Dr Fiona Benson

Senior Lecturer

Research Overview

My research interests focus on (i) Understanding the fundamental mechanisms associated with toxicity of aggregated proteins in neurodegenerative disorders such as Parkinson’s disease and Motor Neurone Disease. Current research is focused on TDP43, FUS, alpha-synuclein and beta-synuclein (ii) Characterising the proteins and mechanisms involved in the recombination of homologous DNA molecules and (iii) Exploiting the use of monoclonal antibodies generated against recombinant human proteins to localise trypanosome proteins.

Variation in Basal Body Localisation and Targeting of Trypanosome RP2 and FOR20 Proteins
Harmer, J., Qi, X., Toniolo, G., Patel, A., Shaw, H., Benson, F.E., Ginger, M.L., McKean, P.G. 08/2017 In: Protist. 168, 4, p. 452-466. 15 p.
Journal article

Plasma phosphorylated-TDP-43 protein levels correlate with brain pathology in frontotemporal lobar degeneration
Foulds, P., Davidson, Y., Mishra, M., Hobson, D.J., Humphreys, K.M., Taylor, M., Johnson, N., Weintraub, S., Akiyama, H., Arai, T., Hasegawa, M., Bigio, E.H., Benson, F.E., Allsop, D., Mann, D.M.A. 2009 In: Acta Neuropathologica. 118, 5, p. 647-658. 12 p.
Journal article

A spectroscopic study of some of the peptidyl radicals formed following hydroxyl radical attack on β-amyloid and α-synuclein.
Tabner, B.J., Turnbull, S., King, J., Benson, F.E., El-Agnaf, O.M.A., Allsop, D. 07/2006 In: Free Radical Research. 40, 7, p. 731-739. 9 p.
Journal article

A strategy for designing inhibitors of α-synuclein aggregation and toxicity as a novel treatment for Parkinson's disease and related disorders.
El-Agnaf, O.M.A., Paleologou, K.E., Greer, B., Abogrein, A.M., King, J., Salem, S.A., Fullwood, N.J., Benson, F.E., Hewitt, R., Ford, K.J., Martin, F., Harriott, P., Cookson, M.R., Allsop, D. 08/2004 In: FASEB Journal. 18, 11, p. 1315-1317. 3 p.
Journal article

Functional interaction between the Bloom's syndrome helicase and the RAD51 paralog, RAD51L3 (RAD51D).
Braybrooke, J.P., Li, J., Wu, L., Caple, F., Benson, F.E., Hickson, I.D. 28/11/2003 In: Journal of Biological Chemistry. 278, 48, p. 48357-48366. 10 p.
Journal article

XRCC3 and RAD51 modulate replication fork progression on damaged vertebrate chromosomes.
Henry-Mowatt, J., Jackson, D., Masson, Y.J., Johnson, P.A., Clements, P.M., Benson, F.E., Thompson, L.H., Takeda, S., West, S.C., Caldecott, K.W. 04/2003 In: Molecular Cell. 11, 4, p. 1109-1117. 9 p.
Journal article

DNA damage responses : a combination of maintenance and fire-fighting.
Benson, F.E., Carr, A.M. 08/2002 In: Microbiology Today. 29, 3, p. 123-124. 2 p.
Journal article

Identification and purification of two distinct complexes containing the five RAD51paralogs.
Masson, J.Y., Tarsounas, M.C., Stasiak, A.Z., Stasiak, A., Shah, R., McIlwraith, M.J., Benson, F.E., West, S.C. 15/12/2001 In: Genes and Development. 15, 24, p. 3296-3307. 12 p.
Journal article

Complex formation by the human RAD51C and XRCC3 recombination repair proteins.
Masson, J.Y., Stasiak, A.Z., Stasiak, A., Benson, F.E., West, S.C. 17/07/2001 In: Proceedings of the National Academy of Sciences. 98, 15, p. 8440-8446. 7 p.
Journal article

Identification and characterisation of a RAD51 gene from Leishmania major.
McKean, P.G., Keen, J.G., Smith, D.F., Benson, F.E. 07/2001 In: Molecular and Biochemical Parasitology. 115, 2, p. 209-216. 8 p.
Journal article

The meiosis-specific recombinase hDmc1 forms ring structures and interacts with hRad51.
Masson, J.Y., Davies, A.A., Hajibagheri, N., Van Dyck, E., Benson, F.E., Stasiak, A.Z., Stasiak, A., West, S.C. 11/1999 In: EMBO Journal. 18, 22, p. 6552-6560. 9 p.
Journal article

Mouse Rad 54 affects DNA conformation and DNA-damage-induced Rad51 foci formation.
Tan, T.L.R., Essers, J., Citterio, E., Swagemakers, S.M.A., De Wit, J., Benson, F.E., Hoeijmakers, J.H.J., Kanaar, R. 26/03/1999 In: Current Biology. 9, 6, p. 325-328. 4 p.
Journal article