Dr Vilius Franckevicius


Research Overview

Our research programme lies at the heart of organic synthesis and contemporary metal catalysis, and focuses on the discovery and development of new waste-minimised and sustainable synthetic tools for the efficient assembly of organic molecules in an asymmetric manner. We are, in particular, interested in decarboxylative C–C bond formation methods, which, unlike traditional catalytic cross-coupling approaches, avoid the use of basic or harsh reaction conditions and, save for carbon dioxide, which is easily removable, do not generate stoichiometric amounts of by-products or harmful waste.

We have several PhD projects available in the area of synthetic organic chemistry and catalysis in its broadest sense, although funding is currently not available. We welcome applications from self-funded students or from students seeking external funding who have a strong passion for synthetic chemistry. As such, you will have access to brand new state-of-the-art laboratories and analytical equipment, including high-field NMR, mass spec, HPLC and others. Training in synthesis and compound characterisation, as well as project supervision will be provided. As part of our research group, you will also have the opportunity to expand your chemical knowledge base, and practise your presentation and writing skills on a regular basis.

Palladium-Catalysed Construction of All-Carbon Quaternary Centres with Propargylic Electrophiles: Challenges in the Simultaneous Control of Regio-, Chemo- and Enantioselectivity
Kenny, M., Schröder, S., Taylor, N., Jackson, P., Kitson, D., Franckevicius, V. 05/2018 In: SYNTHESIS. 50, 9, p. 1796-1814. 19 p.
Journal article

Palladium-catalyzed construction of quaternary carbon centers with propargylic electrophiles
Franckevicius, V. 10/08/2016 In: Tetrahedron Letters. 57, 32, p. 3586-3595. 10 p.
Journal article

Catalytic chemo- and regioselective coupling of 1,3-dicarbonyls with N‐heterocyclic nucleophiles
Kenny, M., Kitson, D.J., Franckevicius, V. 17/06/2016 In: Journal of Organic Chemistry. 81, 12, p. 5162-5172. 11 p.
Journal article

Optical control of NMDA-receptors with a diffusible photoswitch
Laprell, L., Repak, E., Franckevicius, V., Hartrampf, F., Terhag, J., Hollmann, M., Sumser, M., Rebola, N., Di Gregorio, D., Trauner, D. 27/08/2015 In: Nature Communications. 6, 11 p.
Journal article

Regioswitchable palladium-catalyzed decarboxylative coupling of 1,3-dicarbonyl compounds
Kenny, M., Christensen, J., Coles, S., Franckevicius, V. 27/07/2015 In: Organic Letters. 17, 15, p. 3926-3929. 4 p.
Journal article

Palladium-catalysed decarboxylative alkenylation of enolates
Schroeder, S., Taylor, N., Jackson, P., Franckevicius, V. 8/05/2015

Catalytic decarboxylative alkenylation of enolates
Schroeder, S., Taylor, N., Jackson, P., Franckevicius, V. 19/07/2013 In: Organic Letters. 15, 14, p. 3778-3781. 4 p.
Journal article

Copper-catalysed approach to spirocyclic oxindoles via a direct C-H, Ar-H functionalisation
Moody, C.L., Franckevicius, V., Drouhin, P., Klein, J.E.M.N., Taylor, R.J.K. 11/04/2012 In: Tetrahedron Letters. 53, 15, p. 1897-1899. 3 p.
Journal article

Asymmetric Decarboxylative Allylation of Oxindoles
Franckevicius, V., Cuthbertson, J.D., Pickworth, M., Pugh, D.S., Taylor, R.J.K. 19/08/2011 In: Organic Letters. 13, 16, p. 4264-4267. 4 p.
Journal article

Highly diastereoselective desymmetrisation of cyclic meso-anhydrides and derivatisation for use in natural product synthesis
Evans, A.C., Longbottom, D.A., Matsuoka, M., Davies, J.E., Turner, R., Franckevicius, V., Ley, S.V. 2009 In: Organic and Biomolecular Chemistry . 7, 4, p. 747-760. 14 p.
Journal article

Aureggi, V., Franckevicius, V., Kitching, M.O., Ley, S.V., Longbottom, D.A., Oelke, A.J., Sedelmeier, G. 2008 In: Organic Syntheses. 85, p. 72-87. 16 p.
Journal article

Practical organocatalysis with (S)- and (R)-5-pyrrolidin-2-yl-1H-tetrazoles
Longbottom, D.A., Franckevicius, V., Kumarn, S., Oelke, A.J., Wascholowski, V., Ley, S.V. 2008
Literature review

(S)- and (R)-5-Pyrrolidin-2-yl-1H-tetrazoles: Enantiomeric organocatalysts of broad utility in organic synthesis
Longbottom, D.A., Franckevicius, V., Ley, S.V. 2007
Literature review

8,9,10,10a-tetrahydro-6H-tetrazolo[1,5-a]pyrrolo[2,1-c]pyrazines: New heterocyclic frameworks generated by an Ugi-type multicomponent reaction
Franckevicius, V., Longbottom, D.A., Turner, R.M., Ley, S.V. 4/10/2006 In: SYNTHESIS. 2006, 19, p. 3215-3223. 9 p.
Journal article

Practical synthesis of (S)-pyrrolidin-2-yl-1H-tetrazole, incorporating efficient protecting group removal by flow-reactor hydrogenolysis
Franckevicius, V., Knudsen, K., Ladlow, M., Longbottom, D., Ley, S. 4/04/2006 In: SYNLETT. 2006, 6, p. 889-892. 4 p.
Journal article

Structures of 2,4,6-tri-alpha-pyridyl-1,3,5-triazine complexes of the lanthanoid nitrates: A study in the lanthanoid contraction
Cotton, S.A., Franckevicius, V., Mahon, M.F., Ooi, L.L., Raithby, P., Teat, S.J. 6/03/2006 In: Polyhedron. 25, 4, p. 1057-1068. 12 p.
Journal article

Synthesis of medium-ring and iodinated biaryl compounds by organocuprate oxidation
Surry, D., Su, X., Fox, D., Franckevicius, V., Macdonald, S., Spring, D. 11/03/2005 In: Angewandte Chemie International Edition. 44, 12, p. 1870-1873. 4 p.
Journal article

Synthesis of complexes of 2,2 ': 6 ',2 ''-terpyridine and 1,10-phenanthroline with lanthanide thiocyanates; the molecular structures of [Ln(terpy)(2)(NCS)(3)] (Ln = Pr, Nd), [Nd(terpy)(2)(NCS)(3)]center dot 2EtOH and [Ln(phen)(3)(NCS)(3)]center dot EtOH (Ln = Pr, Nd)
Cotton, S.A., Franckevicius, V., How, R.E., Ahrens, B., Ooi, L.L., Mahon, M.F., Raithby, P.R., Teat, S.J. 1/06/2003 In: Polyhedron. 22, 11, p. 1489-1497. 9 p.
Journal article

Syntheses and structures of iron(III) complexes of simple N-donor ligands
Cotton, S.A., Franckevicius, V., Fawcett, J. 1/09/2002 In: Polyhedron. 21, 20, p. 2055-2061. 7 p.
Journal article

Benchmark compounds. Structures of cobalt(II) complexes of triphenylphosphine- and triphenylarsine oxides
Cotton, S.A., Franckevicius, V., Fawcett, J. 02/2002 In: Transition Metal Chemistry. 27, 1, p. 38-41. 4 p.
Journal article

  • Chemical Synthesis