Dr Leonie Unterholzner

Reearch Fellow/Lecturer

Research Overview

My research group is interested in how cells can detect foreign DNA, for example when skin cells have been infected by a virus. This is part of the innate immune response, which acts within the first few hours of infection, with the aim to alert more specialised immune cells, and to eliminate the virus before it can spread to other parts of the body. We are investigating how a cell can distinguish viral DNA from its own DNA genome, and how it signals to alert neighbouring cells. We also study how cells can detect their own DNA as danger signal, when the DNA has been damaged by UV light or chemotherapy.

IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes
Almine, J.F., O'Hare, C.A.J., Dunphy, G., Haga, I.R., Naik, R.J., Atrih, A., Connolly, D.J., Taylor, J., Kelsall, I.R., Bowie, A.G., Beard, P.M., Unterholzner, L. 13/02/2017 In: Nature Communications. 8
Journal article

The interferon response to intracellular DNA: why so many receptors?
Unterholzner, L. 11/2013 In: Immunobiology. 218, 11, p. 1312-1321. 10 p.
Journal article

Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors
Horan, K.A., Hansen, K., Jakobsen, M.R., Holm, C.K., Søby, S., Unterholzner, L., Thompson, M., West, J.A., Iversen, M.B., Rasmussen, S.B., Ellermann-Eriksen, S., Kurt-Jones, E., Landolfo, S., Damania, B., Melchjorsen, J., Bowie, A.G., Fitzgerald, K.A., Paludan, S.R. 1/03/2013 In: Journal of Immunology. 190, 5, p. 2311-2319. 9 p.
Journal article

Poxvirus targeting of E3 ligase β-TrCP by molecular mimicry: a mechanism to inhibit NF-κB activation and promote immune evasion and virulence
Mansur, D.S., Maluquer de Motes, C., Unterholzner, L., Sumner, R.P., Ferguson, B.J., Ren, H., Strnadova, P., Bowie, A.G., Smith, G.L. 02/2013 In: PLoS Pathogens. 9, 2
Journal article

Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor
Jin, T., Perry, A., Jiang, J., Smith, P., Curry, J.A., Unterholzner, L., Jiang, Z., Horvath, G., Rathinam, V.A., Johnstone, R.W., Hornung, V., Latz, E., Bowie, A.G., Fitzgerald, K.A., Xiao, T.S. 20/04/2012 In: Immunity. 36, 4, p. 561-571. 11 p.
Journal article

Vaccinia virus protein C6 is a virulence factor that binds TBK-1 adaptor proteins and inhibits activation of IRF3 and IRF7
Unterholzner, L., Sumner, R.P., Baran, M., Ren, H., Mansur, D.S., Bourke, N.M., Randow, F., Smith, G.L., Bowie, A.G. 09/2011 In: PLoS Pathogens. 7, 9
Journal article

Innate DNA sensing moves to the nucleus
Unterholzner, L., Bowie, A.G. 19/05/2011 In: Cell Host and Microbe. 9, 5, p. 351-353. 3 p.
Journal article

IFI16 is an innate immune sensor for intracellular DNA
Unterholzner, L., Keating, S.E., Baran, M., Horan, K.A., Jensen, S.B., Sharma, S., Sirois, C.M., Jin, T., Latz, E., Xiao, T.S., Fitzgerald, K.A., Paludan, S.R., Bowie, A.G. 11/2010 In: Nature Immunology. 11, 11, p. 997-1004. 8 p.
Journal article

Viral evasion and subversion of pattern-recognition receptor signalling
Bowie, A.G., Unterholzner, L. 12/2008 In: Nature Immunology. 8, 12, p. 911-922. 12 p.
Journal article

The interplay between viruses and innate immune signaling: recent insights and therapeutic opportunities
Unterholzner, L., Bowie, A.G. 1/02/2008 In: Biochemical Pharmacology. 75, 3, p. 589-602. 14 p.
Journal article

SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway
Fukuhara, N., Ebert, J., Unterholzner, L., Lindner, D., Izaurralde, E., Conti, E. 18/02/2005 In: Molecular Cell. 17, 4, p. 537-547. 11 p.
Journal article

SMG7 acts as a molecular link between mRNA surveillance and mRNA decay
Unterholzner, L., Izaurralde, E. 19/11/2004 In: Molecular Cell. 16, 4, p. 587-596. 10 p.
Journal article

Molecular insights into the interaction of PYM with the Mago-Y14 core of the exon junction complex
Bono, F., Ebert, J., Unterholzner, L., Güttler, T., Izaurralde, E., Conti, E. 03/2004 In: EMBO Reports. 5, 3, p. 304-310. 7 p.
Journal article

Nonsense-mediated mRNA decay in Drosophila: at the intersection of the yeast and mammalian pathways
Gatfield, D., Unterholzner, L., Ciccarelli, F.D., Bork, P., Izaurralde, E. 1/08/2003 In: EMBO Journal. 22, 15, p. 3960-3970. 11 p.
Journal article