Professor Ian Nieduszynski

Emeritus

Characterisation of oligosaccharides from the chondroitin/dermatan sulphates: 1H and 13C NMR studies of oligosaccharides generated by nitrous acid depolymerisation
Lauder, R.M., Huckerby, T., Nieduszynski, I., Sadler, I.H. 18/10/2011 In: Carbohydrate Research. 346, 14, p. 2222-2227 . 6 p.
Journal article

Lectin affinity chromatography of articular cartilage fibromodulin: some molecules have keratan sulphate chains exclusively capped by α(2-3)-linked sialic acid.
Lauder, R.M., Huckerby, T., Nieduszynski, I. 10/2011 In: Glycoconjugate Journal. 28, 7, p. 453–461. 9 p.
Journal article

The role of dermatopontin in the stromal organisation of the cornea.
Cooper, L.J., Bentley, A.J., Nieduszynski, I.A., Talabani, S., Thomson, A., Utani, A., Shinkai, H., Fullwood, N.J., Brown, G.M. 08/2006 In: Investigative Ophthalmology and Visual Science. 47, 8, p. 3303-3310. 8 p.
Journal article

Characterization of oligosaccharides from the chondroitin/dermatan sulfates. 1H-NMR and 13C-NMR studies of reduced trisaccharides and hexasaccharides.
Huckerby, T.N., Nieduszynski, I.A., Giannopoulos, M., Weeks, S.D., Sadler, I.H., Lauder, R.M. 12/2005 In: FEBS Journal. 272, 24, p. 6276-6286. 11 p.
Journal article

An ultrastructural investigation of dermato-pontin-knockout mouse corneas
Cooper, L.J., Bentley, A.J., Nieduszynski, I.A., Fullwood, N.J., Ellis, T.S., Thomson, A., Utani, A., Sinkai, H., Brown, G.M. 08/2004 In: International Journal of Experimental Pathology. 85, 4, 2 p.
Special issue

Recent studies on the chondroitin sulfate/dermatan sulfate polymer systems using NMR spectroscopy.
Huckerby, T.N., Lauder, R.M., Nieduszynski, I.A. 2003 In: ACS Polymer Preprints. 44, 1, p. 328-329. 2 p.
Journal article

Keratan sulfates : structural investigations using NMR spectroscopy.
Huckerby, T.N., Brown, G.M., Lauder, R.M., Nieduszynski, I.A. 2002 In: NMR Spectroscopy of Polymers in Solution and in the Solid State (Chapter 22). p. 289-297. 9 p.
Chapter (peer-reviewed)

Age-related changes in the sulphation of the chondroitin sulphate linkage region from human articular cartilage aggrecan.
Lauder, R.M., Huckerby, T.N., Brown, G., Bayliss, M.T., Nieduszynski, I.A. 1/09/2001 In: Biochemical Journal. 358, 2, p. 523-528. 6 p.
Journal article

Localization of TRAMP (Tyrosine-Rich Acidic Matrix Protein)
Bolden, K., Fullwood, N., Nieduszynski, I., Bairaktaris, G. 8/03/2001 In: FASEB Journal. 15, 5, 1 p.
Book/Film/Article review

Characterisation of oligosaccharides from the chondroitin sulfates. 1H-NMR and 13C-NMR studies of reduced disaccharides and tetrasaccharides.
Huckerby, T.N., Lauder, R.M., Brown, G.M., Nieduszynski, I.A., Anderson, K., Boocock, J., Sandall, P.L., Weeks, S.D. 03/2001 In: European Journal of Biochemistry. 268, 5, p. 1181-1189. 9 p.
Journal article

Keratan sulfates : structural investigations using NMR spectroscopy.
Huckerby, T.N., Brown, G.M., Lauder, R.M., Nieduszynski, I.A. 2001 In: Abstracts of Papers of the American Chemical Society. 221, 2, p. 396.
Journal article

Keratan sulfates : structural investigations using NMR spectroscopy.
Huckerby, T.N., Brown, G.M., Lauder, R.M., Nieduszynski, I.A. 2001 In: ACS Polymer Preprints. 42, 1, p. 78-79. 2 p.
Journal article

Increased incidence of unsulphated and 4-sulphated residues in the chondroitin sulphate linkage region observed by high-pH anion-exchange chromatography.
Lauder, R.M., Huckerby, T.N., Nieduszynski, I.A. 15/04/2000 In: Biochemical Journal. 347, 2, p. 339-348. 10 p.
Journal article

A fingerprinting method for chondroitin/dermatan sulfate and hyaluronan oligosaccharides.
Lauder, R.M., Huckerby, T.N., Nieduszynski, I.A. 04/2000 In: Glycobiology. 10, 4, p. 393-401. 9 p.
Journal article

Ultrastructural localization of sulfated and unsulfated keratan sulfate in normal and macular corneal dystrophy type I.
Lewis, D., Davies, Y., Nieduszynski, I.A., Lawrence, F., Quantock, A.J., Bonshek, R., Fullwood, N.J. 03/2000 In: Glycobiology. 10, 3, p. 305-312. 8 p.
Journal article

Structure and function of corneal keratan sulfates.
Nieduszynski, I.A., Ellis, T.S., Brown, G.M., Huckerby, T.N. 2000 In: Abstracts of papers of the American Chemical Society.
Chapter

600 MHz NMR studies of human articular cartilage keratan sulfates.
Huckerby, T.N., Nieduszynski, I.A., Bayliss, M.T., Brown, G.M. 12/1999 In: European Journal of Biochemistry. 266, 3, p. 1174-1183. 10 p.
Journal article

Ultrastructural localisation of sulphated and unsulphated keratan sulphate in normal cornea and macular corneal dystrophy type I
Lewis, D., Fullwood, N.J., Davies, Y., Nieduszynski, I.A., Quantock, A.J., Bonshek, R. 15/03/1999 In: Investigative Ophthalmology and Visual Science. 40, 4, 1 p.
Special issue

An improved method for the structural profiling of keratan sulphates : analysis of keratan suplhates from brain and ovarian tumours.
Whitham, K.M., Hadley, J.L., Morris, H.G., Andrew, S.M., Nieduszynski, I.A., Brown, G.M. 03/1999 In: Glycobiology. 9, 3, p. 285-291. 7 p.
Journal article

Proteoglycans on normal and migrating human corneal endothelium.
Davies, Y., Lewis, D., Fullwood, N.J., Nieduszynski, I.A., Marcyniuk, B., Albon, J., Tullo, A. 03/1999 In: Experimental Eye Research. 68, 3, p. 303-311. 9 p.
Journal article

Isolation and identification of an octasaccharide chondroitin sulphate linkage region fragment.
Lauder, R.M., Huckerby, T.N., Nieduszynski, I.A. 1999 In: Carbohydrate Letters. 3, 5, p. 381-388. 8 p.
Journal article

Human aggrecan keratan sulfate undergoes structural changes during adolescent development
Brown, G., Huckerby, T.N., Bayliss, M.T., Nieduszynski, I.A. 9/10/1998 In: Journal of Biological Chemistry. 273, 41, p. 26408-26414. 7 p.
Journal article

An ultrastructural investigation into proteoglycan distribution in human corneas
Bairaktaris, G., Lewis, D., Fullwood, N.J., Nieduszynski, I.A., Marcyniuk, B., Quantock, A.J., Ridgway, A.E.A. 07/1998 In: Cornea. 17, 4, p. 396-402. 7 p.
Journal article

13C-NMR spectroscopy of keratan sulphates--assignments for five sialylated pentasaccharides derived from the non-reducing chain termini of bovine articular cartilage keratan sulphate by keratanase II digestion
Huckerby, T.N., Brown, G., Nieduszynski, I.A. 02/1998 In: European Journal of Biochemistry. 251, 3, p. 991-997. 7 p.
Journal article

Age-related changes in the structure of the keratan sulphate chains attached to fibromodulin isolated from articular cartilage.
Lauder, R.M., Huckerby, T.N., Nieduszynski, I.A., Plaas, A.H. 1998 In: Biochemical Journal. 330 , p. 753-757. 5 p.
Journal article

Structure determination for octasaccharides derived from the carbohydrate-protein linkage region of chondroitin sulphate chains in the proteoglycan aggrecan from bovine articular cartilage.
Huckerby, T.N., Lauder, R.M., Nieduszynski, I.A. 1998 In: European Journal of Biochemistry. 258, 2, p. 669-676. 8 p.
Journal article

Human corneal keratan sulfates
Tai, G.H., Nieduszynski, I.A., Fullwood, N.J., Huckerby, T.N. 7/11/1997 In: Journal of Biological Chemistry. 272, 45, p. 28227-28231. 5 p.
Journal article

The structure of the keratan sulphate chains attached to fibromodulin from human articular cartilage
Lauder, R.M., Huckerby, T.N., Nieduszynski, I.A. 08/1997 In: Glycoconjugate Journal. 14, 5, p. 651-660. 10 p.
Journal article

Keratan sulphate in the trabecular meshwork and cornea
Davis, Y., Fullwood, N.J., Marcyniuk, B., Bonshek, R., Tullo, A., Nieduszynski, I.A. 07/1997 In: Current Eye Research. 16, 7, p. 677-686. 10 p.
Journal article

Characterisation of a nonreducing terminal fragment from bovine articular-cartilage keratan sulfates containing alpha(2-3)-linked sialic-acid and alpha(1-3)-linked fucose.
Brown, G.M., Huckerby, T.N., Abram, B.L., Nieduszynski, I.A. 10/1996 In: Biochemical Journal. 319, 1, p. 137-141. 5 p.
Journal article

Multiple Non-reducing Chain Termini Isolated from Bovine Corneal Keratan Sulfates.
Tai, G., Huckerby, T.N., Nieduszynski, I.A. 09/1996 In: Journal of Biological Chemistry. 271, 38, p. 23535-23546. 12 p.
Journal article

Cell surface-associated keratan sulfate on normal and migrating corneal endothelium.
Fullwood, N.J., Davies, Y., Nieduszynski, I.A., Marcyniuk, B., Ridgway, A.E.A., Quantock, A.J. 06/1996 In: Investigative Ophthalmology and Visual Science. 37, 7, p. 1256-1270. 15 p.
Journal article

Changes in cell surface glycosaminoglycans during endothelial cell migration
Fullwood, N.J., Davies, Y., Nieduszynski, I.A., Marcyniuk, B., Ridgway, A.E.A., Quantock, A. 15/02/1996 In: Investigative Ophthalmology and Visual Science. 37, 3, 1 p.
Book/Film/Article review

The structure of keratan sulphate chains attached to fibromodulin from bovine articular cartilage.
Lauder, R.M., Huckerby, T.N., Nieduszynski, I.A. 1996 In: European Journal of Biochemistry. 242, 2, p. 402-409. 8 p.
Journal article

THE STRUCTURE OF THE KERATAN SULFATE CHAINS ATTACHED TO FIBROMODULIN ISOLATED FROM BOVINE TRACHEAL CARTILAGE - OLIGOSACCHARIDES GENERATED BY KERATANASE-II DIGESTION
LAUDER, R.M., HUCKERBY, T.N., NIEDUSZYNSKI, I.A. 10/1995 In: Glycoconjugate Journal. 12, 5, p. 651-659. 9 p.
Journal article

Keratanase digestion of keratan sulphates: characterisation of large oligosaccharides from the N-acetyllactosamine repeat sequence and from the non-reducing terminal chain caps.
Huckerby, T.N., Dickenson, J.M., Brown, G.M., Nieduszynski, I.A. 11/05/1995 In: Biochimica et Biophysica Acta (BBA) - General Subjects. 1244, 1, p. 17-29. 13 p.
Journal article

<sup>13</sup>C-NMR spectroscopy of keratan sulphates
Huckerby, T.N., Brown, G.M., Nieduszynski, I.A. 1995 In: European Journal of Biochemistry. 231, 3, p. 779-783. 5 p.
Journal article

Skeletal keratan sulphate structural analysis using keratanase II digestion followed by high-performance anion-exchange chromatography.
Brown, G.M., Nieduszynski, I.A., Morris, H.G., Abram, B.L., Huckerby, T.N., Block, J.A. 1995 In: Glycobiology. 5, 3, p. 311-317. 7 p.
Journal article

Spectroscopic characterisation of disaccharides derived from keratan sulfates.
Huckerby, T.N., Brown, G.M., Dickenson, J.M., Nieduszynski, I.A. 1995 In: European Journal of Biochemistry. 229, 1, p. 119-131. 13 p.
Journal article

The structure of the keratan sulphate attached to fibromodulin isolated from bovine tracheal cartilage, Oligosaccharides isolated following keratanase digestion.
Lauder, R.M., Huckerby, T.N., Nieduszynski, I.A. 1/09/1994 In: Biochemical Journal. 302, 2, p. 417-423. 7 p.
Journal article

600 MHz 1H NMR study of a fucose-containing heptasaccharide derived from a keratanase digestion of bovine articular cartilage keratan sulphate.
Tai, G., Huckerby, T.N., Nieduszynski, I.A. 4/03/1994 In: Carbohydrate Research. 255, p. 303-309. 7 p.
Journal article

Isolation and extractability of fibromodulin.
Lauder, R.M., Morris, H.G., Nieduszynski, I.A., Huckerby, T.N. 1994 In: Bone. 15, 1, p. 128-129. 2 p.
Journal article

Oligosaccharides Derived by Keratanase II Digestion of Bovine Articular Cartilage Keratan Sulphates.
Brown, G., Huckerby, T.N., Nieduszynski, I.A. 1994 In: European Journal of Biochemistry. 224, 2, p. 281-308. 28 p.
Journal article

Oligosaccharides Derived from Bovine Articular Cartilage Keratan Sulfates after Keratanase II Digestion: Implications for Keratan Sulfate Structural Fingerprinting.
Brown, G.M., Huckerby, T.N., Morris, H.G., Abram, B.L., Nieduszynski, I.A. 1994 In: Biochemistry. 33, 16, p. 4836-4846. 11 p.
Journal article

Structure of the keratan sulphate chains attached to fibromodulin isolated from bovine tracheal cartilage. Oligosaccharides generated by keratanase digestion.
Lauder, R.M., Huckerby, T.N., Nieduszynski, I.A. 1994 In: Biochemical Journal. 302, p. 417-423. 7 p.
Journal article

The structure of keratan sulphate attached to fibromodulin from bovine tracheal cartilage.
Lauder, R.M., Huckerby, T.N., Nieduszynski, I.A. 1994 In: International Journal of Experimental Pathology. 74, p. A9-A10.
Journal article

13C NMR spectroscopy of keratan sulphates : assignments for the reduced form of a repeat unit tetrasaccharide derived from keratan sulphate by a keratanase digestion and partial assignments for two fucosylated pentasaccharides.
Huckerby, T., Dickerson, J., Tai, G., Lauder, R., Brown, G., Nieduszynski, I. 1993 In: Magnetic Resonance in Chemistry. 31, 4, p. 394-398. 5 p.
Journal article

N.m.r. spectroscopic studies of fucose-containing oligosaccharides derived from keratanase digestion of articular cartilage keratan sulphates. Influence of fucose residues on keratanase cleavage.
Tai, G., Huckerby, T.N., Nieduszynski, I.A. 1993 In: Biochemical Journal. 291, p. 889-894. 6 p.
Journal article

Characterization of oligosaccharides from the non-reducing termini of keratan sulphate chains.
Huckerby, T.N., Dickenson, J.M., Nieduszynski, I.A. 12/1992 In: Magnetic Resonance in Chemistry. 30, 13, p. S134-S141.
Journal article

A sub-population of keratan sulphates derived from bovine articular cartilage is capped with alpha(2-6)-linked N-acetylneuraminic acid residues. Affinity chromatography using immobilized Sambucus nigra lectin and characterization using 1H n.m.r. spectroscopy
Tai, G.H., Morris, H.G., Brown, G.M., Huckerby, T.N., Nieduszynski, I.A. 1992 In: Biochemical Journal. 286 , 1, p. 231-234. 4 p.
Journal article

Degradation of articular cartilage keratan sulphates using hydrazinolysis and nitrous acid. Environment of fucose residues.
Brown, G., Huckerby, T.N., Morris, H.G., Nieduszynski, I.A. 1992 In: Biochemical Journal. 286, 1, p. 235-241. 7 p.
Journal article

Skeletal keratan sulphate chains isolated from bovine intervertebral disc may terminate in alpha(2----6)-linked N-acetylneuraminic acid.
Dickenson, J.M., Huckerby, T.N., Nieduszynski, I.A. 1992 In: Biochemical Journal. 282, 1, p. 267-271. 5 p.
Journal article

A full assignment of proton resonances for an alpha(1-3)-linked fucose residue in keratan sulphate from bovine articular cartilage
Huckerby, T.N., Nieduszynski, I.A., Brown, G.M., Cockin, G.H. 02/1991 In: Glycoconjugate Journal. 8, 1, p. 39-44. 6 p.
Journal article

Fucose content of keratan sulphates from bovine articular cartilage
Tai, G.H., Brown, G.M., Morris, H.G., Huckerby, T.N., Nieduszynski, I.A. 1991 In: Biochemical Journal. 273, 2, p. 307-310. 4 p.
Journal article

Structural aspects of skeletal keratan sulphates
Nieduszynski, I.A., Huckerby, T.N., Dickenson, J.M., Brown, G.M., Tai, G.H., Bayliss, M.T. 10/1990 In: Biochemical Society Transactions. 18, 5, p. 792-793. 2 p.
Journal article

There are two major types of skeletal keratan sulphates
Nieduszynski, I.A., Huckerby, T.N., Dickenson, J.M., Brown, G., Tai, G.H., Morris, H.G., Eady, S. 1990 In: Biochemical Journal. 271, 1, p. 243-245. 3 p.
Journal article