Dr Alexandre Benedetto


Current Teaching

BIOL114 - Biotechnology

BIOL364 - Biology of Ageing

BIOL383 - Innovations in Biosciences (co-organisor)

BIOL461 - Fundamental Research Skills

Coupling of Rigor Mortis and Intestinal Necrosis during C. elegans Organismal Death
Galimov, E.R., Pryor, R.E., Poole, S.E., Benedetto, A., Pincus, Z., Gems, D. 6/03/2018 In: Cell Reports. 22, 10, p. 2730-2741. 12 p.
Journal article

Autophagy-dependent gut-to-yolk biomass conversion generates visceral polymorbidity in aging C. elegans
Ezcurra, M., Benedetto, A., Sornda, T., Gilliat, A., Au, C., Zhang, Q., van Schelt, S., Petrache, A.L., de la Guardia, Y., Bar-Nun, S., Tyler, E., Wakelam, M.J., Gems, D. 15/12/2017 In: Biorxiv.
Journal article

The SKN-1/Nrf2 transcription factor can protect against oxidative stress and increase lifespan in C. elegans by distinct mechanisms
Tullet, J.M., Green, J.W., Au, C., Benedetto, A., Thompson, M.A., Clark, E., Gilliat, A.F., Young, A., Schmeisser, K., Gems, D. 10/2017 In: Aging Cell. 16, 5, p. 1191-1194. 4 p.
Journal article

LFASS: Label-Free Automated Survival Scoring for High-Throughput Nematode Assays
Benedetto, A., Bambade, T., Au, C., Tullet, J., Dang, H., Cetnar, K., Cabreiro, F., Gems, D. 28/09/2017 In: Biorxiv. 23 p.
Journal article

Monsters in the uterus: a parthenogenetic quasi-program causes teratoma-like tumors during aging in wild-type C. elegans
Wang, H., Zhao, Y., Ezcurra, M., Gilliat, A.F., Hellberg, J., Benedetto, A., Athigapanich, T., Girstmair, J., Telford, M., Zhang, Z., Gems, D. 10/08/2017 In: Biorxiv. 34 p.
Journal article

Involvement of heat shock proteins on Mn-induced toxicity in Caenorhabditis elegans
Avila, D.S., Benedetto, A., Au, C., Bornhorst, J., Aschner, M. 2/11/2016 In: BMC Pharmacology and Toxicology. 17, 1, 9 p.
Journal article

In vivo collective cell migration requires an LPAR2-dependent increase in tissue fluidity
Kuriyama, S., Theveneau, E., Benedetto, A., Parsons, M., Tanaka, M., Charras, G., Kabla, A., Mayor, R. 7/07/2014 In: Journal of Cell Biology. 206, 1, p. 113-127. 15 p.
Journal article

Spatiotemporal control of gene expression using microfluidics
Benedetto, A., Accetta, G., Fujita, Y., Charras, G. 7/04/2014 In: Lab on a Chip. 14, 7, p. 1336-1347. 12 p.
Journal article

DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans
Tullet, J.M.A., Araiz, C., Sanders, M.J., Au, C., Benedetto, A., Papatheodorou, I., Clark, E., Schmeisser, K., Jones, D., Schuster, E.F., Thornton, J.M., Gems, D. 6/02/2014 In: PLOS Genetics. 10, 2, 16 p.
Journal article

Anthranilate fluorescence marks a calcium-propagated necrotic wave that promotes organismal death in C. elegans
Coburn, C., Allman, E., Mahanti, P., Benedetto, A., Cabreiro, F., Pincus, Z., Matthijssens, F., Araiz, C., Mandel, A., Vlachos, M., Edwards, S., Fischer, G., Davidson, A., Pryor, R.E., Stevens, A., Slack, F.J., Tavernarakis, N., Braeckman, B.P., Schroeder, F.C., Nehrke, K., Gems, D. 23/07/2013 In: Plos Biology. 11, 7, 17 p.
Journal article

Organotellurium and organoselenium compounds attenuate Mn-induced toxicity in Caenorhabditis elegans by preventing oxidative stress
Avila, D.S., Benedetto, A., Au, C., Manarin, F., Erikson, K., Soares, F.A., Rocha, J.B.T., Aschner, M. 1/05/2012 In: Free Radical Biology and Medicine. 52, 9, p. 1903-1910. 8 p.
Journal article

Environmental exposure, obesity, and Parkinson's disease: lessons from fat and old worms
Aitlhadj, L., Avila, D.S., Benedetto, A., Aschner, M., Stürzenbaum, S.R. 01/2011 In: Environmental Health Perspectives. 119, 1, p. 20-28. 9 p.
Journal article

Stressed-induced TMEM135 protein is part of a conserved genetic network involved in fat storage and longevity regulation in Caenorhabditis elegans
Exil, V.J., Silva Avila, D., Benedetto, A., Exil, E.A., Adams, M.R., Au, C., Aschner, M. 3/12/2010 In: PLoS ONE. 5, 12, 11 p.
Journal article

Extracellular dopamine potentiates mn-induced oxidative stress, lifespan reduction, and dopaminergic neurodegeneration in a BLI-3-dependent manner in Caenorhabditis elegans
Benedetto, A., Au, C., Avila, D.S., Milatovic, D., Aschner, M. 26/08/2010 In: PLOS Genetics. 6, 8
Journal article

SMF-1, SMF-2 and SMF-3 DMT1 orthologues regulate and are regulated differentially by manganese levels in C. elegans
Au, C., Benedetto, A., Anderson, J., Labrousse, A., Erikson, K., Ewbank, J.J., Aschner, M. 18/11/2009 In: PLoS ONE. 4, 11, 17 p.
Journal article

Manganese-induced dopaminergic neurodegeneration: insights into mechanisms and genetics shared with Parkinson's disease
Benedetto, A., Au, C., Aschner, M. 10/2009 In: Chemical Reviews. 109, 10, p. 4862-4884. 23 p.
Journal article

Caenorhabditis elegans: an emerging model in biomedical and environmental toxicology
Leung, M.C.K., Williams, P.L., Benedetto, A., Au, C., Helmcke, K.J., Aschner, M., Meyer, J.N. 11/2008 In: Toxicological sciences : an official journal of the Society of Toxicology. 106, 1, p. 5-28. 24 p.
Journal article

Antioxidant properties of blirubin in the model organism, Caenorhabditis elegans
McCaughan, D., Au, C., Benedetto, A., Milatovic, D., Aschner, J., Aschner, M. 07/2008 In: International Journal of Neuroprotection and Neuroregeneration. 4, 3, p. 252-262. 11 p.
Journal article

Manganese transport in eukaryotes: the role of DMT1
Au, C., Benedetto, A., Aschner, M. 07/2008 In: NeuroToxicology. 29, 4, p. 569-576. 8 p.
Journal article

Genes required for osmoregulation and apical secretion in Caenorhabditis elegans
Liégeois, S., Benedetto, A., Michaux, G., Belliard, G., Labouesse, M. 1/02/2007 In: Genetics. 175, 2, p. 709-724. 16 p.
Journal article

Etude de l’exocytose à la membrane apicale des cellules épithéliales de Caenorhabditis elegans.
Benedetto, A. 2007 206 p.
Doctoral Thesis

The V0-ATPase mediates apical secretion of exosomes containing Hedgehog-related proteins in Caenorhabditis elegans
Liégeois, S., Benedetto, A., Garnier, J., Schwab, Y., Labouesse, M. 19/06/2006 In: Journal of Cell Biology. 173, 6, p. 949-961. 13 p.
Journal article

Overexpression of toll-like receptor 4 amplifies the host response to lipopolysaccharide and provides a survival advantage in transgenic mice
Bihl, F., Salez, L., Beaubier, M., Torres, D., Larivière, L., Laroche, L., Benedetto, A., Martel, D., Lapointe, J., Ryffel, B., Malo, D. 15/06/2003 In: Journal of Immunology. 170, 12, p. 6141-6150. 10 p.
Journal article