Dr Nigel Fullwood

Senior Lecturer

Research Overview

Dr Fullwood is a cell biologist working on various aspects of the eye, in particular the cornea. He especially interested in the development and refinement of stem cell therapies for eye disease and the development of an artificial cornea. He also carries out extensive research into the causes of eye disease.

Development of proteolytically stable N-methylated peptide inhibitors of aggregation of the amylin peptide implicated in type 2 diabetes
Obasse, I.C., Taylor, M.N., Fullwood, N.J., Allsop, D. 6/12/2017 In: Interface Focus. 7, 6, 11 p.
Journal article

A novel approach to the therapy of Alzheimer's disease based on peptide nanoliposome inhibitors of Aβ and tau aggregation
Allsop, D., Taylor, M.N., Fullwood, N.J., Michael, M., Aggidis, A., Vincent, S., Dale, M. 1/11/2017
Meeting abstract

Retro-inverso peptide inhibitor nanoparticles as potent inhibitors of aggregation of the Alzheimer’s Aβ peptide
Gregori, M., Taylor, M.N., Salvati, E., Re, F., Mancini, S., Balducci, C., Forloni, G., Zambelli, V., Sesana, S., Michael, M., Michail, C., Kolosov, O.V., Tinker-Mill, C.L., Sherer, M., Harris, S., Fullwood, N.J., Masserini, M., Allsop, D. 02/2017 In: Nanomedicine: Nanotechnology, Biology, and Medicine. 13, 2, p. 723-732. 10 p.
Journal article

Diet-sourced carbon-based nanoparticles induce lipid alterations in tissues of zebrafish (Danio rerio) with genomic hypermethylation changes in brain
Gorrochategui, E., Li, J., Fullwood, N.J., Ying, G., Tian, M., Cui, L., Shen, H., Lacorte, S., Tauler, R., Martin, F.L. 1/01/2017 In: Mutagenesis. 32, 1, p. 91-103. 13 p.
Journal article

Immune cells on the corneal endothelium of an allogeneic corneal transplantation rabbit model
Koudouna, E., Okumura, N., Okazaki, Y., Nakano, S., Inoue, R., Fullwood, N.J., Hori, J., Kinoshita, S., Koizumi, N. 1/01/2017 In: Investigative Ophthalmology and Visual Science. 58, 1, p. 242-251. 10 p.
Journal article

Development of functional human oral mucosal epithelial stem/progenitor cell sheets using a feeder-free and serum-free culture system for ocular surface reconstruction
Nakamura, T., Yokoo, S., Bentley, A.J., Nagata, M., Fullwood, N.J., Inatomi, T., Sotozono, C., Yamagami, S., Kinoshita, S. 14/11/2016 In: Scientific Reports. 6, 11 p.
Journal article

A Surgical Cryoprobe for Targeted Transcorneal Freezing to Treat Corneal Endothelial Dysfunction
Akhbanbetova, A., Nakano, S., Littlechild, S.L., Young, R.D., Zvirgzdina, M., Fullwood, N.J., Kinoshita, S., Okumura, N., Koizumi, N., Quantock, A.J. 09/2016
Meeting abstract

Effect of rho-associated kinase inhibitor eye drop (ripasudil) on morphology of corneal endothelial cells in humans and rabbits
Koizumi, N., Okumura, N., Okazaki, Y., Inoue, R., Nakano, S., Suganami, H., Fullwood, N.J., Nakagawa, H., Kinoshita, S. 09/2016
Meeting abstract

Using Raman spectroscopy to characterize biological materials
Butler, H.J., Ashton, L., Bird, B., Cinque, G., Curtis, K., Dorney, J., Esmonde-White, K., Fullwood, N.J., Gardner, B., Martin-Hirsch, P.L., Walsh, M.J., McAinsh, M.R., Stone, N., Martin, F.L. 04/2016 In: Nature Protocols. 11, 4, p. 664-687. 24 p.
Journal article

Low-dose carbon-based nanoparticle-induced effects in A549 lung cells determined by biospectroscopy are associated with increases in genomic methylation
Li, J., Tian, M., Cui, L., Dwyer, J., Fullwood, N.J., Shen, H., Martin, F.L. 2/02/2016 In: Scientific Reports. 6, 11 p.
Journal article

Rho-associated kinase inhibitor eye drop (Ripasudil) transiently alters the morphology of corneal endothelial cells
Okumura, N., Okazaki, Y., Inoue, R., Nakano, S., Fullwood, N.J., Kinoshita, S., Koizumi, N. 30/11/2015 In: Investigative Ophthalmology and Visual Science. 56, 12, p. 7560-7567. 8 p.
Journal article

A preliminary electron microscopic investigation into the interaction between Aβ1-42 peptide and a novel nanoliposome- coupled retro-inverso peptide inhibitor, developed as a potential treatment for Alzheimer's disease
Sherer, M., Fullwood, N.J., Taylor, M., Allsop, D. 1/10/2015 In: Journal of Physics: Conference Series. 644, 1, 4 p.
Journal article

Distinguishing nuclei-specific benzo[a]pyrene-induced effects from whole-cell alterations in MCF-7 cells using Fourier-transform infrared spectroscopy
Obinaju, B., Fullwood, N., Martin, F. 1/09/2015 In: Toxicology. 335, p. 27-34. 8 p.
Journal article

Gold nanoparticles as a substrate in bio-analytical near-infrared surface-enhanced Raman spectroscopy
Butler, H.J., Fogarty, S.W., Kerns, J.G., Martin-Hirsch, P.L., Fullwood, N.J., Martin, F.L. 17/03/2015 In: The Analyst. 140, 9, p. 3090-3097. 8 p.
Journal article

Ocular surface reconstruction with a tissue-engineered nasal mucosal epithelial cell sheet for the treatment of severe ocular surface diseases
Kobayashi, M., Nakamura, T., Yasuda, M., Hata, Y., Okura, S., Iwamoto, M., Nagata, M., Fullwood, N.J., Koizumi, N., Hisa, Y., Kinoshita, S. 01/2015 In: Stem Cells Translational Medicine. 4, 1, p. 99-109. 11 p.
Journal article

Characterisation of the stem cell population in human endometrium
Afami, M.E., Martin, F.L., Fullwood, N.J., Martin-Hirsch, P.L. 11/2014
Meeting abstract

Development of stem cell therapies for the treatment of ocular surface stem cell disease
Chrysostomou, E., Fullwood, N.J., Martin, F.L. 11/2014
Meeting abstract

Mapping the 3-D location of the stem cells in the human prostate
Antoniou, A., Fullwood, N.J., Martin, F.L. 11/2014
Meeting abstract

Surface-enhanced Raman spectroscopy of the endothelial cell membrane
Fogarty, S.W., Patel, I.I., Martin, F.L., Fullwood, N.J. 4/09/2014 In: PLoS ONE. 9, 9, 7 p.
Journal article

Human periodontal ligament cell sheets cultured on amniotic membrane substrate
Adachi, K., Amemiya, T., Nakamura, T., Honjyo, K., Kumamoto, S., Yamamoto, T., Bentley, A., Fullwood, N., Kinoshita, S., Kanamura, N. 09/2014 In: Oral Diseases. 20, 6, p. 582-590. 9 p.
Journal article

Using Fourier transform IR spectroscopy to analyze biological materials
Baker, M.J., Trevisan, J., Bassan, P., Bhargava, R., Butler, H.J., Dorling, K.M., Fielden, P.R., Fogarty, S.W., Fullwood, N.J., Heys, K.A., Hughes, C., Lasch, P., Martin-Hirsch, P.L., Obinaju, B., Sockalingum, G.D., Sulé-Suso, J., Strong, R., Walsh, M.J., Wood, B.R., Gardner, P., Martin, F.L. 08/2014 In: Nature Protocols. 9, 8, p. 1771-1791. 21 p.
Journal article

Infrared microspectroscopy indentifies biomelcular changes associated with chronic oxidative stress in mammary epithelium and stroma of breast tissues from healthy young women: implications for latent stages of breast carcinogenesis
Patel, I., Shearer, D.A., Fogarty, S., Fullwood, N.J., Quaroni, L., Martin, F.L., Weisz, J. 1/02/2014 In: Cancer Biology and Therapy . 15, 2, p. 225-235. 11 p.
Journal article

LRIG1 inhibits STAT3-dependent inflammation to maintain corneal homeostasis
Nakamura, T., Hamuro, J., Takaishi, M., Simmons, S., Maruyama, K., Zaffalon, A., Bentley, A.J., Kawasaki, S., Nagata-Takaoka, M., Fullwood, N.J., Itami, S., Sano, S., Ishii, M., Barrandon, Y., Kinoshita, S. 2/01/2014 In: Journal of Clinical Investigation. 124, 1, p. 385-397. 13 p.
Journal article

Dose-related alterations of carbon nanoparticles in Mammalian cells detected using biospectroscopy: potential for real-world effects
Li, J., Strong, R., Trevisan, J., Fogarty, S.W., Fullwood, N.J., Jones, K.C., Martin, F.L. 3/09/2013 In: Environmental Science and Technology. 47, 17, p. 10005-10011. 7 p.
Journal article

Sub-cellular spectrochemical imaging of isolated human corneal cells employing synchrotron radiation-based Fourier-transform infrared microspectroscopy
Fogarty, S.W., Patel, I.I., Trevisan, J., Nakamura, T., Hirschmugl, C.J., Fullwood, N.J., Martin, F.L. 7/01/2013 In: The Analyst. 138, 1, p. 240-248. 9 p.
Journal article

Classification of test agent-specific effects in the Syrian hamster embryo assay (pH 6.7) using infrared spectroscopy with computational analysis
Ahmadzai, A.A., Trevisan, J., Pang, W., Patel, I.I., Fullwood, N.J., Bruce, S.W., Pant, K., Carmichael, P.L., Scott, A.D., Martin, F.L. 05/2012 In: Mutagenesis. 27, 3, p. 375-382. 8 p.
Journal article

The Syrian hamster embryo (SHE) assay (pH 6.7): mechanisms of cell transformation and application of vibrational spectroscopy to objectively score endpoint alterations
Ahmadzai, A.A., Trevisan, J., Fullwood, N.J., Carmichael, P.L., Scott, A.D., Martin, F.L. 05/2012
Literature review

Effects of Aberrant Pax6 Gene Dosage on Mouse Corneal Pathophysiology and Corneal Epithelial Homeostasis
Mort, R.L., Bentley, A.J., Martin, F.L., Collinson, J.M., Douvaras, P., Hill, R.E., Morley, S.D., Fullwood, N.J., West, J.D. 29/12/2011 In: PLoS ONE. 6, 12, p. -. 11 p.
Journal article

Combining immunolabeling and surface-enhanced Raman spectroscopy on cell membranes
Hodges, M., Kerns , J., Bentley, A.J., Fogarty, S., Patel, I.I., Martin, F.L., Fullwood, N.J. 12/2011 In: ACS Nano. 5, 12, p. 9535-9541. 7 p.
Journal article

Imaging sclera with hard X-ray microscopy
Fullwood, N.J., Martin, F., Bentley, A., Lee, J.P., Lee, S.J. 07/2011
Literature review

Corneal epithelialisation on surface-modified hydrogel implants Artificial cornea
Ma, A., Zhao, B., Bentley, A.J., Brahma, A., MacNeil, S., Martin, F.L., Rimmer, S., Fullwood, N.J. 03/2011 In: Journal of Materials Science: Materials in Medicine. 22, 3, p. 663-670. 8 p.
Journal article

Long-Term Phenotypic Study after Allogeneic Cultivated Corneal Limbal Epithelial Transplantation for Severe Ocular Surface Diseases
Nakamura, T., Sotozono, C., Bentley, A.J., Mano, S., Inatomi, T., Koizumi, N., Fullwood, N.J., Kinoshita, S. 12/2010 In: Ophthalmology. 117, 12, p. 2247-2254. 9 p.
Journal article

Distinguishing cell types or populations based on the computational analysis of their infrared spectra
Martin, F., Kerns, J., Llabjani, V., Martin-Hirsch, P.L., Patel, I.I., Trevisan, J., Fullwood, N.J., Walsh, M.J. 11/2010 In: Nature Protocols. 5, 11, p. 1748-1760. 13 p.
Journal article

Cell Adhesion to Polymethacrylate Networks Prepared by Photopolymerization and Functionalized with GRGDS Peptide or Fibrinogen
Johnson, C., Perlin, L., Wyman, P., Zhao, B., Fullwood, N.J., MacNeil, S., Rimmer, S. 05/2010 In: Macromolecular Symposia. 291-292, 1, p. 314-325. 12 p.
Journal article

Microspectroscopy of spectral biomarkers associated with human corneal stem cells
Nakamura, T., Kerns, J., Trevisan, J., Cooper, L.J., Bentley, A., Carmichael, P.L., Scott, A.D., Cotte, M., Susini, J., Martin-Hirsch, P.L., Kinoshita, S., Fullwood, N.J., Martin, F. 6/03/2010 In: Molecular Vision. 16, 42, p. 359-368. 10 p.
Journal article

Evidence for a stem-cell lineage in corneal squamous cell carcinoma using synchrotron-based Fourier-transform infrared microspectroscopy and multivariate analysis
Kerns, J., Nakamura, T., Kinoshita, S., Fullwood, N.J., Martin, F. 2010 In: The Analyst. 135, 12, p. 3120-3125. 6 p.
Journal article

Tracking the cell hierarchy in the human intestine using biochemical signatures derived by mid-infrared microspectroscopy.
Walsh, M.J., Hammiche, A., Fellous, T.G., Nicholson, J.M., Cotte, M., Susini, J., Fullwood, N.J., Martin-Hirsch, P.L., Alison, M.R., Martin, F.L. 07/2009 In: Stem Cell Research. 3, 1, p. 15-27. 13 p.
Journal article

An investigation into corneal alkali burns using an organ culture model
Zhao, B., Ma, A., Martin, F.L., Fullwood, N.J. 06/2009 In: Cornea. 28, 5, p. 541-546. 6 p.
Journal article

Novel Sutureless Keratoplasty with a Chemically Defined Bioadhesive
Takaoka, M., Nakamura, T., Sugai, H., Bentley, A.J., Nakajima, N., Yokoi, N., Fullwood, N.J., Hyon, S., Kinoshita, S. 06/2009 In: Investigative Ophthalmology and Visual Science. 50, 6, p. 2679-2685. 7 p.
Journal article

Discrimination of human stem cells by photothermal microspectroscopy
Grude, O., Nakamura, T., Hammiche, A., Bentley, A.J., Martin, F.L., Pollock, H.M., Kinoshita, S., Fullwood, N.J. 22/01/2009 In: Vibrational Spectroscopy. 49, 1, p. 22-27. 6 p.
Journal article

Sub-micron poly(N-isopropylacrylamide) particles as temperature responsive vehicles for the detachment and delivery of human cells
Hopkins, S., Carter, S.R., Haycock, J.W., Fullwood, N.J., MacNeil, S., Rimmer, S. 2009 In: Soft Matter. 5, 24, p. 4928-4937. 10 p.
Journal article

Microscopy for life scientists
Fullwood, N.J. 12/09/2008 In: Science. 321, 5895, 1 p.
Letter

The use of trehalose-treated freeze-dried amniotic membrane for ocular surface reconstruction
Nakamura, T., Sekiyama, E., Takaoka, M., Bentley, A.J., Yokoi, N., Fullwood, N.J., Kinoshita, S. 09/2008 In: Biomaterials. 29, 27, p. 3729-3737. 9 p.
Journal article

Targeted cornea limbal stem/progenitor cell transfection in an organ culture model
Zhao, B., Allinson, S.L., Ma, A., Bentley, A.J., Martin, F.L., Fullwood, N.J. 08/2008 In: Investigative Ophthalmology and Visual Science. 49, 8, p. 3395-3401. 7 p.
Journal article

Sutureless amniotic membrane transplantation for ocular surface reconstruction with a chemically defined bioadhesive
Takaoka, M., Nakamura, T., Sugai, H., Bentley, A.J., Nakajima, N., Fullwood, N.J., Yokoi, N., Hyon, S., Kinoshita, S. 07/2008 In: Biomaterials. 29, 19, p. 2923-2931. 9 p.
Journal article

Hes1 regulates corneal development and the function of corneal epithelial stem/progenitor cells
Nakamura, T., Ohtsuka, T., Sekiyama, E., Cooper, L.J., Kokubu, H., Fullwood, N.J., Barrandon, Y., Kageyama, R., Kinoshita, S. 05/2008 In: Stem Cells. 26, 5, p. 1265-1274. 10 p.
Journal article

The Saccharomyces cerevisiae actin cytoskeletal component Bsp1p has an auxiliary role in actomyosin ring function and in the maintenance of bud-neck structure
Wright, D., Munro, E., Corbett, M., Bentley, A.J., Fullwood, N.J., Murray, S., Price, C. 04/2008 In: Genetics. 178, 4, p. 1903-1914. 12 p.
Journal article

FTIR micro-spectroscopy identifies symmetric PO2- modifications as a marker of the putative stem cell region of human intestinal crypts.
Walsh, M.J., Fellous, T.G., Hammiche, A., Lin, W., Fullwood, N.J., Grude, O., Bahrami, F., Nicholson, J.M., Cotte, M., Susini, J., Pollock, H.M., Brittan, M., Martin-Hirsch, P.L., Alison, M.R., Martin, F.L. 01/2008 In: Stem Cells. 26, 10, p. 108-118. 11 p.
Journal article

FTIR Microspectroscopy Coupled with Two-Class Discrimination Segregates Markers Responsible for Inter- and Intra-Category Variance in Exfoliative Cervical Cytology.
Walsh, M.J., Singh, M.N., Stringfellow, H.F., Pollock, H.M., Hammiche, A., Grude, O., Fullwood, N.J., Pitt, M.A., Martin-Hirsch, P.L., Martin, F.L. 2008 In: Biomarker Insights. 3, p. 179-189. 11 p.
Journal article

Fourier transform spectroscopy in diagnostic medicine.
Martin, F.L., Fullwood, N.J. 18/12/2007 In: Proceedings of the National Academy of Sciences. 104, 51, p. E1.
Journal article

Epithelialization of hydrogels achieved by amine functionalization and co-culture with stromal cells
Rimmer, S., Johnson, C., Zhao, B., Collier, J., Gilmore, L., Sabnis, S., Wyman, P., Sammon, C., Fullwood, N.J., MacNeil, S. 12/2007 In: Biomaterials. 28, 35, p. 5319-5331. 13 p.
Journal article

Near-field photothermal microspectroscopy for adult stem-cell identification and characterization.
Grude, O., Hammiche, A., Pollock, H.M., Bentley, A.J., Walsh, M.J., Martin, F.L., Fullwood, N.J. 12/2007 In: Journal of Microscopy. 228, 3, p. 366-372. 7 p.
Journal article

FTIR microspectroscopy coupled with two-class discrimination segregates markers responsible for inter- and intra-category variance in exfoliative cervical cytology.
Walsh, M.J., Singh, M.N., Stringfellow, H.F., Pollock, H.M., Hammiche, A., Grude, O., Fullwood, N.J., Pitt, M.A., Martin-Hirsch, P.L., Martin, F.L. 11/2007 In: Mutagenesis. 22, 6, p. 453.
Journal article

Polymethacrylate networks as substrates for cell culture
Sun, Y., Maughan, J., Haigh, R., Hopkins, S.A., Wyman, P., Johnson, C., Fullwood, N.J., Ebdon, J., MacNeil, S., Rimmer, S. 09/2007 In: Macromolecular Symposia. 256, p. 137-148. 12 p.
Journal article

Neural stem cells, acetylcholine and Alzheimer's disease
Fullwood, N.J. 08/2007 In: Nature Chemical Biology. 3, 8, 1 p.
Letter

Phenotypic investigation of human eyes with transplanted autologous cultivated oral mucosal epithelial sheets for severe ocular surface diseases.
Nakamura, T., Inatomi, T., Cooper, L.J., Rigby, H., Fullwood, N.J., Kinoshita, S. 1/06/2007 In: Ophthalmology. 114, 6, p. 1080-1088. 9 p.
Journal article

Novel sutureless transplantation freeze-dried amniotic membrane surface reconstruction
Sekiyama, E., Nakamura, T., Kurihara, E., Cooper, L.J., Fullwood, N.J., Takaoka, M., Hamuro, J., Kinoshita, S. 04/2007 In: Investigative Ophthalmology and Visual Science. 48, 4, p. 1528-1534. 7 p.
Journal article

Characterisation of human corneal stem cells by synchrotron infrared micro-spectroscopy.
Bentley, A.J., Nakamura, T., Hammiche, A., Pollock, H.M., Martin, F.L., Kinoshita, S., Fullwood, N.J. 22/02/2007 In: Molecular Vision. 13, p. 237-242. 6 p.
Journal article

Characterization of human corneal stem cells by synchrotron infrared micro-spectroscopy.
Bentley, A.J., Nakamura, T., Hammiche, A., Pollock, H.M., Martin, F.L., Kinoshita, S., Fullwood, N.J. 22/02/2007 In: Molecular Vision. 13, p. 237-242. 6 p.
Journal article

Culture of dermal fibroblasts and protein adsorption on block conetworks of poly(butyl methacrylate-block-(2,3 propandiol-1-methacrylate-stat-ethandiol dimethacrylate))
Sun, Y., Collett, J., Fullwood, N.J., Mac Neil, S., Rimmer, S. 02/2007 In: Biomaterials. 28, 4, p. 661-670. 10 p.
Journal article

ATR microspectroscopy with multivariate analysis segregates grades of exfoliative cervical cytology.
Walsh, M.J., Singh, M.N., Pollock, H.M., Cooper, L.J., German, M.J., Stringfellow, H.F., Fullwood, N.J., Paraskevaidis, E., Martin-Hirsch, P.L., Martin, F.L. 5/01/2007 In: Biochemical and Biophysical Research Communications. 352, 1, p. 213-219. 7 p.
Journal article

Comparison of intact and denuded amniotic membrane as a substrate for cell-suspension culture of human limbal epithelial cells
Koizumi, N., Rigby, H., Fullwood, N.J., Kawasaki, S., Tanioka, H., Koizumi, K., Kociok, N., Joussen, A.M., Kinoshita, S. 01/2007 In: Graefes Archive for Clinical and Experimental Ophthalmology. 245, 1, p. 123-134. 12 p.
Journal article

Copper-mediated formation of hydrogen peroxide from the amylin peptide: a novel mechanism for degeneration of islet cells in type-2 diabetes mellitus?
Masad, A., Hayes, L., Tabner, B., Turnbull, S., Cooper, L., Fullwood, N.J., German, M., Kametani, F., El-Agnaf, O.M.A., Allsop, D. 2007 In: FEBS Letters. 581, 18, p. 3489-3493. 5 p.
Journal article

Plasma amyloid-β concentrations in Alzheimer's disease : an alternative hypothesis.
Fullwood, N.J., Hayashi, Y., Allsop, D. 12/2006 In: Lancet Neurology. 5, 12, p. 1000-1001. 2 p.
Journal article

The role of dermatopontin in the stromal organisation of the cornea.
Cooper, L.J., Bentley, A.J., Nieduszynski, I.A., Talabani, S., Thomson, A., Utani, A., Shinkai, H., Fullwood, N.J., Brown, G.M. 08/2006 In: Investigative Ophthalmology and Visual Science. 47, 8, p. 3303-3310. 8 p.
Journal article

Donepezil for severe Alzheimer's disease.
Allsop, D., Martin, F., Moore, S., Fullwood, N.J. 29/07/2006 In: The Lancet. 368, 9533, p. 361-362. 2 p.
Journal article

Infrared spectroscopy with multivariate analysis potentially facilitates the segregation of different types of prostate cell. (vol 90, pg 3738, 2006)
German, M.J., Hammiche, A., Ragavan, N., Tobin, M.J., Fullwood, N.J., Matanhelia, S.S., Hindley, A.C., Nicholson, C.M., Pollock, H.M., Martin, F.L. 15/07/2006 In: Biophysical Journal. 91, 2, p. 775-775. 1 p.
Journal article

Development of a Three-Dimensional Organ Culture Model for Corneal Wound Healing and Corneal Transplantation.
Zhao, B., Cooper, L.J., Brahma, A., MacNeil, S., Rimmer, S., Fullwood, N.J. 07/2006 In: Investigative Ophthalmology and Visual Science. 47, 7, p. 2840-2846. 7 p.
Journal article

Characterization of Putative Stem Cell Populations in the Cornea Using Synchrotron Infrared Microspectroscopy.
German, M.J., Pollock, H.M., Zhao, B., Tobin, M.J., Hammiche, A., Bentley, A., Cooper, L.J., Martin, F.L., Fullwood, N.J. 06/2006 In: Investigative Ophthalmology and Visual Science. 47, 6, p. 2417-2421. 5 p.
Journal article

Infrared Spectroscopy with Multivariate Analysis Potentially Facilitates the Segregation of Different Types of Prostate Cell.
German, M.J., Hammiche, A., Ragavan, N., Tobin, M.J., Cooper, L.J., Matanhelia, S.S., Hindley, A.C., Nicholson, C.M., Fullwood, N.J., Pollock, H.M., Martin, F.L. 05/2006 In: Biophysical Journal. 90, 10, p. 3783-3795. 13 p.
Journal article

Unique Distribution of Thrombospondin-1 in Human Ocular Surface Epithelium.
Sekiyama, E., Nakamura, T., Cooper, L.J., Kawasaki, S., Hamuro, J., Fullwood, N.J., Kinoshita, S., Missing, M. 04/2006 In: Investigative Ophthalmology and Visual Science. 47, 4, p. 1352-1358. 7 p.
Journal article

The Use of Autologous Serum in the Development of Corneal and Oral Epithelial Equivalents in Patients with Stevens-Johnson Syndrome.
Nakamura, T., Ang, L.P.K., Rigby, H., Sekiyama, E., Inatomi, T., Sotozono, C., Fullwood, N.J., Kinoshita, S. 03/2006 In: Investigative Ophthalmology and Visual Science. 47, 3, p. 909-916. 8 p.
Journal article

Protein aggregation, metals and oxidative stress in neurodegenerative diseases.
Tabner, B.J., El-Agnaf, O.M.A., German, M.J., Fullwood, N.J., Allsop, D. 11/2005 In: Biochemical Society Transactions. 33, 5, p. 1082-1086. 5 p.
Journal article

Hydrogen peroxide is generated during the very early stages of aggregation of the amyloid peptides implicated in Alzheimer's disease and familial British dementia.
Tabner, B.J., El-Agnaf, O.M.A., Turnbull, S., German, M.J., Paleologou, K.E., Hayashi, Y., Cooper, L.J., Fullwood, N., Allsop, D. 28/10/2005 In: Journal of Biological Chemistry. 280, 43, p. 35789-35792. 4 p.
Journal article

Supported catalytic epoxidation of polyisobutylene with alkene chain ends
Cross, P., Hunter, R.A., Miller, C., Fullwood, N., Rimmer, S. 10/2005 In: Journal of Chemical Research. 2005, 10, p. 673-676. 4 p.
Journal article

An investigation into the composition of amniotic membrane used for ocular surface reconstruction.
Cooper, L.J., Kinoshita, S., German, M.J., Koizumi, N., Nakamura, T., Fullwood, N.J. 08/2005 In: Cornea. 24, 6, p. 722-729. 8 p.
Journal article

The production of hydrogen peroxide during early-stage protein aggregation: a common pathological mechanism in different neurodegenerative diseases?
Tabner, B., Turnbull, S., Fullwood, N.J., German, M., Allsop, D. 08/2005 In: Biochemical Society Transactions. 33, 4, p. 548-550. 3 p.
Journal article

Synthesis and properties of amphiphilic networks 3 : preparation and characterisation of block conetworks of poly(butyl methacrylate-block-(2,3 propandiol-1-methacrylate-stat-ethandiol dimethacrylate)).
Rimmer, S., German, M.J., Maughan, J., Sun, Y., Fullwood, N.J., Ebdon, J., Macneil, S. 05/2005 In: Biomaterials. 26, 15, p. 2219-2230. 12 p.
Journal article

CYP1B1 expression in prostate is higher in peripheral compared to transition zone.
Ragavan, N., Hewitt, R., Cooper, L.J., Ashton, K.M., Hindley, A.C., Nicholson, C.M., Fullwood, N.J., Matanhelia, S.S., Martin, F.L. 8/11/2004 In: Cancer Letters. 215, 1, p. 69-78. 10 p.
Journal article

A strategy for designing inhibitors of α-synuclein aggregation and toxicity as a novel treatment for Parkinson's disease and related disorders.
El-Agnaf, O.M.A., Paleologou, K.E., Greer, B., Abogrein, A.M., King, J., Salem, S.A., Fullwood, N.J., Benson, F.E., Hewitt, R., Ford, K.J., Martin, F., Harriott, P., Cookson, M.R., Allsop, D. 08/2004 In: FASEB Journal. 18, 11, p. 1315-1317. 3 p.
Journal article

An ultrastructural investigation of dermato-pontin-knockout mouse corneas
Cooper, L.J., Bentley, A.J., Nieduszynski, I.A., Fullwood, N.J., Ellis, T.S., Thomson, A., Utani, A., Sinkai, H., Brown, G.M. 08/2004 In: International Journal of Experimental Pathology. 85, 4, 2 p.
Special issue

The effect of humic substances on barite precipitation-dissolution behaviour in natural and synthetic lake waters.
Smith, E., Hamilton-Taylor, J., Davison, W., Fullwood, N.J., McGrath, M. 26/06/2004 In: Chemical Geology. 207, 1-2, p. 81-89. 9 p.
Journal article

An investigation of removed cultivated epithelial transplants in patients after allo-cultivated corneal epithelial transplantation.
Cooper, L.J., Fullwood, N.J., Koizumi, N., Nakamura, T., Kinoshita, S. 04/2004 In: Cornea. 23, 3, p. 235-242. 8 p.
Journal article

Comparison of intact and denuded amniotic membrane as a substrate for human limbal epithelial cell culture
Koizumi, N., Rigby, H., Fullwood, N.J., Koizumi, K., Joussen, A.M., Kociok, N. 04/2004 In: Investigative Ophthalmology and Visual Science. 45, 1 p.
Special issue

Collagen fibril orientation and corneal curvature.
Fullwood, N.J. 02/2004 In: Structure. 12, 2, p. 169-170. 2 p.
Journal article

Both the D-(+) and L-(-) enantiomers of nicotine inhibit Aβ aggregation and cytotoxicity.
Moore, S.A., Huckerby, T.N., Gibson, G.L., Fullwood, N.J., Turnbull, I., Tabner, B.J., El-Agnaf, O.M.A., Allsop, D. 01/2004 In: Biochemistry. 43, 3, p. 819-826. 8 p.
Journal article

Sterilized, freeze-dried amniotic membrane : a useful substrate for ocular surface reconstruction.
Nakamura, T., Yoshitani, M., Rigby, H., Fullwood, N.J., Ito, W., Inatomi, T., Sotozono, C., Nakamura, T., Shimizu, Y., Kinoshita, S. 01/2004 In: Investigative Ophthalmology and Visual Science. 45, 1, p. 93-99. 7 p.
Journal article

Amniotic membrane as a carrier for cultivated human corneal endothelial cell transportation.
Ishino, Y., Sano, Y., Nakamura, T., Connon, C.J., Rigby, H., Fullwood, N.J., Kinoshita, S. 2004 In: Investigative Ophthalmology and Visual Science. 45, 3, p. 800-806. 7 p.
Journal article

α-Synuclein implicated in Parkinson’s disease is present in extracellular biological fluids, including human plasma.
El-Agnaf, O.M.A., Salem, S.A., Paleologou, K.E., Cooper, L.J., Fullwood, N.J., Gibson, M.J., Curran, M.D., Court, J.A., Mann, D.M.A., Ikeda, S., Cookson, M.R., Hardy, J., Allsop, D. 10/2003 In: FASEB Journal. 17, 13, p. 1945-1947. 3 p.
Journal article

Comparison of ultrastructure, tight junction-related protein expression and barrier function of human corneal epithelial cells with and without air-lifting.
Ban, Y., Cooper, L.J., Fullwood, N.J., Nakamura, T., Tsuzuki, M., Koizumi, N., Dota, A., Mochida, C., Kinoshita, S. 06/2003 In: Experimental Eye Research. 76, 6, p. 735-743. 9 p.
Journal article

Tight junction-related protein expression and distribution in human corneal epithelium.
Ban, Y., Dota, A., Cooper, L.J., Fullwood, N.J., Nakamura, T., Tsuzuki, M., Mochida, C., Kinoshita, S. 06/2003 In: Experimental Eye Research. 76, 6, p. 663-669. 7 p.
Journal article

The successful culture and autologous transplantation of rabbit oral mucosal epithelial cells on amniotic membrane.
Nakamura, T., Endo, K., Cooper, L.J., Fullwood, N.J., Tanifuji, N., Tsuzuki, M., Koizumi, N., Inatomi, T., Sano, Y., Kinoshita, S. 2003 In: Investigative Ophthalmology and Visual Science. 44, p. 106-116. 11 p.
Journal article

Synthesis and properties of amphiphilic networks 2: a differential scanning calorimetric study of poly(dodecyl methacrylate-stat-2,3 propandiol-1-methacrylate-stat-ethandiol dimethacrylate) networks and adhesion and spreading of dermal fibroblasts on these materials.
Haigh, R., Fullwood, N.J., Rimmer, S. 08/2002 In: Biomaterials. 23, 16, p. 3509-3516. 8 p.
Journal article

An investigation or removed cultivated epithelial transplants in patients after allo-cultivated corneal epithelial transplantation
Cooper, L.J., Fullwood, N.J., Koizumi, N., Nakamura, T., Kinoshita, S. 05/2002 In: Investigative Ophthalmology and Visual Science. 43, 1 p.
Special issue

Morphological analysis of polyphenol treated rat corneal endothelium in long-term storage
Sano, Y., Fullwood, N., Ishino, Y., Hyon, S., Kim, D.H., Tokushige, H., Kimura, S. 05/2002 In: Investigative Ophthalmology and Visual Science. 43, 1 p.
Special issue

Quantitative ultrastructural comparison of human corneal epithelial cells cultivated on amniotic membrane with and without air-lifting
Ban, Y., Fullwood, N.J., Cooper, L.J., Nakamura, T., Tsuzuki, M., Kinoshita, S. 05/2002 In: Investigative Ophthalmology and Visual Science. 43, 1 p.
Special issue

Reconstruction of damaged corneal surfaces by transplantation of autologous cultivated oral epithelium
Kinoshita, S., Nakamura, T., Endo, K., Tanifuji, N., Tsuzuki, M., Koizumi, N., Inatomi, T., Sano, Y., Cooper, L., Fullwood, N.J. 05/2002 In: Investigative Ophthalmology and Visual Science. 43, 1 p.
Special issue

Successful culture of rabbit oral epithelial cells on amniotic membrane: a new strategy for ocular surface reconstruction
Nakamura, T., Endo, K., Leanne, C., Fullwood, N.J., Tanifuji, N., Tsuzuki, M., Koizumi, N., Inatomi, T., Sano, Y., Kinoshita, S. 05/2002 In: Investigative Ophthalmology and Visual Science. 43, 1 p.
Special issue

An Evaluation of Cultivated Corneal Limbal Epithelial Cells, Using Cell-Suspension Culture.
Koizumi, N., Cooper, L.J., Fullwood, N.J., Nakamura, T., Inoki, K., Tsuzuki, M., Kinoshita, S. 2002 In: Investigative Ophthalmology and Visual Science. 43, 7, p. 2114-2121. 8 p.
Journal article

Amphiphilic networks: synthesis and biological properties
Rimmer, S., Haigh, R., Maughan, J., Tatersall, P., Fullwood, N., MacNeil, S., Dawson, R., Ebdon, J. 08/2001 In: Abstracts of Papers of the American Chemical Society. 222, 2 p.
Book/Film/Article review

Block amphiphilic networks
Maughan, J., Dawson, R., Rimmer, S., Neil, S.M., Fullwood, N., Ebdon, J. 08/2001 In: Abstracts of Papers of the American Chemical Society. 222, 1 p.
Special issue

The Detection of Bacteria and Bacterial Biofilms in Punctal Plug Holes.
Sugita, J., Yokoi, N., Fullwood, N.J., Quantock, A.J., Takada, Y., Nakamura, Y., Kinoshita, S. 05/2001 In: Cornea. 20, 4, p. 362-365. 4 p.
Journal article

Corneal and scleral collagens—a microscopist’s perspective.
Meek, K.M., Fullwood, N.J. 04/2001 In: Micron. 32, 3, p. 261-272. 12 p.
Journal article

An evaluation of cultivated corneal limbal epithelial cells using cell suspension culture
Koizumi, N., Cooper, L., Fullwood, N.J., Nakamura, T., Inoki, K., Tsuzuki, M., Kinoshita, S. 15/03/2001 In: Investigative Ophthalmology and Visual Science. 42, 4, 1 p.
Special issue

Comparison of the ultrastructure and barrier function of cultivated human corneal epithelial cells on amniotic membrane with and without air-lifting.
Ban, Y., Koizumi, N., Fullwood, N.J., Cooper, L., Nakamura, T., Inoki, K., Tsuzuki, M., Quantock, A.J., Kinoshita, S. 15/03/2001 In: Investigative Ophthalmology and Visual Science. 42, 4, 1 p.
Book/Film/Article review

Localization of TRAMP (Tyrosine-Rich Acidic Matrix Protein)
Bolden, K., Fullwood, N., Nieduszynski, I., Bairaktaris, G. 8/03/2001 In: FASEB Journal. 15, 5, 1 p.
Book/Film/Article review

Cultivation of Corneal Epithelial Cells on Intact and Denuded Human Amniotic Membrane.
Koizumi, N., Fullwood, N.J., Bairaktaris, G., Inatomi, T., Kinoshita, S., Quantock, A. 08/2000 In: Investigative Ophthalmology and Visual Science. 41, 9, p. 2506-2513. 8 p.
Journal article

Epithelial Barrier Function and Ultrastructure of Gelatinous Drop-like Corneal Dystrophy.
Kinoshita, S., Nishida, K., Dota, A., Inatomi, T., Koizumi, N., Elliott, A., Lewis, D., Quantock, A., Fullwood, N.J. 07/2000 In: Cornea. 19, 4, p. 551-555. 5 p.
Journal article

Synthesis and properties of amphiphilic networks. 1: the effect of hydration and polymer composition on the adhesion of immunoglobulin-G to poly(laurylmethacrylate-stat-glycerolmonomethacrylate-stat-ethylene-glycol-dimethacrylate) networks.
Haigh, R., Rimmer, S., Fullwood, N.J. 04/2000 In: Biomaterials. 21, 7, p. 735-739. 5 p.
Journal article

Detection of bacteria and bacterial biofilm formation in punctal plug holes.
Sugita, J., Yokoi, N., Fullwood, N.J., Quantock, A.J., Nakamura, Y., Takada, Y., Komuro, A., Kinoshita, S. 15/03/2000 In: Investigative Ophthalmology and Visual Science. 41, 4, 1 p.
Special issue

Differentiation and growth of human and rabbit corneal epithelial cells on amniotic membrane in vitro.
Inatomi, T., Koizumi, N., Kawasaki, S., Fullwood, N.J., Bairaktaris, G., Quantock, A.J., Kinoshita, S. 15/03/2000 In: Investigative Ophthalmology and Visual Science. 41, 4, 1 p.
Book/Film/Article review

Ultrastructural localization of sulfated and unsulfated keratan sulfate in normal and macular corneal dystrophy type I.
Lewis, D., Davies, Y., Nieduszynski, I.A., Lawrence, F., Quantock, A.J., Bonshek, R., Fullwood, N.J. 03/2000 In: Glycobiology. 10, 3, p. 305-312. 8 p.
Journal article

Amniotic Membrane as a Substrate for Cultivating Limbal Corneal Epithelial Cells for Autologous Transplantation in Rabbits.
Koizumi, N., Inatomi, T., Quantock, A.J., Fullwood, N.J., Dota, A., Kinoshita, S. 01/2000 In: Cornea. 19, 1, p. 65-71. 7 p.
Journal article

Growth factor mRNA and protein in preserved human amniotic membrane.
Koizumi, N., Inatomi, T., Sotozono, C., Fullwood, N.J., Quantock, A.J., Kinoshita, S. 2000 In: Current Eye Research. 20, 3, p. 173-177. 5 p.
Journal article

Synthesis of allyloxycarbonyloxymethyl-5-fluorouracil and copolymerizations with N-vinylpyrrolidinone.
Liu, Z., Fullwood, N.J., Rimmer, S. 2000 In: Journal of Materials Chemistry. 10, 8, p. 1771-1775. 5 p.
Journal article

New strategies for the synthesis of amphiphilic networks.
Rimmer, S., Tattersall, P., Ebdon, J.R., Fullwood, N.J. 07/1999 In: Reactive and Functional Polymers. 41, 1-3, p. 177-184. 8 p.
Journal article

Ultrastructural localisation of sulphated and unsulphated keratan sulphate in normal cornea and macular corneal dystrophy type I
Lewis, D., Fullwood, N.J., Davies, Y., Nieduszynski, I.A., Quantock, A.J., Bonshek, R. 15/03/1999 In: Investigative Ophthalmology and Visual Science. 40, 4, 1 p.
Special issue

Proteoglycans on normal and migrating human corneal endothelium.
Davies, Y., Lewis, D., Fullwood, N.J., Nieduszynski, I.A., Marcyniuk, B., Albon, J., Tullo, A. 03/1999 In: Experimental Eye Research. 68, 3, p. 303-311. 9 p.
Journal article

Endothelial cell surface-associated keratan sulphate after excimer laser photoablation of the anterior rabbit cornea.
Quantock, A.J., Bairaktaris, G., Fullwood, N.J., Ito, M., Suzuki, T., Kinoshita, S. 1999 In: Journal of Refractive Surgery. 15, 3, p. 349-356. 8 p.
Journal article

An ultrastructural investigation into proteoglycan distribution in human corneas
Bairaktaris, G., Lewis, D., Fullwood, N.J., Nieduszynski, I.A., Marcyniuk, B., Quantock, A.J., Ridgway, A.E.A. 07/1998 In: Cornea. 17, 4, p. 396-402. 7 p.
Journal article

Human corneal keratan sulfates
Tai, G.H., Nieduszynski, I.A., Fullwood, N.J., Huckerby, T.N. 7/11/1997 In: Journal of Biological Chemistry. 272, 45, p. 28227-28231. 5 p.
Journal article

Keratan sulphate in the trabecular meshwork and cornea
Davis, Y., Fullwood, N.J., Marcyniuk, B., Bonshek, R., Tullo, A., Nieduszynski, I.A. 07/1997 In: Current Eye Research. 16, 7, p. 677-686. 10 p.
Journal article

Macular corneal dystrophy type II: Multiple studies on a cornea with low levels of sulphated keratan sulphate
Quantock, A.J., Fullwood, N.J., Thonar, E.J.M.A., Waltman, S.R., Capel, M.S., Ito, M., Verity, S.M., Schanzlin, D.J. 1997 In: RNIB Eye Contact. 11, p. 57-67. 11 p.
Journal article

Cell surface-associated keratan sulfate on normal and migrating corneal endothelium.
Fullwood, N.J., Davies, Y., Nieduszynski, I.A., Marcyniuk, B., Ridgway, A.E.A., Quantock, A.J. 06/1996 In: Investigative Ophthalmology and Visual Science. 37, 7, p. 1256-1270. 15 p.
Journal article

Changes in cell surface glycosaminoglycans during endothelial cell migration
Fullwood, N.J., Davies, Y., Nieduszynski, I.A., Marcyniuk, B., Ridgway, A.E.A., Quantock, A. 15/02/1996 In: Investigative Ophthalmology and Visual Science. 37, 3, 1 p.
Book/Film/Article review

Stromal descemet's and endothelial changes in macular corneal dystrophy type II
Quantock, A.J., Fullwood, N.J., Thonar, E.J.M.A., Waltman, S.R., Capel, M.S., Kincaid, M.C., Ito, M., Verity, S.M., Schanzlin, D.J. 15/02/1996 In: Investigative Ophthalmology and Visual Science. 37, 3, 1 p.
Book/Film/Article review

The isolation and characterisation of mutants of the C4 photosynthetic pathway.
Dever, L.V., Blackwell, R.D., Fullwood, N.J., Lacuesta, M., Leegood, R.C., Onek, L.A., Pearson, M., Lea, P.J. 09/1995 In: Journal of Experimental Botany. 46, Specia, p. 1363-1376. 14 p.
Journal article

Atomic force microscopy of the cornea and sclera.
Fullwood, N.J., Hammiche, A., Pollock, H.M., Hourston, D.J., Song, M. 1995 In: Current Eye Research. 14, 7, p. 529-535. 7 p.
Journal article

An Ultrastructural, Time-resolved Study of Freezing in the Corneal Stroma.
Fullwood, N.J., Meek, K.M. 24/02/1994 In: Journal of Molecular Biology. 236, 3, p. 749-758. 10 p.
Journal article

Freezing and thawing in the cornea stroma - a time resolved X-ray diffraction study.
Meek, K.M., Fullwood, N.J. 1994 In: Experimental Eye Research. 59, Supple, p. 336-336. 1 p.
Journal article

The role of subsidiary cells and calcium oxalate in the regulation of calcium ions in the vicinity of the guard cells in Commelina communis.
Ruiz, L.P., Fullwood, N.J., Mansfield, T.A. 1994 In: Journal of Experimental Botany. 45, Supple, p. 52-52. 1 p.
Journal article

SCHEIES-SYNDROME: THE ARCHITECTURE OF CORNEAL COLLAGEN AND DISTRIBUTION OF CORNEAL PROTEOGLYCANS
QUANTOCK, A.J., MEEK, K.M., FULLWOOD, N.J., ZABEL, R.W. 10/1993 In: Canadian Journal of Ophthalmology. 28, 6, p. 266-272. 7 p.
Journal article

STRUCTURAL STUDIES OF THE EXTRAOCULAR-MUSCLES OF PATIENTS WITH THYROID-ASSOCIATED OPHTHALMOPATHY
LEONARD, D.W., PAPPA, A., MEEK, K.M., FULLWOOD, N.J., FELLS, P., LIGHTMAN, S. 15/03/1993 In: Investigative Ophthalmology and Visual Science. 34, 4, 1 p.
Book/Film/Article review

Synchrotron x-ray-diffraction and histochemical-studies of normal and myopic chick eyes
FULLWOOD, N.J., TROILO, D., WALLMAN, J., MEEK, K.M. 02/1993 In: Tissue and Cell. 25, 1, p. 73-85. 13 p.
Journal article

A SYNCHROTRON X-RAY STUDY OF THE CHANGES OCCURRING IN THE CORNEAL STROMA DURING PROCESSING FOR ELECTRON-MICROSCOPY
FULLWOOD, N.J., MEEK, K.M. 01/1993 In: Journal of Microscopy. 169, p. 53-60. 8 p.
Journal article

Synchotron x-ray-diffraction studies of keratoconus corneal stroma
FULLWOOD, N.J., TUFT, S.J., MALIK, N.S., MEEK, K.M., RIDGWAY, A.E.A., HARRISON, R.J. 04/1992 In: Investigative Ophthalmology and Visual Science. 33, 5, p. 1734-1741. 8 p.
Journal article

SYNCHROTRON X-RAY-DIFFRACTION STUDIES OF THE CORNEA, WITH IMPLICATIONS FOR STROMAL HYDRATION
MEEK, K.M., FULLWOOD, N.J., COOKE, P.H., ELLIOTT, G.F., MAURICE, D.M., QUANTOCK, A.J., WALL, R.S., WORTHINGTON, C.R. 08/1991 In: Biophysical Journal. 60, 2, p. 467-474. 8 p.
Journal article

A comparison of proteoglycan arrangement in normal and keratoconus human corneas
Fullwood, N.J., Meek, K.M., Malik, N.S., Tuft, S.J. 10/1990 In: Biochemical Society Transactions. 18, 5, p. 961-962. 2 p.
Journal article