{"id":7809,"date":"2019-05-22T16:00:53","date_gmt":"2019-05-22T16:00:53","guid":{"rendered":"http:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/edward-s_syndrome\/"},"modified":"2019-05-22T16:00:53","modified_gmt":"2019-05-22T16:00:53","slug":"edward-s_syndrome","status":"publish","type":"post","link":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/edward-s_syndrome\/","title":{"rendered":"Edward&#8217;s syndrome"},"content":{"rendered":"<p>Sometimes referred to as trisomy 18 as it arises as a consequence of an extra copy of chromosome 18 (see figure below). &nbsp;It occurs in about 1 in every 3000 to 5000 births, affecting girls more than boys. &nbsp;As with Down&#8217;s syndrome (after which it is the second most common trisomy), the risk of conceiving a child with Edwards syndrome becomes much greater after the age of 35. &nbsp;And as with Down&#8217;s syndrome, mosaic and translocated forms can occur. &nbsp;Most children (90-95%) with the syndrome die within the first year after birth, and the mean lifespan is less than 2 months for 50% of them. &nbsp;It is characterized by dysmorphic features and organ malformations, as well as by severe mental retardation. &nbsp;The syndrome is named after <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2137084\/\" class=\"cc-route-enabled\" target=\"_self\" data-editable-link=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2137084\/&amp;target=_self\" rel=\"noopener noreferrer\">John Hilton Edwards<\/a> (1928-2007) who first described it in 1960.<\/p>\n<p><img decoding=\"async\" src=\"..\/wp-content\/uploads\/2019\/05\/image024.jpg\" \/><\/div>\n<\/div>\n<p class=\"\" style=\"text-align: center;\">&nbsp;The karyotype for Edwards syndrome, with extra copy of chromosome 18.&nbsp;<\/p>\n<p class=\"\">See Chromosome, Down&#8217;s syndrome, Karyotype, Mosaicism, Syndrome<\/p>\n<p><\/p>\n<p><\/p>\n<p><\/body><\/html><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Sometimes referred to as trisomy 18 as it arises as a consequence of an extra copy of chromosome 18 (see figure below). &nbsp;It occurs in about 1 in every 3000 to 5000 births, affecting girls more than boys. &nbsp;As with Down&#8217;s syndrome (after which it is the second most common trisomy), the risk of conceiving &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/edward-s_syndrome\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Edward&#8217;s syndrome&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[2],"class_list":["post-7809","post","type-post","status-publish","format-standard","hentry","category-uncategorized","tag-glossary","entry"],"_links":{"self":[{"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/posts\/7809","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/comments?post=7809"}],"version-history":[{"count":0,"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/posts\/7809\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/media?parent=7809"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/categories?post=7809"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/tags?post=7809"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}