{"id":7273,"date":"2019-05-22T15:55:05","date_gmt":"2019-05-22T15:55:05","guid":{"rendered":"http:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/angelman-s_syndrome\/"},"modified":"2019-05-22T15:55:05","modified_gmt":"2019-05-22T15:55:05","slug":"angelman-s_syndrome","status":"publish","type":"post","link":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/angelman-s_syndrome\/","title":{"rendered":"Angelman&#8217;s syndrome"},"content":{"rendered":"<p>A genetic disorder dominated by learning disability, ataxia, jerky puppet-like movements, epilepsy, and various behaviour problems, including some autistic features; associated with loss of maternal alleles on chromosome 15q11-13 and other genetic abnormalities (see figure below). &nbsp;Some 75% of those with the syndrome have a similar defect as found in the Prader-Willi syndrome, but occurring on chromosome 15. &nbsp;First reported by <a href=\"http:\/\/angelmannetwork.wordpress.com\/learn-about\/dr-harry-angelman\/\" class=\"cc-route-enabled\" target=\"_self\" data-editable-link=\"http:\/\/angelmannetwork.wordpress.com\/learn-about\/dr-harry-angelman\/&amp;target=_self\" rel=\"noopener noreferrer\">Harry Angelman<\/a> (1915-1996) in 1965 in a study of three cases.<\/p>\n<p class=\"\" style=\"text-align: center;\">\n<p><img decoding=\"async\" src=\"..\/wp-content\/uploads\/2019\/05\/image018.jpg\" \/><\/div>\n<\/div>\n<p>See <a href=\"ataxia\">Ataxia<\/a>, <a href=\"autism\">Autism<\/a>, <a href=\"behavioral_phenotype_syndromes\">Behavioral phenotype syndromes<\/a>, <a href=\"epilepsy\">Epilepsy<\/a>, <a href=\"mecp2_gene\">MECP2 gene<\/a>, <a href=\"methylation\">Methylation<\/a>, Prader-Willi syndrome<\/p>\n<p><\/body><\/html><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A genetic disorder dominated by learning disability, ataxia, jerky puppet-like movements, epilepsy, and various behaviour problems, including some autistic features; associated with loss of maternal alleles on chromosome 15q11-13 and other genetic abnormalities (see figure below). &nbsp;Some 75% of those with the syndrome have a similar defect as found in the Prader-Willi syndrome, but occurring &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/angelman-s_syndrome\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Angelman&#8217;s syndrome&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[2],"class_list":["post-7273","post","type-post","status-publish","format-standard","hentry","category-uncategorized","tag-glossary","entry"],"_links":{"self":[{"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/posts\/7273","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/comments?post=7273"}],"version-history":[{"count":0,"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/posts\/7273\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/media?parent=7273"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/categories?post=7273"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/tags?post=7273"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}