Condensed Matter Physics Seminar
Professor David A. Middleton, Lancaster University
Friday 20 June 2014, 1500-1600
C1 Physics Building
Solid-state NMR measurements of nuclear spin interactions for the analysis of biomolecular structure and dynamics
NMR spectroscopic analysis of nuclear spin interactions provides valuable chemical and physical information for a variety of molecules and materials. In the solid state, anisotropic nuclear dipole-dipole, chemical shielding and (for spins ?1) nuclear electric quadrupolar interactions can be exploited to measure interatomic distances, molecular geometries and dynamics. This seminar will illustrate some of the solid-state NMR methodology we are using to examine the structures and dynamics of biological molecules, including biological receptors and self-assembling peptides. The details obtained are guiding the design of therapeutic molecules and novel materials.