Dr Lucy Jackson-Jones
Senior Lecturer in ImmunologyResearch Overview
My laboratory focuses on 'Local immune responses' that occur within the thoracic cavity. In particular the interaction of the macrophages of the pleural cavity and fat associated lymphoid clusters of the pericardium and mediastinum. Inflammation of the pleural space induces the production of innate IgM from B cells residing in FALCs, and causes fluid phase macrophages to divide locally, however it is unclear how these two responses are interlinked. We are working to uncover the mechanism by which macrophages detect IgM, in the context of allergic airway inflammation, parasite infection and cancer.
PhD Supervision Interests
I would be happy to hear from prospective students at MSc by Research or PhD level to discuss supervision of projects in the fields of Immunology and Inflammation research. My group works on fat associated lymphoid clusters and investigates how such novel immune structures co ordinate body cavity immune responses during allergy, infection and disease. Projects include 1. Investigations into the role of locally produced chemokines in mesothelioma like inflammation in the pleural space 2. Understanding how macrophages recognise oxidised phospholipids 3. Investigating the role of FALCs in activation of a local immune response against multi-cellular parasites such as Schistosoma mansoni and Trypanosoma brucei. 4. Understanding how antibodies control macrophage lipid usage during inflammation.
Selected Publications
Stromal cells covering omental fat-associated lymphoid clusters trigger the formation of neutrophil aggregates to capture peritoneal contaminants
Jackson-Jones, L., Smith, P., Portman, J., Magalhaes, M.S., Mylonas, K., Vermeren, M., Nixon, M., Henderson, B., Dobie, R., Vermeren, S., Denby, L., Henderson, N., Mole, D., Bénézech, C. 14/04/2020 In: Immunity. 52, 4, p. 700-715. 16 p.
Journal article
FALC stromal cells define a unique immunological niche for the surveillance of serous cavities
Jackson-Jones, L., Benezech, C. 1/06/2020
Review article
Fat-associated lymphoid clusters control local IgM secretion during pleural infection and lung inflammation
Jackson-Jones, L.H., Duncan, S.M., Magalhaes, M.S., Campbell, S.M., Maizels, R.M., McSorley, H.J., Allen, J.E., Bénézech, C. 1/09/2016 In: Nature Communications. 7, 14 p.
Journal article
Local amplifiers of IL-4Rα-mediated macrophage activation promote repair in lung and liver
Minutti, C.M., Jackson-Jones, L.H., García-Fojeda, B., Knipper, J.A., Sutherland, T.E., Logan, N., Ringqvist, E., Guillamat-Prats, R., Ferenbach, D.A., Artigas, A., Stamme, C., Chroneos, Z.C., Zaiss, D.M., Casals, C., Allen, J.E. 9/06/2017 In: Science. 356, 6342, p. 1076-1080. 5 p.
Journal article
IL-33 delivery induces serous cavity macrophage proliferation independent of interleukin-4 receptor alpha
Jackson-Jones, L.H., Rückerl, D., Svedberg, F., Duncan, S., Maizels, R.M., Sutherland, T.E., Jenkins, S.J., McSorley, H.J., Bénézech, C., MacDonald, A.S., Allen, J.E. 11/10/2016 In: European Journal of Immunology. 46, 10, p. 2311-2321. 11 p.
Journal article
Alternatively activated dendritic cells regulate CD4+ T-cell polarization in vitro and in vivo
Cook, P.C., Jones, L.H., Jenkins, S.J., Wynn, T.A., Allen, J.E., MacDonald, A.S. 19/06/2012 In: Proceedings of the National Academy of Sciences of the United States of America. 109, 25, p. 9977-9982. 6 p.
Journal article
All Publications
A comprehensive study of dysfunctional HDL to identify markers for cardiovascular disease status and risk
01/12/2023 → 30/11/2026
Research
REMIT: Reconstructing the In Vivo Evolution of Mesothelioma for Improved Therapy
01/04/2023 → 31/03/2028
Research
Mesothelioma Disease Evolution (CRUK Discovery Award supplement - REMIT)
01/02/2023 → 31/01/2024
Research
Tropism, Immunity and Pathology in African sleeping sickness (HAT-TIP)
01/01/2022 → 30/09/2022
Research
Local oxidised phospholipids within the pleural cavity: fuelling macrophage response during inflammation?
01/10/2021 → 30/09/2024
Research
NWCR Summer Studentship Renewal
01/07/2021 → 30/09/2021
Research
The local immune response in malignant pleural mesothelioma
01/07/2021 → 31/12/2024
Research
EPSRC Core Equipment 2020
14/11/2020 → 13/05/2022
Research
How is the immune system alerted to persistent replication stress and DNA damage in keratinocytes during immunosurveillance against cutaneous squamous cell carcinoma?
01/10/2019 → 30/09/2024
Research
Investigation of the immune response that occurs during mesothelioma
01/08/2019 → 30/01/2023
Research
Keeping macrophages alive: sensing IgM for survival
01/04/2019 → 01/07/2022
Research
Keeping macrophages alive: sensing IgM for survival
01/04/2019 → 01/10/2021
Research
The STEM Village Immunology Symposium
Symposium
UlverSTEM 2024
Types of Public engagement and outreach - Festival/Exhibition
PhD Viva
Examination
1st European ImmunoMetabolism Conference
Participation in conference - Academic
Collaboration cafe on tour - STEM outreach for younger children
Invited talk
Vilnius University (Lithuania)
Visiting an external academic institution
IgM is a regulator of pleural cavity macrophage metabolism
Invited talk
Broughton-in-Furness C of E Primary & Nursery school
School Engagement
BLS at Furness STEM Show 2024
Types of Public engagement and outreach - Festival/Exhibition
British Society for Immunology Congress 2023
Participation in conference - Academic
British Society for Immunology Congress 2023
Participation in conference - Academic
British Society for Immunology Congress 2023
Participation in conference - Academic
UlverSTEM 2023
Types of Public engagement and outreach - Festival/Exhibition
PhD Viva
Examination
Microbes, Pathogens & Immunity
Invited talk
Catalyst MPI Grant writing workshop
Participation in workshop, seminar, course
British Society for Parasitology Spring Meeting 2023 Edinburgh
Participation in conference - Academic
British Society for Parasitology Spring Meeting 2023 Edinburgh
Participation in conference - Academic
FURNESS STEM SHOW 2023
Other
PhD Viva
Examination
Ulverston Victoria High School
School Engagement
UlverSTEM 2022
Types of Public engagement and outreach - Festival/Exhibition
IgM facilitates pleural macrophage lipid acquisition during type-2 infection & inflammation
Oral presentation
Masters by research viva
Examination
PhD Viva
Examination
Biology society invited talk
Oral presentation
Understanding the Local Immune response in malignant pleural mesothelioma
Invited talk
British Society for Immunology Congress 2021
Participation in conference -Mixed Audience
Immunologists in Conversation with the Grizedale Principal
Other
PhD Viva
Examination
Orchestration of body cavity inflammation by Fat Associated Lymphoid Clusters
Invited talk
Fat associated lymphoid clusters: co-ordinators of mesothelioma-like inflammation
Invited talk
Fat associated lymphoid clusters: co-ordinators of body cavity inflammation?
Invited talk
IgM is required for expansion of macrophages in the pleural cavity during Litomosoides sigmodontis infection
Oral presentation
Woodshole Immuno-parasitology meeting 2021
Other
Broughton-in-Furness C of E Primary & Nursery school
School Engagement
British Society for Immunology Congress 2019
Participation in conference -Mixed Audience
Fat associated lymphoid clusters: co-ordinators of body cavity immune responses?
Invited talk
The Beatson Institute for Cancer Research, Glasgow G61 1BD, UK.
Visiting an external academic institution
Keeping Macrophages dividing: Is IgM required for normal macrophage metabolism?
Invited talk
Fat Associated Lymphoid Clusters, IgM and IL-4 dependent expansion of pleural cavity macrophages
Invited talk
Richard Grencis
Hosting an academic visitor
Broughton-in-Furness C of E Primary & Nursery school
School Engagement
External examiner PhD Viva
Examination
- Cancer Biology and Genome Stability
- Microbes, Pathogens and Immunity