Dr Leonie Unterholzner

Research Fellow/Lecturer

Research Overview

My research group is interested in how cells can detect foreign DNA, for example when skin cells have been infected by a virus. This is part of the innate immune response, which acts within the first few hours of infection, with the aim to alert more specialised immune cells, and to eliminate the virus before it can spread to other parts of the body. We are investigating how a cell can distinguish viral DNA from its own DNA genome, and how it signals to alert neighbouring cells. We also study how cells can detect their own DNA as danger signal, when the DNA has been damaged by UV light or chemotherapy.

Our work investigates molecular mechanisms that underlie the immune response during infection, autoimmunity and cancer.