Professor Hedley Emsley

Professor of Clinical Neuroscience

Research Overview

(1) Cerebrovascular disease and its interface with other neurological disorders - including vascular changes in neurodegeneration and the role of novel neuronal and vascular imaging

(2) Inflammation and infection in cerebrovascular disease and other neurological disorders

(3) Novel mechanisms, therapeutic targets and biomarkers in cerebrovascular disease and other neurological disorders

(4) Clinical trials in cerebrovascular disease and other neurological disorders

(5) Use of routine clinical data for novel applications, including neurological clinical pathways

Integrating acute stroke telemedicine consultations into specialists' usual practice: a qualitative analysis comparing the experience of Australia and the United Kingdom
Bagot, K., Cadilhac, D., Bladin, C., Watkins, C., Vu, M., Donnan, G., Dewey, H., Emsley, H., Davies, D., Day, E., Ford, G., Price, C., May, C., McLoughlin, A., Gibson, J., Lightbody, C., VST, ASTUTE investigators 21/11/2017 In: BMC Health Services Research. 17, 1, 8 p.
Journal article

Structural and physiological neurovascular changes in idiopathic Parkinson's disease and its clinical phenotypes
Al-Bachari, S., Vidyasagar, R., Emsley, H.C.A., Parkes, L.M. 1/10/2017 In: Journal of Cerebral Blood Flow and Metabolism. 37, 10, p. 3409-3421. 13 p.
Journal article

Cluster-Randomized, Crossover Trial of Head Positioning in Acute Stroke
HeadPoST Investigators and Coordinators 22/06/2017 In: New England Journal of Medicine. 376, p. 2437-2447. 11 p.
Journal article

The Utility of FDG-PET/CT in Clinically Suspected Paraneoplastic Neurological Syndrome: A Literature Review and Retrospective Case Series
Maskery, M., Hill, J., Cain, J.R., Emsley, H. 1/06/2017 In: Frontiers in Neurology. 8, 7 p.
Journal article

Outcome of intracerebral hemorrhage associated with different oral anticoagulants
Cromis-2 Collaboration 2/05/2017 In: Neurology. 88, 18, p. 1693-1700. 8 p.
Journal article

Reasons for non-recruitment of eligible patients to a randomised controlled trial of secondary prevention after intracerebral haemorrhage: observational study
Maxwell, A.E., MacLeod, M.J., Joyson, A., Johnson, S., Ramadan, H., Bellfield, R., Byrne, A., McGhee, C., Rudd, A., Price, F., Vasileiadis, E., Holden, M., Hewitt, J., Carpenter, M., Needle, A., Valentine, S., Patel, F., Harrington, F., Mudd, P., Emsley, H., Gregary, B., Kane, I., Muir, K., Tiwari, D., Owusu-Agyei, P., Temple, N., Sekaran, L., Ragab, S., England, T., Hedstrom, A., Jones, P., Jones, S., Doherty, M., McCarron, M.O., Cohen, D.L., Tysoe, S., Al-Shahi Salman, R. 5/04/2017 In: Trials. 18, 1, 5 p.
Journal article

Urgent referral for suspected CNS cancer: which clinical features are associated with a positive predictive value of 3 % or more?
Mohammad, H.R., Boardman, J., Howell, L., Mills, R.J., Emsley, H.C.A. 26/08/2016 In: BMC Neurology. 16, 1, 6 p.
Journal article

'It was like he was in the room with us': Patients' and carers' perspectives of telemedicine in acute stroke
Gibson, J., Lightbody, E., Mcloughlin, A., Mcadam, J., Gibson, A., Day, E., Fitzgerald, J., May, C., Price, C., Emsley, H., Ford, G.A., Watkins, C. 1/02/2016 In: Health Expectations. 19, 1, p. 98-111. 14 p.
Journal article

HIV, antiretroviral treatment, hypertension, and stroke in Malawian adults
Benjamin, L.A., Corbett, E.L., Connor, M.D., Mzinganjira, H., Kampondeni, S., Choko, A., Hopkins, M., Emsley, H.C.A., Bryer, A., Faragher, B., Heyderman, R.S., Allain, T.J., Solomon, T. 26/01/2016 In: Neurology. 86, 4, p. 324-333. 10 p.
Journal article

Volume and functional outcome of intracerebral hemorrhage according to oral anticoagulant type
Wilson, D., Charidimou, A., Shakeshaft, C., Ambler, G., White, M., Cohen, H., Yousry, T., Al-Shahi Salman, R., Lip, G.Y.H., Brown, M.M., Jäger, H.R., Werring, D.J., Emsley, H., CROMIS-2 collaborators 26/01/2016 In: Neurology. 86, 4, p. 360-366. 7 p.
Journal article

Effect of alteplase on the CT hyperdense artery sign and outcome after ischemic stroke
Mair, G., von Kummer, R., Morris, Z., von Heijne, A., Bradey, N., Cala, L., Peeters, A., Farrall, A.J., Adami, A., Potter, G., Cohen, G., Sandercock, P.A.G., Lindley, R.I., Wardlaw, J.M., Emsley, H., IST-3 Collaborative Group 12/01/2016 In: Neurology. 86, 2, p. 118-125. 8 p.
Journal article

Morvan Syndrome: A Case Report With Patient Narrative and Video
Maskery, M., Chhetri, S.K., Dayanandan, R., Gall, C., Emsley, H.C.A. 1/01/2016 In: The Neurohospitalist. 6, 1, p. 32-35. 4 p.
Journal article

Structural and physiological MRI correlates of occult cerebrovascular disease in late-onset epilepsy
Hanby, M.F., Al-Bachari, S., Makin, F., Vidyasagar, R., Parkes, L.M., Emsley, H.C.A. 1/09/2015 In: NeuroImage: Clinical. 9, p. 128-133. 6 p.
Journal article

Response: Myasthenia gravis as a ‘stroke mimic’
Emsley, H.C.A. 1/04/2015 In: Clinical Medicine. 15, 2, 1 p.
Letter

Antiplatelet treatment compared with anticoagulation treatment for cervical artery dissection (CADISS): a randomised trial
Markus, H.S., Hayter, E., Levi, C., Feldman, A., Venables, G., Norris, J., Emsley, H., CADISS trial investigators 04/2015 In: Lancet Neurology. 14, 4, p. 361-367. 7 p.
Journal article

Paroxysmal dysarthria ataxia syndrome responds to lacosamide
Lilleker, J.B., Gall, C., Dayanandan, R., Chhetri, S.K., Emsley, H.C.A. 17/02/2015 In: Multiple Sclerosis. 21, 2, 1 p.
Letter

Myasthenia gravis as a 'stroke mimic'--it's all in the history
Shaik, S., Ul-Haq, M.A.y., Emsley, H.C.A. 1/12/2014 In: Clinical Medicine. 14, 6, p. 640-642. 3 p.
Journal article

Reversible Cerebral Vasoconstriction Syndrome With Involvement of External Carotid Artery Branches
Shaik, S., Chhetri, S.K., Roberts, G., Wuppalapati, S., Emsley, H.C.A. 1/07/2014 In: The Neurohospitalist. 4, 3, p. 141-143. 3 p.
Journal article

Copper deficiency
Chhetri, S.K., Mills, R.J., Shaunak, S., Emsley, H.C.A. 17/06/2014 In: BMJ. 348, 4 p.
Journal article

Variations in inflammation-related genes may be associated with childhood febrile seizure susceptibility
Emsley, H.C.A., Appleton, R.E., Whitmore, C.L., Jury, F., Lamb, J.A., Martin, J.E., Ollier, W.E.R., De La Morandière, K.P., Southern, K.W., Allan, S.M. 06/2014 In: Seizure - European Journal of Epilepsy. 23, 6, p. 457-461. 5 p.
Journal article

Late-onset epilepsy and occult cerebrovascular disease
Gibson, L.M., Hanby, M.F., Al-Bachari, S.M., Parkes, L.M., Allan, S.M., Emsley, H.C.A. 1/04/2014
Review article

Titin founder mutation is a common cause of myofibrillar myopathy with early respiratory failure
Pfeffer, G., Barresi, R., Wilson, I.J., Hardy, S.A., Griffin, H., Hudson, J., Elliott, H.R., Ramesh, A.V., Radunovic, A., Winer, J.B., Vaidya, S., Raman, A., Busby, M., Farrugia, M.E., Ming, A., Everett, C., Emsley, H.C.A., Horvath, R., Straub, V., Bushby, K., Lochmüller, H., Chinnery, P.F., Sarkozy, A. 1/03/2014 In: Journal of Neurology, Neurosurgery and Psychiatry. 85, 3, p. 331-338. 8 p.
Journal article

Arterial spin labelling reveals prolonged arterial arrival time in idiopathic Parkinson's disease
Al-Bachari, S., Parkes, L.M., Vidyasagar, R., Hanby, M.F., Tharaken, V., Leroi, I., Emsley, H.C.A. 2014 In: NeuroImage: Clinical. 6, p. 1-8. 8 p.
Journal article

The challenges of implementing a telestroke network: a systematic review and case study
French, B., Day, E., Watkins, C., McLoughlin, A., Fitzgerald, J., Leathley, M., Davies, P., Emsley, H., Ford, G., Jenkinson, D., May, C., O'Donnell, M., Price, C., Sutton, C., Lightbody, C. 14/11/2013 In: BMC Medical Informatics and Decision Making. 13, 1, 9 p.
Journal article

Intact neurological outcome after neurointerventional treatment for intracranial venous thrombosis with straight sinus involvement
Sidhu, M., Footitt, D., Donaldson, I., Hughes, S., Wuppalapati, S., Emsley, H.C.A. 2/09/2013 In: BMJ Case Reports. 2013
Journal article

Postexertional harlequin syndrome with spontaneous improvement
Emsley, H. 2/09/2013 In: BMJ Case Reports. 1 p.
Comment/debate

Acute Stroke Training and Assessment in Computerised Axial Tomography (ASTRACAT) for stroke physicians: facilitating telestroke implementation in a UK setting
Emsley, H., Blacker, K., Day, E., Punekar, S., O'Donnell, M., Davies, D.P., Turnbull, I. 10/07/2013 In: Journal of Contemporary Medical Education. 1, 3, p. 137-141. 5 p.
Journal article

Posterior circulation stroke: still a Cinderella disease
Emsley, H. 22/06/2013 In: BMJ. 346, 7913, 2 p.
Editorial

Prevalence and subtypes of radiological cerebrovascular disease in late-onset isolated seizures and epilepsy
Maxwell, H., Hanby, M., Parkes, L.M., Gibson, L.M., Coutinho, C., Emsley, H.C.A. 05/2013 In: Clinical Neurology and Neurosurgery. 115, 5, p. 591-596. 6 p.
Journal article

Neurological symptoms in a post-transplant patient: a cautionary tale
Chhetri, S.K., Dayanandan, R., Jacob, J., Sonwalkar, H., Ahmed, A., Kumar, V., Emsley, H. 01/2013 In: Journal of Neurology . 260, 1, 3 p.
Letter

Recurrent stereotyped episodes in cerebral amyloid angiopathy: response to migraine prophylaxis in two patients
Paterson, R.W., Uchino, K., Emsley, H., Pullicino, P. 01/2013 In: Cerebrovascular Diseases Extra. 3, 1, p. 81-84. 4 p.
Journal article

HIV infection and stroke: current perspectives and future directions
Benjamin, L.A., Bryer, A., Emsley, H.C.A., Khoo, S., Solomon, T., Connor, M.D. 10/2012
Review article

Hi4D-ADSIP 3-D dynamic facial articulation database
Matuszewski, B.J., Quan, W., Shark, L.K., McLoughlin, A.S., Lightbody, C.E., Emsley, H.C.A., Watkins, C.L. 10/2012 In: Image and Vision Computing. 30, 10, p. 713-727. 15 p.
Journal article

The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third international stroke trial [IST-3]): a randomised controlled trial
Sandercock, P., Wardlaw, J.M., Lindley, R.I., Dennis, M., Cohen, G., Murray, G., Innes, K., Venables, G., Czlonkowska, A., Kobayashi, A., Ricci, S., Murray, V., Berge, E., Slot, K.B., Hankey, G.J., Correia, M., Peeters, A., Matz, K., Lyrer, P., Gubitz, G., Phillips, S.J., Arauz, A., Emsley, H., IST-3 collaborative group 23/06/2012 In: The Lancet. 379, 9834, p. 2352-2363. 12 p.
Journal article

Interleukin-1 receptor antagonist reverses stroke-associated peripheral immune suppression
Smith, C.J., Emsley, H.C., Udeh, C.T., Vail, A., Hoadley, M.E., Rothwell, N.J., Tyrrell, P.J., Hopkins, S.J. 06/2012 In: Cytokine. 58, 3, p. 384-389. 6 p.
Journal article

When stopping the antiplatelet drugs stopped the 'TIAs'
Emsley, H.C.A., Kowalewska-Zietek, J., Gulati, R.S., Wuppalapati, S. 02/2012 In: Practical Neurology. 12, 1, p. 36-39. 4 p.
Journal article

Calibrated fMRI during a cognitive Stroop task reveals reduced metabolic response with increasing age
Mohtasib, R.S., Lumley, G., Goodwin, J.A., Emsley, H.C.A., Sluming, V., Parkes, L.M. 16/01/2012 In: NeuroImage. 59, 2, p. 1143-1151. 9 p.
Journal article

Recognising stroke and transient ischaemic attack - The role of primary care
Jones, S.P., Emsley, H.C.A., Gibson, J.M.E., Leathley, M.J., Sharma, A., Watkins, C.L. 01/2012
Short survey

A new way of looking at the face?
Emsley, H., Lightbody, C.E., Matuszewski, B.J., Sivaramalingam, M., Watkins, C.L. 12/2011 In: British Journal of Hospital Medicine. 72, 12, 2 p.
Editorial

Prevalence of radiological and clinical cerebrovascular disease in idiopathic Parkinson's disease
Patel, M., Coutinho, C., Emsley, H.C.A. 12/2011 In: Clinical Neurology and Neurosurgery. 113, 10, p. 830-834. 5 p.
Journal article

Update on the third international stroke trial (IST-3) of thrombolysis for acute ischaemic stroke and baseline features of the 3035 patients recruited
Sandercock, P., Lindley, R., Wardlaw, J., Dennis, M., Innes, K., Cohen, G., Whiteley, W., Perry, D., Soosay, V., Buchanan, D., Venables, G., Czlonkowska, A., Kobayashi, A., Berge, E., Slot, K.B., Murray, V., Peeters, A., Hankey, G.J., Matz, K., Brainin, M., Ricci, S., Cantisani, T.A., Gubitz, G., Phillips, S.J., Antonio, A., Correia, M., Lyrer, P., Kane, I., Lundstrom, E., Emsley, H., IST-3 collaborative group 30/11/2011 In: Trials. 12, 9 p.
Journal article

Dermatomes and dogma
Apok, V., Gurusinghe, N.T., Mitchell, J.D., Emsley, H.C.A. 04/2011 In: Practical Neurology. 11, 2, p. 100-105. 6 p.
Journal article

Occult cerebrovascular disease and late-onset epilepsy: could loss of neurovascular unit integrity be a viable model?
Gibson, L.M., Allan, S.M., Parkes, L.M., Emsley, H.C.A. 2011 In: Cardiovascular Psychiatry and Neurology. 2011, 7 p.
Journal article

Rapidly progressive polyneuropathy due to dry beriberi in a man: a case report
Howard, A.J., Kulkarni, O., Lekwuwa, G., Emsley, H.C.A. 21/12/2010 In: Journal of Medical Case Reports. 4
Journal article

Telestroke: when location, location, location doesn't matter
Emsley, H., Blacker, K., Davies, P., O'Donnell, M. 7/10/2010 In: Health Service Journal. 120, 6227, p. 24-25. 2 p.
Journal article

Post-stroke immunodepression and infection: an emerging concept
Emsley, H.C.A., Hopkins, S.J. 2010 In: Infectious Disorders - Drug Targets. 10, 2, p. 91-97. 7 p.
Journal article

Stroke bugs: current and emerging concepts relevant to infection in cerebrovascular disease
Emsley, H.C.A., Chamorro, A. 2010 In: Infectious Disorders - Drug Targets. 10, 2, 2 p.
Editorial

Improving undergraduate clinical neurology bedside teaching: opening the magic circle
Emsley, H. 09/2009 In: Clinical Teacher. 6, 3, p. 172-176. 5 p.
Journal article

The incidence of acute encephalitis syndrome in Western industrialised and tropical countries
Jmor, F., Emsley, H.C.A., Fischer, M., Solomon, T., Lewthwaite, P. 30/10/2008
Review article

Pontine infarction due to intracranial venous thrombosis
Emsley, H.C.A., Ramtahal, J., Das, K.S.V., Ray, P.S. 1/08/2008 In: Practical Neurology. 8, 4, p. 254-255. 2 p.
Journal article

Inflammation in acute ischemic stroke and its relevance to stroke critical care
Emsley, H.C.A., Smith, C.J., Tyrrell, P.J., Hopkins, S.J. 08/2008
Review article

Acute ischaemic stroke and infection: recent and emerging concepts
Emsley, H.C.A., Hopkins, S.J. 04/2008
Review article

Infection and brain-induced immunodepression after acute ischemic stroke [7]
Emsley, H.C.A., Smith, C.J., Hopkins, S.J. 01/2008 In: Stroke. 39, 1
Letter

Clinical outcome following acute ischaemic stroke relates to both activation and autoregulatory inhibition of cytokine production
Emsley, H.C.A., Smith, C.J., Gavin, C.M., Georgiou, R.F., Vail, A., Barberan, E.M., Illingworth, K., Scarth, S., Wickramasinghe, V., Hoadley, M.E., Rothwell, N.J., Tyrrell, P.J., Hopkins, S.J. 28/02/2007 In: BMC Neurology. 7, 12 p.
Journal article

Inflammation and interleukin-1 in clinical stroke
Emsley, H., Tyrrell, P.J. 2007 In: New Developments in Stroke Research. Nova Science Publishers p. 1-48. 48 p.
Chapter (peer-reviewed)

Variability of the systemic acute phase response after ischemic stroke
Smith, C.J., Emsley, H.C.A., Vail, A., Georgiou, R.F., Rothwell, N.J., Tyrrell, P.J., Hopkins, S.J. 21/12/2006 In: Journal of the Neurological Sciences. 251, 1-2, p. 77-81. 5 p.
Journal article

Circle of Willis variation in a complex stroke presentation: a case report
Emsley, H.C.A., Young, C.A., White, R.P. 15/03/2006 In: BMC Neurology. 6
Journal article

A randomised phase II study of interleukin-1 receptor antagonist in acute stroke patients
Emsley, H.C.A., Smith, C.J., Georgiou, R.F., Vail, A., Hopkins, S.J., Rothwell, N.J., Tyrrell, P.J. 10/2005 In: Journal of Neurology, Neurosurgery and Psychiatry. 76, 10, p. 1366-1372. 7 p.
Journal article

Interleukin-6 and acute ischaemic stroke (multiple letters)
Emsley, H.C.A., Smith, C.J., Georgiou, R.F., Vail, A., Barberan, E.M., Rothwell, N.J., Tyrrell, P.J., Hopkins, S.J., Waje-Andreassen, U., Kråkenes, J., Ulvestad, E., Thomassen, L., Myhr, K.M., Aarseth, J., Vedeler, C.A. 10/2005 In: Acta Neurologica Scandinavica. 112, 4, 3 p.
Letter

Evaluation of C-reactive protein measurement for assessing the risk and prognosis in ischemic stroke: a statement for health care professionals from the CRP pooling project members
Di Napoli, M., Schwaninger, M., Cappelli, R., Ceccarelli, E., Di Gianfilippo, G., Donati, C., Emsley, H.C.A., Forconi, S., Hopkins, S.J., Masotti, L., Muir, K.W., Paciucci, A., Papa, F., Roncacci, S., Sander, D., Sander, K., Smith, C.J., Stefanini, A., Weber, D. 06/2005
Review article

Correlation of systemic inflammatory response with infarct volume in acute ischemic stroke patients [2] (multiple letters)
Emsley, H.C.A., Smith, C.J., Georgiou, R.F., Vail, A., Tyrrell, P.J., Barberan, E.M., Rothwell, N.J., Hopkins, S.J., Audebert, H., Haberl, R.L. 02/2005 In: Stroke. 36, 2, 2 p.
Letter

Erratum: Peak plasma interleukin-6 and other peripheral markers of inflammation in the first week of ischaemic stroke correlate with brain infarct volume, stroke severity and long-term outcome (BMC Neurology)
Smith, C.J., Emsley, H.C.A., Gavin, C.M., Georgiou, R.F., Vail, A., Barberan, E.M., del Zoppo, G.J., Hallenbeck, J.M., Rothwell, N.J., Hopkins, S.J., Tyrrell, P.J. 15/03/2004 In: BMC Neurology. 4, 1 p.
Comment/debate

Peak plasma interleukin-6 and other peripheral markers of inflammation in the first week of ischaemic stroke correlate with brain infarct volume, stroke severity and long-term outcome
Smith, C.J., Emsley, H.C.A., Gavin, C.M., Georgiou, R.F., Vail, A., Barberan, E.M., del Zoppo, G.J., Hallenbeck, J.M., Rothwell, N.J., Hopkins, S.J., Tyrrell, P.J. 15/01/2004 In: BMC Neurology. 4
Journal article

Inflammation and cytokine regulation in stroke
Emsley, H. 2004 University of Manchester.
Doctoral Thesis

Reliability of a semi-automated technique of cerebral infarct volume measurement with CT
Gavin, C.M., Smith, C.J., Emsley, H.C.A., Hughes, D.G., Turnbull, I.W., Vail, A., Tyrrell, P.J. 2004 In: Cerebrovascular Diseases. 18, 3, p. 220-226. 7 p.
Journal article

An early and sustained peripheral inflammatory response in acute ischaemic stroke: relationships with infection and atherosclerosis
Emsley, H.C.A., Smith, C.J., Gavin, C.M., Georgiou, R.F., Vail, A., Barberan, E.M., Hallenbeck, J.M., Del Zoppo, G.J., Rothwell, N.J., Tyrrell, P.J., Hopkins, S.J. 06/2003 In: Journal of Neuroimmunology. 139, 1-2, p. 93-101. 9 p.
Journal article

Inflammation and infection in clinical stroke
Emsley, H.C.A., Tyrrell, P.J. 1/12/2002
Review article

Inflammatory demyelinating polyradiculoneuropathy associated with membranous glomerulonephritis and thrombocytopaenia
Emsley, H.C.A., Molloy, J. 12/2002 In: Clinical Neurology and Neurosurgery. 105, 1, p. 23-26. 4 p.
Journal article

The Oxfordshire Community Stroke Project classification in the early hours of ischemic stroke and relation to infarct site and size on cranial computed tomography
Smith, C.J., Emsley, H.C.A., Libetta, C.M., Hughes, D.G., Drennan, R.F., Vail, A., Tyrrell, P.J. 12/09/2001 In: Journal of Stroke and Cerebrovascular Diseases. 10, 5, p. 205-209. 5 p.
Journal article

Extremely premature infants born in 1990 to 1994 had higher survival and disability rates than those born in 1984 to 1989: commentary
Emsley, H.C., Wardle, S.P., Sims, D.G., Chiswick, M.L., D'Souza, S.W. 02/1999 In: Evidence Based Medicine. 4, 1, 1 p.
Comment/debate

Increased survival and deteriorating developmental outcome in 23 to 25 week old gestation infants, 1990-4 compared with 1984-9
Emsley, H.C.A., Wardle, S.P., Sims, D.G., Chiswick, M.L., D'Souza, S.W. 02/1998 In: Archives of Disease in Childhood: Fetal and Neonatal Edition. 78, 2, p. F99-F102. 4 p.
Journal article