Dr John Worthington

Senior Lecturer in Infection Biology and Part I Director of Studies

Research Overview

The intestinal epithelium offers the first interaction between commensal bacteria, pathogens and our bodies’ largest immune system. Inappropriate immune responses drive inflammatory bowel disease (IBD) or excessive inflammation during infection. My research focuses on the epithelial enteroendocrine cells (EECs), which release peptide hormones in response to nutrients allowing their efficient digestion. EEC alterations are strongly associated with inflammation, yet the possibility of interactions between our gut’s endocrine and immune systems remains overlooked. Understanding the mechanistic cross-talk between enteroendocrine and immune cells will identify the immunoendocrine axis as a key feature of intestinal health which could be therapeutically targeted during disease.

Inaugural Event of the Africa Research Hub
Symposium

Grant review
Expert Opinion

Grant Review
Expert Opinion

100 Years, 100 Objects: Stories from the Collections of Lancaster City Museums
Public Lecture/ Debate/Seminar

Gut Microbes (Journal)
Publication peer-review

Immunology (Journal)
Publication peer-review

Carnegie Research Assessor
Expert Opinion

Mucosal Immunology (Journal)
Publication peer-review

Parasite Immunology (Journal)
Publication peer-review

British Society for Immunolgy Annual Congress
Oral presentation

FluWHo
Public Lecture/ Debate/Seminar

Immune-endocrine interactions at the gut barrier
Invited talk

Immune-endocrine interactions at the gut barrier for novel therapeutics
Invited talk

Mucosal Immunology (Journal)
Publication peer-review

Parasite Immunology (Journal)
Publication peer-review

PLoS Pathogens (Journal)
Publication peer-review

Frontiers in Immunology (Journal)
Publication peer-review

Gut Microbes (Journal)
Publication peer-review

Grant Review
Expert Opinion

Grant Review
Expert Opinion

writing your next grant application
Public Lecture/ Debate/Seminar

Covid-the unanswered questions
Public Lecture/ Debate/Seminar

British Society for Immunology Congress 2019
Participation in conference -Mixed Audience

British Society for Immunology Congress 2019
Participation in conference -Mixed Audience

  • Cancer Biology and Genome Stability
  • Microbes, Pathogens and Immunity