{"id":8533,"date":"2019-05-22T16:08:44","date_gmt":"2019-05-22T16:08:44","guid":{"rendered":"http:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/netrins\/"},"modified":"2019-05-22T16:08:44","modified_gmt":"2019-05-22T16:08:44","slug":"netrins","status":"publish","type":"post","link":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/netrins\/","title":{"rendered":"Netrins"},"content":{"rendered":"<p>Aswith nerve growth factors, they form a family of (diffusible) proteins secretedby target cells, generally having attractive influences on outgrowing axons.&nbsp; They not only attract, but also repel other neurons.&nbsp;Netrin-1 is formed and secreted in thefloor plate of the neural tube and netrin-2 in the lower regions of the neuraltube. &nbsp;Netrin-1 is credited with being aguidance factor that attracts or repels axons growing to target sites.&nbsp; All told, though, they guide cell and axon migration,and are thus crucial in brain development (e.g., a lack of netrin in <a href=\"http:\/\/cercor.oxfordjournals.org\/content\/early\/2013\/01\/16\/cercor.bhs395.full\" target=\"_self\" data-editable-link=\"http:\/\/cercor.oxfordjournals.org\/content\/early\/2013\/01\/16\/cercor.bhs395.full&amp;target=_self\" rel=\"noopener noreferrer\">mice<\/a>results in a failure of the corpus callosum or hippocampal commissure to form).&nbsp;Netrin was first identified in thenematode <span class=\"\" style=\"font-style: italic;\">Caenorhabditis elegans<\/span> in1990 and labeled Unc-6, with the mammalian homologue being discovered in 1994(now five netrins have been revealed).&nbsp;&nbsp;<\/p>\n<p>See Caenorhabditiselegans (C.) elegans (or nematode), <a href=\"cell_migration\">Cell migration<\/a>, <a href=\"corpus_callosum\">Corpus callosum<\/a>, <a href=\"dorsal_commissural_interneurons\">Dorsal commissural interneurons<\/a>, <a href=\"growth_cone\">Growth cone<\/a>, <a href=\"hippocampus\">Hippocampus<\/a>, <a href=\"neural_tube\">Neural tube<\/a>, Unc-6  <\/p>\n<\/p>\n<p><\/body><\/html><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Aswith nerve growth factors, they form a family of (diffusible) proteins secretedby target cells, generally having attractive influences on outgrowing axons.&nbsp; They not only attract, but also repel other neurons.&nbsp;Netrin-1 is formed and secreted in thefloor plate of the neural tube and netrin-2 in the lower regions of the neuraltube. &nbsp;Netrin-1 is credited with being &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/netrins\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Netrins&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[2],"class_list":["post-8533","post","type-post","status-publish","format-standard","hentry","category-uncategorized","tag-glossary","entry"],"_links":{"self":[{"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/posts\/8533","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/comments?post=8533"}],"version-history":[{"count":0,"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/posts\/8533\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/media?parent=8533"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/categories?post=8533"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/tags?post=8533"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}