Dr John Hardy M.Sci., Ph.D., MRSC

Lecturer in Materials Chemistry

Research Overview

I am a multidisciplinary scientist with experience in chemistry, materials science, pharmacy and biomedical engineering. I am interested in developing materials for drug delivery, tissue engineering and regenerative medicine. I am particularly interested in bioelectronics (e.g. biodegradable conducting polymers, 3D printable conducting polymers) for drug delivery, tissue engineering and neuromodulation.

Gene delivery with organic electronic biomaterials
Clancy, K., Hardy, J.G. 19/07/2017
Literature review

Sacrificial crystal templated hyaluronic acid hydrogels as biomimetic 3D tissue scaffolds for nerve tissue regeneration
Thomas, R., Vu, P., Modi, S., Chung, P., Landis, R., Khaing, Z., Hardy, J.G., Schmidt, C. 10/07/2017 In: ACS Biomaterials Science and Engineering . 3, 7, p. 1451-1459. 9 p.
Journal article

Sacrificial crystal templating of hyaluronic acid-based hydrogels
Thomas, R., Chung, P., Modi, S.P., Hardy, J.G., Schmidt, C.E. 02/2017 In: European Polymer Journal. 87, p. 487-496. 10 p.
Journal article

Responsive biomaterials: advances in materials based on shape-memory polymers
Hardy, J.G., Palma, M., Wind, S., Biggs, M. 20/07/2016
Literature review

Biomineralization of engineered spider silk protein-based composite materials for bone tissue engineering
Hardy, J.G., Torres-Rendon, J.G., Leal-Egana, A., Walther, A., Schlaad, H., Cölfen, H., Scheibel, T.R. 11/07/2016 In: Materials. 9, 7, 13 p.
Journal article

Hydrogel-forming microneedle arrays made from light-responsive materials for on-demand transdermal drug delivery
Hardy, J.G., Larraneta, E., Donnelly, R., McGoldrick, N., Migalska, K., McCrudden, M., Donnelly, L., McCoy, C. 7/03/2016 In: Molecular Pharmaceutics. 13, 3, p. 907-914. 8 p.
Journal article

Organic electronic materials for gene delivery
Hardy, J.G. 13/01/2016 In: Engineering of nanobiomaterials. Elsevier p. 119-144. 26 p. Electronic ISBN: 9780323417341.
Chapter

Mechanical properties of α-tricalcium phosphate-based bone cements incorporating regenerative biomaterials for filling bone defects exposed to low mechanical loads
Harrison, R., Criss, Z.K., Feller, L., Modi, S.P., Hardy, J.G., Schmidt, C.E., Suggs, L.J., Murphy, M.B. 01/2016 In: Journal of Biomedical Materials Research Part B: Applied Biomaterials. 104, 1, p. 149-157. 9 p.
Journal article

Conductive interpenetrating networks of polypyrrole and polycaprolactone encourage electrophysiological development of cardiac cells
Spearman, B., Hodge, A., Porter, J., Hardy, J.G., Davis, Z., Xu, T., Zhang, X., Schmidt, C.E., Hamilton, M., Lipke, E. 12/2015 In: Acta Biomaterialia. 28, p. 109-120. 12 p.
Journal article

Advances in functional assemblies for regenerative medicine
Palma, M., Hardy, J., Tadayyon, G., Farsari, M., Wind, S., Biggs, M. 18/11/2015
Literature review

Electrical stimulation of human mesenchymal stem cells on biomineralized conducting polymers enhances their differentiation towards osteogenic outcomes
Hardy, J.G., Sukhavasi, R.C., Aguilar Jr., D., Villancio-Wolter, M., Mouser, D.J., Geissler, S., Nguy, L., Chow, J.K., Kaplan, D.L., Schmidt, C.E. 7/11/2015 In: Journal of Materials Chemistry B. 3, 41, p. 8059-8064. 4 p.
Journal article

Conducting polymer-based multilayer films for instructive biomaterial coatings
Hardy, J.G., Li, H., Chow, J.K., Geissler, S., McElroy, A., Nguy, L., Hernandez, D.S., Schmidt, C.E. 2/11/2015 In: Future Science OA. 1, 4, p. 1. 1 p.
Journal article

Electrical stimulation of human mesenchymal stem cells on conductive nanofibers enhances their differentiation toward osteogenic outcomes
Hardy, J., Villancio-Wolter, M., Sukhavasi, R., Mouser, D., Aguilar, D., Geissler, S., Kaplan, D., Schmidt, C. 2/11/2015 In: Macromolecular Rapid Communications. 36, 21, p. 1884-1890. 7 p.
Journal article

Instructive conductive 3D silk foam-based bone tissue scaffolds enable electrical stimulation of stem cells for enhanced osteogenic differentiation
Hardy, J.G., Geissler, S.A., Aguilar Jr., D., Villancio-Wolter, M.K., Mouser, D.J., Sukhavasi, R.C., Cornelison, R.C., Tien, L.W., Preda, R.C., Hayden, R.S., Chow, J.K., Nguy, L., Kaplan, D.L., Schmidt, C.E. 11/2015 In: Macromolecular Bioscience . 15, 11, p. 1490-1496. 7 p.
Journal article

Into the groove: instructive conductive silk films with topological guidance cues
Hardy, J., Khaing, Z., Xin, S., Tien, L., Ghezzi, C., Mouser, D., Sukhavasi, R.C., Preda, R., Gil, E., Kaplan, D.L., Schmidt, C.E. 11/2015 In: Journal of Biomaterials Science, Polymer Edition. 26, 17, p. 1327-1342. 16 p.
Journal article

Supracolloidal assemblies as sacrificial templates for porous silk-based biomaterials
Hardy, J., Ghezzi, C., Saballos, R., Kaplan, D.L., Schmidt, P.C.E. 28/08/2015 In: International Journal of Molecular Sciences. 16, 9, p. 20511-20522. 12 p.
Journal article

Multiphoton microfabrication of conducting polymer-based biomaterials
Hardy, J.G., Hernandez, D.S., Cummings, D.M., Edwards, F.A., Shear, J.B., Schmidt, C.E. 7/07/2015 In: Journal of Materials Chemistry B. 3, 25, p. 5001-5004. 4 p.
Journal article

Towards organic electronic materials for electrically stimulated gene delivery: nanoparticles for biotherapeutic therapy
Hardy, J., Schmidt, P.C.E. 07/2015 In: Nanoparticles for biotherapeutic delivery. Future Science Group p. 58-70. 13 p. Electronic ISBN: 9781910420430.
Chapter

Peptide-directed assembly of functional supramolecular polymers for biomedical applications: electroactive molecular tongue-twisters (oligoalanine-oligoaniline-oligoalanine) for electrochemically enhanced drug delivery
Hardy, J.G., Amend, M.N., Geissler, S., Lynch, V.M., Schmidt, C.E. 8/06/2015 In: Journal of Materials Chemistry B. 3, 25, p. 5005-5009. 5 p.
Journal article

Bioactive gyroid scaffolds formed by sacrificial templating of nanocellulose and nanochitin hydrogels as instructive platforms for biomimetic tissue engineering
Torres-Rendon, J.G., Femmer, T., De Laporte, L., Tigges, T., Rahimi, K., Gremse, F., Zafarnia, S., Lederle, W., Ifuku, S., Wessling, M., Hardy, J.G., Walther, A. 2/04/2015 In: Advanced Materials. 27, 19, p. 2989-2995. 7 p.
Journal article

Drug delivery using electrochemically-triggered biodegradable electroactive materials
Hardy, J., Schmidt, C. 20/03/2015
Patent

Electroactive tissue scaffolds with aligned pores as instructive platforms for biomimetic tissue engineering
Hardy, J.G., Cornelison, R.C., Sukhavasi, R.C., Saballos, R.J., Vu, P., Kaplan, D.L., Schmidt, C.E. 14/01/2015 In: Bioengineering. 2, 1, p. 15-34. 20 p.
Journal article

Biodegradable hydrogels composed of oxime cross-linked poly(ethylene glycol), hyaluronic acid and collagen: a platform for soft tissue engineering
Hardy, J.G., Lin, P., Schmidt, C.E. 2/01/2015 In: Journal of Biomaterials Science, Polymer Edition. 26, 3, p. 143-161. 19 p.
Journal article

Biodegradable electroactive polymers for electrochemically-triggered drug delivery
Hardy, J.G., Mouser, D.J., Arroyo-Currás, N., Geissler, S., Chow, J.K., Nguy, L., Kim, J.M., Schmidt, C.E. 21/10/2014 In: Journal of Materials Chemistry B. 2, 39, p. 6809-6822. 14 p.
Journal article

Electroactive polymeric scaffolds and method for delivering nerve growth factor to nerve tissue
Hardy, J.G., Schmidt, P.C.E. 19/09/2014
Patent

Using EPR spectroscopy as a unique probe of molecular-scale reorganization and solvation in self-assembled gel-phase materials
Caragheorgheopol, A., Edwards, W., Hardy, J.G., Smith, D.K., Chechik, V. 13/07/2014 In: Langmuir. 30, 30, p. 9210-9218. 9 p.
Journal article

Electrical stimuli in the central nervous system microenvironment
Thompson, D.M., Koppes, A.N., Hardy, J.G., Schmidt, C.E. 11/07/2014
Literature review

Glycopolymer functionalization of engineered spider silk protein-based materials for improved cell adhesion
Hardy, J.G., Pfaff, A., Leal-Egana, A., Mueller, A.H.E., Scheibel, T.R. 07/2014 In: Macromolecular Bioscience . 14, 7, p. 936-942. 7 p.
Journal article

Structure and post-translational modifications of the web silk protein spidroin-1 from Nephila spiders
dos Santos-Pinto, J.R.A., Lamprecht, G., Chen, W., Heo, S., Hardy, J.G., Priewalder, H., Scheibel, T.R., Palma, M.S., Lubec, G. 13/06/2014 In: Journal of Proteomics. 105, p. 174-185. 12 p.
Journal article

Metallosupramolecular grid complexes: towards nanostructured materials with high-tech applications
Hardy, J.G. 7/10/2013
Literature review

Biomimetic conducting polymer-based tissue scaffolds
Hardy, J.G., Lee, J.Y., Schmidt, C.E. 10/2013
Literature review

Engineered spider silk protein-based composites for drug delivery
Hardy, J., Leal-Egana, A., Scheibel, T.R. 10/2013 In: Macromolecular Bioscience . 13, 10, p. 1431-1437. 7 p.
Journal article

Exploring molecular recognition pathways in one- and two-component gels formed by dendritic lysine-based gelators
Hardy, J.G., Hirst, A.R., Smith, D.K. 6/02/2012 In: Soft Matter. 8, 12, p. 3399-3406. 8 p.
Journal article

Generation of metallosupramolecular polymer gels from multiply functionalized grid-type complexes
Hardy, J.G., Cao, X., Harrowfield, J., Lehn, J. 2012 In: New Journal of Chemistry. 36, 3, p. 668-673. 6 p.
Journal article

Composite materials based on silk proteins
Hardy, J.G., Scheibel, T.R. 09/2010
Literature review

A conserved spider silk domain acts as a molecular switch that controls fibre assembly
Hagn, F., Eisoldt, L., Hardy, J.G., Vendrely, C., Coles, M., Scheibel, T., Kessler, H. 13/05/2010 In: Nature. 465, 7295, p. 239-242. 4 p.
Journal article

The role of salt and shear on the storage and assembly of spider silk proteins
Eisoldt, L., Hardy, J.G., Heim, M., Scheibel, T.R. 05/2010 In: Journal of Structural Biology. 170, 2, p. 413-419. 7 p.
Journal article

Production and processing of spider silk proteins
Hardy, J.G., Scheibel, T.R. 15/08/2009
Literature review

Silk-inspired polymers and proteins
Hardy, J.G., Scheibel, T.R. 1/08/2009
Literature review

Synergistic effects on gene delivery - co-formulation of small disulfide-linked dendritic polycations with Lipofectamine 2000 (TM)
Hardy, J.G., Love, C.S., Gabrielson, N.P., Pack, D.W., Smith, D.K. 21/02/2009 In: Organic and Biomolecular Chemistry . 7, 4, p. 789-793. 5 p.
Journal article

Polymeric materials based on silk proteins
Hardy, J.G., Roemer, L.M., Scheibel, T.R. 23/09/2008
Literature review

Exploring molecular recognition pathways within a family of gelators with different hydrogen bonding motifs
Hardy, J.G., Hirst, A.R., Ashworth, I., Brennan, C., Smith, D.K. 30/07/2007 In: Tetrahedron. 63, 31, p. 7397-7406. 10 p.
Journal article

Dendritic receptors designed to bind polyanions in both organic and aqueous media
Hardy, J.G., Ashworth, I., Brennan, C., Smith, D.K. 26/01/2007 In: Organic and Biomolecular Chemistry . 5, 6, p. 900-906. 7 p.
Journal article

Dendrons with spermine surface groups as potential building blocks for nonviral vectors in gene therapy
Hardy, J.G., Kostiainen, M.A., Smith, D.K., Gabrielson, N.P., Pack, D.W. 4/11/2006 In: Bioconjugate Chemistry. 17, 1, p. 172-178. 7 p.
Journal article

High-affinity ultivalent DNA binding by using low-molecular-weight dendrons
Kostiainen, M.A., Hardy, J.G., Smith, D.K. 22/04/2005 In: Angewandte Chemie International Edition. 44, 17, p. 2556-2559. 4 p.
Journal article

Self-assembly using dendritic building blocks - towards controllable nanomaterials
Smith, D.K., Hirst, A.R., Love, C.S., Hardy, J.G., Brignell, S.V., Huang, B. 03/2005
Literature review

Controlling the materials properties and nanostructure of a single-component dendritic gel by adding a second component
Hardy, J.G., Hirst, A.R., Smith, D.K., Brennan, C., Ashworth, I. 2005 In: Chemical Communications. 3, p. 385-387. 3 p.
Journal article

Preparation of aqueous core/polymer shell microcapsules by internal phase separation
Atkin, R., Davies, P., Hardy, J., Vincent, B. 19/10/2004 In: Macromolecules. 37, 21, p. 7979-7985. 7 p.
Journal article