African Sleeping Sickness Breakthrough
Story supplied by LU Press Office
Researchers have made a crucial breakthrough in the journey towards finding a treatment for African Sleeping Sickness. The team from Lancaster, Oxford and Manchester Universities have discovered a weakness in the parasite that causes the disease - it cannot survive in the human bloodstream without the use of its flagellum, a protein 'tail' that allows it to swim.
This unexpected discovery offers up a valuable lead in the search for new drugs to control the killer disease.
The study is published this week (March 9) in the leading scientific journal Nature.
The sleeping sickness parasite, Trypanosoma brucei, is a single-celled organism equipped with a whip-like tail or flagellum. The parasite initially lives in the bloodstream of the human host causing fever and headaches, but eventually crosses into the brain where it causes irreversible neurological damage. Without treatment, the disease is fatal.
According to the latest figures from the World Health Organisation (WHO), African Sleeping sickness threatens over 60 million people in 36 countries of sub-Saharan Africa. The number of new cases per year is estimated to be between 300,000 to 500,000 with at least 60,000 people dying annually from the disease.
Until now doctors have struggled to treat the disease as most of the drugs currently used to combat this disease have undesirable side-effects and parasites are beginning to show evidence of increasing drug resistance. Furthermore there is little hope of a vaccine.
Lancaster University Biologist Dr Paul McKean said: "In this study we describe, for the first time, a full catalogue of the proteins required to build the trypanosome flagellum (the sleeping sickness parasite's tail).
"We also show that many of these proteins are specific to the trypanosome flagellum. This latter finding is of critical importance since we also show that flagellum function is essential to the survival of bloodstream trypanosomes. These two observations raise the possibility that the flagellum may represent a novel target for the development of new drugs against this important medical pathogen."
Wed 15 March 2006
Lancaster Physics graduates have produced an excellent description of the use of scientific method in the search for the Higgs Boson.
Fri 27 February 2015
Congratulations to fourth year Physics student, Jorden Senior, for winning first prize for his blog entry into The Ogden Trust’s annual ‘Blogden’ competition.
Fri 20 February 2015
Vice-Chancellor, Professor Mark E Smith, recently visited CERN, to see the important research being conducted by Lancaster staff. Joined by Professor Peter Ratoff, Professor Roger Jones and Dr Graeme Burt who are leading CERN based projects, Professor Smith was given a VIP tour of CERN including the Compact Muon Solenoid (CMS) and the ATLAS Collaboration visitor centre.
Fri 20 February 2015
Lancaster University is enhancing its position as a global leader in cyber security research by agreeing links with Japan’s national ICT institute.
Wed 11 February 2015