{"id":8156,"date":"2019-05-22T16:04:38","date_gmt":"2019-05-22T16:04:38","guid":{"rendered":"http:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/huntington-s_disease_-or_chorea\/"},"modified":"2019-05-22T16:04:38","modified_gmt":"2019-05-22T16:04:38","slug":"huntington-s_disease_-or_chorea","status":"publish","type":"post","link":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/huntington-s_disease_-or_chorea\/","title":{"rendered":"Huntington&#8217;s disease (or chorea)"},"content":{"rendered":"<p>An inherited adult-onset disorder of the nervous system due to a dominant gene mutation on chromosome 4 causing neurological degeneration, especially to GABA-ergic neurons in the caudate nucleus and putamen of the basal ganglia. Signs include uncoordinated movements, irritability, and attention span deficits. &nbsp;Leads to death with 15-20 years of onset. &nbsp;The first thorough description of chorea was made by <a href=\"http:\/\/www.sydenham.org.uk\/thomas_sydenham.html\" data-editable-link=\"http:\/\/www.sydenham.org.uk\/thomas_sydenham.html&amp;target=_self\" target=\"_self\" rel=\"noopener noreferrer\">Thomas Sydenham<\/a> (1624-1689), now known as Sydenham&#8217;s chorea (a childhood chorea, distinct from Huntington&#8217;s disease, it is associated with rheumatic fever, and is also known as <a href=\"http:\/\/neurophilosophy.wordpress.com\/2007\/05\/04\/saint-vituss-dance\/\" data-editable-link=\"http:\/\/neurophilosophy.wordpress.com\/2007\/05\/04\/saint-vituss-dance\/&amp;target=_self\" target=\"_self\" rel=\"noopener noreferrer\">St. Vitus&#8217;s dance<\/a>). &nbsp;Huntington&#8217;s disease was concisely described as a specific disease entity in 1872 by the physician <a href=\"http:\/\/brainblogger.com\/2008\/09\/13\/george-huntington-and-the-disease-bearing-his-name\/\" data-editable-link=\"http:\/\/brainblogger.com\/2008\/09\/13\/george-huntington-and-the-disease-bearing-his-name\/&amp;target=_self\" target=\"_self\" rel=\"noopener noreferrer\">George Huntington<\/a> (1850-1916).&nbsp;<\/p>\n<p>See <a href=\"athetoid_-or_athetotiform-_movements\">Athetoid (or athetotiform) movements<\/a>, <a href=\"alzheimer-s_disease\">Alzheimer&#8217;s disease<\/a>, <a href=\"autosomal_dominant_condition-disease\">Autosomal dominant condition\/disease<\/a>, <a href=\"basal_ganglia_-anatomy-\">Basal ganglia (anatomy)<\/a>, <a href=\"basal_ganglia_-disorders-\">Basal ganglia (disorders)<\/a>, <a href=\"choreiform_movements\">Choreiform movements<\/a>, <a href=\"conditional_knockouts\">Conditional knockouts<\/a>, <a href=\"gamma_aminobutyric_acid_-gaba-\">Gamma aminobutyric acid (GABA)<\/a>, <a href=\"mutation_-biology-\">Mutation (biology)<\/a>, <a href=\"prefrontal-frontal-striatal_loops\">Prefrontal-frontal-striatal loops<\/a>, Protein-folding problem<\/p>\n<p><\/p>\n<p><\/p>\n<p><\/body><\/html><\/p>\n","protected":false},"excerpt":{"rendered":"<p>An inherited adult-onset disorder of the nervous system due to a dominant gene mutation on chromosome 4 causing neurological degeneration, especially to GABA-ergic neurons in the caudate nucleus and putamen of the basal ganglia. Signs include uncoordinated movements, irritability, and attention span deficits. &nbsp;Leads to death with 15-20 years of onset. &nbsp;The first thorough description &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/huntington-s_disease_-or_chorea\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Huntington&#8217;s disease (or chorea)&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[2],"class_list":["post-8156","post","type-post","status-publish","format-standard","hentry","category-uncategorized","tag-glossary","entry"],"_links":{"self":[{"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/posts\/8156","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/comments?post=8156"}],"version-history":[{"count":0,"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/posts\/8156\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/media?parent=8156"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/categories?post=8156"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/tags?post=8156"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}