Dr Karen Grant

Director of Admissions & Deputy Director of Medical Studies

Research Overview

I have two main areas of research: parasitology and medical education. In parasitology, my research focused on the identification, characterisation and validation of novel drug targets for the medically important protozoan parasites, Leishmania and Trypanosoma brucei, with a particular emphasis on protein kinases. In medical education, my research focuses on evidence-based admissions procedures, the application of learning theories in the medical education context, the use of simulation in medical education and the teaching & assessment of professionalism.

Evaluation of the transferability of skills learnt using simulation into real life practice
Horrocks, J.L., Curtis, F., Grant, K. 2014
Poster

Proteomic insights into parasite biology
Ginger, M.L., McKean, P.G., Burchmore, R., Grant, K.M. 08/2012 In: Parasitology. 139, 9, p. 1101-1102. 2 p.
Journal article

High Throughput Screens Yield Small Molecule Inhibitors of Leishmania CRK3:CYC6 Cyclin-Dependent Kinase
Walker, R.G., Thomson, G., Malone, K., Nowicki, M.W., Brown, E., Blake, D.G., Turner, N.J., Walkinshaw, M.D., Grant, K., Mottram, J.C. 5/04/2011 In: PLoS Neglected Tropical Diseases. 5, 4, 11 p.
Journal article

Recombinant Leishmania mexicana CRK3:CYCA has protein kinase activity in the absence of phosphorylation on the T-loop residue Thr178.
Gomez, F.C., Ali, N.O.M., Brown, E., Walker, R.G., Grant, K.M., Mottram, J.C. 06/2010 In: Molecular and Biochemical Parasitology. 171, 2, p. 89-96. 8 p.
Journal article

6-Br-5methylindirubin-3′oxime (5-Me-6-BIO) targeting the leishmanial glycogen synthase kinase-3 (GSK-3) short form affects cell-cycle progression and induces apoptosis-like death: Exploitation of GSK-3 for treating leishmaniasis
Xingi, E., Smirlis, D., Myrianthopoulos, V., Prokopios, M., Grant, K., Meijer, L., Mikros, E., Skaltsounis, A., Soteriadou, K. 10/2009 In: International Journal for Parasitology. 39, 12, p. 1289-1303. 15 p.
Journal article

Malaria ookinetes exhibit multiple markers for apoptosis-like programmed cell death in vitro.
Arambage, S.C., Grant, K.M., Pardo, I., Ranford-Cartwright, L., Hurd, H. 15/07/2009 In: Parasites and Vectors. 2, 1, 16 p.
Journal article

Trypanosomatid protein kinases as potential drug targets.
Wiese, M., Morris, A., Grant, K.M. 2009 In: Antiparasitic and antibacterial drug discovery : from molecular targets to drug candidates.. Weinheim : Wiley-VCH p. 227-247. 21 p. ISBN: 978-3-527-32327-2.
Chapter

Targeting the Cell Cycle in the Pursuit of Novel Chemotherapies against Parasitic Protozoa.
Grant, K.M. 2008 In: Current Pharmaceutical Design. 14, 9, p. 917-924. 8 p.
Journal article

Apoptosis-like death as a feature of malaria infection in mosquitoes.
Hurd, H., Grant, K.M., Arambage, S.C. 03/2006 In: Parasitology. 132, Supple, p. S33-S47.
Journal article

The selective biological activity of indirubin-based inhibitors : applications in parasitology.
Wells, C., McNae, I., Walkinshaw, M., Westwood, N.J., Grant, K.M. 2006 In: Indirubin, the red shade of indigo. Roscoff, France : Life in Progress Editions p. 259-267. 9 p. ISBN: 2951802900.
Chapter

Inhibitors of Leishmania mexicana CRK3 Cyclin-Dependent Kinase: Chemical Library Screen and Antileishmanial Activity.
Grant, K.M., Dunion, M.H., Yardley, V., Skaltsounis, A., Marko, D., Eisenbrand, G., Croft, S.L., Meijer, L., Mottram, J.C. 08/2004 In: Antimicrobial Agents and Chemotherapy. 48, 8, p. 3033-3042. 10 p.
Journal article

Intracellular targets of paullones : identification by affinity chromatography using immobilized inhibitor.
Knockaert, M., Wieking, K., Schmitt, S., Leost, M., Grant, K.M., Mottram, J.C., Kunick, C., Meijer, L. 12/07/2002 In: Journal of Biological Chemistry. 277, 28, p. 25493-25501. 9 p.
Journal article

The CRK3 protein kinase is essential for cell cycle progression of Leishmania mexicana.
Hassan, P., Fergusson, D., Grant, K.M., Mottram, J.C. 6/04/2001 In: Molecular and Biochemical Parasitology. 113, 2, p. 189-198. 10 p.
Journal article

Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors.
Knockaert, M., Gray, N., Damiens, E., Chang, Y., Grellier, P., Grant, K.M., Fergusson, D., Mottram, J.C., Soete, M., Dubremetz, J., Le Roch, K., Doerig, C., Schultz, P.G., Meijer, L. 1/06/2000 In: Chemistry and Biology. 7, 6, p. 411-422. 12 p.
Journal article