Professor John Whitehead

Emeritus

Bayesian sample sizes for exploratory clinical trials comparing multiple experimental treatments with a control
Whitehead, J., Cleary, F., Turner, A. 26/08/2014 In: arxiv.org.
Journal article

Partial stochastic dominance for the multivariate Gaussian distribution
Turner, A., Whitehead, J. 3/07/2014 In: arxiv.org.
Journal article

R software to accompany "Bayesian methods for the design and interpretation of clinical trials in very rare diseases".
Hampson, L., Whitehead, J. 2014
Software

Designing exploratory cancer trials using change in tumour size as primary endpoint
Jaki, T., Andre, V., Su, T., Whitehead, J. 10/07/2013 In: Statistics in Medicine. 32, 15, p. 2544-2554. 11 p.
Journal article

A bivariate Bayesian dose-finding procedure applied to a seamless phase I/II trial in rheumatoid arthritis
Thygesen, H., Dragalin, V., Whitehead, A., Whitehead, J. 11/2012 In: Pharmaceutical Statistics. 11, 6, p. 476-484. 9 p.
Journal article

A novel phase I/IIa design for early phase oncology studies and its application in the evaluation of MK-0752 in pancreatic cancer
Whitehead, J., Thygesen, H., Jaki, T., Davis, S., Halford, S., Turner, H., Cook, N., Jodrell, D. 15/08/2012 In: Statistics in Medicine. 31, 18, p. 1931-1943. 13 p.
Journal article

A generalized Dunnett Test for Multi-arm Multi-stage Clinical Studies with Treatment Selection
Magirr, D., Jaki, T., Whitehead, J. 06/2012 In: Biometrika. 99, 2, p. 494-501. 8 p.
Journal article

Bayesian procedures for phase I/II clinical trials investigating the safety and efficacy of drug combinations
Whitehead, J., Thygesen, H., Whitehead, A. 20/07/2011 In: Statistics in Medicine. 30, 16, p. 1952-1970. 19 p.
Journal article

A Bayesian dose-escalation procedure for phase I clinical trials based only on the assumption of monotonicity.
Whitehead, J., Thygesen, H., Whitehead, A. 30/07/2010 In: Statistics in Medicine. 29, 17, p. 1808-1824. 17 p.
Journal article

A combined score test for binary and ordinal endpoints from clinical trials.
Whitehead, J., Branson, M., Todd, S. 28/02/2010 In: Statistics in Medicine. 29, 5, p. 521-532. 12 p.
Journal article

Action following the discovery of a global association between the whole genome and adverse event risk in a clinical drug-development programme.
Whitehead, J., Kelly, P., Zhou, Y., Stallard, N., Thygesen, H., Bowman, C. 10/2009 In: Pharmaceutical Statistics. 8, 4, p. 287-300. 14 p.
Journal article

A simple two-stage design for quantitative responses with appliction to a study in diabectic neuropathic pain.
Whitehead, J., Valdés-Márquez, E., Lissmats, A. 04/2009 In: Pharmaceutical Statistics. 8, 2, p. 125-135. 11 p.
Journal article

Evaluation of a sequential global test of improved recovery following stroke as applied to the ICTUS trial of citicoline.
Bolland, K., Whitehead, J., Cobo, E., Secades, J.J. 04/2009 In: Pharmaceutical Statistics. 8, 2, p. 136-149. 14 p.
Journal article

Using historical lesion volume data in the design of a new phase II clinical trial in acute stroke.
Whitehead, J., Bolland, K., Valdés-Márquez, E., Lihic, A., Ali, M., Lees, K. 04/2009 In: Stroke. 40, 4, p. 1347-1352. 6 p.
Journal article

One- and two-stage design proposals for a phase II trial comparing three active treatments with control using an ordered categorical endpoint.
Whitehead, J., Jaki, T. 28/02/2009 In: Statistics in Medicine. 28, 5, p. 828-847. 20 p.
Journal article

Fitting models for the joint action of two drugs using SAS(R).
Whitehead, A., Whitehead, J., Todd, S., Zhou, Y., Smith, M.K. 10/2008 In: Pharmaceutical Statistics. 7, 4, p. 272-284. 13 p.
Journal article

Estimation following selection of the largest of two normal means. Journal of Statistical Planning and Inference 138, 1629-1638.
Stallard, N., Todd, S., Whitehead, J. 1/07/2008 In: Journal of Statistical Planning and Inference. 138, 6, p. 1629-1638. 10 p.
Journal article

A safety monitoring procesure for a clinical drug development programme, with application to the accessment of a novel COX-2 inhibitor.
Bolland, K., Whitehead, J., Oldham, M. 07/2008 In: Journal of Biopharmaceutical Statistics. 18, 4, p. 737-749. 13 p.
Journal article

Bayesian sample size for exploratory clinical trials incorporating historical data.
Whitehead, J., Valdés-Márquez, E., Johnson, P., Graham, G. 06/2008 In: Statistics in Medicine. 27, 13, p. 2307-2327. 21 p.
Journal article

Sequentially testing for a gene-drug interaction in a genomewide analysis.
Kelly, P., Zhou, Y., Whitehead, J., Stallard, N., Bowman, C. 20/05/2008 In: Statistics in Medicine. 27, 11, p. 2022-2034. 13 p.
Journal article

Incorporating intermediate binary responses into interim analyses of clinical trials : a comparison of four methods.
Whitehead, A., Sooriyarachchi, M.R., Whitehead, J., Bolland, K. 10/05/2008 In: Statistics in Medicine. 27, 10, p. 1646-1666. 21 p.
Journal article

Implementation of a Bayesian design in a dose-escalation study of an experimental agent in healthy volunteers.
Whitehead, J., Korhonen, P., Mustonen, M., Zhou, Y. 03/2008 In: Biometrics. 64, 1, p. 299-308. 10 p.
Journal article

A Bayesian approach for dose-escalation in a phase I clinical trial incorporating pharmacodynamic endpoints .
Whitehead, J., Hampson, L., Zhou, Y., Ledent, E., Pereira, A. 11/2007 In: Journal of Biopharmaceutical Statistics. 17, 6, p. 1117-1129. 13 p.
Journal article

Sequential genome-wide association studies for monitoring adverse events in clinical evaluation of new drugs.
Whitehead, J., Kelly, P.J., Stallard, N., Zhou, Y., Bowman, C. 30/09/2006 In: Statistics in Medicine. 25, 18, p. 3081-3092. 12 p.
Journal article

The sequential analysis of repeated binary responses: a score test for the case of three time points.
Sooriyarachchi, M.R., Whitehead, J., Whitehead, A., Bolland, K. 15/07/2006 In: Statistics in Medicine. 25, 13, p. 2196-2214. 19 p.
Journal article

Incorporating data received after a sequential trial has stopped into the final analysis: implementation and comparison of methods.
Whitehead, J., Bollard, K., Matsushita, T., Sooriyarachchi, M.R., Whitehead, A. 09/2003 In: Biometrics. 59, 3, p. 701-709. 9 p.
Journal article

Easy-to-implement Bayesian methods for dose-escalation studies in healthy volunteers.
Whitehead, J., Patterson, S., Webber, D., Zhou, Y. 03/2001 In: Biostatistics. 2, 1, p. 47-61. 15 p.
Journal article

Analysis of failure time data with ordinal categories of response
Berridge, D., Whitehead, J. 11/1991 In: Statistics in Medicine. 10, 11, p. 1703-1710. 8 p.
Journal article

Mammographic dysplasia as entry criterion for breast cancer prevention trials
Berridge, D., Whitehead, J., Cuzick, J. 18/05/1991 In: The Lancet. 337, 8751, 1 p.
Letter