{"id":7191,"date":"2019-05-22T15:54:11","date_gmt":"2019-05-22T15:54:11","guid":{"rendered":"http:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/22q11_deletion_-catch_22-_syndrome\/"},"modified":"2019-06-26T15:34:38","modified_gmt":"2019-06-26T15:34:38","slug":"22q11_deletion_-catch_22-_syndrome","status":"publish","type":"post","link":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/22q11_deletion_-catch_22-_syndrome\/","title":{"rendered":"CATCH 22 syndrome (22q11 deletion)"},"content":{"rendered":"<p>It is a genetic disorder standing for the acronym cardiac abnormalities, abnormal facies, thymic hypoplasia, cleft palate and hypocalcemia, which are its defining phenotypical features. &nbsp;Including the <a href=\"http:\/\/www.bbc.co.uk\/health\/physical_health\/conditions\/digeorge1.shtml\" class=\"cc-route-enabled\" target=\"_self\" data-editable-link=\"http:\/\/www.bbc.co.uk\/health\/physical_health\/conditions\/digeorge1.shtml&amp;target=_self\" rel=\"noopener noreferrer\">DiGeorge syndrome<\/a> and more commonly referred to as the velocardio-facial or <a href=\"http:\/\/www.rightdiagnosis.com\/medical\/shprintzen_syndrome.htm\" class=\"cc-route-enabled\" target=\"_self\" data-editable-link=\"http:\/\/www.rightdiagnosis.com\/medical\/shprintzen_syndrome.htm&amp;target=_self\" rel=\"noopener noreferrer\">Shprintzen syndrome<\/a>, it is associated with a specific abnormality or microdeletion on the long arm of chromosome 22. &nbsp;It occurs in about 1 in 700 births, thus making it one of the most common genetic disorders in humans probably due the fact it covers a number of similar syndromes, and has a 50% chance of resulting in mental retardation. &nbsp;It also associated with major psychoses, but particularly schizophrenia. &nbsp;The 22q11-dependent abnormalities are thought to engender dysfunctioning of the limbic system and to interfere with the interhemipheric exchange of information, thereby predisposing individuals to the syndrome.<\/p>\n<p>See Behavior phenotype syndromes, <a href=\"corpus_callosum\">Corpus callosum<\/a>, <a href=\"limbic_system\">Limbic system<\/a>, Reelin<\/p>\n","protected":false},"excerpt":{"rendered":"<p>It is a genetic disorder standing for the acronym cardiac abnormalities, abnormal facies, thymic hypoplasia, cleft palate and hypocalcemia, which are its defining phenotypical features. &nbsp;Including the DiGeorge syndrome and more commonly referred to as the velocardio-facial or Shprintzen syndrome, it is associated with a specific abnormality or microdeletion on the long arm of chromosome &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/22q11_deletion_-catch_22-_syndrome\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;CATCH 22 syndrome (22q11 deletion)&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[2],"class_list":["post-7191","post","type-post","status-publish","format-standard","hentry","category-uncategorized","tag-glossary","entry"],"_links":{"self":[{"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/posts\/7191","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/comments?post=7191"}],"version-history":[{"count":1,"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/posts\/7191\/revisions"}],"predecessor-version":[{"id":9487,"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/posts\/7191\/revisions\/9487"}],"wp:attachment":[{"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/media?parent=7191"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/categories?post=7191"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/tags?post=7191"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}