Professor Frank Martin

Professor Frank Martin

Professor

LEC Building
Lancaster University
Bailrigg
Lancaster
United Kingdom
LA1 4YQ

+44 (0)1524 510206

Research Interests

The main focus of my research is directed towards characterising factors governing susceptibility of epithelial-cell populations to the DNA-damaging (genotoxic) events that occur during the initiation and promotion of cancer. I am especially interested in the aetiology of sporadic breast and prostate cancer. Strong epidemiological evidence suggests that environmental and/or dietary factors play a significant role in the causation of these gender-associated cancers. To this end I am especially interested in the DNA-damage mechanism of action of DNA-reactive carcinogens and how this may inter-relate with the effects of endocrine-active agents. This involves the use of short-term genotoxicity assays, quantitative gene expression analyses (especially of hormone-associated metabolising enzymes), infrared micro-spectroscopy, immunohistochemistry and other cell toxicity studies. Of course, several of these experimental platforms are readily translatable to an ecotoxicological platform.

Frank Martin's Publications

2014

Using Fourier transform IR spectroscopy to analyze biological materials

Trevisan, J. , Butler, H. J. , Fielden, P. R. , Fullwood, N. J. , Heys, K. A. , Martin-Hirsch, P. L. , Obinaju, B. , Martin, F. L. & 13 others Baker, M. J., Bassan, P., Bhargava, R., Dorling, K. M., Fogarty, S. W., Hughes, C., Lasch, P., Sockalingum, G. D., Sulé-Suso, J., Strong, R. J., Walsh, M. J., Wood, B. R. & Gardner, P. 08/2014 In : Nature Protocols. 9, 8, p. 1771-1791 21 p.

Research output: Contribution to journalJournal article

Stability and coherence of biomarker identification methods in Fourier-transform infrared (FTIR) spectroscopy

Trevisan, J., Park, J., Angelov, P., Ahmadzai, A., Gajjar, K., Scott, A., Carmichael, P. & Martin, F. 04/2014 In : Journal of Biophotonics. 7, 3-4, p. 254-265 12 p.

Research output: Contribution to journalJournal article

Mid-infrared spectroscopic assessment of nanotoxicity in gram-negative vs. gram-positive bacteria

Heys, K. A., Riding, M. J., Strong, R. J., Shore, R. F., Pereira, M. G., Jones, K. C., Semple, K. T. & Martin, F. L. 7/03/2014 In : Analyst. 139, 5, p. 896-905 10 p.

Research output: Contribution to journalJournal article

2013

Chemical measures of bioavailability/bioaccessibility of PAHs in soil: fundamentals to application

Riding, M. J., Doick, K. J., Martin, F. L., Jones, K. C. & Semple, K. T. 15/10/2013 In : Journal of Hazardous Materials. 261, p. 687–700 14 p.

Research output: Contribution to journalJournal article

Dose-related alterations of carbon nanoparticles in Mammalian cells detected using biospectroscopy: potential for real-world effects

Li, J., Strong, R., Trevisan, J., Fogarty, S. W., Fullwood, N. J., Jones, K. C. & Martin, F. L. 3/09/2013 In : Environmental Science and Technology. 47, 17, p. 10005-10011 7 p.

Research output: Contribution to journalJournal article

Sub-cellular spectrochemical imaging of isolated human corneal cells employing synchrotron radiation-based Fourier-transform infrared microspectroscopy

Fogarty, S. W., Patel, I. I., Trevisan, J., Nakamura, T., Hirschmugl, C. J., Fullwood, N. J. & Martin, F. L. 7/01/2013 In : Analyst. 138, 1, p. 240-248 9 p.

Research output: Contribution to journalJournal article

Diagnostic segregation of human brain tumours using Fourier-transform infrared and/or Raman spectroscopy coupled with discriminant analysis

Gajjar, K., Heppenstall, L. D., Pang, W., Ashton, K. M., Trevisan, J., Patel, I. I., Llabjani, V., Stringfellow, H. F., Martin-Hirsch, P. L., Dawson, T., Martin, F. L. & Llabjani, V. 2013 In : Analytical Methods. 5, 1, p. 89-102 14 p.

Research output: Contribution to journalJournal article

2012

Cytochrome P1B1 gene (CYP1B1) polymorphisms and ovarian cancer risk: a meta-analysis

Gajjar, K., Owens, G., Sperrin, M., Martin-Hirsch, P. L. & Martin, F. L. 16/12/2012 In : Toxicology. 302, 2-3, p. 157-162 6 p.

Research output: Contribution to journalJournal article

Mechanistic insights into nanotoxicity determined by synchrotron radiation-based Fourier-transform infrared imaging and multivariate analysis

Riding, M. J., Trevisan, J., Hirschmugl, C. J., Jones, K. C., Semple, K. T. & Martin, F. L. 1/12/2012 In : Environment International. 50, p. 56-65 10 p.

Research output: Contribution to journalJournal article

Alterations in the infrared spectral signature of avian feathers reflect potential chemical exposure: a pilot study comparing two sites in Pakistan

Llabjani, V., Malik, R. N., Trevisan, J., Hoti - Llabjani, V., Ukpebor, J., Shinwari, Z. K., Moeckel, C., Jones, K. C., Shore, R. F. & Martin, F. L. 1/11/2012 In : Environment International. 48, p. 39-46 8 p.

Research output: Contribution to journalJournal article

Advances in Fourier-transform infrared spectroscopy analysis to characterise chemical-induced alterations in the Syrian hamster embryo assay-towards biomarkers stability

Trevisan, J., Angelov, P. P., Carmichael, P. L., Scott, A. & Martin, F. L. 11/2012 In : Mutagenesis. 27, 6, p. 792-792 1 p.

Research output: Contribution to journalMeeting abstract

Environmentally relevant levels of the genotoxin cyclophosphamide induce alterations in MCF-7 cells detectable by biospectroscopy approaches

Strong, R., Halsall, C. J., Jones, K. C. & Martin, F. L. 11/2012 In : Mutagenesis. 27, 6, p. 814-814 1 p.

Research output: Contribution to journalMeeting abstract

Evidence for a stem-cell lineage in human intestinal adenocarcinoma using synchrotron radiation-based Fourier-transform infrared microspectroscopy

Ahmadzai, A. A., Patel, I. I., Llabjani, V. & Martin, F. L. 11/2012 In : Mutagenesis. 27, 6, p. 801-801 1 p.

Research output: Contribution to journalMeeting abstract

Isolating stem cells in the inter-follicular epidermis employing synchrotron radiation-based Fourier-transform infrared microspectroscopy and focal plane array imaging

Patel, I. I., Harrison, W. J., Kerns, J. G., Filik, J., Wehbe, K., Carmichael, P. L., Scott, A. D., Philpott, M. P., Frogley, M. D., Cinque, G. & Martin, F. L. 10/2012 In : Analytical and Bioanalytical Chemistry. 404, 6-7, p. 1745-1758 14 p.

Research output: Contribution to journalJournal article

Identification of benzo[a]pyrene-induced cell cycle-associated alterations in MCF-7 cells using infrared spectroscopy with computational analysis

Pang, W., Li, J., Ahmadzai, A. A., Heppenstall, L. D., Llabjani, V., Trevisan, J., Qiu, X. & Martin, F. L. 16/08/2012 In : Toxicology. 298, 1-3, p. 24-29 6 p.

Research output: Contribution to journalJournal article

Classification of test agent-specific effects in the Syrian hamster embryo assay (pH 6.7) using infrared spectroscopy with computational analysis

Ahmadzai, A. A., Trevisan, J., Pang, W., Patel, I. I., Fullwood, N. J., Bruce, S. W., Pant, K., Carmichael, P. L., Scott, A. D. & Martin, F. L. 05/2012 In : Mutagenesis. 27, 3, p. 375-382 8 p.

Research output: Contribution to journalJournal article

The Syrian hamster embryo (SHE) assay (pH 6.7): mechanisms of cell transformation and application of vibrational spectroscopy to objectively score endpoint alterations

Ahmadzai, A. A., Trevisan, J., Fullwood, N. J., Carmichael, P. L., Scott, A. D. & Martin, F. L. 05/2012 In : Mutagenesis. 27, 3, p. 257-266 10 p.

Research output: Contribution to journalScientific review

Concentration-dependent effects of carbon nanoparticles in gram-negative bacteria determined by infrared spectroscopy with multivariate analysis

Riding, M. J., Martin, F. L., Trevisan, J., Llabjani, V., Patel, I. I., Jones, K. C. & Semple, K. T. 04/2012 In : Environmental Pollution. 163, p. 226-234 9 p.

Research output: Contribution to journalJournal article

Designing open, multi-class computational strategies to classify infrared spectroscopy data derived from the Syrian hamster embryo (SHE) assay

Trevisan, J., Angelov, P. P., Carmichael, P. L., Scott, A. D. & Martin, F. L. 01/2012 In : Mutagenesis. 27, 1, p. 111-111 1 p.

Research output: Contribution to journalMeeting abstract

Infrared spectroscopy detects contaminant-induced bimodal dose-responses in MCF-7 cells

Llabjani, V., Trevisan, J., Jones, K. C., Shore, R. F. & Martin, F. L. 01/2012 In : Mutagenesis. 27, 1, p. 128-129 2 p.

Research output: Contribution to journalMeeting abstract

Raman spectroscopy of pentanary GaInAsSbP narrow gap alloys lattice matched to InAs and GaSb

Cheetham, K. J., Carrington, P. J., Krier, A., Patel, I. I. & Martin, F. L. 01/2012 In : Semiconductor Science and Technology. 27, 1, p. - 4 p.015004

Research output: Contribution to journalJournal article

Extracting biological information with computational analysis of Fourier transform infrared (FTIR) biospectroscopy datasets: current practices to future perspectives

Trevisan, J., Angelov, P., Carmichael, P. L., Scott, A. & Martin, F. 2012 In : Analyst. 137, 14, p. 3202-3215 14 p.

Research output: Contribution to journalJournal article

2011

Effects of Aberrant Pax6 Gene Dosage on Mouse Corneal Pathophysiology and Corneal Epithelial Homeostasis

Mort, R. L., Bentley, A. J., Martin, F. L., Collinson, J. M., Douvaras, P., Hill, R. E., Morley, S. D., Fullwood, N. J. & West, J. D. 29/12/2011 In : PloS ONE. 6, 12, p. - 11 p.e28895

Research output: Contribution to journalJournal article

Differential Effects in Mammalian Cells Induced by Chemical Mixtures in Environmental Biota As Profiled Using Infrared Spectroscopy

Llabjani, V., Crosse, J. D., Ahmadzai, A. A., Patel, I. I., Pang, W., Trevisan, J., Jones, K. C., Shore, R. F. & Martin, F. 15/12/2011 In : Environmental Science and Technology. 45, 24, p. 10706-10712 7 p.

Research output: Contribution to journalJournal article

Combining immunolabeling and surface-enhanced Raman spectroscopy on cell membranes

Hodges, M., Kerns , J., Bentley, A. J., Fogarty, S., Patel, I. I., Martin, F. L. & Fullwood, N. J. 12/2011 In : ACS Nano. 5, 12, p. 9535-9541 7 p.

Research output: Contribution to journalJournal article

A biospectroscopic interrogation of fine needle aspirates points towards segregation between graded categories: an initial study towards diagnostic screening

Kelly, J. G., Ahmadzai, A. A., Hermansen, P., Pitt, M. A., Saidan, Z., Martin-Hirsch, P. L. & Martin, F. L. 08/2011 In : Analytical and Bioanalytical Chemistry. 401, 3, p. 957-967 11 p.

Research output: Contribution to journalJournal article

Derivation by Infrared Spectroscopy with Multivariate Analysis of Bimodal Contaminant-Induced Dose-Response Effects in MCF-7 Cells

Llabjani, V., Trevisan, J., Jones, K. C., Shore, R. F. & Martin, F. 15/07/2011 In : Environmental Science and Technology. 45, 14, p. 6129-6135 7 p.

Research output: Contribution to journalJournal article

Imaging sclera with hard X-ray microscopy

Fullwood, N. J., Martin, F., Bentley, A., Lee, J. P. & Lee, S. J. 07/2011 In : Micron. 42, 5, p. 506-511 6 p.

Research output: Contribution to journalScientific review

Fourier-transform infrared spectroscopy discriminates a spectral signature of endometriosis independent of inter-individual variation

Cheung, K. T., Trevisan, J., Kelly, J. G., Ashton, K. M., Stringfellow, H. F., Taylor, S. E., Singh, M. N., Martin-Hirsch, P. L. & Martin, F. L. 21/05/2011 In : Analyst. 136, 10, p. 2047-2055 9 p.

Research output: Contribution to journalJournal article

Characterisation of DNA methylation status using spectroscopy (mid-IR versus Raman) with multivariate analysis

Kelly, J. G., Najand, G. M. & Martin, F. L. 05/2011 In : Journal of Biophotonics. 4, 5, p. 345-354 10 p.

Research output: Contribution to journalJournal article

Raman scattering in InAsxSbyP1-x-y alloys grown by gas source MBE.

Cheetham, K. J., Krier, A., Patel, I. I., Martin, F. L., Tzeng, J-S., Wu, C-J., Lin, H-H. & EPSRC Studentship for KJC (Funder) 2/03/2011 In : Journal of Physics D-Applied Physics. 44, 8, p. 085405

Research output: Contribution to journalJournal article

Biospectroscopy to metabolically profile biomolecular structure: a multistage approach linking computational analysis with biomarkers

Kerns, J., Trevisan, J., Scott, A. D., Carmichael, P. L., Pollock, H. M., Martin-Hirsch, P. L. & Martin, F. L. 2011 In : Journal of Proteome Research. 10, 4, p. 1437-1448 12 p.

Research output: Contribution to journalJournal article

High contrast images of uterine tissue derived using Raman microspectroscopy with the empty modelling approach of multivariate curve resolution-alternating least squares

Patel, I. I., Trevisan, J., Evans, G., Llabjani, V., Martin-Hirsch, P. L., Stringfellow, H. F. & Martin, F. L. 2011 In : Analyst. 136, 23, p. 4950-4959 10 p.

Research output: Contribution to journalJournal article

Sublethal genotoxicity and cell alterations by organophosphorus pesticides in MCF-7 cells: implications for environmentally relevant concentrations

Ukpebor, J., Llabjani, V., Martin, F. & Halsall, C. J. 2011 In : Environmental toxicology and chemistry / SETAC. 30, 3, p. 632-639 8 p.

Research output: Contribution to journalJournal article

Understanding and harnessing the health effects of rapid urbanization in China.

Zhu, Y-G., Ioannidis, J. P. A., Li, H., Jones, K. C., Martin, F. L., Yong-Guan Zhu & Francis L. Martin 2011 In : Environmental Science and Technology. 45, 12, p. 5099-5104 6 p.

Research output: Contribution to journalJournal article

2010

A mathematical framework for spectroscopy data analysis to characterize chemical-induced alterations in the SHE assay

Trevisan, J., Angelov, P. P., Carmichael, P. L., Scott, A. D. & Martin, F. L. 11/2010 In : Mutagenesis. 25, 6, p. 658-658 1 p.

Research output: Contribution to journalMeeting abstract

Application of infrared spectroscopy to biochemically signature the effects of chemical mixtures in mammalian cells

Llabjani, V., Trevisan, J. & Martin, F. L. 11/2010 In : Mutagenesis. 25, 6, p. 655-655 1 p.

Research output: Contribution to journalMeeting abstract

Distinguishing cell types or populations based on the computational analysis of their infrared spectra

Martin, F., Kelly, J. G., Llabjani, V., Martin-Hirsch, P. L., Patel, I. I., Trevisan, J., Fullwood, N. J. & Walsh, M. J. 11/2010 In : Nature Protocols. 5, 11, p. 1748-1760 13 p.

Research output: Contribution to journalJournal article

Robust classification of low-grade cervical cytology following analysis with ATR-FTIR spectroscopy and subsequent application of self-learning classifier eClass

Kelly, J., Angelov, P., Trevisan, J., Vlachopoulou, N., Paraskevaidis, E., Martin-Hirsch, P. & Martin, F. 11/2010 In : Analytical and Bioanalytical Chemistry. 398, 5, p. 2191-2201 21 p.

Research output: Contribution to journalJournal article

Syrian hamster embryo (SHE) assay (pH 6.7) coupled with infrared spectroscopy and chemometrics towards toxicological assessment

Trevisan, J., Angelov, P. P., Patel, I. I., Najand, G. M., Cheung, K. T., Llabjani, V., Pollock, H. M., Bruce, S. W., Pant, K., Carmichael, P. M., Scott, A. D. & Martin, F. L. 11/2010 In : Analyst. 135, 12, p. 3266-3272 7 p.

Research output: Contribution to journalJournal article

Binary Mixture Effects by PBDE Congeners (47, 153, 183, or 209) and PCB Congeners (126 or 153) in MCF-7 Cells: Biochemical Alterations Assessed by IR Spectroscopy and Multivariate Analysis

Llabjani, V., Trevisan, J., Jones, K. C., Shore, R. F. & Martin, F. L. 15/05/2010 In : Environmental Science and Technology. 44, 10, p. 3992-3998 7 p.

Research output: Contribution to journalJournal article

Microspectroscopy of spectral biomarkers associated with human corneal stem cells

Nakamura, T., Kelly, J. G., Trevisan, J., Cooper, L. J., Bentley, A., Carmichael, P. L., Scott, A. D., Cotte, M., Susini, J., Martin-Hirsch, P. L., Kinoshita, S., Fullwood, N. J. & Martin, F. 6/03/2010 In : Molecular Vision. 16, 42, p. 359-368 10 p.

Research output: Contribution to journalJournal article

Evidence for a stem-cell lineage in corneal squamous cell carcinoma using synchrotron-based Fourier-transform infrared microspectroscopy and multivariate analysis

Kelly, J. G., Nakamura, T., Kinoshita, S., Fullwood, N. J. & Martin, F. 2010 In : Analyst. 135, 12, p. 3120-3125 6 p.

Research output: Contribution to journalJournal article

Microspectroscopy as a tool to discriminate nano-molecular cellular alterations in biomedical research.

Martin, F. L. & Pollock, H. M. 2010 Oxford Handbook of Nanoscience and Technology. Narlikar, A. V. & Fu, Y. Y. (eds.). Oxford: Oxford University Press, Vol. 2, 2816 p.

Research output: Contribution in Book/Report/ProceedingsChapter

2009

Derivation of a computational approach to iteratively discriminate a transformation phenotype in Syrian hamster embryo (SHE) cells

Trevisan, J., Angelov, P. & Martin, F. 11/2009 In : Mutagenesis. 24, 6, p. 543-543 1 p.

Research output: Contribution to journalJournal article

Infrared microspectroscopy to biochemically distinguish the effects of genotoxic versus endocrine-disrupting agents

Llabjani, V. & Martin, F. L. 11/2009 In : Mutagenesis. 24, 6, p. 542-543 2 p.

Research output: Contribution to journalMeeting abstract

Discrimination of base differences in oligonucleotides using mid-infrared spectroscopy and multivariate analysis.

Kelly, J. G., Martin-Hirsch, P. L. & Martin, F. L. 1/07/2009 In : Analytical Chemistry. 81, 13, p. 5314-5319 6 p.

Research output: Contribution to journalJournal article

Tracking the cell hierarchy in the human intestine using biochemical signatures derived by mid-infrared microspectroscopy.

Walsh, M. J., Hammiche, A., Fellous, T. G., Nicholson, J. M., Cotte, M., Susini, J., Fullwood, N. J., Martin-Hirsch, P. L., Alison, M. R. & Martin, F. L. 07/2009 In : Stem Cell Research. 3, 1, p. 15-27 13 p.

Research output: Contribution to journalJournal article

An investigation into corneal alkali burns using an organ culture model

Zhao, B., Ma, A., Martin, F. L. & Fullwood, N. J. 06/2009 In : Cornea. 28, 5, p. 541-546 6 p.

Research output: Contribution to journalJournal article

Risk of prostate cancer after isolated high-grade prostatic intraepithelial neoplasia (HGPIN) detected on extended core needle biopsy : a UK hospital experience.

Singh, P. B., Nicholson, C. M., Ragavan, N., Blades, R. A., Martin, F. L. & Matanhelia, S. S. 27/05/2009 In : BMC Urology. 9, 3

Research output: Contribution to journalJournal article

Discrimination of a transformation phenotype in Syrian golden hamster embryo (SHE) cells using ATR-FTIR spectroscopy.

Walsh, M., Bruce, S. W., Pant, K., Carmichael, P. L., Scott, A. D. & Martin, F. L. 5/04/2009 In : Toxicology. 258, 1, p. 33-38 6 p.

Research output: Contribution to journalJournal article

Quantification of phase I/II metabolizing enzyme gene expression and polycyclic aromatic hydrocarbon-DNA adduct levels in human prostate.

John, K., Ragavan, N., Pratt, M. M., Singh, P. B., Al-Buheissi, S., Matanhelia, S. S., Phillips, D. H., Poirier, M. C. & Martin, F. L. 1/04/2009 In : The Prostate. 69, 5, p. 505-519 15 p.

Research output: Contribution to journalJournal article

Derivation of a subtype-specific biochemical signature of endometrial carcinoma using synchrotron-based Fourier-transform infrared microspectroscopy.

Kelly, J. G., Singh, M. N., Stringfellow, H. F., Walsh, M. J., Nicholson, J. M., Bahrami, F., Ashton, K. M., Pitt, M. A., Martin-Hirsch, P. L. & Martin, F. L. 18/02/2009 In : Cancer Letters. 274, 2, p. 208-217 10 p.

Research output: Contribution to journalJournal article

The risk of prostate cancer amongst South Asian men in southern England : the PROCESS cohort study.

Singh, P. B., Ragavan, N. & Martin, F. 02/2009 In : BJU International. 103, 4, p. 553-553 1 p.

Research output: Contribution to journalJournal article

The multiple applications of tamoxifen : an example pointing to SERM modulation being the aspirin of the 21st century?

Singh, M., Martin-Hirsch, P. L. & Martin, F. L. 2009 In : Medical Science Monitor. 14, 9, p. RA144-RA148

Research output: Contribution to journalJournal article

2008

ATR-FTIR spectroscopy detects alterations induced by organotin(IV) carboxylates in MCF-7 cells at sub-cytotoxic/-genotoxic concentrations.

Ahmad, M. S., Mirza, B., Hussain, M., Hanif, M., Ali, S., Walsh, M. J. & Martin, F. L. 5/11/2008 In : PMC Biophysics. 1, 3

Research output: Contribution to journalJournal article

Elevated expression of CYP1A1 and y-SYNUCLEIN in human ectopic (ovarian) endometriosis compared with eutopic endometrium.

Singh, M. N., Stringfellow, H. F., Taylor, S. E., Ashton, K. M., Ahmad, M., Abdo, K. R., El-Agnaf, O. M. A., Martin-Hirsch, P. L. & Martin, F. L. 11/2008 In : Molecular Human Reproduction. 14, 11, p. 655-663 9 p.

Research output: Contribution to journalJournal article

The future of cancer diagnostics: next generation molecular technologies - Cambridge Healthtech Institute’s Inaugural Conference.

Martin, F. L. 11/2008 In : IDrugs. 11, p. 787-790 4 p.

Research output: Contribution to journalJournal article

Use of tissue ink to maintain identification of individual cores on needle biopsies of the prostate.

Singh, P. B., Saw, N. K., Haq, A., Blades, R. A., Martin, F. L., Matanhelia, S. S. & Nicholson, C. M. 09/2008 In : Journal of Clinical Pathology. 61, 9, p. 1055-1057 3 p.

Research output: Contribution to journalJournal article

Gene expression of phase I and phase II enzymes and PAH-DNA adduct formation in human prostate as risk factors in prostate cancer etiology.

John, K., Singh, P. B., Pratt, M. M., Ragavan, N., Cole, K. C., Matanhelia, S. S., Phillips, D. H. & Martin, F. L. 08/2008 In : Environmental and Molecular Mutagenesis. 49, 7, p. 557-557 1 p.

Research output: Contribution to journalJournal article

Quantifiable mRNA transcripts for tamoxifen-metabolising enzymes in human endometrium.

Singh, M. N., Stringfellow, H. F., Walsh, M. J., Ashton, K. M., Paraskevaidis, E., Abdo, K. R., Martin-Hirsch, P. L., Phillips, D. H. & Martin, F. L. 10/07/2008 In : Toxicology. 249, 1, p. 85-90 6 p.

Research output: Contribution to journalJournal article

Differential gene expression in the peripheral zone compared to the transition zone of the human prostate gland.

Noel, E. E., Ragavan, N., Walsh, M. J., James, S. Y., Matanhelia, S. S., Nicholson, C. M., Lu, Y-J. & Martin, F. L. 06/2008 In : Prostate Cancer and Prostatic Diseases. 11, 2, p. 173-180 8 p.

Research output: Contribution to journalJournal article

A potential paradox in prostate adenocarcinoma progression : oestrogen as the initiating agent.

Singh, P. B., Matanhelia, S. S. & Martin, F. L. 05/2008 In : European Journal of Cancer. 44, 7, p. 928-936 9 p.

Research output: Contribution to journalJournal article

An integrated laparoscopic simulator (i-SIM™) to develop surgical skills outside the operating theatre : a novel means to improve training facilities in the UK.

Singh, P. B., Saw, N. K., Mokete, M., Martin, F. L. & Matanhelia, S. S. 1/02/2008 In : International Journal of Surgery. 6, 1, p. 64-70 7 p.

Research output: Contribution to journalJournal article

FTIR micro-spectroscopy identifies symmetric PO2- modifications as a marker of the putative stem cell region of human intestinal crypts.

Walsh, M. J., Fellous, T. G., Hammiche, A., Lin, W-R., Fullwood, N. J., Grude, O., Bahrami, F., Nicholson, J. M., Cotte, M., Susini, J., Pollock, H. M., Brittan, M., Martin-Hirsch, P. L., Alison, M. R. & Martin, F. L. 01/2008 In : Stem Cells. 26, 10, p. 108-118 11 p.

Research output: Contribution to journalJournal article

A Self-Learning Fuzzy Classifier with Feature Selection for Intelligent interrogation of mid-IR spectroscopy data from exfoliative cervical cytology using selflearning classifier eClass.

Kelly, J. G., Angelov, P. P., Walsh, M. J., Pollock, H. M., Pitt, M. A., Martin-Hirsch, P. L. & Martin, F. L. 2008 In : International Journal of Computational Intelligence Research. 4, 4, p. 392-401 10 p.

Research output: Contribution to journalJournal article

FTIR Microspectroscopy Coupled with Two-Class Discrimination Segregates Markers Responsible for Inter- and Intra-Category Variance in Exfoliative Cervical Cytology.

Walsh, M. J., Singh, M. N., Stringfellow, H. F., Pollock, H. M., Hammiche, A., Grude, O., Fullwood, N. J., Pitt, M. A., Martin-Hirsch, P. L. & Martin, F. L. 2008 In : Biomarker Insights. 3, p. 179-189 11 p.

Research output: Contribution to journalJournal article

Locating stem cells with infrared light.

Martin, F. L. & Nicholson, J. M. 2008 Synchrotron Radiation Department (STFC, Daresbury Laboratory) Annual Report 2007-2008. p. 32-33 2 p.

Research output: Contribution in Book/Report/ProceedingsChapter

Spotting cancer before it spreads.

Martin, F. L. & Walsh, M. J. 2008 Synchrotron Radiation Department (CCLRC, Daresbury Laboratory) Annual Report 2006-2007. p. 3695-37 3659 p.

Research output: Contribution in Book/Report/ProceedingsChapter

Stem cell characterisation in the human intestine derived by mid-infrared light.

Martin, F. L. 2008 ESRF Highlights 2008. p. 109-110 2 p.

Research output: Contribution in Book/Report/ProceedingsChapter

2007

Fourier transform spectroscopy in diagnostic medicine.

Martin, F. L. & Fullwood, N. J. 18/12/2007 In : Proceedings of the National Academy of Sciences. 104, 51, p. E1

Research output: Contribution to journalJournal article

Near-field photothermal microspectroscopy for adult stem-cell identification and characterization.

Grude, O., Hammiche, A., Pollock, H. M., Bentley, A. J., Walsh, M. J., Martin, F. L. & Fullwood, N. J. 12/2007 In : Journal of Microscopy. 228, 3, p. 366-372 7 p.

Research output: Contribution to journalJournal article

FTIR microspectroscopy coupled with two-class discrimination segregates markers responsible for inter- and intra-category variance in exfoliative cervical cytology.

Walsh, M. J., Singh, M. N., Stringfellow, H. F., Pollock, H. M., Hammiche, A., Grude, O., Fullwood, N. J., Pitt, M. A., Martin-Hirsch, P. L. & Martin, F. L. 11/2007 In : Mutagenesis. 22, 6, p. 453

Research output: Contribution to journalJournal article

g-Synuclein and the progression of cancer.

Ahmad, M., Attoub, S., Singh, M. N., Martin, F. L. & El-Agnaf, O. M. A. 11/2007 In : FASEB Journal. 21, 13, p. 3419-3430 12 p.

Research output: Contribution to journalJournal article

Identifying variables responsible for clustering in discriminant analysis of data from infrared microspectroscopy of a biological sample.

Martin, F. L., German, M., Wit, E., Fearn, T., Ragavan, N. & Pollock, H. M. 11/2007 In : Journal of Computational Biology. 14, 9, p. 1176-1184 9 p.

Research output: Contribution to journalJournal article

Potential for phase I/II metabolism of tamoxifen in human endometrium: expression of CYP3A4 and SULT2A1.

Singh, M. N., Stringfellow, H. F., Walsh, M. J., Ashton, K. M., Phillips, D. H., Martin-Hirsch, P. L. & Martin, F. L. 11/2007 In : Mutagenesis. 22, 6, p. 450

Research output: Contribution to journalJournal article

Infrared spectral analysis of MCF-7 cells treated with serum-lipid extracts of Chinese origin segregates predominantly brominated flame retardant-exposed subjects from those with mainly organochlorine exposures.

Bi, X., Walsh, M. J., Wei, X., Sheng, G., Fu, J., Martin-Hirsch, P. L., Thomas, G. O., Jones, K. C. & Martin, F. L. 15/08/2007 In : Environmental Science and Technology. 41, 16, p. 5915-5922 8 p.

Research output: Contribution to journalJournal article

Ras-MEK-ERK signaling cascade regulates androgen receptor element-inducible gene transcription and DNA synthesis in prostate cancer cells.

Carey, A-M., Pramanik, R., Nicholson, L. J., Dew, T. K., Martin, F. L., Muir, G. H. & Morris, J. D. H. 1/08/2007 In : International Journal of Cancer. 121, 3, p. 520-527 8 p.

Research output: Contribution to journalJournal article

Exposure of electronics dismantling workers to polybrominated diphenyl ethers, polychlorinated biphenyls, and organochlorine pesticides in south China.

Bi, X., Thomas, G., Jones, K. C., Qu, W., Sheng, G., Martin, F. L. & Fu, J. 07/2007 In : Environmental Science and Technology. 41, 16, p. 5647-5653 7 p.

Research output: Contribution to journalJournal article

Non-contact micro-cantilevers detect photothermally induced vibrations that can segregate different categories of exfoliative cervical cytology.

Hammiche, A., Walsh, M. J., Pollock, H. M., Martin-Hirsch, P. L. & Martin, F. L. 10/06/2007 In : Journal of Biochemical and Biophysical Methods. 70, 4, p. 675-677 3 p.

Research output: Contribution to journalJournal article

Diversity of TMPRSS2-ERG fusion transcripts in the human prostate.

Clark, J., Merson, S., Jhavar, S., Flohr, P., Edwards, S., Foster, C. S., Eeles, R., Martin, F. L., Phillips, D. H., Crundwell, M., Christmas, T., Thompson, A., Fisher, C., Kovacs, G. & Cooper, C. S. 04/2007 In : Oncogene. 26, 18, p. 2667-2673 7 p.

Research output: Contribution to journalJournal article

Tamoxifen : important considerations of a multi-functional compound with organ-specific properties.

Singh, M. N., Stringfellow, H. F., Paraskevaidis, E., Martin-Hirsch, P. L. & Martin, F. L. 04/2007 In : Cancer Treatment Reviews. 33, 2, p. 91-100 10 p.

Research output: Contribution to journalJournal article

Growth kinetics in MCF-7 cells modulate benzo[a]pyrene-induced CYP1A1 up-regulation.

Jiao, H., Allinson, S. L., Walsh, M. J., Hewitt, R., Cole, K. J., Phillips, D. H. & Martin, F. L. 03/2007 In : Mutagenesis. 22, 2, p. 111-116 6 p.

Research output: Contribution to journalJournal article

Characterisation of human corneal stem cells by synchrotron infrared micro-spectroscopy.

Bentley, A. J., Nakamura, T., Hammiche, A., Pollock, H. M., Martin, F. L., Kinoshita, S. & Fullwood, N. J. 22/02/2007 In : Molecular Vision. 13, p. 237-242 6 p.

Research output: Contribution to journalJournal article

ATR microspectroscopy with multivariate analysis segregates grades of exfoliative cervical cytology.

Walsh, M. J., Singh, M. N., Pollock, H. M., Cooper, L. J., German, M. J., Stringfellow, H. F., Fullwood, N. J., Paraskevaidis, E., Martin-Hirsch, P. L. & Martin, F. L. 5/01/2007 In : Biochemical and Biophysical Research Communications. 352, 1, p. 213-219 7 p.

Research output: Contribution to journalJournal article

Gene expression profiling of the human prostate zones.

Ragavan, N. & Martin, F. L. 01/2007 In : BJU International. 99, 1, p. 212

Research output: Contribution to journalJournal article

Enhanced micronucleus formation and modulation of Bcl-2 : Bax in MCF-7 cells after exposure to binary mixtures.

Hewitt, R., Forero, A., Luncsford, P. J. & Martin, F. L. 2007 In : Environmental Health Perspectives. 115, Supple, p. 129-136 8 p.

Research output: Contribution to journalJournal article

Infrared spectral analysis of MCF-7 cells treated with serum-lipid extracts of Chinese origin segregates predominantly brominated flame retardant-exposed subjects from those with mainly organochlorine exposures.

Martin, F. L., Bi, X., Walsh, M. J., Wei, X., Sheng, G., Fu, J., Martin-Hirsch, P. L., Thomas, G. & Jones, K. C. 2007 In : Proceedings for the American Association for Cancer Research. 48, Procee, p. 77

Research output: Contribution to journalJournal article

Sources, fate, behaviour and effects of organic chemicals at the regional and global scale.

Jones, K. C., Halsall, C. J., Martin, F. L., Semple, K., Sweetman, A. J. & Thomas, G. O. 2007 In : Journal of Environmental Monitoring. 9, 6, p. 500

Research output: Contribution to journalJournal article

2006

Lycopene inhibits DNA synthesis in primary prostate epithelial cells in vitro and its administration is associated with a reduced prostate-specific antigen velocity in a phase II clinical study.

Barber, N. J., Zhang, X., Zhu, G., Pramanik, R., Barber, J. A., Martin, F. L., Morris, J. D. H. & Muir, G. H. 12/2006 In : Prostate Cancer and Prostatic Diseases. 9, 4, p. 407-413 7 p.

Research output: Contribution to journalJournal article

An observational study of cancers among female partners of UK-resident prostate cancer patients.

Ragavan, N., Grover, P., Balasubramanian, S. P., Hindley, A. C., Matanhelia, S. S. & Martin, F. L. 8/10/2006 In : Cancer Letters. 242, 1, p. 88-94 7 p.

Research output: Contribution to journalJournal article

Low dose treatment with polybrominated diphenyl ethers (PBDEs) induce altered characteristics in MCF-7 cells.

Barber, J. L., Walsh, M. J., Hewitt, R., Jones, K. C. & Martin, F. L. 21/09/2006 In : Mutagenesis. 21, 5, p. 351-360 10 p.

Research output: Contribution to journalJournal article

Tamoxifen induces a pro-apoptotic state in MCF-7 breast cells in the absence of marked decreases in survival.

Llabjani, V., Walsh, M., Singh, M., Martin-Hirsch, P. L. & Martin, F. L. 1/09/2006 In : Toxicology. 226, 1, p. 56-57 2 p.

Research output: Contribution to journalJournal article

CYP1B1 expression is higher in the peripheral zone compared to the transition zone : a difference underlying zonal susceptibility to prostate adenocarcinoma?

Ragavan, N., Hewitt, R., Hindley, A. C., Nicholson, C. M., Matanhelia, S. S. & Martin, F. L. 09/2006 In : Prostate Cancer and Prostatic Diseases. 9, 3, p. 316

Research output: Contribution to journalJournal article

Donepezil for severe Alzheimer's disease.

Allsop, D., Martin, F., Moore, S. & Fullwood, N. J. 29/07/2006 In : Lancet. 368, 9533, p. 361-362 2 p.

Research output: Contribution to journalJournal article

Selenium- or quercetin-induced retardation of DNA synthesis in primary prostate cells occurs in the presence of a concomitant reduction in androgen-receptor activity.

Morris, J. D., Pramanik, R., Zhang, X., Carey, A. M., Ragavan, N., Martin, F. L. & Muir, G. H. 28/07/2006 In : Cancer Letters. 239, 1, p. 111-122 12 p.

Research output: Contribution to journalJournal article

Discrimination of exfoliative cytology samples employing ATR-FTIR microspectroscopy.

Walsh, M. J., German, M. J., Pollock, H. M., Hammiche, A., Singh, M., Kyrgiou, M., Stringfellow, H., Paraskevaidis, E., Martin-Hirsch, P. L. & Martin, F. L. 07/2006 In : Mutagenesis. 21, 4, p. 289

Research output: Contribution to journalJournal article

Imaging and semiquantitation of polycyclic aromatic hydrocarbon (PAH)-DNA adducts in human reproductive tissues.

Pratt, M. M., Sirajuddin, P., Castle, P. E., Phillips, D. H., Afework, S., MacLean, A. B., Ragavan, N., Martin, F. L., Olivero, O. A. & Poirier, M. C. 07/2006 In : Environmental and Molecular Mutagenesis. 47, 6, p. 475

Research output: Contribution to journalJournal article

Infrared Spectroscopy with Multivariate Analysis Potentially Facilitates the Segregation of Different Types of Prostate Cell.

German, M. J., Hammiche, A., Ragavan, N., Tobin, M. J., Cooper, L. J., Matanhelia, S. S., Hindley, A. C., Nicholson, C. M., Fullwood, N. J., Pollock, H. M. & Martin, F. L. 05/2006 In : Biophysical Journal. 90, 10, p. 3783-3795 13 p.

Research output: Contribution to journalJournal article

An observational study of cancers among female partners of UK-resident prostate cancer patients.

Ragavan, N., Grover, P., Balasubramanian, S. P., Hindley, A. C., Matanhelia, S. S. & Martin, F. L. 04/2006 In : European Urology Supplements. 5, 2, p. 165

Research output: Contribution to journalJournal article

Expression of hormone-/carcinogen-metabolising enzymes in the prostate : clues into peripheral-zone susceptability?

Ragavan, N., Hewitt, R., Hindley, A. C., Nicholson, C. M., Matanhelia, S. S. & Martin, F. L. 04/2006 In : European Urology Supplements. 5, 2, p. 165

Research output: Contribution to journalJournal article

Short and medium chain length chlorinated paraffins in UK human milk fat

Thomas, G. O., Farrar, D., Braekvelt, E., Stern, G., Kalantzi, O. L., Martin, F. L. & Jones, K. C. 01/2006 In : Environment International. 32, 1, p. 34-40 7 p.

Research output: Contribution to journalJournal article

Benzo[a]pyrene-induced CYP1A1 expression in MCF-7 cells is S-phase dependent.

Martin, F. L. 2006 In : Proceedings of the American Association for Cancer Research. 46, p. 1224

Research output: Contribution to journalJournal article

CYP1A1 up-regulation in MCF-7 cells following benzo[a]pyrene treatment occurs primarily during S-phase : a significant modulator of consequent genotoxicity.

Martin, F. L., Allinson, S. L., Walsh, M. J., Hewitt, R., Cole, K. J., Phillips, D. H. & Jiao, H. 2006 In : European Journal of Genetic and Molecular Toxicology. 36

Research output: Contribution to journalJournal article

Imaging and semiquantitation of polycyclic aromatic hydrocarbon (PAH)-DNA adducts in human cervix, vuvla, placenta and prostate using Immunohistochemistry (ICH) and the Automated Cellular Imaging System (ACIS).

Pratt, M. M., Sirajuddin, P., Castle, P. E., Shiffman, M., Phillips, D. H., Afework, S., Ragavan, N., Martin, F. L., Sram, R. J., Manchester, D. K., Olivero, O. A. & Poirier, M. C. 2006 In : Proceedings of the American Association for Cancer Research. 46, p. 486

Research output: Contribution to journalJournal article

Review of the Predatory Bird Monitoring Scheme (PBMS).

Shore, R. F., Walker, L., Thomas, G. O., Barber, J. L., Martin, F. R., Jones, K. C., Beresford, N. A., Rowland, P. & Pickup, R. W. 2006 Unknown Publisher. (JNCC)

Research output: Book/Report/ProceedingsBook

2005

A biomarker model of sublethal genotoxicity (DNA single-strand breaks and adducts) using the sentinel organism Aporrectodea longa in spiked soil.

Martin, F. L., Piearce, T. G., Hewer, A., Phillips, D. H. & Semple, K. T. 11/2005 In : Environmental Pollution. 138, 2, p. 307-315 9 p.

Research output: Contribution to journalJournal article

Monitoring cell cycle distributions in MCF-7 cells using near-field photothermal microspectroscopy.

Hammiche, A., German, M. J., Hewitt, R., Pollock, H. M. & Martin, F. L. 05/2005 In : Biophysical Journal. 88, 5, p. 3699-3706 8 p.

Research output: Contribution to journalJournal article

CYP1B1 expression and peripheral-zone susceptibility to prostate adenocarcinoma : comparisons with other carcinogen/hormone-metabolising enzymes.

Martin, F. L., Ragavan, N., Hewitt, R., Hindley, A. C., Nicholson, C. M. & Matanhelia, S. S. 2005 In : Proceedings of the American Association for Cancer Research. 46, 162, p. 316

Research output: Contribution to journalJournal article

2004

CYP1B1 expression in prostate is higher in peripheral compared to transition zone.

Ragavan, N., Hewitt, R., Cooper, L. J., Ashton, K. M., Hindley, A. C., Nicholson, C. M., Fullwood, N. J., Matanhelia, S. S. & Martin, F. L. 8/11/2004 In : Cancer Letters. 215, 1, p. 69-78 10 p.

Research output: Contribution to journalJournal article

Inter-and intra-individual variations in prostate CYP1B1 expression suggest a role in peripheral-zone susceptibility to adenocarcinoma.

Ragavan, N., Hewitt, R., Hindley, A. C., Nicholson, C. M., Matanhelia, S. S. & Martin, F. L. 11/2004 In : Mutagenesis. 19, 6, p. 503

Research output: Contribution to journalJournal article

Environmental health impacts : occurrence, explosure and significance : meeting report, held at University of Lancaster, UK in September 2003.

Martin, F. L. & Semple, K. T. 09/2004 In : Mutagenesis. 19, 5, p. 423-429 7 p.

Research output: Contribution to journalJournal article

A strategy for designing inhibitors of α-synuclein aggregation and toxicity as a novel treatment for Parkinson's disease and related disorders.

El-Agnaf, O. M. A., Paleologou, K. E., Greer, B., Abogrein, A. M., King, J., Salem, S. A., Fullwood, N. J., Benson, F. E., Hewitt, R., Ford, K. J., Martin, F., Harriott, P., Cookson, M. R. & Allsop, D. 08/2004 In : FASEB Journal. 18, 11, p. 1315-1317 3 p.

Research output: Contribution to journalJournal article

Different levels of polybrominated diphenyl ethers (PBDEs) and chlorinated compounds in breast milk from two UK regions.

Kalantzi, O. I., Martin, F. L., Thomas, G. O., Alcock, R. E., Tang, H. R., Drury, S. C., Carmichael, P. L., Nicholson, J. K. & Jones, K. C. 07/2004 In : Environmental Health Perspectives. 112, 10, p. 1085-1091 7 p.

Research output: Contribution to journalJournal article

Inter-individual differences in the ability of human milk-fat extracts to enhance the genotoxic potential of the procarcinogen benzo[a]pyrene in MCF-7 breast cells.

Kalantzi, O. I., Hewitt, R., Ford, K. J., Alcock, R. E., Thomas, G. O., Morris, J. A., Hewer, A., Phillips, D. H., Jones, K. C. & Martin, F. L. 2004 In : Environmental Science and Technology. 38, 13, p. 3614-3622 9 p.

Research output: Contribution to journalJournal article

Mid-infrared micro-spectroscopy of difficult and awkward samples using near-field photothermal microspectroscopy (PTMS).

Hammiche, A., Bozec, L., German, M. J., Chalmers, J. M., Everall, N. J., Poulter, G., Reading, M., Grandy, D. B., Martin, F. L. & Pollock, H. M. 2004 In : Spectroscopy. 19, 2, p. 20-42 23 p.

Research output: Contribution to journalJournal article

Pre-existing levels of CYP1B1 expression in human prostate tissues modulated by 17 b-oestradiol in the presence of bezo[a]pyrene.

Martin, F. L., Ragavan, N., Hewitt, R., Nicholson, C. M., Matanhelia, S. S., Hindley, A. C. & McMillan, T. J. 2004 Proceedings of the American Association for Cancer Research 45 Conference.. p. 95

Research output: Contribution in Book/Report/ProceedingsChapter

α-Synuclein and the pathogenesis of Parkinson’s disease.

Martin, F., Allsop, D., Williamson, S. J. M., Paleologou, K. E. & El-Agnaf, O. M. A. 2004 In : Protein and Peptide Letters. 11, 3, p. 229-237 9 p.

Research output: Contribution to journalJournal article

2003

Fe(II)-induced DNA damage in α-synuclein-transfected human dopaminergic BE(2)-M17 neuroblastoma cells: detection by the Comet assay.

Martin, F., Williamson, S. J. M., Paleologou, K. E., Hewitt, R., El-Agnaf, O. M. A. & Allsop, D. 11/2003 In : Journal of Neurochemistry. 87, 3, p. 620-630 11 p.

Research output: Contribution to journalJournal article

Exclusive production of pion and kaon meson pairs in two photon collisions at LEP.

Martin, F. , Jones, R. W. L. , Smizanska, M. & 19 others ALEPH Collaboration, ., Heister, A., Schael, S., Barate, R., Brunelière, R., De Bonis, I., Decamp, D., Goy, C., Jezequel, S., Lees, J. -P., Merle, E., Minard, M. -N., Pietrzyk, B., Trocmé, B., Bravo, S., Casado, M. P., Chmeissani, M., Crespo, J. M. & Fernandez, E. 11/09/2003 In : Physics Letters B. 569, 3-4, p. 140-150 11 p.

Research output: Contribution to journalJournal article

Oestrogens induce G1 arrest in benzo[a]pyrene-treated MCF-7 breast cells while enhancing genotoxicity and clonogenic survival.

Davis, C., Bhana, S., Shorrocks, A. J. & Martin, F. L. 09/2003 In : Mutagenesis. 17, 5, p. 431-438 8 p.

Research output: Contribution to journalJournal article

Hormone-induced DNA damage in breast and prostate cells.

Martin, F. L., Kalantzi, O. I., Jones, K. C., Alcock, R. E., Thomas, G. O. & Cooper, L. 2003 American Association for Cancer Research

Research output: Other contribution

Polybrominated diphenyl ethers (PBDEs) and selected organochlorines in human breast milk samples from the United Kingdom.

Kalantzi, O. I., Alcock, R. E., Martin, F. L., Thomas, G. O. & Jones, K. C. 2003 In : Organohalogen Compounds. 61, p. 9-12 4 p.

Research output: Contribution to journalJournal article

2002

Genotoxic effects of oestrogens in breast cells as detected by ther micronucleus assay and the Comet assay.

Yared, E., McMillan, T. J. & Martin, F. L. 07/2002 In : Mutagenesis. 17, 4, p. 345-352 8 p.

Research output: Contribution to journalJournal article

The initiation of breast and prostate cancer.

Grover, P. L. & Martin, F. L. 07/2002 In : Carcinogenesis. 23, 7, p. 1095-1102 8 p.

Research output: Contribution to journalJournal article

Primary cultures of prostate epithelial cells and their ability to activate carcinogens.

Martin, F. L., Cole, K. J., Muir, G. H., Kooiman, G. G., Williams, J. A., Sherwood, R. A., Grover, P. L. & Phillips, D. H. 06/2002 In : Prostate Cancer and Prostatic Diseases. 5, 2, p. 96-104 9 p.

Research output: Contribution to journalJournal article

The proteolytic release of gentoxins from cooked beef.

Martin, F. L., Cole, K. J., Phillips, D. H. & Grover, P. L. 24/05/2002 In : Biochemical and Biophysical Research Communications. 293, 5, p. 1497-1501 5 p.

Research output: Contribution to journalJournal article

Endogenous hormones enhance benzo[a]pyrene-induced genotoxicity in human breast cells.

Martin, F. L., Davis, C., Yared, E. & McMillan, T. J. 2002 Proceedings for the American Association of Cancer Research. Vol. 42, p. 1038

Research output: Contribution in Book/Report/ProceedingsChapter

Mutagens in human breast lipid and milk : the search for environmental agents that initiate breast cancer.

Phillips, D. H., Martin, F. L., Williams, J. A., Wheat, L. M. C., Nolan, L., Cole, K. J. & Grover, P. L. 2002 In : Environmental and Molecular Mutagenesis. 39, 2-3, p. 143-149 7 p.

Research output: Contribution to journalJournal article

2001

Morphological transformation of C3H/M2 mouse fibroblasts by, and genotoxicity of, extracts of human milk.

Pfau, W., Martin, F. L., Cole, K. J., Weaver, G., Marquardt, H., Phillips, D. H. & Grover, P. L. 15/11/2001 In : Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 498, 1-2, p. 207-217 11 p.

Research output: Contribution to journalJournal article

Genotoxicity of human breast milk from different countries.

Martin, F. L., Cole, K. J., Weaver, G., Hong, G. S., Lam, B. C., Balaram, P., Grover, P. L. & Phillips, D. H. 09/2001 In : Mutagenesis. 16, 5, p. 401-406 6 p.

Research output: Contribution to journalJournal article

Genotoxins and the initiation of sporadic breast cancer.

Martin, F. L. 03/2001 In : Mutagenesis. 16, 2, p. 155-161 7 p.

Research output: Contribution to journalJournal article

Genotoxic agents in human milk.

Wheat, L. M. C., Martin, F. L. & Phillips, D. H. 2001 In : Mutagenesis. 16

Research output: Contribution to journalJournal article

Genotoxicity of human breast milk from different countries.

Phillips, D. H., Martin, F. L., Grover, P. L., Cole, K. J., Weaver, G., Hong, G. S., Lam, B. S. & Balaram, P. 2001 In : Proceedings of the American Association for Cancer Research. 42, p. 601

Research output: Contribution to journalJournal article

Genotoxins in human milk.

Wheat, L. M. C., Martin, F. L. & Phillips, D. H. 2001 In : Proceedings of the American Association for Cancer Research. 42, p. 601

Research output: Contribution to journalJournal article

Mechanisms of carcinogenicity and DNA adduct formation by tamoxifen.

Phillips, D. H., Martin, F. L., Hewer, A. & Osborne, M. R. 2001 Proceedings of the 8th ICEM conference, Japan 2001.

Research output: Contribution in Book/Report/ProceedingsChapter

Toxicological basis for a possible association of breast cancer with smoking and other sources of environmental carcinogens.

Phillips, D. H., Martin, F. L., Grover, P. L. & Williams, J. A. 2001 In : Journal of Women's Cancer. 3, p. 9-16 8 p.

Research output: Contribution to journalJournal article

You are what you eat : diet and prostate cancer.

Kooiman, G. G., Martin, F. L., Williams, J. A., Grover, P. L., Phillips, D. H. & Muir, G. H. 2001 In : European Urology.

Research output: Contribution to journalJournal article

2000

The influence of dietary and environmental factors on prostate cancer risk.

Kooiman, G., Martin, F. L., Williams, J. A., Grover, P. L., Phillips, D. H. & Muir, G. H. 12/2000 In : Prostate Cancer and Prostatic Diseases. 3, 4, p. 256-258 3 p.

Research output: Contribution to journalJournal article

Activation of genotoxins to DNA-damaging species in exfoliated breast milk cells.

Martin, F. L., Cole, K. J., Williams, J. A., Millar, B. C., Harvey, D. R., Weaver, G., Grover, P. L. & Phillips, D. H. 31/10/2000 In : Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 470, 2, p. 115-125 11 p.

Research output: Contribution to journalJournal article

Detection of DNA damage by the Comet assay in MCL-5 cells exposed to urban air particulate matter.

Khan, Q. M., Phillips, D. H., Martin, F. L., Hewer, A., Cole, K. J., Hussain, I. H. & Khalid, Z. M. 09/2000 In : Mutagenesis. 15, 5, p. 444

Research output: Contribution to journalJournal article

Enhanced sensitivity of the Comet assay towards benzo[a]pyrene.

Wheat, L. M. C., Martin, F. L. & Phillips, D. H. 09/2000 In : Mutagenesis. 15, 5, p. 455

Research output: Contribution to journalJournal article

Genotoxins and the initiation of sporadic breast cancer.

Martin, F. L. 09/2000 In : Mutagenesis. 15, 5, p. 447

Research output: Contribution to journalJournal article

Human prostate tissue expresses CYP1A2 mNRA transcripts and metabolically activates potential prostate carcinogens.

Williams, J. A., Martin, F. L., Muir, G. H., Grover, P. L. & Phillips, D. H. 09/2000 In : Carcinogenesis. 21, 9, p. 1683-1689 7 p.

Research output: Contribution to journalJournal article

Susceptibility of primary cultures of human prostate epilthelial cells to chemical carcinogens as detected using the Comet assay.

Martin, F. L., Williams, J. A., Cole, K. J., Muir, G. H., Grover, P. L. & Phillips, D. H. 09/2000 In : Mutagenesis. 15, 5, p. 447

Research output: Contribution to journalJournal article

An introduction to human molecular genetics : mechanisms of inherited diseases.

Martin, F. L. 05/2000 In : Mutagenesis. 15, 3, p. 287

Research output: Contribution to journalJournal article

DNA damage in breast milk cells and its induction by "early" and "late" milk extracts.

Martin, F. L., Cole, K. J., Harvey, D. R., Weaver, G., Williams, J. A., Millar, B. C., Phillips, D. H. & Grover, P. L. 04/2000 In : Carcinogenesis. 21, 4, p. 799-804 6 p.

Research output: Contribution to journalJournal article

DNA recombination and repair (book review).

Martin, F. L. 03/2000 In : Mutagenesis. 15, 2, p. 185

Research output: Contribution to journalJournal article

Cell transformation and genotoxicity of bis(2,3-dichloro-1-propyl)ether.

Neurath, G., Martin, F. L., Piasecki, A., Ruge, A., Cole, K. J., Franke, S., Franke, W. & Marquardt, H. 2000 In : Environmental and Molecular Mutagenesis. 35, 4, p. 312-318 7 p.

Research output: Contribution to journalJournal article

Cover photograph.

Martin, F. L. 2000 The use of short-and medium-term tests for carcinogens and data on genetic effects in carcinogenic hazard evaluation. McGregor, D. B., Rice, J. M. & Venitt, S. (eds.). Oxford: IARC Scientific Publications

Research output: Contribution in Book/Report/ProceedingsChapter

DNA damage in human breast milk cells and induction by milk extracts.

Martin, F. L., Cole, K. J., Williams, J. A., Millar, B. C., Phillips, D. H. & Grover, P. L. 2000 In : Proceedings of the American Association for Cancer Research. 41, p. 835

Research output: Contribution to journalJournal article

Frank Martin's Activities

2012

Member of the OECD cell transformation assay (CTA) Expert Group for the generation of a CTA test guideline

Professor Frank Martin (Member), 10/2012 → …

Activity: External academic engagementContribution to the work of national or international committees and working groups

Appointed to COM (Committee on Mutagenicity of Chemicals in Food, Consumer Products and the Environment)

Professor Frank Martin (Member), 04/2012 → …

Activity: External academic engagementContribution to the work of national or international committees and working groups

2011

Vice-president of UK Environmental Mutagenicity Society

Professor Frank Martin (Member), 12/2011 → …

Activity: External academic engagementContribution to the work of national or international committees and working groups

2006

Visiting Professor in Medical Genetics at Ningxia Medical University, P.R. China

Professor Frank Martin (Visitor), 2006 → …

Activity: External academic engagementMembership of external research organisation

2001

Toxicology

Professor Frank Martin (Editorial board member), 1/01/2001 → …

Activity: Editorial work or peer review of publicationsEditorial activity