Dr Elaine Taylor

Director of Student Support & Senior Lecturer in Medical Sciences

Research Overview

My research interests are in understanding how cells normally function to prevent, or reverse, deleterious genetic alterations and chromosomal abnormalities. Such loss of genome integrity can lead to a range of disorders including cancer and neurodegeneration. Ubiquitin and SUMO modification of specific proteins is recognised as an important element of the cellular response to genetic damage. A key focus of my research is to identify and characterise Ub/SUMO modification targets involved in genetic maintenance through a combination of biochemical and cell biological approaches. In doing so, we aim to uncover novel targets for future drug discovery.

Selected Publications

Cip29 is phosphorylated following activation of the DNA damage response in Xenopus egg extracts
Holden, J., Taylor, E.M., Lindsay, H.D. 17/07/2017 In: PLoS ONE. 12, 7, 20 p.
Journal article

Molecular basis for PrimPol recruitment to replication forks by RPA
Guilliam, T.A., Brissett, N.C., Ehlinger, A., Keen, B.A., Kolesar, P., Taylor, E.M., Bailey, L., Lindsay, H.D., Chazin, W.J., Doherty, A.J. 23/05/2017 In: Nature Communications. 8, 14 p.
Journal article

DNA replication stress and cancer: cause or cure?
Taylor, E.M., Lindsay, H.D. 01/2016 In: Future Oncology. 12, 2, p. 221-237. 17 p.
Journal article

PrimPol bypasses UV photoproducts during chromosomal DNA replication
Bianchi, J., Rudd, S.G., Jozwiakowski, S.K., Bailey, L.J., Soura, V., Taylor, E., Stevanovic, I., Green, A.J., Stracker, T.H., Lindsay, H., Doherty, A.J. 21/11/2013 In: Molecular Cell. 52, 4, p. 566-573. 8 p.
Journal article

SMC6 is an essential gene in mice, but a hypomorphic mutant in the ATPase domain has a mild phenotype with a range of subtle abnormalities
Ju, L., Wing, J., Taylor, E., Brandt, R., Slijepcevic, P., Horsch, M., Rathkolb, B., Racz, I., Becker, L., Hans, W., Adler, T., Beckers, J., Rozman, J., Klingenspor, M., Wolf, E., Zimmer, A., Klopstock, T., Busch, D., Gailus-Durner, V., Fuchs, H., Hrabe de Angelis, M., van der Horst, G., Lehmann, A. 1/05/2013 In: DNA Repair. 12, 5, p. 356-366. 11 p.
Journal article

Depletion of Uhrf1 inhibits chromosomal DNA replication in Xenopus egg extracts
Taylor, E., Bonsu-Dartnall, N., Price, J., Lindsay, H. 20/06/2013 In: Nucleic Acids Research. 41, 16, p. 7725-7737. 13 p.
Journal article

The Mre11/Rad50/Nbs1 complex functions in resection-based DNA end joining in Xenopus laevis.
Taylor, E.M., Cecillon, S.M., Bonis, A., Chapman, J.R., Povirk, L.F., Lindsay, H.D. 01/2010 In: Nucleic Acids Research. 38, 2, p. 441-454. 14 p.
Journal article

Identification of the proteins, including MAGE-G1, that make up the human SMC5-6 protein complex.
Taylor, E.M., Copsey, A., Hudson, J., Vidot, S., Lehmann, A. 15/02/2008 In: Molecular and Cellular Biology. 28, 4, p. 1197-1206. 10 p.
Journal article

Composition and architecture of the Schizosaccharomyces pombe Rad18 (Smc5-6) complex.
Sergeant, J., Taylor, E., Palecek, J., Fousteri, M., Andrews, E., Sweeney, S., Shinagawa, H., Watts, F. 01/2005 In: Molecular and Cellular Biology. 25, 1, p. 172-184. 13 p.
Journal article

Nse2, a component of the Smc5-6 complex, is a SUMO ligase required for the response to DNA damage.
Andrews, E., Palecek, J., Sergeant, J., Taylor, E., Lehmann, A., Watts, F. 01/2005 In: Molecular and Cellular Biology. 25, 1, p. 185-196. 12 p.
Journal article

  • Cancer Biology and Genome Stability
  • Experimental Medicine