{"id":8141,"date":"2019-05-22T16:04:28","date_gmt":"2019-05-22T16:04:28","guid":{"rendered":"http:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/holoprosencephaly\/"},"modified":"2019-05-22T16:04:28","modified_gmt":"2019-05-22T16:04:28","slug":"holoprosencephaly","status":"publish","type":"post","link":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/holoprosencephaly\/","title":{"rendered":"Holoprosencephaly"},"content":{"rendered":"<p>Congenital brainmalformation occurring during embryonic development in which the two halves of the prosencephalon or forebrain fail todivide properly into left and right hemispheres, the outcome being a single-lobed brain .&nbsp; Four types include alobar (no hemispheric division usually associated with severe facial defects, e.g.,&nbsp;<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4324465\/\" data-editable-link=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4324465\/?target=_self\" target=\"_self\" rel=\"noopener noreferrer\">cyclopia<\/a>,&nbsp;a single eye, and stillbirth), semi-lobar (some hemispheric division and intermediate in its effects), and lobar (clear separation of hemispheres and least severe in terms of effects, e.g., cleft palate)), as well as a variety of middle interhemispheric variants. &nbsp;The causes of the malformation are unknown, but there is recent evidence to suggest that it could be associated with mutations in the sonic hedgehog gene &nbsp;The incidence is between 1 in 16,000 and 1 in55,000.<\/p>\n<p>See&nbsp;Congenital abnormalities, Neurulation, Prosencephalon<\/p>\n<p><\/body><\/html><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Congenital brainmalformation occurring during embryonic development in which the two halves of the prosencephalon or forebrain fail todivide properly into left and right hemispheres, the outcome being a single-lobed brain .&nbsp; Four types include alobar (no hemispheric division usually associated with severe facial defects, e.g.,&nbsp;cyclopia,&nbsp;a single eye, and stillbirth), semi-lobar (some hemispheric division and intermediate &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/holoprosencephaly\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Holoprosencephaly&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[2],"class_list":["post-8141","post","type-post","status-publish","format-standard","hentry","category-uncategorized","tag-glossary","entry"],"_links":{"self":[{"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/posts\/8141","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/comments?post=8141"}],"version-history":[{"count":0,"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/posts\/8141\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/media?parent=8141"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/categories?post=8141"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/tags?post=8141"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}