Dr Lucy Jackson-Jones

Lecturer in Biomedicine

Research Overview

My laboratory focuses on 'Local immune responses' that occur within the thoracic cavity. In particular the interaction of the macrophages of the pleural cavity and fat associated lymphoid clusters of the pericardium and mediastinum. Inflammation of the pleural space induces the production of innate IgM from B cells residing in FALCs, and causes fluid phase macrophages to divide locally, however it is unclear how these two responses are interlinked. We will uncover the mechanism by which macrophages detect IgM, in the context of allergic airway inflammation, parasite infection and cancer.

Selected Publications

Stromal cells covering omental fat-associated lymphoid clusters trigger the formation of neutrophil aggregates to capture peritoneal contaminants
Jackson-Jones, L., Smith, P., Portman, J., Magalhaes, M.S., Mylonas, K., Vermeren, M., Nixon, M., Henderson, B., Dobie, R., Vermeren, S., Denby, L., Henderson, N., Mole, D., Bénézech, C. 14/04/2020 In: Immunity. 52, 4, p. 700-715. 16 p.
Journal article

FALC stromal cells define a unique immunological niche for the surveillance of serous cavities
Jackson-Jones, L., Benezech, C. 1/06/2020
Review article

Fat-associated lymphoid clusters control local IgM secretion during pleural infection and lung inflammation
Jackson-Jones, L.H., Duncan, S.M., Magalhaes, M.S., Campbell, S.M., Maizels, R.M., McSorley, H.J., Allen, J.E., Bénézech, C. 1/09/2016 In: Nature Communications. 7, 14 p.
Journal article

Local amplifiers of IL-4Rα-mediated macrophage activation promote repair in lung and liver
Minutti, C.M., Jackson-Jones, L.H., García-Fojeda, B., Knipper, J.A., Sutherland, T.E., Logan, N., Ringqvist, E., Guillamat-Prats, R., Ferenbach, D.A., Artigas, A., Stamme, C., Chroneos, Z.C., Zaiss, D.M., Casals, C., Allen, J.E. 9/06/2017 In: Science. 356, 6342, p. 1076-1080. 5 p.
Journal article

IL-33 delivery induces serous cavity macrophage proliferation independent of interleukin-4 receptor alpha
Jackson-Jones, L.H., Rückerl, D., Svedberg, F., Duncan, S., Maizels, R.M., Sutherland, T.E., Jenkins, S.J., McSorley, H.J., Bénézech, C., MacDonald, A.S., Allen, J.E. 11/10/2016 In: European Journal of Immunology. 46, 10, p. 2311-2321. 11 p.
Journal article

Alternatively activated dendritic cells regulate CD4+ T-cell polarization in vitro and in vivo
Cook, P.C., Jones, L.H., Jenkins, S.J., Wynn, T.A., Allen, J.E., MacDonald, A.S. 19/06/2012 In: Proceedings of the National Academy of Sciences of the United States of America. 109, 25, p. 9977-9982. 6 p.
Journal article