Dr Nick Fletcher

Senior Lecturer

Research Overview

Nick Fletcher's principle interests lie in the structural considerations in discrete transition metal complexes, with particular emphasis on their application in sensing within a biological environment. Current research interests include structures to understand the selective binding to phosphates, and enantioselective recognition of biologically important anions, and structural probes to determine secondary structure in DNA.

Infrared and Raman screening of seized novel psychoactive substances: a large scale study of >200 samples
Jones, L.E., Stewart, A., Peters, K.L., McNaul, M., Speers, S.J., Fletcher, N.C., Bell, S.E.J. 7/02/2016 In: The Analyst. 141, 3, p. 902-909. 8 p.
Journal article

Surface-enhanced Raman spectroscopy of novel psychoactive substances using polymer-stabilized Ag nanoparticle aggregates
Lee, W.W.Y., Silverson, V.A.D., Jones, L.E., Ho, Y.C., Fletcher, N.C., McNaul, M., Peters, K.L., Speers, S.J., Bell, S.E.J. 11/01/2016 In: Chemical Communications. 52, 3, p. 493-496. 4 p.
Journal article

Isolation and structural determination of non-racemic tertiary cathinone derivatives
Zhou, M., Bouazzaoui, S., Jones, L.E., Goodrich, P., Bell, S.J., Sheldrake, G.N., Horton, P.N., Coles, S.J., Fletcher, N. 7/10/2015 In: Organic and Biomolecular Chemistry . 13, 37, p. 9629-9636. 8 p.
Journal article

New insights into dihydrogenphosphate recognition with dirhenium(I) tricarbonyl complexes bridged by a thiourea moiety
Blackburn, A.L., Baker, N.C.A., Fletcher, N.C. 2014 In: RSC Advances. 4, 35, p. 18442-18452. 11 p.
Journal article

Protein destabilisation by ruthenium(II) tris-bipyridine based protein-surface mimetics
Wilson, A.J., Ault, J.R., Filby, M.H., Philips, H.I.A., Ashcroft, A.E., Fletcher, N.C. 7/04/2013 In: Organic and Biomolecular Chemistry . 11, 13, p. 2206-2212. 7 p.
Journal article

The use of electrospray mass spectrometry to determine speciation in a dynamic combinatorial library for anion recognition
Phillips, H.I.A., Chernikov, A.V., Fletcher, N.C., Ashcroft, A.E., Ault, J.R., Filby, M.H., Wilson, A.J. 22/10/2012 In: Chemistry - A European Journal. 18, 43, p. 13733-13742. 10 p.
Journal article

Raman spectroscopy for forensic examination of beta-ketophenethylamine "legal highs": reference and seized samples of cathinone derivatives
Stewart, S.P., Bell, S.E.J., Fletcher, N.C., Bouazzaoui, S., Ho, Y.C., Speers, S.J., Peters, K.L. 20/01/2012 In: Analytica Chimica Acta. 711, p. 1-6. 6 p.
Journal article

Ruthenium cryptates with an unusual selectivity for nitrate
Baker, N.C.A., Fletcher, N.C., Horton, P.N., Hursthouse, M.B. 2012 In: Dalton Transactions. 41, 23, p. 7005-7012. 8 p.
Journal article

Diastereoselective assembly of pentanuclear circular helicates
Clegg, O.R., Fennessy, R.V., Harding, L.P., Rice, C.R., Riis-Johannessen, T., Fletcher, N.C. 7/12/2011 In: Dalton Transactions. 40, 45, p. 12381-12387. 7 p.
Journal article

Examination of the silver colloid binding behavior of disulfide-tethered bipyridine ligands and their fac-tricarbonylrhenium(I) complexes
Montgomery, H.J., Pelleteret, D., Bell, S.E.J., Fletcher, N.C. 4/04/2011 In: Inorganic Chemistry. 50, 7, p. 2738-2747. 10 p.
Journal article

Protein surface recognition using geometrically pure Ru(II) tris(bipyridine) derivatives
Filby, M.H., Muldoon, J., Dabb, S., Fletcher, N.C., Ashcroft, A.E., Wilson, A.J. 2011 In: Chemical Communications. 47, 1, p. 559-561. 3 p.
Journal article

Substituted dipyridophenazine complexes of Cr(III): synthesis, enantiomeric resolution and binding interactions with calf thymus DNA (vol 39, pg 3990, 2010)
Vasudevan, S., Smith, J.A., Wojdyla, M., DiTrapani, A., Kruger, P.E., McCabe, T., Fletcher, N.C., Quinn, S.J., Kelly, J.M. 2010 In: Dalton Transactions. 39, 48, p. 11687-11687. 1 p.
Journal article

The comparison of fac and mer ruthenium(II) trischelate complexes in anion binding
Baker, N.C.A., McGaughey, N., Fletcher, N.C., Chernikov, A.V., Hortonb, P.N., Hursthouse, M.B. 2009 In: Dalton Transactions. 6, p. 965-972. 8 p.
Journal article

A modular approach to luminescent dinuclear ruthenium(II) and rhenium(I) complexes
Pelleteret, D., Fletcher, N.C. 08/2008 In: European Journal of Inorganic Chemistry. 2008, 23, p. 3597-3605. 9 p.
Journal article

The dichotomy in the DNA-binding behaviour of ruthenium(II) complexes bearing benzoxazole and benzothiazole groups
Spillane, C.B., Dabo, M.N.V., Fletcher, N.C., Morgan, J.L., Keene, F.R., Haq, I., Buurma, N.J. 04/2008 In: Journal of Inorganic Biochemistry. 102, 4, p. 673-683. 11 p.
Journal article