Dr Nikki Copeland

Lecturer in Biomedicine

Research Overview

My research aims to understand how DNA is replicated in mammalian cells. Each cell division requires the precise copying of the genome, failure to regulate this process leads to mutation and chromosome abnormalities that are associated with cancer.

The key research aims are to better understand the replication licensing and initiation process of DNA replication. Use of cell-based and cell-free DNA replication techniques provide powerful tools to monitor key regulatory steps in this process. The long term goal is to identify differences between regulation of DNA replication in cancerous cells and normal tissues, to identify new therapeutic targets.

Emerging Roles for Ciz1 in Cell Cycle Regulation and as a Driver of Tumorigenesis
Pauzaite, T., Thacker, U., Tollitt, J., Copeland, N.A. 2017 In: Biomolecules. 7, 1
Journal article

NUDT2 disruption elevates diadenosine tetraphosphate (Ap4A) and down-regulates immune response and cancer promotion genes
Marriott, A.S., Vasieva, O., Fang, Y., Copeland, N.A., McLennan, A.G., Jones, N.J. 4/05/2016 In: PLoS ONE. 11, 5, 35 p.
Journal article

Diadenosine 5′, 5′′′-P1,P4-tetraphosphate (Ap4A) is synthesized in response to DNA damage and inhibits the initiation of DNA replication.
Marriott, A.S., Copeland, N., Cunningham, R., Wilkinson, M.C., McLennan, A.G., Jones, N.J. 09/2015 In: DNA Repair. 33, p. 90-100. 11 p.
Journal article

Supramolecular assemblies underpin turnover of outer membrane proteins in bacteria
Rassam, P., Copeland, N., Birkholz, O., Toth, C., Chavent, M., Cross, S., Housden, N., Kaminska, R., Seger, U., Quinn, D., Garrod, T., Sansom, M.S., Piehler, J., Baumann, C.G., Kleanthous, C. 10/06/2015 In: Nature. 18 p.
Journal article

Cyclin A/CDK2 mediated phosphorylation of CIZ1 blocks replisome formation and initiation of mammalian DNA replication
Copeland, N., Sercombe, H.E., Wilson, R.H.C., Coverley, D. 15/04/2015 In: Journal of Cell Science. 128, 8, p. 1518-1527. 10 p.
Journal article

Cancer-associated variant expression and interaction of CIZ1 with cyclin A1 in differentiating male germ cells
Greaves, E.A., Copeland, N.A., Coverley, D., Ainscough, J.F.X. 15/05/2012 In: Journal of Cell Science. 125, p. 2466-2477. 12 p.
Journal article

Cyclin E is recruited to the nuclear matrix during differentiation, but is not recruited in cancer cells
Munkley, J., Copeland, N.A., Moignard, V., Knight, J.R.P., Greaves, E., Ramsbottom, S.A., Pownall, M.E., Southgate, J., Ainscough, J.F., Coverley, D. 2011 In: Nucleic Acids Research. 39, 7, p. 2671-2677. 7 p.
Journal article

Ciz1 cooperates with cyclin-A-CDK2 to activate mammalian DNA replication in vitro
Copeland, N.A., Sercombe, H.E., Ainscough, J.F.X., Coverley, D. 1/04/2010 In: Journal of Cell Science. 123, 7, p. 1108-1115. 8 p.
Journal article

Cancer-associated missplicing of exon 4 influences the subnuclear distribution of the DNA replication factor CIZ1.
Rahman, F.A., Ainscough, J.F.X., Copeland, N., Coverley, D. 10/2007 In: Human Mutation. 28, 10, p. 993-1004. 12 p.
Journal article

The role of an activating peptide in protease-mediated suicide of Escherichia coli K12.
Copeland, N., Kleanthous, C. 7/01/2005 In: Journal of Biological Chemistry. 280, 1, p. 112-117. 6 p.
Journal article

Identification of essential residues within Lit, a cell death peptidase of Escherichia coli K-12.
Copeland, N., Bingham, R., Georgiou, T., Cooper, P., Kleanthous, C. 22/06/2004 In: Biochemistry. 43, 24, p. 7948-7953. 6 p.
Journal article