The Faculty of Health and Medicine is pleased to offer a number of scholarships to include a range of 'fees only' and 'fees plus stipend' awards for outstanding UK/EU and overseas students wishing to undertake full time doctoral research in any Department within the Faculty of Health and Medicine.
Awards will be made for a maximum of three years full-time study. Applications from individuals who are able to demonstrate an ability to contribute to their fees or living expenses are particularly welcome.
Applications must be linked to one of the Faculty's core research areas of:
Leishmaniasis is a medically important disease exclusively transmitted by phlebotomine sand flies. The ecology of the sand fly-Leishmania relationship is complex, the possibility that larval stressors carry over to impact on the adult sand fly-Leishmania relationship have not been considered. Knowledge of the impact of larval stress on adult transmission of disease would help us understand the basis of susceptibility/refractoriness to Leishmania and affect our capacity to contain disease outbreaks. The project will involve working on a Brazilian strain of Lutzomyia longipalpis that is the vector for Leishmania infantum in S. America. The project is in collaboration with Dr Mauricio Sant'Anna at a Brazilian University (UFMG, Belo Horizonte) and will involve a collaborative visit to Brazil.
Based on preliminary data it is proposed to undertake a Synthetic Genetic Analysis (SGA) screen in fission yeast designed to identify and analyse the functional genetic architecture supporting TopBP1 activity. TopBP1 is highly conserved in the eukaryota and functions in the initiation of eukaryotic DNA replication as well as having a central role in the cellular response to the presence of DNA damage. Compromise of both the initiation of DNA replication and checkpoint function have been widely implicated in the initiation of neoplastic growth. A preliminary screen has identified a number of functional groups of genes that when mutated are synthetically lethal in combination with a hypomorhic allele (rad4-116) of the gene encoding the S. pombe TopBP1 homologue. It is proposed to repeat the preliminary screening process to generate a statistically robust dataset and in parallel to analyse some of the potential genetic interactions uncovered in that preliminary screen. These functions relate to chromatin structure and maintenance, with a particular focus on the replication and structure of heterochromatin at centromeres and telomeres and the role of recombinational repair under conditions of replication stress. Methodology to be employed beyond the initial synthetic lethality screening will include quantative fitness analysis, gene expression analysis by quantitative PCR, two dimensional gel analysis of DNA replication intermediates, time resolved study of DNA replication using fluorescent labelling technologies and microscopy (DNA combing), time resolved live cell imaging microscopy.
Overseas applications from Brazil, China and India are particularly welcome.
Applicants wishing to be considered for these awards must have identified a topic and a named supervisor from within the Faculty who is willing to supervise their proposed research, and should complete and submit the Expression of Interest Form together with a one page CV by the deadline date of: May 7th at 5.00 p.m.
Contact Dawn McCracken for further information by email or telephone her on:
+44 (0)1524 593936.
Your CV should clearly indicate your educational achievements to date (indicating the class of degree award achieved). Overseas students whose first language is NOT English, must also clearly indicate their IELTS (or equivalent) score.
Applicants shortlisted to progress to the second stage of the application process will be informed by Friday May 18th at the latest.
If you have not heard from the Faculty by May 18th your application will not have been selected to continue to Stage 2. Due to the number of applications received, the Faculty is unfortunately not able to enter into correspondence about why your application was not shortlisted.
Shortlisted applicants will be required to complete a full application via the electronic applications portal (http://www.postgraduate.lancs.ac.uk/Applying/Pages/applying.aspx) and have received an offer of a place to study by the deadline date of Monday June 18th. Applicants should be registered to commence their studies in October 2013.
The application process for shortlisted applicants is as follows:
The terms of the award are as follows:
We recommend that you contact the staff involved before making your application.
For more information see applying for doctoral study.