Professor Thomas Jaki

Professor in Statistics

Research Interests

  • Design and analysis of clinical trials
  • Early phase drug development
  • Personalized medicine
  • Biostatistics

Selected Publications

A practical design for a dual-agent dose-escalation trial that incorporates pharmacokinetic data
Cotterill, A., Lorand, D., Wang, J., Jaki, T. 15/06/2015 In: Statistics in Medicine. 34, 13, p. 2138-2164. 27 p.
Journal article

A generalized Dunnett Test for Multi-arm Multi-stage Clinical Studies with Treatment Selection
Magirr, D., Jaki, T., Whitehead, J. 06/2012 In: Biometrika. 99, 2, p. 494-501. 8 p.
Journal article

Simultaneous confidence intervals that are compatible with closed testing in adaptive designs
Magirr, D., Jaki, T., Posch, M., Klingelmueller, F. 5/10/2013 In: Biometrika. 100, 4, p. 985-996. 12 p.
Journal article

An information-theoretic Phase I/II design for molecularly targeted agents that does not require an assumption of monotonicity
Mozgunov, P., Jaki, T.F. 15/06/2018 In: Journal of the Royal Statistical Society: Series C (Applied Statistics). 68, 2, p. 347-367. 21 p.
Journal article

Instrumental variable estimation in semi-parametric additive hazards models
Brueckner, M., Titman, A.C., Jaki, T.F. 1/03/2019 In: Biometrics. 75, 1, p. 110-120. 11 p.
Journal article

MSI: Plasma-activated antimicrobial hydrogel therapy (PAHT) for combatting infections in diabetic foot ulcers
01/11/2020 → 31/10/2023

Trials Methodology Research Network
01/06/2019 → 31/05/2022

A practical adaptive designs toolkit
01/01/2019 → 30/09/2020

STOR-i : Rare Disease Trials: Beyond the Randomised Controlled Trial
01/10/2018 → 31/03/2022

A self-management Intervention to Support Physical Activity for People with Rare Neurological Conditions (PARC)
01/09/2018 → 31/08/2019

Phase IIb, Randomised, Double-blinded, Placebo Controlled, Multicentre Trial of Infliximab with Transcriptomic Biomarker and Mechanism Evaluation – RAPID-1
01/01/2018 → 30/04/2021

MICA: Towards using historical data for research prioritisation in children
08/06/2015 → 30/09/2018

HMT: Accuracy Vs. Precision - Developing Optimal Estimators for Trials with Multiple Hypothesis Tests
01/02/2015 → 31/07/2018

Bayesian Adaptive Designs for Multiple Ascending Dose Stuides (Fellowship Extension)
28/01/2015 → 31/12/2017

IDEAS: Improving Design, Evaluation and Analysis of early drug development Studies
01/01/2015 → 31/12/2018

Improving the design and analysis of antimalarial drug clinical trials
01/11/2014 → 31/10/2017

PITE: Heterogeneity in Treatment Effects: Can Modelling Techniques Provide Personalised Prediction of Treatment Response and Uncover Groups of Respondents
01/10/2014 → 30/03/2018

Extrapolation Approaches in Paediatric Drug Development: Current Practices
06/01/2014 → 05/01/2015

MRC NW Hub for Trials Methodology Research
01/10/2013 → 30/09/2018

Towards Full Use of Available Data to Improve Clinical Outcome Prediction
01/10/2013 → 30/09/2014

Developing and refining methods of analysing malaria genetic data obtained from infected human blood samples
01/06/2013 → 31/05/2016

Adaptive Designs for Multiple Ascending Dose Studies
01/10/2012 → 31/01/2016

Designing and analysing multi-arm multi stage clinical trials with one or more endpoints
01/09/2012 → 30/06/2016

Cross-Hub research visits to discuss improving multi-arm, multi stage clinical trials
01/05/2011 → 31/12/2011

Risk in Context: New Methodology for Modelling Risk in Context
01/04/2011 → 31/03/2019

Career Development Fellow
01/03/2011 → 28/02/2015

STOR-i Centre for Doctoral Training

  • DSI - Health
  • Medical and Pharmaceutical Statistics Research Unit
  • Medical and Social Statistics
  • STOR-i Centre for Doctoral Training