Groundwork Training Workshop

30th November 2015

Venue: Council Chamber, Royal Statistical Society, London

Target audience: Statisticians and numerate scientists

Provisional programme

  • 09:30-10:00 - Registration and tea/coffee
  • 10:00-10:10 - Welcome address
  • 10:10-10:40 - Case Study 1: The use of Bayesian designs for trials in rare cancers: application to the LINES trial. Peter Dutton (Centre of Statistics in Medicine, University of Oxford) Case study 1‌
  • 10:40-11.10 - Case Study 2: A Bayesian clinical trial in children with polyarteritis nodosa (PAN). Catrin Tudur Smith (North-West Hub for Trials Methodology Research, University of Liverpool) Case study 2‌
  • 11:10-11:50 - Tutorial 1: Bayesian methods. Lisa Hampson (Lancaster University)
  • 11:50-12:30 - Practical 1: Examples of Bayesian methods. Lisa Hampson (Lancaster University)
  • 12:30-13:15 - Lunch
  • 13:15-13:45 - Case Study 3: A clinical study using a mutation-specific investigational drug in DMD: how to go about conducting a clinical trial in a very small population. Michela Guglieri (John Walton Muscular Dystrophy Research Centre) Case study 3‌
  • 13:45-14:15 - Case Study 4: Application of a Bayesian approach to treatment selection in rare diseases. Andrew Hall (Clinical Trials Research Unit, University of Leeds) Case study 4‌
  • 14:30-15:00 - Tutorial 2: Adaptive clinical trial design. Sofia Villar (MRC Biostatistics Unit, Cambridge)
  • 15:00-15:15 - Coffee
  • 15:15-15:45 - Practical 2: Worked examples of adaptive methods. Matt Sydes (MRC Clinical Trials Unit, London), Sofia Villar (MRC Biostatistics Unit, Cambridge)
  • 15:45-16:15 - Case Study 5: Statistical planning and analysis of a randomized trial on genital erosive lichen planus. Are Hugo Pripp (Oslo University Hospital) Case study 5‌
  • 16:15-16:45 - Case Study 6: A randomised controlled trial in Duchenne Muscular Dystrophy. Jinhui Ma (Children’s Hospital of Eastern Ontario Research Institute, University of Ottawa) Case study 6‌
  • 16:45-17:00 - Closing remarks and end of the meeting

Practical sessions will provide participants with the opportunity to gain hands-on experience with novel methods. Participants will be expected to bring their own laptops with R installed. R can be freely downloaded from the CRAN website.

The materials from the tutorials and practical sessions are now publicly available via this link: Day 1 tutorials archive.

Registration

This workshop will be open to a selected audience of statisticians and numerate scientists. Since the number of places on this training workshop is limited, priority will be given to applicants involved with clinical trials in small populations and those wishing to present case studies. If demand exceeds the number of places, places will be awarded to those who the organising committee consider will benefit most from the workshop.