Dr Lucy Jackson-Jones

Lecturer in Biomedicine

Research Overview

My laboratory focuses on 'Local immune responses' that occur within the thoracic cavity. In particular the interaction of the macrophages of the pleural cavity and fat associated lymphoid clusters of the pericardium and mediastinum. Inflammation of the pleural space induces the production of innate IgM from B cells residing in FALCs, and causes fluid phase macrophages to divide locally, however it is unclear how these two responses are interlinked. We will uncover the mechanism by which macrophages detect IgM, in the context of allergic airway inflammation, parasite infection and cancer.

Selected Publications

Neutrophils mediate the capture of peritoneal contaminants by fat-associated lymphoid clusters of the omentum
Jackson-Jones, L., Smith, P., Magalhaes, M., Portman, J., Mylonas, K., Nixon, M., Dobie, R., Henderson, B., Henderson, N., Mole, D., Benezech, C. 19/09/2019 In: Biorxiv.
Journal article

Fat-associated lymphoid clusters control local IgM secretion during pleural infection and lung inflammation
Jackson-Jones, L.H., Duncan, S.M., Magalhaes, M.S., Campbell, S.M., Maizels, R.M., McSorley, H.J., Allen, J.E., Bénézech, C. 1/09/2016 In: Nature Communications. 7, 14 p.
Journal article

Local amplifiers of IL-4Rα-mediated macrophage activation promote repair in lung and liver
Minutti, C.M., Jackson-Jones, L.H., García-Fojeda, B., Knipper, J.A., Sutherland, T.E., Logan, N., Ringqvist, E., Guillamat-Prats, R., Ferenbach, D.A., Artigas, A., Stamme, C., Chroneos, Z.C., Zaiss, D.M., Casals, C., Allen, J.E. 9/06/2017 In: Science. 356, 6342, p. 1076-1080. 5 p.
Journal article

ILC2 orchestration of local immune function in adipose tissue: ILC2 orchestration of immune adipose function
Benezech, C., Jackson-Jones, L. 7/02/2019
Review article

IL-33 delivery induces serous cavity macrophage proliferation independent of interleukin-4 receptor alpha
Jackson-Jones, L.H., Rückerl, D., Svedberg, F., Duncan, S., Maizels, R.M., Sutherland, T.E., Jenkins, S.J., McSorley, H.J., Bénézech, C., MacDonald, A.S., Allen, J.E. 11/10/2016 In: European Journal of Immunology. 46, 10, p. 2311-2321. 11 p.
Journal article

Alternatively activated dendritic cells regulate CD4+ T-cell polarization in vitro and in vivo
Cook, P.C., Jones, L.H., Jenkins, S.J., Wynn, T.A., Allen, J.E., MacDonald, A.S. 19/06/2012 In: Proceedings of the National Academy of Sciences. 109, 25, p. 9977-9982. 6 p.
Journal article