.J., Christensen, P.U., Murray, J.M., Osman, F., Walworth, N., Carr, A.M. 1/02/1998 In: Genes and Development. 12, 3, p. 382-395. 14 p.
Journal article

Post-translational activation of non-homologous DNA end-joining in Xenopus oocyte extracts.
Aoufouchi, S., Patrick, T., Lindsay, H.D., Shall, S., Ford, C.C. 07/1997 In: FEBS Journal. 247, 2, p. 518-525. 8 p.
Journal article

Dissection of the cell cycle using cell-free extracts from Xenopus laevis
Ford, C., Lindsay, H. 3/04/1996 In: Advances in molecular and cell biology. Elsevier Science Ltd. p. 117-211. 95 p.
Chapter (peer-reviewed)

Calcium requirements during mitotic cdc2 kinase activation and cyclin degradation in Xenopus egg extracts.
Lindsay, H.D., Whitaker, M.J., Ford, C.C. 11/1995 In: Journal of Cell Science. 108, 11, p. 3557-3568. 12 p.
Journal article