Dr Sarah Allinson

Senior Lecturer

Research Overview

Dr Allinson's work is aimed at gaining a better understanding of how cells respond to DNA damage. The two main areas of her research are (i) understanding how skin cells respond to damage caused by ultraviolet radiation and (ii) the mechanisms underlying the repair of breaks in the DNA backbone and factors that might affect their efficiency.

Platinum trimethyl bipyridyl thiolates – new, tunable, red- to near IR emitting luminophores for bioimaging applications
Steel, H., Allinson, S., Andre, J., Coogan, M., Platts, J.A. 1/07/2015 In: Chemical Communications. 51, 57, p. 11441-11444. 4 p.
Journal article

Characterisation of the p53-Mediated Cellular Responses Evoked in Primary Mouse Cells Following Exposure to Ultraviolet Radiation
McFeat, G., Allinson, S., McMillan, T. 30/09/2013 In: PLoS ONE. 8, 9, 9 p.
Journal article

Timeframes of UVA-induced bystander effects in human keratinocytes.
Whiteside, J.R., Allinson, S.L., McMillan, T.J. 03/2011 In: Photochemistry and Photobiology. 87, 2, p. 435-440. 6 p.
Journal article

Cadmium and copper inhibit both DNA repair activities of polynucleotide kinase.
Whiteside, J.R., Box, C.L., McMillan, T.J., Allinson, S.L. 01/2010 In: DNA Repair. 9, 1, p. 83-89. 7 p.
Journal article

DNA end-processing enzyme polynucleotide kinase as a potential target in the treatment of cancer
Allinson, S. 2010 In: Future Oncology. 6, 6, p. 1031-1042. 12 p.
Journal article

Cellular and sub-cellular responses to UVA in relation to carcinogenesis
Ridley, A.J., Whiteside, J.R., McMillan, T.J., Allinson, S.L. 2009 In: International Journal of Radiation Biology. 85, 3, p. 177-195. 19 p.
Journal article

Targeted cornea limbal stem/progenitor cell transfection in an organ culture model
Zhao, B., Allinson, S.L., Ma, A., Bentley, A.J., Martin, F.L., Fullwood, N.J. 08/2008 In: Investigative Ophthalmology and Visual Science. 49, 8, p. 3395-3401. 7 p.
Journal article

CHIP-Mediated Degradation and DNA Damage-Dependent Stabilization Regulate Base Excision Repair Proteins.
Parsons, J.L., Tait, P.S., Finch, D., Dianova, I.I., Allinson, S.L., Dianov, G.L. 29/02/2008 In: Molecular Cell. 29, 4, p. 477-487. 11 p.
Journal article

Ectopic overexpression of theta class glutathione transferases in a human keratinocyte cell line.
Jackson, K.M., Allinson, S.L., McMillan, T.J. 11/2007 In: Mutagenesis. 22, 6, p. 444-445. 2 p.
Journal article

Growth kinetics in MCF-7 cells modulate benzo[a]pyrene-induced CYP1A1 up-regulation.
Jiao, H., Allinson, S.L., Walsh, M.J., Hewitt, R., Cole, K.J., Phillips, D.H., Martin, F.L. 03/2007 In: Mutagenesis. 22, 2, p. 111-116. 6 p.
Journal article

The phosphatase activity of mammalian polynucleotide kinase takes precedence over its kinase activity repair of single strand breaks.
Dobson, C.J., Allinson, S.L. 05/2006 In: Nucleic Acids Research. 34, 8, p. 2230-2237. 8 p.
Journal article

CYP1A1 up-regulation in MCF-7 cells following benzo[a]pyrene treatment occurs primarily during S-phase : a significant modulator of consequent genotoxicity.
Martin, F.L., Allinson, S.L., Walsh, M.J., Hewitt, R., Cole, K.J., Phillips, D.H., Jiao, H. 2006 In: European Journal of Genetic and Molecular Toxicology. 36
Journal article

DNA base damage recognition and processing.
Dianov, G.L., Allinson, S.L. 2006 In: Genome dynamics and stability. Berlin : Springer p. 287-314. 28 p.
Chapter

DNA polymerase Beta promotes recruitment of XRCC1-Ligase III alpha to sites of base excision repair.
Parsons, J.L., Dianova, I.I., Allinson, S.L., Dianov, G.L. 9/08/2005 In: Biochemistry. 44, 31, p. 10613-10619. 7 p.
Journal article

Poly(ADP-ribose) polymerase-1 protects excessive DNA strand breaks from deterioration during repair in human cell extracts.
Parsons, J.L., Dianova, I.I., Allinson, S.L., Dianov, G.L. 04/2005 In: FEBS Journal. 272, 8, p. 2012-2021. 10 p.
Journal article

XRCC1–DNA polymerase ß interaction is required for efficient base excision repair.
Sleeth, K.M., Dianova, I.I., Allinson, S.L., Parsons, J.L., Breslin, C., Caldecott, K.W., Dianov, G.L. 04/2004 In: Nucleic Acids Research. 32, 8, p. 2550-2555. 6 p.
Journal article

Orchestration of base excision repair by controlling the rates of enzymatic activities.
Allinson, S.L., Sleeth, K.M., Matthewman, G.E., Dianov, G.L. 01/2004 In: DNA Repair. 3, 1, p. 23-31. 9 p.
Journal article

Repair of abasic sites in DNA.
Dianov, G.L., Sleeth, K.M., Dianova, I.I., Allinson, S.L. 29/10/2003 In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 531, 1-2, p. 157-163. 7 p.
Journal article

Mammalian base excision repair.
Dianov, G.L., Allinson, S.L., Budworth, H., Sleeth, K.M. 2003 In: Eukaryotic DNA damage surveillance and repair. Amsterdam : Kluwer Academic Publishers
Chapter

Poly(ADP-ribose) polymerase in base excision repair: always engaged, but not essential for DNA damage processing.
Allinson, S.L., Dianova, I.I., Dianov, G.L. 2003 In: Acta Biochimica Polonica. 50, 1, p. 169-179. 11 p.
Journal article

Co-ordination of base excision repair.
Allinson, S.L., Dianov, G.L. 2002 In: Recent research development in repair and mutagenesis. Research Signpost
Chapter

DNA polymerase B is the major dRP lyase involved in repair of oxidative base lesions in DNA by mammalian cell extracts
Allinson, S.L., Dianova, I.I., Dianov, G.L. 3/12/2001 In: EMBO Journal. 20, 23, p. 6919-6926. 8 p.
Journal article