Date: 13th - 16th Feb 2017
Duration: 3.0 days (From Monday Midday to Thursday Midday)
Delivered by: Fang Wan
Registration deadline has passed.
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The course fees include all supporting documentation and refreshments.
- External from industry/commerce - £810
- External from academic institution/public sector/charity - £690
- External postgraduate student - £450
- Members of Lancaster University - £0
Pharmacological models are used to describe the pharmacokinetics and pharmacodynamics of drug administration. The former concerns how the drug becomes distributed within the body and the latter how drug concentrations are related to physiological effects. The way in which models are derived from simplified representations of the body, and approaches to the estimation of model parameters, will be described. More advanced hierarchical models and Bayesian methods for population pharmacokinetics will be discussed, and their fitting using PROC NLMIXED in SAS described. The course will also cover the design and analysis of phase I clinical trials in human volunteers designed to establish a maximum safe dose and to identify indications of therapeutic activity. In particular, modern designs for dose-escalation based on Bayesian procedures will be studied.
Practicals will provide an opportunity for participants to fit simple models to data, and to design and evaluate phase I dose-escalation studies.
- Summarising pharmacokinetic data
- Emax models and compartmental models
- Hierarchical and Bayesian models
- Designing PK studies
- Models for repeated dosing
- The uses of simulation
- Dose escalation studies in healthy volunteers
- Phase I/II studies
Students will be able to:
Registrations are transferable to another course or individual at any time. Full refunds will be given for cancellation 10 or more working days before the course start date. Otherwise the full course fee will be charged.