Professor John Whitehead

Professor John Whitehead

Emeritus

Fylde College
Lancaster University
Bailrigg
Lancaster
United Kingdom
LA1 4YF

+44 (0)1524 592350

John Whitehead's Publications

2014

2013

Designing exploratory cancer trials using change in tumour size as primary endpoint

Jaki, T., Andre, V., Su, T-L. & Whitehead, J. 10/07/2013 In : Statistics in Medicine. 32, 15, p. 2544-2554 11 p.

Research output: Contribution to journalJournal article

2012

A bivariate Bayesian dose-finding procedure applied to a seamless phase I/II trial in rheumatoid arthritis

Thygesen, H., Dragalin, V., Whitehead, A. & Whitehead, J. 11/2012 In : Pharmaceutical Statistics. 11, 6, p. 476-484 9 p.

Research output: Contribution to journalJournal article

A novel phase I/IIa design for early phase oncology studies and its application in the evaluation of MK-0752 in pancreatic cancer

Whitehead, J., Thygesen, H., Jaki, T., Davis, S., Halford, S., Turner, H., Cook, N. & Jodrell, D. 15/08/2012 In : Statistics in Medicine. 31, 18, p. 1931-1943 13 p.

Research output: Contribution to journalJournal article

A generalized Dunnett Test for Multi-arm Multi-stage Clinical Studies with Treatment Selection

Magirr, D., Jaki, T. & Whitehead, J. 06/2012 In : Biometrika. 99, 2, p. 494-501 8 p.

Research output: Contribution to journalJournal article

2011

Bayesian procedures for phase I/II clinical trials investigating the safety and efficacy of drug combinations

Whitehead, J., Thygesen, H. & Whitehead, A. 20/07/2011 In : Statistics in Medicine. 30, 16, p. 1952-1970 19 p.

Research output: Contribution to journalJournal article

2010

A Bayesian dose-escalation procedure for phase I clinical trials based only on the assumption of monotonicity.

Whitehead, J., Thygesen, H. & Whitehead, A. 30/07/2010 In : Statistics in Medicine. 29, 17, p. 1808-1824 17 p.

Research output: Contribution to journalJournal article

A combined score test for binary and ordinal endpoints from clinical trials.

Whitehead, J., Branson, M. & Todd, S. 28/02/2010 In : Statistics in Medicine. 29, 5, p. 521-532 12 p.

Research output: Contribution to journalJournal article

2009

Action following the discovery of a global association between the whole genome and adverse event risk in a clinical drug-development programme.

Whitehead, J., Kelly, P., Zhou, Y., Stallard, N., Thygesen, H. & Bowman, C. 10/2009 In : Pharmaceutical Statistics. 8, 4, p. 287-300 14 p.

Research output: Contribution to journalJournal article

A simple two-stage design for quantitative responses with appliction to a study in diabectic neuropathic pain.

Whitehead, J., Valdés-Márquez, E. & Lissmats, A. 04/2009 In : Pharmaceutical Statistics. 8, 2, p. 125-135 11 p.

Research output: Contribution to journalJournal article

Evaluation of a sequential global test of improved recovery following stroke as applied to the ICTUS trial of citicoline.

Bolland, K., Whitehead, J., Cobo, E. & Secades, J. J. 04/2009 In : Pharmaceutical Statistics. 8, 2, p. 136-149 14 p.

Research output: Contribution to journalJournal article

Using historical lesion volume data in the design of a new phase II clinical trial in acute stroke.

Whitehead, J., Bolland, K., Valdés-Márquez, E., Lihic, A., Ali, M. & Lees, K. 04/2009 In : Stroke. 40, 4, p. 1347-1352 6 p.

Research output: Contribution to journalJournal article

One- and two-stage design proposals for a phase II trial comparing three active treatments with control using an ordered categorical endpoint.

Whitehead, J. & Jaki, T. 28/02/2009 In : Statistics in Medicine. 28, 5, p. 828-847 20 p.

Research output: Contribution to journalJournal article

2008

Fitting models for the joint action of two drugs using SAS(R).

Whitehead, A., Whitehead, J., Todd, S., Zhou, Y. & Smith, M. K. 10/2008 In : Pharmaceutical Statistics. 7, 4, p. 272-284 13 p.

Research output: Contribution to journalJournal article

Estimation following selection of the largest of two normal means. Journal of Statistical Planning and Inference 138, 1629-1638.

Stallard, N., Todd, S. & Whitehead, J. 1/07/2008 In : Journal of Statistical Planning and Inference. 138, 6, p. 1629-1638 10 p.

Research output: Contribution to journalJournal article

A safety monitoring procesure for a clinical drug development programme, with application to the accessment of a novel COX-2 inhibitor.

Bolland, K., Whitehead, J. & Oldham, M. 07/2008 In : Journal of Biopharmaceutical Statistics. 18, 4, p. 737-749 13 p.

Research output: Contribution to journalJournal article

Bayesian sample size for exploratory clinical trials incorporating historical data.

Whitehead, J., Valdés-Márquez, E., Johnson, P. & Graham, G. 06/2008 In : Statistics in Medicine. 27, 13, p. 2307-2327 21 p.

Research output: Contribution to journalJournal article

Sequentially testing for a gene-drug interaction in a genomewide analysis.

Kelly, P., Zhou, Y., Whitehead, J., Stallard, N. & Bowman, C. 20/05/2008 In : Statistics in Medicine. 27, 11, p. 2022-2034 13 p.

Research output: Contribution to journalJournal article

Incorporating intermediate binary responses into interim analyses of clinical trials : a comparison of four methods.

Whitehead, A., Sooriyarachchi, M. R., Whitehead, J. & Bolland, K. 10/05/2008 In : Statistics in Medicine. 27, 10, p. 1646-1666 21 p.

Research output: Contribution to journalJournal article

Implementation of a Bayesian design in a dose-escalation study of an experimental agent in healthy volunteers.

Whitehead, J., Korhonen, P., Mustonen, M. & Zhou, Y. 03/2008 In : Biometrics. 64, 1, p. 299-308 10 p.

Research output: Contribution to journalJournal article

2007

A Bayesian approach for dose-escalation in a phase I clinical trial incorporating pharmacodynamic endpoints .

Whitehead, J., Hampson, L., Zhou, Y., Ledent, E. & Pereira, A. 11/2007 In : Journal of Biopharmaceutical Statistics. 17, 6, p. 1117-1129 13 p.

Research output: Contribution to journalJournal article

2006

Sequential genome-wide association studies for monitoring adverse events in clinical evaluation of new drugs.

Whitehead, J., Kelly, P. J., Stallard, N., Zhou, Y. & Bowman, C. 30/09/2006 In : Statistics in Medicine. 25, 18, p. 3081-3092 12 p.

Research output: Contribution to journalJournal article

The sequential analysis of repeated binary responses: a score test for the case of three time points.

Sooriyarachchi, M. R., Whitehead, J., Whitehead, A. & Bolland, K. 15/07/2006 In : Statistics in Medicine. 25, 13, p. 2196-2214 19 p.

Research output: Contribution to journalJournal article

2003

Incorporating data received after a sequential trial has stopped into the final analysis: implementation and comparison of methods.

Whitehead, J., Bollard, K., Matsushita, T., Sooriyarachchi, M. R. & Whitehead, A. 09/2003 In : Biometrics. 59, 3, p. 701-709 9 p.

Research output: Contribution to journalJournal article

2001

Easy-to-implement Bayesian methods for dose-escalation studies in healthy volunteers.

Whitehead, J., Patterson, S., Webber, D. & Zhou, Y. 03/2001 In : Biostatistics. 2, 1, p. 47-61 15 p.

Research output: Contribution to journalJournal article

1991

Analysis of failure time data with ordinal categories of response

Berridge, D. & Whitehead, J. 11/1991 In : Statistics in Medicine. 10, 11, p. 1703-1710 8 p.

Research output: Contribution to journalJournal article

Mammographic dysplasia as entry criterion for breast cancer prevention trials

Berridge, D., Whitehead, J. & Cuzick, J. 18/05/1991 In : The Lancet. 337, 8751, p. 1225 1 p.

Research output: Contribution to journalLetter

Current Students

Research students currently supervised by John Whitehead include: