Dr Lucy Jackson-Jones

Lecturer in Biomedicine

Research Overview

My laboratory focuses on 'Local immune responses' that occur within the thoracic cavity. In particular the interaction of the macrophages of the pleural cavity and fat associated lymphoid clusters of the pericardium and mediastinum. Inflammation of the pleural space induces the production of innate IgM from B cells residing in FALCs, and causes fluid phase macrophages to divide locally, however it is unclear how these two responses are interlinked. We are working to uncover the mechanism by which macrophages detect IgM, in the context of allergic airway inflammation, parasite infection and cancer.

Selected Publications

Stromal cells covering omental fat-associated lymphoid clusters trigger the formation of neutrophil aggregates to capture peritoneal contaminants
Jackson-Jones, L., Smith, P., Portman, J., Magalhaes, M.S., Mylonas, K., Vermeren, M., Nixon, M., Henderson, B., Dobie, R., Vermeren, S., Denby, L., Henderson, N., Mole, D., Bénézech, C. 14/04/2020 In: Immunity. 52, 4, p. 700-715. 16 p.
Journal article

FALC stromal cells define a unique immunological niche for the surveillance of serous cavities
Jackson-Jones, L., Benezech, C. 1/06/2020
Review article

Fat-associated lymphoid clusters control local IgM secretion during pleural infection and lung inflammation
Jackson-Jones, L.H., Duncan, S.M., Magalhaes, M.S., Campbell, S.M., Maizels, R.M., McSorley, H.J., Allen, J.E., Bénézech, C. 1/09/2016 In: Nature Communications. 7, 14 p.
Journal article

Local amplifiers of IL-4Rα-mediated macrophage activation promote repair in lung and liver
Minutti, C.M., Jackson-Jones, L.H., García-Fojeda, B., Knipper, J.A., Sutherland, T.E., Logan, N., Ringqvist, E., Guillamat-Prats, R., Ferenbach, D.A., Artigas, A., Stamme, C., Chroneos, Z.C., Zaiss, D.M., Casals, C., Allen, J.E. 9/06/2017 In: Science. 356, 6342, p. 1076-1080. 5 p.
Journal article

IL-33 delivery induces serous cavity macrophage proliferation independent of interleukin-4 receptor alpha
Jackson-Jones, L.H., Rückerl, D., Svedberg, F., Duncan, S., Maizels, R.M., Sutherland, T.E., Jenkins, S.J., McSorley, H.J., Bénézech, C., MacDonald, A.S., Allen, J.E. 11/10/2016 In: European Journal of Immunology. 46, 10, p. 2311-2321. 11 p.
Journal article

Alternatively activated dendritic cells regulate CD4+ T-cell polarization in vitro and in vivo
Cook, P.C., Jones, L.H., Jenkins, S.J., Wynn, T.A., Allen, J.E., MacDonald, A.S. 19/06/2012 In: Proceedings of the National Academy of Sciences of the United States of America. 109, 25, p. 9977-9982. 6 p.
Journal article

Ulverston Victoria High School
School Engagement

Masters by research viva
Examination

PhD Viva
Examination

Biology society invited talk
Oral presentation

Understanding the Local Immune response in malignant pleural mesothelioma
Invited talk

British Society for Immunology Congress 2021
Participation in conference -Mixed Audience

Immunologists in Conversation with the Grizedale Principal
Other

PhD Viva
Examination

Single cell RNA-sequencing and spatial analysis of fat-associated lymphoid clusters of the omentum reveals novel facets of the stromal-immune axis within the peritoneal cavity 
Invited talk

Orchestration of body cavity inflammation by Fat Associated Lymphoid Clusters
Invited talk

Fat associated lymphoid clusters: co-ordinators of mesothelioma-like inflammation
Invited talk

Fat associated lymphoid clusters: co-ordinators of body cavity inflammation?
Invited talk

IgM is required for expansion of macrophages in the pleural cavity during Litomosoides sigmodontis infection
Oral presentation

Woodshole Immuno-parasitology meeting 2021
Other

Broughton-in-Furness C of E Primary & Nursery school
School Engagement

British Society for Immunology Congress 2019
Participation in conference -Mixed Audience

Fat associated lymphoid clusters: co-ordinators of body cavity immune responses?
Invited talk

The Beatson Institute for Cancer Research, Glasgow G61 1BD, UK.
Visiting an external academic institution

Keeping Macrophages dividing: Is IgM required for normal macrophage metabolism? 
Invited talk

Fat Associated Lymphoid Clusters, IgM and IL-4 dependent expansion of pleural cavity macrophages
Invited talk

Richard Grencis
Hosting an academic visitor

Broughton-in-Furness C of E Primary & Nursery school
School Engagement