Dr Adam Taylor SFHEA

Director of the Clinical Anatomy Learning Centre & Senior Lecturer in Anatomy

Research Overview

My research interests lie within the field of osteoarthritis and the degeneration and turnover of cartilage and bone. My work commenced on a rare form of osteoarthritis; alkaptonuria, which is still studied in my lab. My work on this condition has lead me to also focus on arthritis and the turnover of joint tissues in response to disease(s) due to discoveries made whilst studying alkaptonuria.

I also have research interests allied to my delivery of anatomy teaching. I am interested in anatomy teaching and its delivery as part of modern medical and allied health curricula.

My most recent research is in public engagement in anatomy and the use of of public knowledge of anatomy in teaching and healthcare.

Anecdotes to the life and times of Sir Richard Owen (1804-1892) in Lancaster
Wessels, Q., Taylor, A.M. 1/11/2017 In: Journal of Medical Biography. 25, 4, p. 226-233. 8 p.
Journal article

What do the public know about anatomy?: Anatomy education to the public and the implications
Taylor, A.M., Diggle, P.J., Wessels, Q.B. 11/10/2017 In: Anatomical Sciences Education.
Journal article

Effects of superoxide dismutase on chondrocytes in osteoarthropathy of alkaptonuria.
Kammath, V., Bukhari, M.A.S., Taylor, A.M. 04/2017
Meeting abstract

Nitisinone therapy shows beneficial effects on the chondrocytes and extracellular matrix in the osteoarthropathy of alkaptonuria
Mistry, J., Jackson, D., Bukhari, M.A.S., Taylor, A.M. 04/2017
Meeting abstract

Cartilage biomarkers in the osteoarthropathy of alkaptonuria reveal low turnover and accelerated ageing
Taylor, A.M., Hsueh, M., Ranganath, L., Gallagher, J., Dillon, J., Huebner, J., Catterall, J., Byers Kraus, V. 01/2017 In: Rheumatology. 56, 1, p. 156-164. 9 p.
Journal article

Analysis of melanin-like pigment synthesized from homogentisic acid, with or without tyrosine, and its implications in Alkaptonuria
Taylor, A.M., Vercruysse, K. 10/12/2016 In: Journal of Inherited Metabolic Disease Reports. 7 p.
Journal article

Sir William Turner (1832–1916) – Lancastrian, anatomist and champion of the Victorian era
Wessels, Q., Correia, J.C., Taylor, A. 11/2016 In: Journal of Medical Biography. 24, 4, p. 500-506. 7 p.
Journal article

The social life of the dead: the role of post-mortem examinations in medical student socialisation
Goodwin, D.S., Machin, L.L., Taylor, A.M. 1/07/2016 In: Social Science and Medicine. 161, p. 100-108. 9 p.
Journal article

A role for interleukins in ochronosis in a chondrocyte in vitro model of alkaptonuria
Mistry, J., Jackson, D., Bukhari, M., Taylor, A. 07/2016 In: Clinical Rheumatology. 35, 7, p. 1849-1856. 7 p.
Journal article

Tyrosinase, could it be a missing link in ochronosis in alkaptonuria?
Taylor, A.M., Kammath, V., Bleakley, A. 1/06/2016 In: Medical Hypotheses. 91, p. 77-80. 4 p.
Journal article

Health, disease and society in nineteenth century Lancaster
Dass, S., Wessels, Q.B., Taylor, A.M. 06/2016 In: Morecambe Bay Medical Journal. 7, 6, p. 160-165. 6 p.
Journal article

Health, disease and society
Dass, S., Wessels, Q.B., Taylor, A.M. 30/04/2016 In: The medical pioneers of nineteenth century Lancaster. Neopubli GmbH p. 6-19. 14 p.
Chapter (peer-reviewed)

Medicine and the evolving medical market
Taylor, A.M., Wessels, Q.B., Correia, J.C. 30/04/2016 In: The medical pioneers of nineteenth century Lancaster. Neopubli GmbH p. 20-35. 16 p.
Chapter (peer-reviewed)

The asylums and pioneers of psychiatric care
Shaw, H., Wessels, Q.B., Taylor, A.M., Chin-Quee, E. 30/04/2016 In: The medical pioneers of nineteenth century Lancaster. Neopubli GmbH p. 99-121. 23 p.
Chapter (peer-reviewed)

The educationalist and medical reformer
Wessels, Q.B., Correia, J.C., Taylor, A.M. 30/04/2016 In: The medical pioneers of nineteenth century Lancaster. Neopubli GmbH p. 122-136. 15 p.
Chapter (peer-reviewed)

The sanitary reformers and public health
Wessels, Q.B., Taylor, A.M., Denfhy, J. 30/04/2016 In: The medical pioneers of nineteenth century Lancaster. Neopubli GmbH p. 81-98. 18 p.
Chapter (peer-reviewed)

Bacterial toxins in the urine of patients with rheumatoid arthritis: a cause of the condition or an opportunistic result of it?
Grace, L., Bukhari, M., Lauder, R.M., Bishop, L.A., Taylor, A.M. 04/2016
Meeting abstract

Osteoarticular cells tolerate short-term exposure to nitisinone-implications in alkaptonuria
Mistry, J.B., Jackson, D.J., Bukhari, M., Taylor, A. 02/2016 In: Clinical Rheumatology. 35, 2, p. 513-516. 4 p.
Journal article

Development of a technique to identify Staphylococcal Enterotoxin fragments in urine from patients with Rheumatoid Arthritis
Grace, L.E., Bukhari, M.A.S., Lauder, R.M., Taylor, A.M. 20/04/2015
Meeting abstract

Analysis of cartilage biomarkers of aging and turnover in the osteoarthropathy of alkaptonuria.
Taylor, A.M., Hsueh, M., Ranganath, L., Gallagher, J., Huebner, J., Catterall, J., Byers Kraus, V. 2015
Poster

Ochronotic osteoarthropathy in a mouse model of alkaptonuria, and its inhibition by nitisinone.
Preston, A.J., Keenan, C.M., Sutherland, H., Wilson, P.J., Wlodarski, B., Taylor, A., Williams, D.P., Ranganath, L.R., Gallagher, J.A., Jarvis, J.C. 01/2014 In: Annals of the Rheumatic Diseases. 73, 1, p. 284-289. 6 p.
Journal article

A role for interleukins in the rapid progression of osteoarthritis in alkaptonuria.
Taylor, A.M., Bukhari, M.A.S., Mistry, J. 2014
Poster

New Lessons From An Old Disease - What Alkaptonuria Teaches Us About Cartilage and Bone Remodelling
Keenan, C., Boyde, A., Ranganath, L., Gallagher, J., Jeffery , N., Jarvis, J.C., Taylor, A.M. 2014
Poster

Alkaptonuria
Mistry, J., Bukhari, M., Taylor, A. 18/12/2013 In: Rare Diseases. 1, 7 p.
Journal article

Metabolic and endocrine diseases, cartilage calcification and arthritis
Taylor, A. 03/2013 In: Current Opinion in Rheumatology. 25, 2, p. 198-203. 6 p.
Journal article

Analysis of cartilage biomarkers of aging and turnover in the osteoarthropathy of alkaptonuria.
Taylor, A.M., Hsueh, M., Ranganath, L., Gallagher, J., Huebner, J., Catterall, J., Byers Kraus, V. 2013
Poster

Ochronosis in a murine model of alkaptonuria, a new experimental model of osteoarthropathy.
Keenan, C., Preston, A., Sutherland, H., Wilson, P.J.M., Wlodarski, B., Taylor, A.M., Williams, D., Ranganath, L., Gallagher, J., Jarvis, J.C. 2013
Poster

The early onset and severe osteoarthropathy of alkaptonuria has major lessons for the pathogenesis of osteoarthritis.
Gallagher, J., Taylor, A.M., Keenan, C., Preston, A., Wilson, P.J.M., Jarvis, J., Ranganath, L., Boyde, A. 2013
Poster

Recent advances in understanding the pathogenesis of ochronosis: Najnowsze postępy w zrozumieniu patogenezy ochronozy
Gallagher, J., Taylor, A., Boyde, A., Jarvis, J., Ranganath, L. 7/09/2012 In: Reumatologia. 50, 4, p. 316–323. 8 p.
Journal article

Ochronosis in a murine model of alkaptonuria is synonymous to that in the human condition
Taylor, A., Preston, A.J., Paulk, N.K., Sutherland, H., Keenan, C.M., Wilson, P.J.M., Wlodarski, B., Grompe, M., Ranganath, L.R., Gallagher, J.A., Jarvis, J.C. 08/2012 In: Osteoarthritis and Cartilage. 20, 8, p. 880-886. 7 p.
Journal article

Identification of trabecular excrescences, novel microanatomical structures, present in bone in osteoarthropathies
Taylor, A., Boyde, A., Davidson, J.S., Jarvis, J.C., Ranganath, L.R., Gallagher, J.A. 21/04/2012 In: European Cells and Materials. 23, p. 300-309. 10 p.
Journal article

Identification of an extraordinary bone phenotype in a patient with alkaptonuria.
Taylor, A.M., Davidson, J.S., Jarvis, J.C., Ranganath, L., Gallagher, J. 2012
Poster

Trabecular excrescences are present in osteoarthropathies including osteoarthritis.
Taylor, A.M., Boyde, A., Davidson, J.S., Jarvis, J.C., Ranganath, L., Gallagher, J. 2012
Poster

Primary human osteoblast cultures
Dillon, J.P., Waring-Green, V.J., Taylor, A., Wilson, P.J.M., Birch, M., Gartland, A., Gallagher, J.A. 31/12/2011 In: Bone research protocols . Springer p. 3-18. 16 p.
Chapter (peer-reviewed)

Collagen atomic scale molecular disorder in ochronotic cartilage from an alkaptonuria patient, observed by solid state NMR.
Chow, W.Y., Taylor, A., Reid, D.G., Gallagher, J.A., Duer, M.J. 12/2011 In: Journal of Inherited Metabolic Disease. 34, 6, p. 1137-1140. 4 p.
Journal article

The role of calcified cartilage and subchondral bone in the initiation and progression of ochronotic arthropathy in alkaptonuria.
Taylor, A., Boyde, A., Wilson, P.J.M., Jarvis, J.C., Davidson, J.S., Hunt, J.A., Ranganath, L.R., Gallagher, J.A. 12/2011 In: Arthritis and Rheumatism. 63, 12, p. 3887-3896. 10 p.
Journal article

Ochronosis and calcification in the mediastinal mass of a patient with alkaptonuria.
Taylor, A., Batchelor, T.J.P., Adams, V.L., Helliwell, T.R., Gallagher, J.A., Ranganath, L.R. 10/2011 In: Journal of Clinical Pathology. 64, 10, p. 935-936. 2 p.
Journal article

Identification of alkaptonuria in the general population: a United Kingdom experience describing the challenges, possible solutions and persistent barriers.
Ranganath, L.R., Taylor, A., Shenkin, A., Fraser, W.D., Jarvis, J.C., Gallagher, J.A., Sireau, N. 06/2011 In: Journal of Inherited Metabolic Disease. 34, 3, p. 723-730. 8 p.
Journal article

Development of an in vitro model to investigate joint ochronosis in alkaptonuria.
Tinti, L., Taylor, A., Santucci, A., Wlodarski, B., Wilson, P.J.M., Jarvis, J.C., Fraser, W.D., Davidson, J.S., Ranganath, L.R., Gallagher, J.A. 02/2011 In: Rheumatology. 50, 2, p. 271-277. 7 p.
Journal article

Analysis of cartilage biomarkers of aging and turnover in the osteoarthropathy of alkaptonuria.
Taylor, A.M., Hsueh, M., Ranganath, L., Gallagher, J., Huebner, J., Catterall, J., Byers Kraus, V. 2011
Poster

Detection of novel microanatomical structures in bone from a patient with alkaptonuria (AKU).
Taylor, A.M., Boyde, A., Davidson, J.S., Jarvis, J.C., Ranganath, L., Gallagher, J. 2011
Poster

Proteomic and redox-proteomic evaluation of homogentisic acid and ascorbic acid effects on human articular chondrocytes.
Braconi , D., Laschi, M., Taylor, A., Bernardini, G., Spreafico, A., Tinti, L., Gallagher, J.A., Santucci, A. 1/11/2010 In: Journal of Cellular Biochemistry. 111, 4, p. 922-932. 11 p.
Journal article

Ultrastructural examination of tissue in a patient with alkaptonuric arthropathy reveals a distinct pattern of binding of ochronotic pigment.
Taylor, A., Wlodarski, B., Prior, I.A., Wilson, P.J.M., Jarvis, J.C., Ranganath, L.R., Gallagher, J.A. 07/2010 In: Rheumatology. 49, 7, p. 1412-1414. 3 p.
Journal article

Calculi and intracellular ochronosis in the submandibular tissues from a patient with alkaptonuria.
Taylor, A., Wilson, P.J.M., Ingrams, D.R., Helliwell, T.R., Gallagher, J.A., Ranganath, L.R. 02/2010 In: Journal of Clinical Pathology. 63, 2, p. 186-188. 3 p.
Journal article

Elucidating the mechanism of osteoarthropathy in alkaptonuria: lessons for osteoarthritis.
Taylor, A.M., Boyde, A., Wlodarski, B., Davidson, J.S., Wilson, P.J.M., Jarvis, J.C., Ranganath, L., Gallagher, J. 2010
Poster

Identification of joint ochronosis in a mouse model of alkaptonuria
Taylor, A.M., Preston, A., Paulk, N., Sutherland, H., Keenan, C., Wilson, P.J.M., Wlodarski, B., Grompe, M., Ranganath, L., Gallagher, J., Jarvis, J.C. 2010
Poster

High resolution electron microscopy identifies distinctive binding of ochronotic pigment to collagen fibres in alkaptonuria
Taylor, A.M. 2008
Poster

Studies on the Deposition of Ochronotic Pigment in Alkaptonuria Reveal Tyrosine Metabolism in Human Chondrocytes
Taylor, A.M., Wilson, P.J.M., Fraser, W.D., Ranganath, L., Gallagher, J. 2008
Poster