Dr Neil Dawson


Research Overview

My research interests are focused on further understanding the mechanisms through which genetic and environmental risk factors for psychiatric and neurodegenerative disease impact on brain functioning, behaviour and cognition. I also have a primary interest in developing and validating translational preclinical models for these diseases for utilization in the drug discovery process, in the hope that we can use these models to identify novel drugs to treat these disorders.

Chronic, intermittent treatment with a cannabinoid receptor agonist impairs recognition memory and brain network functional connectivity
Mouro, F.M., Ribeiro, J.A., Sebastião, A.M., Dawson, N. 10/2018 In: Journal of Neurochemistry. 147, 1, p. 71-83. 13 p.
Journal article

Deconstructing Schizophrenia: Advances in Preclinical Models for Biomarker Identification
Pratt, J.A., Morris, B., Dawson, N. 3/05/2018 In: Current Topics in Behavioral Neurosciences. Berlin : Springer
Chapter (peer-reviewed)

Glutamatergic regulation of cognition and functional brain connectivity: insights from pharmacological, genetic and translational schizophrenia research
Dauvermann, M.R., Lee, G., Dawson, N. 10/2017 In: British Journal of Pharmacology. 174, 19, p. 3136-3160. 25 p.
Journal article

Thalamo-cortical communication, glutamatergic neurotransmission and neural oscillations: a unique window into the origins of ScZ?
Pratt, J., Dawson, N., Morris, B.J., Grent-'t-Jong, T., Roux, F., Uhlhaas, P.J. 02/2017 In: Schizophrenia Research. 180, p. 4-12. 9 p.
Journal article

Altered functional brain network connectivity and glutamate system function in transgenic mice expressing truncated Disrupted-in-Schizophrenia 1
Dawson, N., Kurihara, M., Thomson, D.M., Winchester, C.L., McVie, A., Hedde, J.R., Randall, A.D., Shen, S., Seymour, P.A., Hughes, Z.A., Dunlop, J., Brown, J.T., Brandon, N.J., Morris, B.J., Pratt, J.A. 19/05/2015 In: Translational Psychiatry. 5, 12 p.
Journal article

Functional brain connectivity phenotypes for schizophrenia drug discovery
Dawson, N., Morris, B.J., Pratt, J. 02/2015 In: Journal of Psychopharmacology. 29, 2, p. 169-177. 9 p.
Journal article

Subanaesthetic ketamine treatment promotes abnormal interactions between neural subsystems and alters the properties of functional brain networks
Dawson, N., McDonald, M., Higham, D.J., Morris, B.J., Pratt, J.A. 06/2014 In: Neuropsychopharmacology. 39, 7, p. 1786-1798. 13 p.
Journal article

Sustained NMDA receptor hypofunction induces compromised neural systems integration and schizophrenia-like alterations in functional brain networks
Dawson, N., Xiao, X., McDonald, M., Higham, D.J., Morris, B.J., Pratt, J.A. 02/2014 In: Cerebral Cortex. 24, 2, p. 452-464. 13 p.
Journal article

Alternating hemiplegia of childhood-related neural and behavioural phenotypes in Na+, K+-ATPase a3 missense mutant mice
Kirshenbaum, G., Dawson, N., Mullins, J., Johnston, T., Drinkhill, M., Edwards, I., Fox, S., Pratt, J., Brotchie, J., Roder, J., Clapcote, S. 20/03/2013 In: PLoS ONE. 8, 3, 15 p.
Journal article

Subanaesthetic ketamine treatment alters prefrontal cortex connectivity with thalamus and ascending subcortical systems
Dawson, N., Morris, B.J., Pratt, J.A. 2013 In: Schizophrenia Bulletin. 39, 2, p. 366-377. 12 p.
Journal article

Modafinil reverses phencyclidine-induced deficits in cognitive flexibility, cerebral metabolism and functional brain connectivity
Dawson, N., Thompson, R.J., McVie, A., Thomson, D.M., Morris, B.J., Pratt, J.A. 1/09/2012 In: Schizophrenia Bulletin. 38, 3, p. 457-474. 18 p.
Journal article

Advancing schizophrenia drug discovery: optimizing rodent models to bridge the translational gap
Pratt, J., Winchester, C., Dawson, N., Morris, B. 07/2012 In: Nature Reviews Drug Discovery. 11, p. 560-579. 20 p.
Journal article

Exploring metabolic pathway disruption in the subchronic phencyclidine model of schizophrenia with the generalized singular value decomposition
Xiao, X., Dawson, N., MacIntyre, L., Morris, B., Pratt, J., Watson, D., Higham, D. 16/05/2011 In: BMC Systems Biology. 5
Journal article

Cerbral metabolic responses to 5-HT2A/C receptor activation in mice with genetically modified serotonin transporter (SERT) expression
Dawson, N., Ferrington, L., Lesch, K., Kelly, P. 01/2011 In: European Neuropsychopharmacology. 21, 1, p. 117-128. 12 p.
Journal article

Acute tryptophan depletion potentiates 3,4-methylenedioxymethamphetamine-induced cerebrovascular hyperperfusion in rats
van Donkelaar, E., Kelly, P., Dawson, N., Blokland, A., Prickaerts, J., Steinbusch, H., Ferrington, L. 15/05/2010 In: Journal of Neuroscience Research. 88, 7, p. 1557-1568. 12 p.
Journal article

Sex influences the effect of a lifelong increase in serotonin transporter function on cerebral metabolism
Dawson, N., Ferrington, L., Olverman, H., Harmar, A., Kelly, P. 1/08/2009 In: Journal of Neuroscience Research. 87, 10, p. 2375-2385. 11 p.
Journal article