{"id":8627,"date":"2019-05-22T16:09:46","date_gmt":"2019-05-22T16:09:46","guid":{"rendered":"http:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/oligogenic_mode_of_inheritance\/"},"modified":"2019-05-22T16:09:46","modified_gmt":"2019-05-22T16:09:46","slug":"oligogenic_mode_of_inheritance","status":"publish","type":"post","link":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/oligogenic_mode_of_inheritance\/","title":{"rendered":"Oligogenic mode of inheritance"},"content":{"rendered":"<\/p>\n<p>Inheritance pattern requiring the influence of a few (two or three) genes. &nbsp;Previously, diseases regarded as monogenic have in recent years been revealed as the product of by an additional gene or genes, and such diseases have been now classified as &#8216;oligogenic&#8217; rather than &#8216;polygenic&#8217;, as they involve a relatively smaller number of genes. &nbsp;One example is <a href=\"http:\/\/www.nhlbi.nih.gov\/health\/health-topics\/topics\/cf\/\" class=\"cc-route-enabled\" target=\"_self\" data-editable-link=\"http:\/\/www.nhlbi.nih.gov\/health\/health-topics\/topics\/cf\/&amp;target=_self\" rel=\"noopener noreferrer\">cystic fibrosis<\/a>, which has for years been regarded as as a single gene disease associated with recessive mutations in the CFTR (<a href=\"http:\/\/ghr.nlm.nih.gov\/gene\/CFTR\" class=\"cc-route-enabled\" target=\"_self\" data-editable-link=\"http:\/\/ghr.nlm.nih.gov\/gene\/CFTR&amp;target=_self\" rel=\"noopener noreferrer\">Cystic fibrosis conductance regulator) gene<\/a>. &nbsp;However, further studies of CFTR carried out in more diverse and larger populations have shown that mutations in additional genes could be implicated in modulating the severity of the disease. &nbsp;Thus, diseases stemming from a single gene, with further investigation can reveal a more complex scenario with the identification of additional modulating (or causative) genes. &nbsp;<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15389703\" class=\"cc-route-enabled\" target=\"_self\" data-editable-link=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15389703&amp;target=_self\" rel=\"noopener noreferrer\">Autism<\/a> may also be a case important involving oligogenic inheritance together with major or epigenetic contributions. &nbsp; &nbsp; &nbsp; &nbsp;&nbsp;<\/p>\n<p>See <a href=\"autism\">Autism<\/a>, <a href=\"epigenetics\">Epigenetics<\/a>, <a href=\"gene\">Gene<\/a>, <a href=\"hereditary\">Hereditary<\/a>, <a href=\"heritability\">Heritability<\/a>, <a href=\"mutation_-biology-\">Mutation (biology)<\/a>, <a href=\"polygenic_mode_of_inheritance\">Polygenic mode of inheritance<\/a><\/p>\n<\/p>\n<p><\/body><\/html><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Inheritance pattern requiring the influence of a few (two or three) genes. &nbsp;Previously, diseases regarded as monogenic have in recent years been revealed as the product of by an additional gene or genes, and such diseases have been now classified as &#8216;oligogenic&#8217; rather than &#8216;polygenic&#8217;, as they involve a relatively smaller number of genes. &nbsp;One &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/oligogenic_mode_of_inheritance\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Oligogenic mode of inheritance&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[2],"class_list":["post-8627","post","type-post","status-publish","format-standard","hentry","category-uncategorized","tag-glossary","entry"],"_links":{"self":[{"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/posts\/8627","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/comments?post=8627"}],"version-history":[{"count":0,"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/posts\/8627\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/media?parent=8627"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/categories?post=8627"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/tags?post=8627"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}