The first part of this module focuses on conformational analysis of chains and rings, with a particular focus on conformations of acyclic and cyclic hydrocarbons, and the conformations and reactivity of substituted cyclohexanes. Conformations and reactivity of cyclohexene, cyclohexanone, strained and bridgehead-containing rings will also be explored. Students will then concentrate on the application of spectroscopic methods in organic structure determination. The importance of geminal, vicinal and long range coupling in 1H NMR will be assessed, as will the uses of Nuclear Overhauser effect. 2D NMR in structure elucidation will be examined as well.
Students will gain knowledge, understanding and skills in the conformational analysis and structural determination of organic molecules. Additionally, they will improve their skills in problem solving and analysing and interpreting data.