Cancer Biology and Genome Stability

Members of this research group contribute to the cross-faculty research theme on Ageing.

Our research is aimed at understanding the cellular and molecular basis of cancer to develop better ways of preventing, diagnosing and treating the disease.

Genome stability is one major focus of our work - several of our research groups are studying how cells maintain the integrity of their DNA and how these processes can become disrupted in cancer.

We also have several groups who are interested in how other important cellular processes become disrupted in cancer and whether these can be targeted to develop new treatments or used as biomarkers to improve diagnosis.

We work closely with local charity North West Cancer Research, who fund both staff and individual projects in the Division.


Researchers working in this area, together with a short description of their research interests, are listed below.

  • Dr Sarah Allinson: Eukaryotic DNA Repair; Effects of UV Radiation on Human Skin Cells; Heavy Metal Carcinogenesis
  • Dr Alexandre Benedetto: Cell cycle regulation, lab on a chip approaches to studying cancer progression
  • Dr Fiona Benson: DNA repair, homologous recombination
  • Dr Nikki Copeland: Regulation of DNA Replication, cancer cell proliferation
  • Dr Howard Lindsay: (Lancaster Medical School) Cell Signalling Pathways Related to DNA Replication and DNA Damage
  • Dr Richard Mort: Melanocyte development, melanoma, and tissue homeostasis
  • Dr Edward Parkin: ADAM Proteases; Prostate Cancer
  • Dr Rachael Rigby: Colorectal Cancer; Intestinal Epithelial Cell Homeostasis
  • Dr Nick Robinson: Archael models; DNA replication, DNA repair, protein homeostasis and genomic stability
  • Dr Elaine Taylor: (Lancaster Medical School) Eukaryotic DNA Repair; DNA Replication; Cell Division; Post-translational Modification
  • Dr Leonie Unterholzner: The innate immune response to DNA damage, skin cancer
  • Dr Karen Wright: Colorectal Cancer; Cannabinoids