'Sewing machine' idea gives insight into origins of Alzheimer's
Story supplied by LU Press Office
Researchers at Lancaster University have invented a new imaging tool inspired by the humble sewing machine which is providing fresh insight into the origins of Alzheimer's and Parkinson's disease.
These diseases are caused by tiny toxic proteins too small to be studied with traditional optical microscopy.
Previously it was thought that Alzheimer's was caused by the accumulation of long 'amyloid' fibres at the centre of senile plaques in the brain, due to improper folding of a protein called amyloid-?.
But new research suggests that these fibres and plaques are actually the body's protective response to the presence of even smaller, more toxic structures made from amyloid-? called 'oligomers'.
Existing techniques are not sufficient to get a good look at these proteins; optical microscopy does not provide enough resolution at this scale, and electron microscopy gives the resolution but not the contrast.
To solve the problem, Physicist Dr Oleg Kolosov and his team at Lancaster have developed a new imaging technique - Ultrasonic Force Microscopy (UFM) - inspired by the motion of a sewing machine. Their work has been published in Scientific Reports.
Dr Kolosov said: "By using a vibrating scanner, which moves quickly up and down like the foot of a sewing machine needle, the friction between the sample and the scanner was reduced - resulting in a better quality, and high contrast nanometre scale resolution image."
It is one of a new generation of tools being developed worldwide to bring the oligomers into focus, enabling medical researchers to understand how they behave.
At Lancaster, Claire Tinker used UFM to image these oligomers. To help see them more clearly she needed to increase the contrast of the image and used poly-L-lysine (PLL) which kept the proteins stuck to the slides as the vibrating scanner was passed over them.
Lancaster University Biomedical Scientist Professor David Allsop said: "These high quality images are vitally important if we are to understand the pathways involved in formation of these oligomers, and this new technique will now be used to test the effects of inhibitors of oligomer formation that we are developing as a possible new treatment for Alzheimer's disease."
The technique worked so well that the team now hopes to develop it so that oligomer formation can be monitored as they are made in real time.
This would give researchers a clearer understanding of the early phases of Alzheimer's and Parkinson's and could potentially be one way of developing a future test for these diseases.
Wed 02 April 2014
'Motorsport Engineering: Fabulous or Frivolous?'
Mon 26 January 2015
In this report we provide some case studies of our work with external partners during 2013-2014. Read about R&D opportunities with China, new science and technology start-up companies, research with IBM, Booths and regional Small and Medium Enterprises, seed funding for new products and processes, new facilities for hire, free events and training, new companies on campus, plugging the data science skills gap, the Engineering Design Academy, and much more...
Tue 20 January 2015
The Faculty is pleased to announce that Professor Peter M Atkinson has been appointed as Dean of the Faculty of Science and Technology.
Mon 05 January 2015
Police and intelligence agencies around the world have for almost 100 years relied on lie-detectors to help convict criminals or unearth spies and traitors.
Mon 05 January 2015