Dr Susan Broughton


Research Overview

Dr Broughton's research interests lie in the mechanisms of ageing, particularly the relationship between lifespan and healthspan, using the fruit fly, Drosophila melanogaster, as a model organism.

She has a particular interest in the role of the insulin/IGF-like signalling pathway and diet in modulating lifespan and age-related functional and cognitive decline using behavioural and anatomical measures of brain ageing.

Behavioral Senescence and Aging-Related Changes in Motor Neurons and Brain Neuromodulator Levels Are Ameliorated by Lifespan-Extending Reproductive Dormancy in Drosophila
Liao, S., Broughton, S.J., Nässel, D.R. 20/04/2017 In: Frontiers in Cellular Neuroscience. 11, 20 p.
Journal article

Microbes, molecular mimicry and molecules of mood and motivation
Morris, J., Broughton, S.J., Wessels, Q.B. 02/2016 In: Medical Hypotheses. 87, p. 40-43. 4 p.
Journal article

The Drosophila insulin receptor independently modulates lifespan and locomotor senescence
Hodges, M., Haji Ismail, M.Z.B., Boylan, M., Achall , R., Shirras, A., Broughton, S. 28/05/2015 In: PLoS ONE.
Journal article

Cell-nonautonomous effects of dFOXO/DAF-16 in aging
Alic, N., Tullet, J.M., Niccoli, T., Broughton, S., Hoddinott, M.P., Slack, C., Gems, D., Partridge, L. 27/02/2014 In: Cell Reports. 6, 4, p. 608-616. 9 p.
Journal article

Differential regulation of E-cadherin expression by the soluble ectodomain and intracellular domain of jagged1
Delury, C., Tinker, C., Rivers, S., Hodges, M., Broughton, S., Parkin, E. 2/08/2013 In: International Journal of Biochemistry Research and Review. 3, 4, p. 278-290. 13 p.
Journal article

DILP-producing median neurosecretory cells in the Drosophila brain mediate the response of lifespan to nutrition
Broughton, S.J., Slack, C., Alic, N., Metaxakis, A., Bass, T.M., Driege, Y., Partridge, L. 06/2010 In: Aging Cell. 9, 3, p. 336-46. 11 p.
Journal article

Molecular evolution and functional characterization of Drosophila insulin-like peptides
Grönke, S., Clarke, D., Broughton, S., Andrews, T.D., Partridge, L. 2010 In: PLoS Genetics. 6, 2
Journal article

The endosymbiont Wolbachia increases insulin/IGF-like signalling in Drosophila
Ikeya, T., Broughton, S., Alic, N., Grandison, R., Partridge, L. 11/2009 In: Proceedings of the Royal Society B: Biological Sciences. 276, 1674, p. 3799-3807. 9 p.
Journal article

Insulin/IGF-like signalling, the central nervous system and aging
Broughton, S., Partridge, L. 2009 In: Biochemical Journal. 418, 1, p. 1-12. 12 p.
Journal article

Reduction of DILP2 in Drosophila triages a metabolic phenotype from lifespan revealing redundancy and compensation among DILPs
Broughton, S., Alic, N., Slack, C., Bass, T., Ikeya, T., Vinti, G., Tommasi, A.M., Driege, Y., Hafen, E., Partridge, L. 2008 In: PLoS ONE. 3, 11
Journal article

Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands
Broughton, S.J., Piper, M.D.W., Ikeya, T., Bass, T.M., Jacobson, J., Driege, Y., Martinez, P., Hafen, E., Withers, D.J., Leevers, S.J., Partridge, L. 22/02/2005 In: Proceedings of the National Academy of Sciences. 102, 8, p. 3105-3110. 6 p.
Journal article

Excitatory and inhibitory switches for courtship in the brain of Drosophila melanogaster
Broughton, S.J., Kitamoto, T., Greenspan, R.J. 6/04/2004 In: Current biology : CB. 14, 7, p. 538-547. 10 p.
Journal article

Conditioning deficits of CaM-kinase transgenic Drosophila melanogaster in a new excitatory courtship assay
Broughton, S.J., Tully, T., Greenspan, R.J. 2003 In: Journal of Neurogenetics. 17, 1, p. 91-102. 12 p.
Journal article

Transport of CaM kinase along processes elicited by neuronal contact evokes an inhibition of arborization and outgrowth in D. melanogaster cultured neurons
Broughton, S.J., Kane, N.S., Yoder, M., Greenspan, R.J., Robichon, A. 15/09/1996 In: Journal of Cellular Biochemistry. 62, 4, p. 484-494. 11 p.
Journal article

Endogenously inhibited protein kinase C in transgenic Drosophila embryonic neuroblasts down regulates the outgrowth of type I and II processes of cultured mature neurons
Broughton, S.J., Kane, N.S., Arthur, B., Yoder, M., Greenspan, R.J., Robichon, A. 15/03/1996 In: Journal of Cellular Biochemistry. 60, 4, p. 584-599. 16 p.
Journal article