{"id":8595,"date":"2019-05-22T16:09:25","date_gmt":"2019-05-22T16:09:25","guid":{"rendered":"http:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/notch\/"},"modified":"2019-05-22T16:09:25","modified_gmt":"2019-05-22T16:09:25","slug":"notch","status":"publish","type":"post","link":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/notch\/","title":{"rendered":"Notch"},"content":{"rendered":"<p>A gene involved in cell fate specification. &nbsp;It is found in all metazoans and in mammals there are four different notch receptors (NOTCH1-NOTCH4). &nbsp;<a href=\"http:\/\/joe.endocrinology-journals.org\/content\/194\/3\/459.full.pdf\" data-editable-link=\"http:\/\/joe.endocrinology-journals.org\/content\/194\/3\/459.full.pdf&amp;target=_self\" target=\"_self\" rel=\"noopener noreferrer\">Notch signalling <\/a>in conjunction with other gene encoded proteins plays a crucial role in the development and maintenance of a wide variety of tissues during both embryonic and adult life. &nbsp;For example, it is has a role in gliogenesis (glial cell specification), development of neurites and the heart, as well as in the maintenance of neural plasticity during the life span. &nbsp;Aberrations in notch signalling are associated with cancer, immune disorders, stroke, cognitive disorders and developmental syndromes. &nbsp; &nbsp;&nbsp;<\/p>\n<p>See Bone Morphogenetic Protein (BMaP), <a href=\"glial_cells\">Glial cells<\/a>, <a href=\"metazoan\">Metazoan<\/a>, <a href=\"neurite\">Neurite<\/a>, <a href=\"noggin\">Noggin<\/a>, <a href=\"permissive_interaction\">Permissive interaction<\/a>, <a href=\"plasticity_-neural-\">Plasticity (neural)<\/a><\/p>\n<p><\/body><\/html><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A gene involved in cell fate specification. &nbsp;It is found in all metazoans and in mammals there are four different notch receptors (NOTCH1-NOTCH4). &nbsp;Notch signalling in conjunction with other gene encoded proteins plays a crucial role in the development and maintenance of a wide variety of tissues during both embryonic and adult life. &nbsp;For example, &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/notch\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Notch&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[2],"class_list":["post-8595","post","type-post","status-publish","format-standard","hentry","category-uncategorized","tag-glossary","entry"],"_links":{"self":[{"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/posts\/8595","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/comments?post=8595"}],"version-history":[{"count":0,"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/posts\/8595\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/media?parent=8595"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/categories?post=8595"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/tags?post=8595"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}