{"id":8719,"date":"2019-05-22T16:10:46","date_gmt":"2019-05-22T16:10:46","guid":{"rendered":"http:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/periventricular_leucomalacia_-pvl\/"},"modified":"2019-05-22T16:10:46","modified_gmt":"2019-05-22T16:10:46","slug":"periventricular_leucomalacia_-pvl","status":"publish","type":"post","link":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/periventricular_leucomalacia_-pvl\/","title":{"rendered":"Periventricular leucomalacia (PVL)"},"content":{"rendered":"<p>A bilateral lesion of the periventricular white matter thought to be due to ischema, although there is some debate about its causes. &nbsp;First described in 1869 by&nbsp;<a href=\"https:\/\/www.famousscientists.org\/rudolf-virchow\/\" data-editable-link=\"https:\/\/www.famousscientists.org\/rudolf-virchow\/?target=_self\" target=\"_self\" rel=\"noopener noreferrer\">Rudolf Ludwig Karl Virchow<\/a>&nbsp;(1821-1902), it is typified by damage to the cerebral white matter bordering on the lateral ventricles. &nbsp;Consists of areas of necrosis that often form cavitating cysts, and the resulting lesions can damage the corticospinal tracts innervating the lower extremities, leading to spastic diplegia. &nbsp;It occurs more in preterm infants of less than 30 weeks gestation.&nbsp;<\/p>\n<p>See Corticospinal tract (CST), <a href=\"diffusion_tensor_imaging\">Diffusion tensor imaging<\/a>, <a href=\"hypertonia\">Hypertonia<\/a>, <a href=\"intraventricular_hemorrhage_-ivh-\">Intraventricular hemorrhage (IVH)<\/a>, <a href=\"ischemia\">Ischemia<\/a>, Periventricular hemorrhagic infarction (PVI), <a href=\"spastic_diplegia\">Spastic diplegia<\/a>, <a href=\"ventricle\">Ventricle<\/a>, <a href=\"periventricular_white_matter\">Periventricular white matter<\/a>, <a href=\"preterm_infant\">Preterm infant<\/a><\/p>\n<p><\/body><\/html><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A bilateral lesion of the periventricular white matter thought to be due to ischema, although there is some debate about its causes. &nbsp;First described in 1869 by&nbsp;Rudolf Ludwig Karl Virchow&nbsp;(1821-1902), it is typified by damage to the cerebral white matter bordering on the lateral ventricles. &nbsp;Consists of areas of necrosis that often form cavitating cysts, &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/periventricular_leucomalacia_-pvl\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Periventricular leucomalacia (PVL)&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[2],"class_list":["post-8719","post","type-post","status-publish","format-standard","hentry","category-uncategorized","tag-glossary","entry"],"_links":{"self":[{"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/posts\/8719","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/comments?post=8719"}],"version-history":[{"count":0,"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/posts\/8719\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/media?parent=8719"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/categories?post=8719"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.lancaster.ac.uk\/fas\/psych\/glossary\/wp-json\/wp\/v2\/tags?post=8719"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}