{"id":7292,"date":"2019-05-22T15:55:18","date_gmt":"2019-05-22T15:55:18","guid":{"rendered":"http:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/apoptosis_-or_cell_death\/"},"modified":"2019-05-22T15:55:18","modified_gmt":"2019-05-22T15:55:18","slug":"apoptosis_-or_cell_death","status":"publish","type":"post","link":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/apoptosis_-or_cell_death\/","title":{"rendered":"Apoptosis (or cell death)"},"content":{"rendered":"<p>Derived from the Greek word meaning &#8216;a flower losing its petals&#8217;, it refers to programmed cell death and replacement. &nbsp;It is a normal biological process in metazoan development that allows the elimination of unwanted cells through activation of the cell death program. &nbsp;The products of apoptosis are absorbed by neighboring cells and by white blood cells called macrophages (see figure below). &nbsp;In contrast to necrosis, which is a form of cell death resulting from acute tissue injury, apoptosis occurs in an ordered process that generally confers advantages during an organism&#8217;s life cycle. &nbsp;For example, the differentiation of human fingers requires the cells in between the fingers to initiate apoptosis so that the fingers separate. &nbsp;Abnormal control of apoptosis can have serious consequences, leading to a wide range of diseases, including cancer and schizophrenia.<\/p>\n<p class=\"\" style=\"text-align: center;\">\n<p><img decoding=\"async\" src=\"..\/wp-content\/uploads\/2019\/05\/image023.png\" \/><\/div>\n<\/div>\n<p class=\"\" style=\"text-align: center;\">A white blood cell consuming the debris of an apoptotic cell<\/p>\n<p><\/p>\n<p>See <a href=\"astrocyte\">Astrocyte<\/a>, <a href=\"cell_death\">Cell death<\/a>, <a href=\"cytokines\">Cytokines<\/a>, <a href=\"hormones\">Hormones<\/a>, <a href=\"interdigital_necrotic_zone_-inz-\">Interdigital necrotic zone (INZ)<\/a>, <a href=\"lysosomes\">Lysosomes<\/a>, <a href=\"metazoan\">Metazoan<\/a>, <a href=\"nerve_growth_factor_-ngf-\">Nerve Growth Factor (NGF)<\/a>, <a href=\"oligodendrocytes\">Oligodendrocytes<\/a>, <a href=\"polyneural_to_mononeural_innervation\">Polyneural to mononeural innervation<\/a>, <a href=\"proliferative_cells\">Proliferative cells<\/a>, <a href=\"regressive_event\">Regressive event<\/a>, Synapse elimination.<\/p>\n<p><\/body><\/html><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Derived from the Greek word meaning &#8216;a flower losing its petals&#8217;, it refers to programmed cell death and replacement. &nbsp;It is a normal biological process in metazoan development that allows the elimination of unwanted cells through activation of the cell death program. &nbsp;The products of apoptosis are absorbed by neighboring cells and by white blood &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/apoptosis_-or_cell_death\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Apoptosis (or cell death)&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[2],"class_list":["post-7292","post","type-post","status-publish","format-standard","hentry","category-uncategorized","tag-glossary","entry"],"_links":{"self":[{"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/posts\/7292","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/comments?post=7292"}],"version-history":[{"count":0,"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/posts\/7292\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/media?parent=7292"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/categories?post=7292"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/tags?post=7292"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}