This module is an introduction to cellular biochemistry focusing on the core pathways of intermediary metabolism which are central to cellular function. Specifically, it focuses on two related and key areas of biochemistry. The first is enzymology; how do proteins function as biological catalysts and how are chemical reactions controlled within a cell? Students will investigate how the many chemical reactions which participate in metabolism are accurately regulated and organised.
The second is cellular metabolism; particularly, how do cells obtain energy from their surroundings to maintain their complex order?
The module will cover several seminal and Nobel Prize winning research topics including a detailed look at the key reactions of the citric acid cycle and the coupling of electron transport, proton pumping and ATP synthesis. The concepts and areas of biochemistry covered will be further illustrated by reference to the pathological state and human diseases which result from specific malfunctions in biochemical pathways and reactions.